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    Margo Haygood

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentScripps Institution of Oceanography Department
    Address9500 Gilman Drive #0202
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine Mollusks
      NIH/FIC U19TW008163Aug 1, 2008 - Jul 31, 2019
      Role: Principal Investigator
      Diverse drug lead compounds from bacterial symbionts in tropical marine mollusks
      NIH/FIC U01TW008163Aug 1, 2008 - May 31, 2014
      Role: Principal Investigator
      Role of Bacteria in production of ET-743 in E. turbinata
      NIH/NIGMS R21GM072816Sep 30, 2005 - Sep 29, 2008
      Role: Principal Investigator
      ROLE OF BACTERIA IN THE PRODUCTION OF BRYOSTATINS
      NIH/NCI R01CA079678May 12, 2000 - Mar 31, 2005
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lin Z, Smith MD, Concepcion GP, Haygood M, Olivera BM, Light A, Schmidt EW. Modulating the Serotonin Receptor Spectrum of Pulicatin Natural Products. J Nat Prod. 2017 Aug 25; 80(8):2360-2370. PMID: 28745513.
        View in: PubMed
      2. Kem MP, Naka H, Iinishi A, Haygood M, Butler A. Fatty acid hydrolysis of acyl marinobactin siderophores by Marinobacter acylases. Biochemistry. 2015 Jan 27; 54(3):744-52. PMID: 25588131.
        View in: PubMed
      3. O'Connor RM, Fung JM, Sharp KH, Benner JS, McClung C, Cushing S, Lamkin ER, Fomenkov AI, Henrissat B, Londer YY, Scholz MB, Posfai J, Malfatti S, Tringe SG, Woyke T, Malmstrom RR, Coleman-Derr D, Altamia MA, Dedrick S, Kaluziak ST, Haygood M, Distel DL. Gill bacteria enable a novel digestive strategy in a wood-feeding mollusk. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):E5096-104. PMID: 25385629; PMCID: PMC4250168.
      4. Lin Z, Zachariah MM, Marett L, Hughen RW, Teichert RW, Concepcion GP, Haygood M, Olivera BM, Light AR, Schmidt EW. Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. J Nat Prod. 2014 May 23; 77(5):1224-30. PMID: 24786728; PMCID: PMC4039362.
      5. Zane HK, Naka H, Rosconi F, Sandy M, Haygood M, Butler A. Biosynthesis of amphi-enterobactin siderophores by Vibrio harveyi BAA-1116: identification of a bifunctional nonribosomal peptide synthetase condensation domain. J Am Chem Soc. 2014 Apr 16; 136(15):5615-8. PMID: 24701966.
        View in: PubMed
      6. Altamia MA, Wood N, Fung JM, Dedrick S, Linton EW, Concepcion GP, Haygood M, Distel DL. Genetic differentiation among isolates of Teredinibacter turnerae, a widely occurring intracellular endosymbiont of shipworms. Mol Ecol. 2014 Mar; 23(6):1418-32. PMID: 24765662; PMCID: PMC4621784.
      7. Han AW, Sandy M, Fishman B, Trindade-Silva AE, Soares CA, Distel DL, Butler A, Haygood M. Turnerbactin, a novel triscatecholate siderophore from the shipworm endosymbiont Teredinibacter turnerae T7901. PLoS One. 2013; 8(10):e76151. PMID: 24146831; PMCID: PMC3795760.
      8. Lin Z, Marett L, Hughen RW, Flores M, Forteza I, Ammon MA, Concepcion GP, Espino S, Olivera BM, Rosenberg G, Haygood M, Light AR, Schmidt EW. Neuroactive diol and acyloin metabolites from cone snail-associated bacteria. Bioorg Med Chem Lett. 2013 Sep 01; 23(17):4867-9. PMID: 23880542; PMCID: PMC3779075.
      9. Lin Z, Torres JP, Ammon MA, Marett L, Teichert RW, Reilly CA, Kwan JC, Hughen RW, Flores M, Tianero MD, Peraud O, Cox JE, Light AR, Villaraza AJ, Haygood M, Concepcion GP, Olivera BM, Schmidt EW. A bacterial source for mollusk pyrone polyketides. Chem Biol. 2013 Jan 24; 20(1):73-81. PMID: 23352141; PMCID: PMC3558931.
      10. Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood M. Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):E295-304. PMID: 23288898; PMCID: PMC3557025.
      11. Kwan JC, Donia MS, Han AW, Hirose E, Haygood M, Schmidt EW. Genome streamlining and chemical defense in a coral reef symbiosis. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):20655-60. PMID: 23185008; PMCID: PMC3528492.
      12. Betcher MA, Fung JM, Han AW, O'Connor R, Seronay R, Concepcion GP, Distel DL, Haygood M. Microbial distribution and abundance in the digestive system of five shipworm species (Bivalvia: Teredinidae). PLoS One. 2012; 7(9):e45309. PMID: 23028923; PMCID: PMC3447940.
      13. Lin Z, Flores M, Forteza I, Henriksen NM, Concepcion GP, Rosenberg G, Haygood M, Olivera BM, Light AR, Cheatham TE, Schmidt EW. Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp. J Nat Prod. 2012 Apr 27; 75(4):644-9. PMID: 22439622; PMCID: PMC3338888.
      14. Dias GM, Thompson CC, Fishman B, Naka H, Haygood M, Crosa JH, Thompson FL. Genome sequence of the marine bacterium Vibrio campbellii DS40M4, isolated from open ocean water. J Bacteriol. 2012 Feb; 194(4):904. PMID: 22275102; PMCID: PMC3272966.
      15. Donia MS, Fricke WF, Partensky F, Cox J, Elshahawi SI, White JR, Phillippy AM, Schatz MC, Piel J, Haygood M, Ravel J, Schmidt EW. Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):E1423-32. PMID: 22123943; PMCID: PMC3251135.
      16. Roe KL, Barbeau K, Mann EL, Haygood M. Acquisition of iron by Trichodesmium and associated bacteria in culture. Environ Microbiol. 2012 Jul; 14(7):1681-95. PMID: 22118517.
        View in: PubMed
      17. Lin Z, Reilly CA, Antemano R, Hughen RW, Marett L, Concepcion GP, Haygood M, Olivera BM, Light A, Schmidt EW. Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria. J Med Chem. 2011 Jun 09; 54(11):3746-55. PMID: 21524089; PMCID: PMC3133741.
      18. Trindade-Silva AE, Lim-Fong GE, Sharp KH, Haygood M. Bryostatins: biological context and biotechnological prospects. Curr Opin Biotechnol. 2010 Dec; 21(6):834-42. PMID: 20971628; PMCID: PMC4497553.
      19. Lin Z, Antemano RR, Hughen RW, Tianero MD, Peraud O, Haygood M, Concepcion GP, Olivera BM, Light A, Schmidt EW. Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. J Nat Prod. 2010 Nov 29; 73(11):1922-6. PMID: 21028889; PMCID: PMC2993768.
      20. Sandy M, Han A, Blunt J, Munro M, Haygood M, Butler A. Vanchrobactin and anguibactin siderophores produced by Vibrio sp. DS40M4. J Nat Prod. 2010 Jun 25; 73(6):1038-43. PMID: 20521785; PMCID: PMC3065854.
      21. Yang JC, Madupu R, Durkin AS, Ekborg NA, Pedamallu CS, Hostetler JB, Radune D, Toms BS, Henrissat B, Coutinho PM, Schwarz S, Field L, Trindade-Silva AE, Soares CA, Elshahawi S, Hanora A, Schmidt EW, Haygood M, Posfai J, Benner J, Madinger C, Nove J, Anton B, Chaudhary K, Foster J, Holman A, Kumar S, Lessard PA, Luyten YA, Slatko B, Wood N, Wu B, Teplitski M, Mougous JD, Ward N, Eisen JA, Badger JH, Distel DL. The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). PLoS One. 2009 Jul 01; 4(7):e6085. PMID: 19568419; PMCID: PMC2699552.
      22. Lopanik NB, Shields JA, Buchholz TJ, Rath CM, Hothersall J, Haygood M, HÃ¥kansson K, Thomas CM, Sherman DH. In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem Biol. 2008 Nov 24; 15(11):1175-86. PMID: 19022178; PMCID: PMC2861360.
      23. Lim-Fong GE, Regali LA, Haygood M. Evolutionary relationships of "Candidatus endobugula" bacterial symbionts and their Bugula bryozoan hosts. Appl Environ Microbiol. 2008 Jun; 74(11):3605-9. PMID: 18390670; PMCID: PMC2423044.
      24. Sharp KH, Davidson SK, Haygood M. Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina. ISME J. 2007 Dec; 1(8):693-702. PMID: 18059493.
        View in: PubMed
      25. Sudek S, Lopanik NB, Waggoner LE, Hildebrand M, Anderson C, Liu H, Patel A, Sherman DH, Haygood M. Identification of the putative bryostatin polyketide synthase gene cluster from "Candidatus Endobugula sertula", the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J Nat Prod. 2007 Jan; 70(1):67-74. PMID: 17253852.
        View in: PubMed
      26. Sharp KH, Eam B, Faulkner DJ, Haygood M. Vertical transmission of diverse microbes in the tropical sponge Corticium sp. Appl Environ Microbiol. 2007 Jan; 73(2):622-9. PMID: 17122394; PMCID: PMC1796987.
      27. Donia MS, Hathaway BJ, Sudek S, Haygood M, Rosovitz MJ, Ravel J, Schmidt EW. Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians. Nat Chem Biol. 2006 Dec; 2(12):729-35. PMID: 17086177.
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      28. Anderson CM, Haygood M. Alpha-proteobacterial symbionts of marine bryozoans in the genus Watersipora. Appl Environ Microbiol. 2007 Jan; 73(1):303-11. PMID: 17071786; PMCID: PMC1797102.
      29. Sudek S, Haygood M, Youssef DT, Schmidt EW. Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence. Appl Environ Microbiol. 2006 Jun; 72(6):4382-7. PMID: 16751554; PMCID: PMC1489667.
      30. Martin JD, Ito Y, Homann VV, Haygood M, Butler A. Structure and membrane affinity of new amphiphilic siderophores produced by Ochrobactrum sp. SP18. J Biol Inorg Chem. 2006 Jul; 11(5):633-41. PMID: 16791646.
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      31. Ridley CP, John Faulkner D, Haygood M. Investigation of Oscillatoria spongeliae-dominated bacterial communities in four dictyoceratid sponges. Appl Environ Microbiol. 2005 Nov; 71(11):7366-75. PMID: 16269779; PMCID: PMC1287642.
      32. Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood M, Ravel J. Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni, the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7315-20. PMID: 15883371; PMCID: PMC1091749.
      33. Ridley CP, Bergquist PR, Harper MK, Faulkner DJ, Hooper JN, Haygood M. Speciation and biosynthetic variation in four dictyoceratid sponges and their cyanobacterial symbiont, Oscillatoria spongeliae. Chem Biol. 2005 Mar; 12(3):397-406. PMID: 15797223.
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      34. Hildebrand M, Waggoner LE, Liu H, Sudek S, Allen S, Anderson C, Sherman DH, Haygood M. bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol. 2004 Nov; 11(11):1543-52. PMID: 15556005.
        View in: PubMed
      35. Lim GE, Haygood M. "Candidatus Endobugula glebosa," a specific bacterial symbiont of the marine bryozoan Bugula simplex. Appl Environ Microbiol. 2004 Aug; 70(8):4921-9. PMID: 15294832; PMCID: PMC492373.
      36. Schmidt EW, Sudek S, Haygood M. Genetic evidence supports secondary metabolic diversity in Prochloron spp., the cyanobacterial symbiont of a tropical ascidian. J Nat Prod. 2004 Aug; 67(8):1341-5. PMID: 15332852.
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      37. Hildebrand M, Waggoner LE, Lim GE, Sharp KH, Ridley CP, Haygood M. Approaches to identify, clone, and express symbiont bioactive metabolite genes. Nat Prod Rep. 2004 Feb; 21(1):122-42. PMID: 15039839.
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      38. Martinez JS, Carter-Franklin JN, Mann EL, Martin JD, Haygood M, Butler A. Structure and membrane affinity of a suite of amphiphilic siderophores produced by a marine bacterium. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):3754-9. PMID: 12651947; PMCID: PMC152994.
      39. Davidson SK, Allen SW, Lim GE, Anderson CM, Haygood M. Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina. Appl Environ Microbiol. 2001 Oct; 67(10):4531-7. PMID: 11571152; PMCID: PMC93199.
      40. Martinez JS, Zhang GP, Holt PD, Jung HT, Carrano CJ, Haygood M, Butler A. Self-assembling amphiphilic siderophores from marine bacteria. Science. 2000 Feb 18; 287(5456):1245-7. PMID: 10678827.
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      41. Haygood M, Schmidt EW, Davidson SK, Faulkner DJ. Microbial symbionts of marine invertebrates: opportunities for microbial biotechnology. J Mol Microbiol Biotechnol. 1999 Aug; 1(1):33-43. PMID: 10941782.
        View in: PubMed
      42. Davidson SK, Haygood M. Identification of sibling species of the bryozoan Bugula neritina that produce different anticancer bryostatins and harbor distinct strains of the bacterial symbiont "Candidatus Endobugula sertula". Biol Bull. 1999 Jun; 196(3):273-80. PMID: 10390826.
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      43. Caspi R, Tebo BM, Haygood M. c-type cytochromes and manganese oxidation in Pseudomonas putida MnB1. Appl Environ Microbiol. 1998 Oct; 64(10):3549-55. PMID: 9758766; PMCID: PMC106463.
      44. Haygood M, Davidson SK. Small-subunit rRNA genes and in situ hybridization with oligonucleotides specific for the bacterial symbionts in the larvae of the bryozoan Bugula neritina and proposal of "Candidatus endobugula sertula". Appl Environ Microbiol. 1997 Nov; 63(11):4612-6. PMID: 9361448; PMCID: PMC168781.
      45. Shedlock AM, Haygood M, Pietsch TW, Bentzen P. Enhanced DNA extraction and PCR amplification of mitochondrial genes from formalin-fixed museum specimens. Biotechniques. 1997 Mar; 22(3):394-6, 398, 400. PMID: 9067006.
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      46. Caspi R, Haygood M, Tebo BM. Unusual ribulose-1,5-bisphosphate carboxylase/oxygenase genes from a marine manganese-oxidizing bacterium. Microbiology. 1996 Sep; 142 ( Pt 9):2549-59. PMID: 8828223.
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      47. Rosel PE, Haygood M, Perrin WF. Phylogenetic relationships among the true porpoises (Cetacea:Phocoenidae). Mol Phylogenet Evol. 1995 Dec; 4(4):463-74. PMID: 8747302.
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      48. Alves-Gomes JA, Ortí G, Haygood M, Heiligenberg W, Meyer A. Phylogenetic analysis of the South American electric fishes (order Gymnotiformes) and the evolution of their electrogenic system: a synthesis based on morphology, electrophysiology, and mitochondrial sequence data. Mol Biol Evol. 1995 Mar; 12(2):298-318. PMID: 7700155.
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      49. Haygood M. Spreadsheet macros for coloring sequence alignments. Biotechniques. 1993 Dec; 15(6):1084-9. PMID: 8292342.
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      50. Wolfe CJ, Haygood M. Bioluminescent symbionts of the Caribbean flashlight fish (Kryptophanaron alfredi) have a single rRNA operon. Mol Mar Biol Biotechnol. 1993 Aug; 2(4):189-97. PMID: 7507392.
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      51. Haygood M, Distel DL. Bioluminescent symbionts of flashlight fishes and deep-sea anglerfishes form unique lineages related to the genus Vibrio. Nature. 1993 May 13; 363(6425):154-6. PMID: 7683390.
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      52. Haygood M. Light organ symbioses in fishes. Crit Rev Microbiol. 1993; 19(4):191-216. PMID: 8305135.
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      53. Stein JL, Haygood M, Felbeck H. Nucleotide sequence and expression of a deep-sea ribulose-1,5-bisphosphate carboxylase gene cloned from a chemoautotrophic bacterial endosymbiont. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8850-4. PMID: 2247456; PMCID: PMC55057.
      54. Haygood M. Relationship of the luminous bacterial symbiont of the Caribbean flashlight fish, Kryptophanaron alfredi (family Anomalopidae) to other luminous bacteria based on bacterial luciferase (luxA) genes. Arch Microbiol. 1990; 154(5):496-503. PMID: 2256783.
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      55. Stephens RL, Haygood M, Lidstrom ME. Identification of putative methanol dehydrogenase (moxF) structural genes in methylotrophs and cloning of moxF genes from Methylococcus capsulatus bath and Methylomonas albus BG8. J Bacteriol. 1988 May; 170(5):2063-9. PMID: 3129400; PMCID: PMC211087.
      56. Haygood M, Cohn DH. Luciferase genes cloned from the unculturable luminous bacteroid symbiont of the Caribbean flashlight fish, Kryptophanaron alfredi. Gene. 1986; 45(2):203-9. PMID: 3026908.
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      57. Haygood M, Nealson KH. Mechanisms of iron regulation of luminescence in Vibrio fischeri. J Bacteriol. 1985 Apr; 162(1):209-16. PMID: 3920202; PMCID: PMC218976.
      58. Nealson KH, Haygood M, Tebo BM, Roman M, Miller E, McCosker JE. Contribution by symbiotically luminous fishes to the occurrence and bioluminescence of luminous bacteria in seawater. Microb Ecol. 1984 Mar; 10(1):69-77. PMID: 24221051.
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