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    Mark Ginsberg

    Address9500 Gilman Drive #0726
    CA La Jolla 92093
    Phone858-822-6432
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Mark H. Ginsberg is a professor of medicine and director of the Physician-Scientist Training Pathway at UC San Diego. Dr. Ginsberg moved his research laboratory from the Scripps Research Institute to the Department of Medicine at the University of California, San Diego in July 2004.

      Research Interests
      Molecular structure and function of integrins in immune responses.

      Education and Training
      Psychology - McGill University, Montreal, Canada - 1965
      MD (Summa cum laude) - State University of NY - 1970
      Intern/Resident - University of Chicago - 1970-1973
      Rheumatology Fellow - University of Chicago - 1973-1975


      Collapse Research 
      Collapse Research Activities and Funding
      Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis
      NIH P01NS092521Sep 1, 2015 - Jun 30, 2020
      Role: Co-Investigator
      Tilting the Balance of Integrin Activation
      NIH/NHLBI R01HL126844Apr 2, 2015 - Mar 31, 2019
      Role: Principal Investigator
      Composition and Functions of the Integrin Activation Complex
      NIH/NHLBI R01HL117807May 1, 2014 - Apr 30, 2018
      Role: Principal Investigator
      KRIT1 and Vascular Integrity
      NIH/NHLBI R01HL106489Jan 3, 2011 - Dec 31, 2020
      Role: Principal Investigator
      Assembly, dynamics and evolution of cell-cell and cell-matrix adhesions
      NIH U01GM094663Sep 30, 2010 - Jun 30, 2015
      Role: Co-Investigator
      Assay Development for HT Molecular Screening for Inhibitors of Integrin Signaling
      NIH/NINDS R21NS059433Sep 30, 2007 - Aug 31, 2008
      Role: Principal Investigator
      alpha4beta1 Intergrin Signaling In Immunity And Arthritis
      NIH/NIAMS R01AR052367Jul 1, 2007 - May 31, 2012
      Role: Principal Investigator
      Blood Cells in Hemostasis and Thrombosis
      NIH/NHLBI T32HL086344Jan 1, 2007 - Apr 30, 2019
      Role: Principal Investigator
      Regulation of Fibronectin Matrix Assembly
      NIH/NHLBI R01HL080529Apr 1, 2005 - Aug 31, 2005
      Role: Principal Investigator
      Cell Adhesion Mechanisms in Vascular Disease & Thrombosis
      NIH/NHLBI P01HL078784Dec 1, 2004 - Apr 30, 2020
      Role: Principal Investigator
      A Proteomics Research Resource for Integrative Biology
      NIH P41RR018522Sep 15, 2003 - Jun 30, 2013
      Role: Co-Investigator
      Cytoplasmic Regulation of a4b1 Avidity under Flow
      NIH/FIC R03TW006425Jul 1, 2003 - Jun 30, 2007
      Role: Principal Investigator
      Cell Migration Consortium
      NIH U54GM064346Sep 15, 2001 - Jul 31, 2014
      Role: Co-Investigator
      Integrin Signaling in Hemostasis and Blood Diseases
      NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
      Role: Co-Investigator
      GORDON CONFERENCE--FIBRONECTIN AND MACROMOLECULES
      NIH/NHLBI R13HL049091Feb 1, 1993 - Jan 31, 1994
      Role: Principal Investigator
      CELL ADHESION MECHANISMS IN VASCULAR DISEASE
      NIH/NHLBI P01HL048728Sep 30, 1992 - Aug 31, 2004
      Role: Principal Investigator
      VASCULAR BIOLOGY, THROMBOSIS, AND HEMOSTASIS
      NIH/NHLBI T32HL007695Jul 1, 1991 - Jun 30, 2007
      Role: Principal Investigator
      Thrombus Formation and Antithrombotic Intervention
      NIH/NHLBI P01HL031950Apr 1, 1984 - Jun 30, 2016
      Role: Co-Investigator
      FIBRONECTIN AND PLATELETS
      NIH/NHLBI R01HL028235Jan 1, 1982 - Jun 30, 1996
      Role: Principal Investigator
      Regulation of Integrin Alpha4 Betal
      NIH/NIAMS R01AR027214Aug 1, 1980 - Nov 30, 2011
      Role: Principal Investigator
      PLATELETS IN RHEUMATIC DISEASE
      NIH/NIAMS R37AR027214Aug 1, 1980 - Jan 31, 2001
      Role: Principal Investigator
      GENERAL CLINICAL RESEARCH CENTER
      NIH M01RR000833Dec 1, 1977 - Sep 30, 2005
      Role: Co-Investigator

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      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Klann JE, Remedios KA, Kim SH, Metz PJ, Lopez J, Mack LA, Zheng Y, Ginsberg M, Petrich BG, Chang JT. Talin Plays a Critical Role in the Maintenance of the Regulatory T Cell Pool. J Immunol. 2017 Jun 15; 198(12):4639-4651. PMID: 28515282.
        View in: PubMed
      2. Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg M, Ruggeri ZM, Ruf W. Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arterioscler Thromb Vasc Biol. 2017 Jul; 37(7):1323-1331. PMID: 28495929.
        View in: PubMed
      3. Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg M, Kim C. Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. J Biol Chem. 2017 Jun 16; 292(24):9858-9864. PMID: 28487468.
        View in: PubMed
      4. Lagarrigue F, Gertler FB, Ginsberg M, Cantor JM. Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. J Immunol. 2017 May 01; 198(9):3410-3415. PMID: 28348273.
        View in: PubMed
      5. Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg M, Reya T. CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. Cancer Cell. 2016 Nov 14; 30(5):792-805. PMID: 27908736.
        View in: PubMed
      6. Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K. Neutrophil recruitment limited by high-affinity bent ß2 integrin binding ligand in cis. Nat Commun. 2016; 7:12658. PMID: 27578049.
        View in: PubMed
      7. Abplanalp WT, Conklin DJ, Cantor JM, Ginsberg M, Wysoczynski M, Bhatnagar A, O'Toole TE. Enhanced Integrin a4ß1-Mediated Adhesion Contributes to a Mobilization Defect of Endothelial Progenitor Cells in Diabetes. Diabetes. 2016 Aug 5. PMID: 27495221.
        View in: PubMed
      8. Schmidt T, Ye F, Situ AJ, An W, Ginsberg M, Ulmer TS. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 Aug 19; 291(34):17536-46. PMID: 27365391.
        View in: PubMed
      9. Lagarrigue F, Kim C, Ginsberg M. The Rap1-RIAM-talin axis of integrin activation and blood cell function. Blood. 2016 Jul 28; 128(4):479-87. PMID: 27207789.
        View in: PubMed
      10. de la Ballina LR, Cano-Crespo S, González-Muñoz E, Bial S, Estrach S, Cailleteau L, Tissot F, Daniel H, Zorzano A, Ginsberg M, Palacín M, Féral CC. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. J Biol Chem. 2016 Apr 29; 291(18):9700-11. PMID: 26945935.
        View in: PubMed
      11. de Kreuk BJ, Gingras AR, Knight JD, Liu JJ, Gingras AC, Ginsberg M. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. Elife. 2016; 5. PMID: 26780829.
        View in: PubMed
      12. Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg M, Goldfinger LE. RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes. Biochem Biophys Res Commun. 2015 Nov 27; 467(4):785-91. PMID: 26498519.
        View in: PubMed
      13. Lagarrigue F, Vikas Anekal P, Lee HS, Bachir AI, Ablack JN, Horwitz AF, Ginsberg M. A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nat Commun. 2015; 6:8492. PMID: 26419705.
        View in: PubMed
      14. Dai A, Ye F, Taylor DW, Hu G, Ginsberg M, Taylor KA. The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem. 2015 Nov 6; 290(45):27168-75. PMID: 26391523.
        View in: PubMed
      15. Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg M, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure. 2015 Sep 1; 23(9):1563-72. PMID: 26278174.
        View in: PubMed
      16. Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg M, McEver RP. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med. 2015 Jul 27; 212(8):1267-81. PMID: 26169939.
        View in: PubMed
      17. Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg M, Ruggeri ZM, Ruf W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. J Clin Invest. 2015 Apr; 125(4):1471-84. PMID: 25705884.
        View in: PubMed
      18. Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg M, Ulmer TS. Annular anionic lipids stabilize the integrin aIIbß3 transmembrane complex. J Biol Chem. 2015 Mar 27; 290(13):8283-93. PMID: 25632962.
        View in: PubMed
      19. Cantor JM, Rose DM, Slepak M, Ginsberg M. Fine-tuning Tumor Immunity with Integrin Trans-regulation. Cancer Immunol Res. 2015 Jun; 3(6):661-7. PMID: 25600437.
        View in: PubMed
      20. Hayes GM, Chinn L, Cantor JM, Cairns B, Levashova Z, Tran H, Velilla T, Duey D, Lippincott J, Zachwieja J, Ginsberg M, H van der Horst E. Antitumor activity of an anti-CD98 antibody. Int J Cancer. 2015 Aug 1; 137(3):710-20. PMID: 25556716.
        View in: PubMed
      21. Liao Z, Kato H, Pandey M, Cantor JM, Ablooglu AJ, Ginsberg M, Shattil SJ. Interaction of kindlin-2 with integrin ß3 promotes outside-in signaling responses by the aVß3 vitronectin receptor. Blood. 2015 Mar 19; 125(12):1995-2004. PMID: 25587038.
        View in: PubMed
      22. Ginsberg M. Integrin activation. BMB Rep. 2014 Dec; 47(12):655-9. PMID: 25388208.
        View in: PubMed
      23. Estrach S, Lee SA, Boulter E, Pisano S, Errante A, Tissot FS, Cailleteau L, Pons C, Ginsberg M, Féral CC. CD98hc (SLC3A2) loss protects against ras-driven tumorigenesis by modulating integrin-mediated mechanotransduction. Cancer Res. 2014 Dec 1; 74(23):6878-89. PMID: 25267066.
        View in: PubMed
      24. Ye F, Lagarrigue F, Ginsberg M. SnapShot: Talin and the Modular Nature of the Integrin Adhesome. Cell. 2014 Mar 13; 156(6):1340-1340.e1. PMID: 24630731.
        View in: PubMed
      25. Kasirer-Friede A, Kang J, Kahner B, Ye F, Ginsberg M, Shattil SJ. ADAP interactions with talin and kindlin promote platelet integrin aIIbß3 activation and stable fibrinogen binding. Blood. 2014 May 15; 123(20):3156-65. PMID: 24523237.
        View in: PubMed
      26. Ye F, Snider AK, Ginsberg M. Talin and kindlin: the one-two punch in integrin activation. Front Med. 2014 Mar; 8(1):6-16. PMID: 24477625.
        View in: PubMed
      27. Spiegler S, Najm J, Liu J, Gkalympoudis S, Schröder W, Borck G, Brockmann K, Elbracht M, Fauth C, Ferbert A, Freudenberg L, Grasshoff U, Hellenbroich Y, Henn W, Hoffjan S, Hüning I, Korenke GC, Kroisel PM, Kunstmann E, Mair M, Munk-Schulenburg S, Nikoubashman O, Pauli S, Rudnik-Schöneborn S, Sudholt I, Sure U, Tinschert S, Wiednig M, Zoll B, Ginsberg M, Felbor U. High mutation detection rates in cerebral cavernous malformation upon stringent inclusion criteria: one-third of probands are minors. Mol Genet Genomic Med. 2014 Mar; 2(2):176-85. PMID: 24689081.
        View in: PubMed
      28. Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fässler R, Ginsberg M. The Mechanism of Kindlin-Mediated Activation of Integrin aIIbß3. Curr Biol. 2013 Nov 18; 23(22):2288-95. PMID: 24210614.
        View in: PubMed
      29. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg M. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710.
        View in: PubMed
      30. Gingras AR, Puzon-McLaughlin W, Ginsberg M. The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail. J Biol Chem. 2013 Aug 16; 288(33):23639-49. PMID: 23814056.
        View in: PubMed
      31. Lee HS, Anekal P, Lim CJ, Liu CC, Ginsberg M. Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell. 2013 May; 24(9):1354-62. PMID: 23468527.
        View in: PubMed
      32. Gingras AR, Ye F, Ginsberg M. Reconstructing integrin activation in vitro. Methods Mol Biol. 2013; 1046:1-17. PMID: 23868579.
        View in: PubMed
      33. Zou W, Izawa T, Zhu T, Chappel J, Otero K, Monkley SJ, Critchley DR, Petrich BG, Morozov A, Ginsberg M, Teitelbaum SL. Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol. 2013 Feb; 33(4):830-44. PMID: 23230271.
        View in: PubMed
      34. Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg M, Collard JG, Kaibuchi K. Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol. 2012 Oct 15; 199(2):331-45. PMID: 23071154.
        View in: PubMed
      35. Gingras AR, Liu JJ, Ginsberg M. Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. J Cell Biol. 2012 Oct 1; 199(1):39-48. PMID: 23007647.
        View in: PubMed
      36. Kim C, Ye F, Hu X, Ginsberg M. Talin activates integrins by altering the topology of the ß transmembrane domain. J Cell Biol. 2012 May 28; 197(5):605-11. PMID: 22641344.
        View in: PubMed
      37. Kahner BN, Kato H, Banno A, Ginsberg M, Shattil SJ, Ye F. Kindlins, integrin activation and the regulation of talin recruitment to aIIbß3. PLoS One. 2012; 7(3):e34056. PMID: 22457811.
        View in: PubMed
      38. Lefort CT, Rossaint J, Moser M, Petrich BG, Zarbock A, Monkley SJ, Critchley DR, Ginsberg M, Fässler R, Ley K. Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood. 2012 May 3; 119(18):4275-82. PMID: 22431571.
        View in: PubMed
      39. Cantor JM, Ginsberg M. CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci. 2012 Mar 15; 125(Pt 6):1373-82. PMID: 22499670.
        View in: PubMed
      40. Banno A, Goult BT, Lee H, Bate N, Critchley DR, Ginsberg M. Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem. 2012 Apr 20; 287(17):13799-812. PMID: 22351767.
        View in: PubMed
      41. Kim C, Schmidt T, Cho EG, Ye F, Ulmer TS, Ginsberg M. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 2012 Jan 12; 481(7380):209-13. PMID: 22178926.
        View in: PubMed
      42. Kim J, Sherman NE, Fox JW, Ginsberg M. Phosphorylation sites in the cerebral cavernous malformations complex. J Cell Sci. 2011 Dec 1; 124(Pt 23):3929-32. PMID: 22194303.
        View in: PubMed
      43. McDonald DA, Shi C, Shenkar R, Stockton RA, Liu F, Ginsberg M, Marchuk DA, Awad IA. Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke. 2012 Feb; 43(2):571-4. PMID: 22034008.
        View in: PubMed
      44. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg M, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031.
        View in: PubMed
      45. Ye F, Kim C, Ginsberg M. Reconstruction of integrin activation. Blood. 2012 Jan 5; 119(1):26-33. PMID: 21921044.
        View in: PubMed
      46. Ye F, Kim C, Ginsberg M. Molecular mechanism of inside-out integrin regulation. J Thromb Haemost. 2011 Jul; 9 Suppl 1:20-5. PMID: 21781238.
        View in: PubMed
      47. Sundd P, Gutierrez E, Petrich BG, Ginsberg M, Groisman A, Ley K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011 Jul; 18(5):361-72. PMID: 21418380.
        View in: PubMed
      48. Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg M, Cheresh DA, Hirsch E, Field SJ, Varner JA. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression. Cancer Cell. 2011 Jun 14; 19(6):715-27. PMID: 21665146.
        View in: PubMed
      49. Cantor J, Slepak M, Ege N, Chang JT, Ginsberg M. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol. 2011 Jul 15; 187(2):851-60. PMID: 21670318.
        View in: PubMed
      50. Kim C, Ye F, Ginsberg M. Regulation of integrin activation. Annu Rev Cell Dev Biol. 2011; 27:321-45. PMID: 21663444.
        View in: PubMed
      51. Liu JJ, Stockton RA, Gingras AR, Ablooglu AJ, Han J, Bobkov AA, Ginsberg M. A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell. 2011 Jul 15; 22(14):2509-19. PMID: 21633110.
        View in: PubMed
      52. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg M. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420.
        View in: PubMed
      53. Ring C, Ginsberg M, Haling J, Pendergast AM. Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A. 2011 Jan 4; 108(1):149-54. PMID: 21173240.
        View in: PubMed
      54. Monkley SJ, Kostourou V, Spence L, Petrich B, Coleman S, Ginsberg M, Pritchard CA, Critchley DR. Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol. 2011 Jan 15; 349(2):494-502. PMID: 21081121.
        View in: PubMed
      55. McDonald DA, Shenkar R, Shi C, Stockton RA, Akers AL, Kucherlapati MH, Kucherlapati R, Brainer J, Ginsberg M, Awad IA, Marchuk DA. A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet. 2011 Jan 15; 20(2):211-22. PMID: 20940147.
        View in: PubMed
      56. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. PMID: 20388801.
        View in: PubMed
      57. Shattil SJ, Kim C, Ginsberg M. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):288-300. PMID: 20308986.
        View in: PubMed
      58. Stockton RA, Shenkar R, Awad IA, Ginsberg M. Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med. 2010 Apr 12; 207(4):881-96. PMID: 20308363.
        View in: PubMed
      59. Kummer C, Petrich BG, Rose DM, Ginsberg M. A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem. 2010 Mar 26; 285(13):9462-9. PMID: 20097761.
        View in: PubMed
      60. Ye F, Hu G, Taylor D, Ratnikov B, Bobkov AA, McLean MA, Sligar SG, Taylor KA, Ginsberg M. Recreation of the terminal events in physiological integrin activation. J Cell Biol. 2010 Jan 11; 188(1):157-73. PMID: 20048261.
        View in: PubMed
      61. Haling JR, Wang F, Ginsberg M. Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. Mol Biol Cell. 2010 Feb 15; 21(4):664-73. PMID: 20032303.
        View in: PubMed
      62. Glading AJ, Ginsberg M. Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech. 2010 Jan-Feb; 3(1-2):73-83. PMID: 20007487.
        View in: PubMed
      63. Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg M, Campbell ID. Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem. 2009 Dec 25; 284(52):36700-10. PMID: 19843520.
        View in: PubMed
      64. Fogelstrand P, Féral CC, Zargham R, Ginsberg M. Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2). J Exp Med. 2009 Oct 26; 206(11):2397-406. PMID: 19841087.
        View in: PubMed
      65. Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg M, Li DY. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol. 2009 Nov; 11(11):1325-31. PMID: 19855388.
        View in: PubMed
      66. Anthis NJ, Wegener KL, Ye F, Kim C, Goult BT, Lowe ED, Vakonakis I, Bate N, Critchley DR, Ginsberg M, Campbell ID. The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J. 2009 Nov 18; 28(22):3623-32. PMID: 19798053.
        View in: PubMed
      67. Huang C, Rajfur Z, Yousefi N, Chen Z, Jacobson K, Ginsberg M. Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol. 2009 May; 11(5):624-30. PMID: 19363486.
        View in: PubMed
      68. Lau TL, Kim C, Ginsberg M, Ulmer TS. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J. 2009 May 6; 28(9):1351-61. PMID: 19279667.
        View in: PubMed
      69. Cantor J, Browne CD, Ruppert R, Féral CC, Fässler R, Rickert RC, Ginsberg M. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol. 2009 Apr; 10(4):412-9. PMID: 19270713.
        View in: PubMed
      70. Kim C, Lau TL, Ulmer TS, Ginsberg M. Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood. 2009 May 7; 113(19):4747-53. PMID: 19218549.
        View in: PubMed
      71. Tkachenko E, Gutierrez E, Ginsberg M, Groisman A. An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip. 2009 Apr 21; 9(8):1085-95. PMID: 19350090.
        View in: PubMed
      72. Gingras AR, Ziegler WH, Bobkov AA, Joyce MG, Fasci D, Himmel M, Rothemund S, Ritter A, Grossmann JG, Patel B, Bate N, Goult BT, Emsley J, Barsukov IL, Roberts GC, Liddington RC, Ginsberg M, Critchley DR. Structural determinants of integrin binding to the talin rod. J Biol Chem. 2009 Mar 27; 284(13):8866-76. PMID: 19176533.
        View in: PubMed
      73. Kleaveland B, Zheng X, Liu JJ, Blum Y, Tung JJ, Zou Z, Sweeney SM, Chen M, Guo L, Lu MM, Zhou D, Kitajewski J, Affolter M, Ginsberg M, Kahn ML. Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med. 2009 Feb; 15(2):169-76. PMID: 19151727.
        View in: PubMed
      74. Lee HS, Lim CJ, Puzon-McLaughlin W, Shattil SJ, Ginsberg M. RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem. 2009 Feb 20; 284(8):5119-27. PMID: 19098287.
        View in: PubMed
      75. Ablooglu AJ, Kang J, Petrich BG, Ginsberg M, Shattil SJ. Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood. 2009 Apr 9; 113(15):3585-92. PMID: 19005179.
        View in: PubMed
      76. Verhaar R, Dekkers DW, De Cuyper IM, Ginsberg M, de Korte D, Verhoeven AJ. UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood. 2008 Dec 15; 112(13):4935-9. PMID: 18796633.
        View in: PubMed
      77. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg M. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell. 2008 Nov; 19(11):4930-41. PMID: 18784251.
        View in: PubMed
      78. Ginsberg M, Schwarzbauer JE. Cell-to-cell contact and extracellular matrix. Curr Opin Cell Biol. 2008 Oct; 20(5):492-4. PMID: 18656543.
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      84. Féral CC, Neels JG, Kummer C, Slepak M, Olefsky JM, Ginsberg M. Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes. 2008 Jul; 57(7):1842-51. PMID: 18426864.
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      88. Lee J, Hong J, Nam TG, Peters EC, Orth AP, Geierstanger BH, Goldfinger LE, Ginsberg M, Cho CY, Schultz PG. A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorg Med Chem. 2009 Feb 1; 17(3):977-80. PMID: 18329275.
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      90. Glading A, Han J, Stockton RA, Ginsberg M. KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol. 2007 Oct 22; 179(2):247-54. PMID: 17954608.
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      91. Féral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg M. CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol. 2007 Aug 13; 178(4):701-11. PMID: 17682053.
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      92. Petrich BG, Fogelstrand P, Partridge AW, Yousefi N, Ablooglu AJ, Shattil SJ, Ginsberg M. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest. 2007 Aug; 117(8):2250-9. PMID: 17627302.
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      93. Rose DM, Alon R, Ginsberg M. Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev. 2007 Aug; 218:126-34. PMID: 17624949.
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      96. Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg M, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7444-8. PMID: 17460038.
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      97. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Han J, Haling JR, Sherman NE, Fox JW, Hunt DF, Ginsberg M. An experimentally derived database of candidate Ras-interacting proteins. J Proteome Res. 2007 May; 6(5):1806-11. PMID: 17439166.
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      98. Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg M. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol. 2007 Apr; 9(4):415-21. PMID: 17369818.
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      99. Zou W, Kitaura H, Reeve J, Long F, Tybulewicz VL, Shattil SJ, Ginsberg M, Ross FP, Teitelbaum SL. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007 Mar 12; 176(6):877-88. PMID: 17353363.
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      100. Glading A, Koziol JA, Krueger J, Ginsberg M. PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. Cancer Res. 2007 Feb 15; 67(4):1536-44. PMID: 17308092.
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      102. Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg M. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806. PMID: 16979556.
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      103. Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg M. RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol. 2006 Sep 11; 174(6):877-88. PMID: 16966426.
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      104. Orr AW, Ginsberg M, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell. 2006 Nov; 17(11):4686-97. PMID: 16928957.
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      106. Kummer C, Ginsberg M. New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. Biochem Pharmacol. 2006 Nov 30; 72(11):1460-8. PMID: 16870156.
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      107. Féral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg M. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest. 2006 Mar; 116(3):715-23. PMID: 16470243.
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      108. Alon R, Feigelson SW, Manevich E, Rose DM, Schmitz J, Overby DR, Winter E, Grabovsky V, Shinder V, Matthews BD, Sokolovsky-Eisenberg M, Ingber DE, Benoit M, Ginsberg M. Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol. 2005 Dec 19; 171(6):1073-84. PMID: 16365170.
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      109. Hsia DA, Lim ST, Bernard-Trifilo JA, Mitra SK, Tanaka S, den Hertog J, Streblow DN, Ilic D, Ginsberg M, Schlaepfer DD. Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol. 2005 Nov; 25(21):9700-12. PMID: 16227616.
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      110. Ratnikov B, Ptak C, Han J, Shabanowitz J, Hunt DF, Ginsberg M. Talin phosphorylation sites mapped by mass spectrometry. J Cell Sci. 2005 Nov 1; 118(Pt 21):4921-3. PMID: 16254238.
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      111. Ginsberg M, Partridge A, Shattil SJ. Integrin regulation. Curr Opin Cell Biol. 2005 Oct; 17(5):509-16. PMID: 16099636.
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      113. Krueger J, Chou FL, Glading A, Schaefer E, Ginsberg M. Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell. 2005 Aug; 16(8):3552-61. PMID: 15917297.
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      114. Nishiya N, Kiosses WB, Han J, Ginsberg M. An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol. 2005 Apr; 7(4):343-52. PMID: 15793570.
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      115. Feral CC, Nishiya N, Fenczik CA, Stuhlmann H, Slepak M, Ginsberg M. CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):355-60. PMID: 15625115.
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      116. de Pereda JM, Wegener KL, Santelli E, Bate N, Ginsberg M, Critchley DR, Campbell ID, Liddington RC. Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem. 2005 Mar 4; 280(9):8381-6. PMID: 15623515.
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      117. Partridge AW, Liu S, Kim S, Bowie JU, Ginsberg M. Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. J Biol Chem. 2005 Feb 25; 280(8):7294-300. PMID: 15591321.
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      118. Henderson NC, Collis EA, Mackinnon AC, Simpson KJ, Haslett C, Zent R, Ginsberg M, Sethi T. CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation. J Biol Chem. 2004 Dec 24; 279(52):54731-41. PMID: 15485886.
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      119. Campbell ID, Ginsberg M. The talin-tail interaction places integrin activation on FERM ground. Trends Biochem Sci. 2004 Aug; 29(8):429-35. PMID: 15362227.
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      120. Calderwood DA, Tai V, Di Paolo G, De Camilli P, Ginsberg M. Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem. 2004 Jul 9; 279(28):28889-95. PMID: 15143061.
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      121. Nakamoto T, Kain KH, Ginsberg M. Neurobiology: New connections between integrins and axon guidance. Curr Biol. 2004 Feb 3; 14(3):R121-3. PMID: 14986683.
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      122. Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg M, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science. 2003 Dec 5; 302(5651):1704-9. PMID: 14657486.
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      123. Hansen M, Prior IA, Hughes PE, Oertli B, Chou FL, Willumsen BM, Hancock JF, Ginsberg M. C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution. Biochem Biophys Res Commun. 2003 Nov 28; 311(4):829-38. PMID: 14623256.
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      124. Kloeker S, Major MB, Calderwood DA, Ginsberg M, Jones DA, Beckerle MC. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem. 2004 Feb 20; 279(8):6824-33. PMID: 14634021.
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      125. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg M, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13298-302. PMID: 14593208.
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      126. Tadokoro S, Shattil SJ, Eto K, Tai V, Liddington RC, de Pereda JM, Ginsberg M, Calderwood DA. Talin binding to integrin beta tails: a final common step in integrin activation. Science. 2003 Oct 3; 302(5642):103-6. PMID: 14526080.
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      127. Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg M. Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol. 2003 Oct; 4(10):767-76. PMID: 14570053.
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      128. Chou FL, Hill JM, Hsieh JC, Pouyssegur J, Brunet A, Glading A, Uberall F, Ramos JW, Werner MH, Ginsberg M. PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J Biol Chem. 2003 Dec 26; 278(52):52587-97. PMID: 14506247.
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      129. Goldfinger LE, Han J, Kiosses WB, Howe AK, Ginsberg M. Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol. 2003 Aug 18; 162(4):731-41. PMID: 12913113.
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      130. Calderwood DA, Ginsberg M. Talin forges the links between integrins and actin. Nat Cell Biol. 2003 Aug; 5(8):694-7. PMID: 12894175.
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      131. Ulmer TS, Calderwood DA, Ginsberg M, Campbell ID. Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 2003 Jul 15; 42(27):8307-12. PMID: 12846579.
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      132. Han J, Rose DM, Woodside DG, Goldfinger LE, Ginsberg M. Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem. 2003 Sep 12; 278(37):34845-53. PMID: 12837751.
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      133. Rose DM, Liu S, Woodside DG, Han J, Schlaepfer DD, Ginsberg M. Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15; 170(12):5912-8. PMID: 12794117.
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      134. Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg M. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003 Mar 4; 100(5):2272-7. PMID: 12606711.
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      135. García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg M, Liddington RC. Structural determinants of integrin recognition by talin. Mol Cell. 2003 Jan; 11(1):49-58. PMID: 12535520.
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      136. Hill JM, Vaidyanathan H, Ramos JW, Ginsberg M, Werner MH. Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J. 2002 Dec 2; 21(23):6494-504. PMID: 12456656.
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      137. Riederer MA, Ginsberg M, Steiner B. Blockade of platelet GPIIB-IIIA (Integrin alphaII(b)beta(3)) in flowing human blood leads to passivation of prothrombotic surfaces. Thromb Haemost. 2002 Nov; 88(5):858-64. PMID: 12428106.
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      138. Ambroise Y, Yaspan B, Ginsberg M, Boger DL. Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries. Chem Biol. 2002 Nov; 9(11):1219-26. PMID: 12445772.
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      139. Baker SE, Lorenzen JA, Miller SW, Bunch TA, Jannuzi AL, Ginsberg M, Perkins LA, Brower DL. Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7. Genetics. 2002 Sep; 162(1):285-96. PMID: 12242240.
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      140. Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg M. The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem. 2002 Oct 18; 277(42):39401-8. PMID: 12171941.
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      141. Rose DM, Han J, Ginsberg M. Alpha4 integrins and the immune response. Immunol Rev. 2002 Aug; 186:118-24. PMID: 12234367.
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      142. Hughes PE, Oertli B, Hansen M, Chou FL, Willumsen BM, Ginsberg M. Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase. Mol Biol Cell. 2002 Jul; 13(7):2256-65. PMID: 12134066.
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      143. Hansen M, Rusyn EV, Hughes PE, Ginsberg M, Cox AD, Willumsen BM. R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras. Oncogene. 2002 Jun 27; 21(28):4448-61. PMID: 12080475.
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      144. Lin JY, Pollack JR, Chou FL, Rees CA, Christian AT, Bedford JS, Brown PO, Ginsberg M. Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays. Genome Biol. 2002; 3(6):RESEARCH0026. PMID: 12093373.
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      145. Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg M. The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem. 2002 Jun 14; 277(24):21749-58. PMID: 11932255.
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      146. Schwartz MA, Ginsberg M. Networks and crosstalk: integrin signalling spreads. Nat Cell Biol. 2002 Apr; 4(4):E65-8. PMID: 11944032.
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      147. Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg M. A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem. 2002 Jun 7; 277(23):20887-94. PMID: 11919182.
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      148. Ramos JW, Ginsberg M. Expression cloning strategies for the identification of adhesion molecules. Methods Cell Biol. 2002; 69:209-21. PMID: 12070994.
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