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    Mana Parast

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Human Trophoblast Stem Cells: the In Vivo Niche and Relationship to Pluripotent Stem Cells
      NIH/NICHD R01HD089537Mar 15, 2017 - Feb 28, 2022
      Role: Principal Investigator
      Endocervical Trophoblast-derived Biomarkers Across Gestation
      NIH/NICHD R21HD089683Sep 20, 2016 - Aug 31, 2018
      Role: Principal Investigator
      Modeling human trophoblast stem cells using iPS cells derived from molar placenta
      NIH/NICHD R21HD073673Jul 15, 2013 - Jun 30, 2015
      Role: Principal Investigator
      Sirt1-PPARgamma signaling in placental development and fetal growth disorders
      NIH/NICHD R01HD071100Apr 1, 2012 - Mar 31, 2017
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Wakeland AK, Soncin F, Moretto-Zita M, Chang CW, Horii M, Pizzo D, Nelson KK, Laurent LC, Parast M. Hypoxia Directs Human Extravillous Trophoblast Differentiation in a Hypoxia-Inducible Factor-Dependent Manner. Am J Pathol. 2017 Apr; 187(4):767-780. PMID: 28167044.
        View in: PubMed
      2. Chang CW, Parast M. Human trophoblast stem cells: Real or not real? Placenta. 2017 Jan 05. PMID: 28087122.
        View in: PubMed
      3. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast M, Murry CE, Laurent LC, Salzman J. Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2016 Dec 19; 17(1):263. PMID: 27993159.
        View in: PubMed
      4. Qiao L, Wattez JS, Lee S, Guo Z, Schaack J, Hay WW, Zita MM, Parast M, Shao J. Knockout maternal adiponectin increases fetal growth in mice: potential role for trophoblast IGFBP-1. Diabetologia. 2016 Nov; 59(11):2417-2425. PMID: 27495989.
        View in: PubMed
      5. Horii M, Li Y, Wakeland AK, Pizzo DP, Nelson KK, Sabatini K, Laurent LC, Liu Y, Parast M. Human pluripotent stem cells as a model of trophoblast differentiation in both normal development and disease. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3882-91. PMID: 27325764; PMCID: PMC4941448 [Available on 01/05/17].
      6. Leon-Garcia SM, Roeder HA, Nelson KK, Liao X, Pizzo DP, Laurent LC, Parast M, LaCoursiere DY. Maternal obesity and sex-specific differences in placental pathology. Placenta. 2016 Feb; 38:33-40. PMID: 26907380.
        View in: PubMed
      7. Moretto Zita M, Soncin F, Natale D, Pizzo D, Parast M. Gene Expression Profiling Reveals a Novel Regulatory Role for Sox21 Protein in Mouse Trophoblast Stem Cell Differentiation. J Biol Chem. 2015 Dec 11; 290(50):30152-62. PMID: 26491013; PMCID: PMC4705987 [Available on 12/11/16].
      8. Horii M, Moretto-Zita M, Nelson KK, Li Y, Parast M. MTA3 regulates differentiation of human cytotrophoblast stem cells. Placenta. 2015 Sep; 36(9):974-80. PMID: 26198267; PMCID: PMC4554833.
      9. Gallego Romero I, Pavlovic BJ, Hernando-Herraez I, Zhou X, Ward MC, Banovich NE, Kagan CL, Burnett JE, Huang CH, Mitrano A, Chavarria CI, Friedrich Ben-Nun I, Li Y, Sabatini K, Leonardo TR, Parast M, Marques-Bonet T, Laurent LC, Loring JF, Gilad Y. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics. Elife. 2015 Jun 23; 4:e07103. PMID: 26102527; PMCID: PMC4502404.
      10. Szabo L, Morey R, Palpant NJ, Wang PL, Afari N, Jiang C, Parast M, Murry CE, Laurent LC, Salzman J. Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Genome Biol. 2015 Jun 16; 16:126. PMID: 26076956; PMCID: PMC4506483.
      11. Qiao L, Guo Z, Bosco C, Guidotti S, Wang Y, Wang M, Parast M, Schaack J, Hay WW, Moore TR, Shao J. Maternal High-Fat Feeding Increases Placental Lipoprotein Lipase Activity by Reducing SIRT1 Expression in Mice. Diabetes. 2015 Sep; 64(9):3111-20. PMID: 25948680; PMCID: PMC4542442.
      12. Garitaonandia I, Amir H, Boscolo FS, Wambua GK, Schultheisz HL, Sabatini K, Morey R, Waltz S, Wang YC, Tran H, Leonardo TR, Nazor K, Slavin I, Lynch C, Li Y, Coleman R, Gallego Romero I, Altun G, Reynolds D, Dalton S, Parast M, Loring JF, Laurent LC. Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions. PLoS One. 2015; 10(2):e0118307. PMID: 25714340; PMCID: PMC4340884.
      13. Barbaux S, Erwich JJ, Favaron PO, Gil S, Gallot D, Golos TG, Gonzalez-Bulnes A, Guibourdenche J, Heazell AE, Jansson T, Laprévote O, Lewis RM, Miller RK, Monk D, Novakovic B, Oudejans C, Parast M, Peugnet P, Pfarrer C, Pinar H, Roberts CT, Robinson W, Saffery R, Salomon C, Sexton A, Staff AC, Suter M, Tarrade A, Wallace J, Vaillancourt C, Vaiman D, Worton SA, Lash GE. IFPA meeting 2014 workshop report: Animal models to study pregnancy pathologies; new approaches to study human placental exposure to xenobiotics; biomarkers of pregnancy pathologies; placental genetics and epigenetics; the placenta and stillbirth and fetal growth restriction. Placenta. 2015 Apr; 36 Suppl 1:S5-10. PMID: 25703592.
        View in: PubMed
      14. Soncin F, Natale D, Parast M. Signaling pathways in mouse and human trophoblast differentiation: a comparative review. Cell Mol Life Sci. 2015 Apr; 72(7):1291-302. PMID: 25430479; PMCID: PMC4366325.
      15. Roeder HA, Dejbakhsh SZ, Parast M, Laurent LC, Woelkers DA. Abnormal uterine artery Doppler velocimetry predicts adverse outcomes in patients with abnormal analytes. Pregnancy Hypertens. 2014 Oct; 4(4):296-301. PMID: 26104819.
        View in: PubMed
      16. Li Y, Moretto-Zita M, Leon-Garcia S, Parast M. p63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state. Am J Pathol. 2014 Dec; 184(12):3332-43. PMID: 25307348; PMCID: PMC4258507.
      17. Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast M, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat Commun. 2014 Jul 18; 5:4430. PMID: 25034944; PMCID: PMC4109022.
      18. Wolfe LM, Thiagarajan RD, Boscolo F, Taché V, Coleman RL, Kim J, Kwan WK, Loring JF, Parast M, Laurent LC. Banking placental tissue: an optimized collection procedure for genome-wide analysis of nucleic acids. Placenta. 2014 Aug; 35(8):645-54. PMID: 24951174; PMCID: PMC4847722.
      19. Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med. 2014 Jun 02; 211(6):1231-42. PMID: 24799499; PMCID: PMC4042635.
      20. Li Y, Parast M. BMP4 regulation of human trophoblast development. Int J Dev Biol. 2014; 58(2-4):239-46. PMID: 25023690.
        View in: PubMed
      21. Abumaree MH, Brownbill P, Burton G, Castillo C, Chamley L, Croy BA, Drewlo S, Dunk C, Girard S, Hansson S, Jones S, Jurisicova A, Lewis R, Letarte M, Parast M, Pehrson C, Rappolee D, Schneider H, Tannetta D, Varmuza S, Wadsack C, Wallace AE, Zenerino C, Lash GE. IFPA Meeting 2013 Workshop Report III: maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta. Placenta. 2014 Feb; 35 Suppl:S15-9. PMID: 24321780.
        View in: PubMed
      22. Li Y, Moretto-Zita M, Soncin F, Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D, Cui L, Nazor K, Loring JF, Crum CP, Laurent LC, Parast M. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ?Np63+ cytotrophoblast stem cell state. Development. 2013 Oct; 140(19):3965-76. PMID: 24004950; PMCID: PMC3775414.
      23. Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast M. Hypoxia and trophoblast differentiation: a key role for PPAR?. Stem Cells Dev. 2013 Nov 01; 22(21):2815-24. PMID: 23767827; PMCID: PMC3804243.
      24. Jones JC, Sabatini K, Liao X, Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo FS, Yang Q, Parast M, Liu Y, Peterson SE, Laurent LC, Loring JF, Wang YC. Melanocytes derived from transgene-free human induced pluripotent stem cells. J Invest Dermatol. 2013 Aug; 133(8):2104-8. PMID: 23514962; PMCID: PMC3714355.
      25. Song HW, Anderson RA, Bayne RA, Gromoll J, Shimasaki S, Chang RJ, Parast M, Laurent LC, de Rooij DG, Hsieh TC, Wilkinson MF. The RHOX homeobox gene cluster is selectively expressed in human oocytes and male germ cells. Hum Reprod. 2013 Jun; 28(6):1635-46. PMID: 23482336; PMCID: PMC3657123.
      26. Quinn KH, Parast M. Decidual regulatory T cells in placental pathology and pregnancy complications. Am J Reprod Immunol. 2013 Jun; 69(6):533-8. PMID: 23384284.
        View in: PubMed
      27. Ackerman WE, Carter AM, De Mestre AM, Golos TG, Jeschke U, Kusakabe K, Laurent LC, Parast M, Roberts RM, Robinson JM, Rutherford J, Soma H, Takizawa T, Ui-Tei K, Lash GE. IFPA Meeting 2012 Workshop Report I: comparative placentation and animal models, advanced techniques in placental histopathology, human pluripotent stem cells as a model for trophoblast differentiation. Placenta. 2013 Mar; 34 Suppl:S3-5. PMID: 23206905.
        View in: PubMed
      28. Nazor KL, Altun G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia I, Müller FJ, Wang YC, Boscolo FS, Fakunle E, Dumevska B, Lee S, Park HS, Olee T, D'Lima DD, Semechkin R, Parast M, Galat V, Laslett AL, Schmidt U, Keirstead HS, Loring JF, Laurent LC. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell. 2012 May 04; 10(5):620-34. PMID: 22560082; PMCID: PMC3348513.
      29. Wang W, Feng L, Zhang H, Hachy S, Satohisa S, Laurent LC, Parast M, Zheng J, Chen DB. Preeclampsia up-regulates angiogenesis-associated microRNA (i.e., miR-17, -20a, and -20b) that target ephrin-B2 and EPHB4 in human placenta. J Clin Endocrinol Metab. 2012 Jun; 97(6):E1051-9. PMID: 22438230; PMCID: PMC3387422.
      30. Ryan WD, Trivedi N, Benirschke K, Lacoursiere DY, Parast M. Placental histologic criteria for diagnosis of cord accident: sensitivity and specificity. Pediatr Dev Pathol. 2012 Jul-Aug; 15(4):275-80. PMID: 22400796.
        View in: PubMed
      31. Laury AR, Ning G, Quick CM, Bijron J, Parast M, Betensky RA, Vargas SO, McKeon FD, Xian W, Nucci MR, Crum CP. Fallopian tube correlates of ovarian serous borderline tumors. Am J Surg Pathol. 2011 Dec; 35(12):1759-65. PMID: 22089527; PMCID: PMC3219906.
      32. Quinn KH, Lacoursiere DY, Cui L, Bui J, Parast M. The unique pathophysiology of early-onset severe preeclampsia: role of decidual T regulatory cells. J Reprod Immunol. 2011 Sep; 91(1-2):76-82. PMID: 21782252.
        View in: PubMed
      33. Rose JA, Rabenold JJ, Parast M, Milstone DS, Abrahams VM, Riley JK. Peptidoglycan induces necrosis and regulates cytokine production in murine trophoblast stem cells. Am J Reprod Immunol. 2011 Sep; 66(3):209-22. PMID: 21385270; PMCID: PMC3137696.
      34. Taché V, LaCoursiere DY, Saleemuddin A, Parast M. Placental expression of vascular endothelial growth factor receptor-1/soluble vascular endothelial growth factor receptor-1 correlates with severity of clinical preeclampsia and villous hypermaturity. Hum Pathol. 2011 Sep; 42(9):1283-8. PMID: 21334711.
        View in: PubMed
      35. Saleemuddin A, Tantbirojn P, Sirois K, Crum CP, Boyd TK, Tworoger S, Parast M. Obstetric and perinatal complications in placentas with fetal thrombotic vasculopathy. Pediatr Dev Pathol. 2010 Nov-Dec; 13(6):459-64. PMID: 20438299.
        View in: PubMed
      36. Parast M, Yu H, Ciric A, Salata MW, Davis V, Milstone DS. PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS One. 2009 Nov 30; 4(11):e8055. PMID: 19956639; PMCID: PMC2778869.
      37. Tantbirojn P, Saleemuddin A, Sirois K, Crum CP, Boyd TK, Tworoger S, Parast M. Gross abnormalities of the umbilical cord: related placental histology and clinical significance. Placenta. 2009 Dec; 30(12):1083-8. PMID: 19853300.
        View in: PubMed
      38. Wintermark P, Boyd T, Parast M, Van Marter LJ, Warfield SK, Robertson RL, Ringer SA. Fetal placental thrombosis and neonatal implications. Am J Perinatol. 2010 Mar; 27(3):251-6. PMID: 19806531; PMCID: PMC3694425.
      39. Quintero-Rivera F, Abreu-E-Lima P, Zhang IH, Parast M. Homozygous alpha-thalassemia with trisomy 7 mosaicism in a live-born infant. Pediatr Hematol Oncol. 2009 Sep; 26(6):426-31. PMID: 19657992.
        View in: PubMed
      40. Carlson JW, Miron A, Jarboe EA, Parast M, Hirsch MS, Lee Y, Muto MG, Kindelberger D, Crum CP. Serous tubal intraepithelial carcinoma: its potential role in primary peritoneal serous carcinoma and serous cancer prevention. J Clin Oncol. 2008 Sep 01; 26(25):4160-5. PMID: 18757330; PMCID: PMC2654373.
      41. Nagymanyoki Z, Callahan MJ, Parast M, Fulop V, Mok SC, Berkowitz RS. Immune cell profiling in intraplacental and postmolar choriocarcinomas. J Reprod Med. 2008 Aug; 53(8):558-64. PMID: 18773618.
        View in: PubMed
      42. Nagymanyoki Z, Growdon WB, Sarno J, Callahan MJ, Parast M, Fulop V, Mok SC, Horowitz N, Berkowitz RS. Vascularization and expression of angiogenic factors in partial and complete molar pregnancies. J Reprod Med. 2008 Aug; 53(8):589-94. PMID: 18773623.
        View in: PubMed
      43. Nagymanyoki Z, Butler MO, Callahan MJ, Parast M, Fulop V, Mok SC, Berkowitz RS. Antigen-specific T cell immune response detected by skewed T cell receptor usage in normal placenta and complete molar pregnancy. J Reprod Med. 2008 Jul; 53(7):528-34. PMID: 18720929.
        View in: PubMed
      44. Tantbirojn P, Crum CP, Parast M. Pathophysiology of placenta creta: the role of decidua and extravillous trophoblast. Placenta. 2008 Jul; 29(7):639-45. PMID: 18514815.
        View in: PubMed
      45. Parast M, Crum CP, Boyd TK. Placental histologic criteria for umbilical blood flow restriction in unexplained stillbirth. Hum Pathol. 2008 Jun; 39(6):948-53. PMID: 18430456.
        View in: PubMed
      46. Nagymanyoki Z, Callahan MJ, Parast M, Berkowitz RS, Mok SC, Fulop V. Overexpression of laminin receptor 1 on decidual cells in partial and complete mole. Gynecol Oncol. 2008 Jan; 108(1):121-5. PMID: 17928039.
        View in: PubMed
      47. Nagymanyoki Z, Callahan MJ, Parast M, Fulop V, Mok SC, Berkowitz RS. Immune cell profiling in normal pregnancy, partial and complete molar pregnancy. Gynecol Oncol. 2007 Nov; 107(2):292-7. PMID: 17878059.
        View in: PubMed
      48. Lee Y, Kim KR, McKeon F, Yang A, Boyd TK, Crum CP, Parast M. A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression. Hum Pathol. 2007 Jul; 38(7):1003-13. PMID: 17397906.
        View in: PubMed
      49. Boukhelifa M, Moza M, Johansson T, Rachlin A, Parast M, Huttelmaier S, Roy P, Jockusch BM, Carpen O, Karlsson R, Otey CA. The proline-rich protein palladin is a binding partner for profilin. FEBS J. 2006 Jan; 273(1):26-33. PMID: 16367745.
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      50. Parast M, Eudy G, Gow KW, Amin M, Shehata B. A unique case of renal carcinoma with Xp11.2 translocations/ TFE3 gene fusions in a 3-year-old child, with coexistent von Hippel-Lindau gene mutation. Pediatr Dev Pathol. 2004 Jul-Aug; 7(4):403-6. PMID: 15383938.
        View in: PubMed
      51. Boukhelifa M, Parast M, Bear JE, Gertler FB, Otey CA. Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton. 2004 May; 58(1):17-29. PMID: 14983521.
        View in: PubMed
      52. Ono K, Parast M, Alberico C, Benian GM, Ono S. Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans. J Cell Sci. 2003 May 15; 116(Pt 10):2073-85. PMID: 12679387.
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      53. Boukhelifa M, Parast M, Valtschanoff JG, LaMantia AS, Meeker RB, Otey CA. A role for the cytoskeleton-associated protein palladin in neurite outgrowth. Mol Biol Cell. 2001 Sep; 12(9):2721-9. PMID: 11553711; PMCID: PMC59707.
      54. Hwang SJ, Pagliardini S, Boukhelifa M, Parast M, Otey CA, Rustioni A, Valtschanoff JG. Palladin is expressed preferentially in excitatory terminals in the rat central nervous system. J Comp Neurol. 2001 Jul 23; 436(2):211-24. PMID: 11438925.
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      55. Parast M, Aeder S, Sutherland AE. Trophoblast giant-cell differentiation involves changes in cytoskeleton and cell motility. Dev Biol. 2001 Feb 01; 230(1):43-60. PMID: 11161561.
        View in: PubMed
      56. Parast M, Otey CA. Characterization of palladin, a novel protein localized to stress fibers and cell adhesions. J Cell Biol. 2000 Aug 07; 150(3):643-56. PMID: 10931874; PMCID: PMC2175193.
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