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    Marianna Alperin

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentReproductive Medicine
    Address9500 Gilman Drive #0863
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      St. Louis University, SOM, St. Louis, MOM.D.05/2002Medicine
      Brigham and Women's and MGH Hospitals, Harvard SOM, Boston, MA06/2005Obstetrics and Gynecology
      University of Pittsburgh, Pittsburgh, PAM.S.06/2007Research Design
      Magee Womens Hospital, University of Pittsburgh, Pittsburgh, PA06/2008Female Pelvic Medicine and Reconstructive Surgery

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Injectable Tissue-Specific Extracellular Matrix Hydrogel for Pelvic Skeletal Muscle Regeneration Following Birth Injury
      NIH/NICHD R21HD094566Dec 1, 2017 - Nov 30, 2019
      Role: Principal Investigator
      Mechanisms and impact of pregnancy-induced adaptations in pelvic floor muscles
      NIH R01HD092515Aug 1, 2017 - Apr 30, 2022
      Role: Principal Investigator
      Impact of Aging on Structure and Function of Pelvic Floor Muscles
      NIH R03AG050951Aug 1, 2016 - Apr 30, 2018
      Role: Principal Investigator
      Architectural Design of the Pelvic Floor Skeletal Muscles
      NIH R03HD075994Jun 25, 2013 - May 31, 2015
      Role: Principal Investigator
      UC San Diego Womens Reproductive Health Research Program
      NIH/NICHD K12HD001259Jul 23, 1999 - Jun 30, 2020
      Role: Scholar

      Collapse ORNG Applications 
      Collapse Twitter

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Eilber KS, Alperin M, Khan A, Wu N, Pashos CL, Clemens JQ, Anger JT. The Role of the Surgeon on Outcomes of Vaginal Prolapse Surgery With Mesh. Female Pelvic Med Reconstr Surg. 2017 Sep/Oct; 23(5):293-296. PMID: 28134701.
        View in: PubMed
      2. Stewart AM, Cook MS, Dyer KY, Alperin M. Structure-function relationship of the human external anal sphincter. Int Urogynecol J. 2017 Jul 08. PMID: 28689239.
        View in: PubMed
      3. Stewart AM, Cook MS, Esparza MC, Slayden OD, Alperin M. Architectural assessment of rhesus macaque pelvic floor muscles: comparison for use as a human model. Int Urogynecol J. 2017 Mar 11. PMID: 28285397.
        View in: PubMed
      4. Cook MS, Bou-Malham L, Esparza MC, Alperin M. Age-related alterations in female obturator internus muscle. Int Urogynecol J. 2017 May; 28(5):729-734. PMID: 27704154.
        View in: PubMed
      5. Evans EC, Matteson KA, Orejuela FJ, Alperin M, Balk EM, El-Nashar S, Gleason JL, Grimes C, Jeppson P, Mathews C, Wheeler TL, Murphy M. Salpingo-oophorectomy at the Time of Benign Hysterectomy: A Systematic Review. Obstet Gynecol. 2016 Sep; 128(3):476-85. PMID: 27500347.
        View in: PubMed
      6. Alperin M, Cook M, Tuttle LJ, Esparza MC, Lieber RL. Impact of vaginal parity and aging on the architectural design of pelvic floor muscles. Am J Obstet Gynecol. 2016 Sep; 215(3):312.e1-9. PMID: 26953079; PMCID: PMC5003683 [Available on 09/01/17].
      7. Alperin M, Kaddis T, Pichika R, Esparza MC, Lieber RL. Pregnancy-induced adaptations in intramuscular extracellular matrix of rat pelvic floor muscles. Am J Obstet Gynecol. 2016 Aug; 215(2):210.e1-7. PMID: 26875952.
        View in: PubMed
      8. Alperin M, Lawley DM, Esparza MC, Lieber RL. Pregnancy-induced adaptations in the intrinsic structure of rat pelvic floor muscles. Am J Obstet Gynecol. 2015 Aug; 213(2):191.e1-7. PMID: 25979618; PMCID: PMC4757427.
      9. Batalden RP, Weinstein MM, Foust-Wright C, Alperin M, Wakamatsu MM, Pulliam SJ. Clinical application of IUGA/ICS classification system for mesh erosion. Neurourol Urodyn. 2016 Jun; 35(5):589-94. PMID: 25874639; PMCID: PMC4757498.
      10. Alperin M, Tuttle LJ, Conner BR, Dixon DM, Mathewson MA, Ward SR, Lieber RL. Comparison of pelvic muscle architecture between humans and commonly used laboratory species. Int Urogynecol J. 2014 Nov; 25(11):1507-15. PMID: 24915840; PMCID: PMC4264598.
      11. Alperin M. Collagen scaffold: a treatment for large mesh exposure following vaginal prolapse repair. Int Urogynecol J. 2014 Nov; 25(11):1597-9. PMID: 24832859.
        View in: PubMed
      12. Tuttle LJ, Alperin M, Lieber RL. Post-mortem timing of skeletal muscle biochemical and mechanical degradation. J Biomech. 2014 Apr 11; 47(6):1506-9. PMID: 24589021; PMCID: PMC3992263.
      13. Eilber KS, Alperin M, Khan A, Wu N, Pashos CL, Clemens JQ, Anger JT. Outcomes of vaginal prolapse surgery among female Medicare beneficiaries: the role of apical support. Obstet Gynecol. 2013 Nov; 122(5):981-7. PMID: 24104778; PMCID: PMC3857933.
      14. Frankman EA, Alperin M, Sutkin G, Meyn L, Zyczynski HM. Mesh exposure and associated risk factors in women undergoing transvaginal prolapse repair with mesh. Obstet Gynecol Int. 2013; 2013:926313. PMID: 24194763; PMCID: PMC3782123.
      15. Tuttle LJ, Nguyen OT, Cook MS, Alperin M, Shah SB, Ward SR, Lieber RL. Architectural design of the pelvic floor is consistent with muscle functional subspecialization. Int Urogynecol J. 2014 Feb; 25(2):205-12. PMID: 23903821; PMCID: PMC4104205.
      16. Clemons JL, Weinstein M, Guess MK, Alperin M, Moalli P, Gregory WT, Lukacz ES, Sung VW, Chen BH, Bradley CS. Impact of the 2011 FDA transvaginal mesh safety update on AUGS members' use of synthetic mesh and biologic grafts in pelvic reconstructive surgery. Female Pelvic Med Reconstr Surg. 2013 Jul-Aug; 19(4):191-8. PMID: 23797515.
        View in: PubMed
      17. Khan A, Alperin M, Wu N, Clemens JQ, Dubina E, Pashos CL, Anger JT. Comparative outcomes of open versus laparoscopic sacrocolpopexy among Medicare beneficiaries. Int Urogynecol J. 2013 Nov; 24(11):1883-91. PMID: 23652338; PMCID: PMC3906125.
      18. Alperin M, Khan A, Dubina E, Tarnay C, Wu N, Pashos CL, Anger JT. Patterns of pessary care and outcomes for medicare beneficiaries with pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2013 May-Jun; 19(3):142-7. PMID: 23611931; PMCID: PMC3635496.
      19. Alperin M, Weinstein M, Kivnick S, Duong TH, Menefee S. A randomized trial of prophylactic uterosacral ligament suspension at the time of hysterectomy for Prevention of Vaginal Vault Prolapse (PULS): design and methods. Contemp Clin Trials. 2013 Jul; 35(2):8-12. PMID: 23587538.
        View in: PubMed
      20. Alperin M, Ellison R, Meyn L, Frankman E, Zyczynski HM. Two-year outcomes after vaginal prolapse reconstruction with mesh pelvic floor repair system. Female Pelvic Med Reconstr Surg. 2013 Mar-Apr; 19(2):72-8. PMID: 23442503; PMCID: PMC4261688.
      21. Alperin M, Kivnick S, Poon KY. Outpatient laparoscopic hysterectomy for large uteri. J Minim Invasive Gynecol. 2012 Nov-Dec; 19(6):689-94. PMID: 23084671.
        View in: PubMed
      22. Shepherd JP, Alperin M, Meyn LA, Frankman EA, Zyczynski HM. Now or later...Does timing of a midurethral sling in relation to transvaginal prolapse repair affect continence outcomes at 1 year? Female Pelvic Med Reconstr Surg. 2010 Sep; 16(5):299-303. PMID: 22453509.
        View in: PubMed
      23. Alperin M, Feola A, Meyn L, Duerr R, Abramowitch S, Moalli P. Collagen scaffold: a treatment for simulated maternal birth injury in the rat model. Am J Obstet Gynecol. 2010 Jun; 202(6):589.e1-8. PMID: 20510960; PMCID: PMC2921182.
      24. Alperin M, Feola A, Duerr R, Moalli P, Abramowitch S. Pregnancy- and delivery-induced biomechanical changes in rat vagina persist postpartum. Int Urogynecol J. 2010 Sep; 21(9):1169-74. PMID: 20424824; PMCID: PMC2939831.
      25. Sutkin G, Alperin M, Meyn L, Wiesenfeld HC, Ellison R, Zyczynski HM. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010 Aug; 21(8):955-61. PMID: 20354678.
        View in: PubMed
      26. Alperin M, Sutkin G, Ellison R, Meyn L, Moalli P, Zyczynski H, Zyczynki H. Perioperative outcomes of the Prolift pelvic floor repair systems following introduction to a urogynecology teaching service. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Dec; 19(12):1617-22. PMID: 18712268.
        View in: PubMed
      27. Alperin M, Mantia-Smaldone G, Sagan ER. Conservative management of postoperatively diagnosed cystotomy. Urology. 2009 May; 73(5):1163.e17-9. PMID: 18514295.
        View in: PubMed
      28. Alperin M, Krohn MA, Parviainen K. Episiotomy and increase in the risk of obstetric laceration in a subsequent vaginal delivery. Obstet Gynecol. 2008 Jun; 111(6):1274-8. PMID: 18515508.
        View in: PubMed
      29. Alperin M, Debes K, Abramowitch S, Meyn L, Moalli PA. LOXL1 deficiency negatively impacts the biomechanical properties of the mouse vagina and supportive tissues. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Jul; 19(7):977-86. PMID: 18265927; PMCID: PMC3037182.
      30. Alperin M, Abrahams-Gessel S, Wakamatsu MM. Development of de novo urge incontinence in women post sling: the role of preoperative urodynamics in assessing the risk. Neurourol Urodyn. 2008; 27(5):407-11. PMID: 17985373.
        View in: PubMed
      31. Alperin M, Quaas A, Johnson NR, Hornstein MD. Endometrial ablation in a woman with a persistent uterine hemorrhage due to acute promyelocytic leukemia: a case report. J Reprod Med. 2007 Jun; 52(6):548-50. PMID: 17694980.
        View in: PubMed
      32. Alperin M, Moalli PA. Remodeling of vaginal connective tissue in patients with prolapse. Curr Opin Obstet Gynecol. 2006 Oct; 18(5):544-50. PMID: 16932050.
        View in: PubMed
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