Lori Broderick

Title(s)	Associate Professor Of Clinical, Pediatrics
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndrome
NIH K08HD075830May 1, 2014 - Apr 30, 2019
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2024 Jan; 25(1):455. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 38216786; PMCID: PMC10897131.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Translation:Humans Animals Cells
The discovery of NLRP3 and its function in cryopyrin-associated periodic syndromes and innate immunity. Immunol Rev. 2023 Dec 25. Putnam CD, Broderick L, Hoffman HM. PMID: 38146057.

View in: PubMed Mentions: Fields:
All Allergy and Immunology Tra Transplantation
Translation:Humans Animals
Refractory Status Epilepticus Associated With a Pathogenic Variant in TNFRSF13B. Cureus. 2023 Nov; 15(11):e48222. Yang JH, Scanlon N, Woo W, LaBuzetta JN, Gonzalez C, Broderick L, Doherty T, Riedl M, Dunn-Pirio A. PMID: 38054159; PMCID: PMC10694393.

View in: PubMed Mentions:
Variant STAT4 and Treatment of an Autoinflammatory Syndrome. Reply. N Engl J Med. 2023 Sep 21; 389(12):1151-1152. Broderick L, Kastner DL. PMID: 37733321.

View in: PubMed Mentions: Fields:
Med Medicine (General)
Translation:Humans
Antisense Oligonucleotide Therapy Decreases IL-1β Expression and Prolongs Survival in Mutant Nlrp3 Mice. J Immunol. 2023 07 15; 211(2):287-294. Kaufmann B, de Los Reyes Jiménez M, Booshehri LM, Onyuru J, Leszczynska A, Uri A, Michel S, Klar R, Jaschinski F, Feldstein AE, Broderick L, Hoffman HM. PMID: 37256266.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology
Translation:Animals
Cold Urticaria Syndromes: Diagnosis and Management. J Allergy Clin Immunol Pract. 2023 08; 11(8):2275-2285. Diaz VL, Gribbons KB, Yazdi-Nejad K, Kuemmerle-Deschner J, Wanderer AA, Broderick L, Hoffman HM. PMID: 37290539.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Humans
Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome. N Engl J Med. 2023 Jun 15; 388(24):2241-2252. Baghdassarian H, Blackstone SA, Clay OS, Philips R, Matthiasardottir B, Nehrebecky M, Hua VK, McVicar R, Liu Y, Tucker SM, Randazzo D, Deuitch N, Rosenzweig S, Mark A, Sasik R, Fisch KM, Pimpale Chavan P, Eren E, Watts NR, Ma CA, Gadina M, Schwartz DM, Sanyal A, Werner G, Murdock DR, Horita N, Chowdhury S, Dimmock D, Jepsen K, Remmers EF, Goldbach-Mansky R, Gahl WA, O'Shea JJ, Milner JD, Lewis NE, Chang J, Kastner DL, Torok K, Oda H, Putnam CD, Broderick L. PMID: 37256972; PMCID: PMC10392571.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)
Lentiviral Gene Therapy for Artemis-Deficient SCID. N Engl J Med. 2022 12 22; 387(25):2344-2355. Cowan MJ, Yu J, Facchino J, Fraser-Browne C, Sanford U, Kawahara M, Dara J, Long-Boyle J, Oh J, Chan W, Chag S, Broderick L, Chellapandian D, Decaluwe H, Golski C, Hu D, Kuo CY, Miller HK, Petrovic A, Currier R, Hilton JF, Punwani D, Dvorak CC, Malech HL, McIvor RS, Puck JM. PMID: 36546626; PMCID: PMC9884487.

View in: PubMed Mentions: 12 Fields:
Med Medicine (General)
Translation:Humans Cells CTClinical Trials
NLRP3 activation in neutrophils induces lethal autoinflammation, liver inflammation, and fibrosis. EMBO Rep. 2022 11 07; 23(11):e54446. Kaufmann B, Leszczynska A, Reca A, Booshehri LM, Onyuru J, Tan Z, Wree A, Friess H, Hartmann D, Papouchado B, Broderick L, Hoffman HM, Croker BA, Zhu YP, Feldstein AE. PMID: 36194627; PMCID: PMC9638850.

View in: PubMed Mentions: 13 Fields:
Mol Molecular Biology
Translation:Animals Cells
Cell-specific Deletion of NLRP3 Inflammasome Identifies Myeloid Cells as Key Drivers of Liver Inflammation and Fibrosis in Murine Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2022; 14(4):751-767. Kaufmann B, Kui L, Reca A, Leszczynska A, Kim AD, Booshehri LM, Wree A, Friess H, Hartmann D, Broderick L, Hoffman HM, Feldstein AE. PMID: 35787975; PMCID: PMC9424559.

View in: PubMed Mentions: 8 Fields:
Gas Gastroenterology
Translation:Humans Animals Cells
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting. Nat Rev Rheumatol. 2022 08; 18(8):448-463. Broderick L, Hoffman HM. PMID: 35729334; PMCID: PMC9210802.

View in: PubMed Mentions: 17 Fields:
Rhe Rheumatology
Translation:Humans Animals
Disease-associated mutations in topoisomerase IIβ result in defective NK cells. J Allergy Clin Immunol. 2022 06; 149(6):2171-2176.e3. Broderick L, Clay GM, Blum RH, Liu Y, McVicar R, Papes F, Booshehri LM, Cowell IG, Austin CA, Putnam CD, Kaufman DS. PMID: 35063500.

View in: PubMed Mentions: 4 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Undifferentiated recurrent fevers in pediatrics are clinically distinct from PFAPA syndrome but retain an IL-1 signature. Clin Immunol. 2021 05; 226:108697. Luu I, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Pransky S, Broderick L. PMID: 33636366; PMCID: PMC8089050.

View in: PubMed Mentions: 3 Fields:
All Allergy and Immunology
Translation:Humans Cells
Pediatric recurrent fever and autoinflammation from the perspective of an allergist/immunologist. J Allergy Clin Immunol. 2020 11; 146(5):960-966.e2. Broderick L, Hoffman HM. PMID: 33002514; PMCID: PMC8559310.

View in: PubMed Mentions: 6 Fields:
All Allergy and Immunology
Translation:Humans
Immune Dysregulation in the Tonsillar Microenvironment of Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA) Syndrome. J Clin Immunol. 2020 01; 40(1):179-190. Luu I, Sharma A, Guaderrama M, Peru M, Nation J, Page N, Carvalho D, Magit A, Jiang W, Leuin S, Bliss M, Bothwell M, Brigger M, Kearns D, Newbury R, Pransky S, Gilbert JA, Broderick L. PMID: 31807979; PMCID: PMC7085444.

View in: PubMed Mentions: 10 Fields:
All Allergy and Immunology
Translation:Humans Cells
Mutations in topoisomerase IIβ result in a B cell immunodeficiency. Nat Commun. 2019 08 13; 10(1):3644. Broderick L, Yost S, Li D, McGeough MD, Booshehri LM, Guaderrama M, Brydges SD, Kucharova K, Patel NC, Harr M, Hakonarson H, Zackai E, Cowell IG, Austin CA, Hügle B, Gebauer C, Zhang J, Xu X, Wang J, Croker BA, Frazer KA, Putnam CD, Hoffman HM. PMID: 31409799; PMCID: PMC6692411.

View in: PubMed Mentions: 18 Fields:
Bio Biology Sci Science
Translation:Humans Animals Cells
Hereditary Autoinflammatory Disorders: Recognition and Treatment. Immunol Allergy Clin North Am. 2019 02; 39(1):13-29. Broderick L. PMID: 30466770.

View in: PubMed Mentions: 7 Fields:
All Allergy and Immunology
Translation:Humans
TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies. J Clin Invest. 2017 12 01; 127(12):4488-4497. McGeough MD, Wree A, Inzaugarat ME, Haimovich A, Johnson CD, Peña CA, Goldbach-Mansky R, Broderick L, Feldstein AE, Hoffman HM. PMID: 29130929; PMCID: PMC5707143.

View in: PubMed Mentions: 77 Fields:
Med Medicine (General)
Translation:Animals Cells
Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report. BMC Pediatr. 2017 04 20; 17(1):108. Radhakrishna SM, Grimm A, Broderick L. PMID: 28427379; PMCID: PMC5399385.

View in: PubMed Mentions: 1 Fields:
Ped Pediatrics
Translation:Humans
Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease. Arthritis Rheumatol. 2017 02; 69(2):253-256. Hoffman HM, Broderick L. PMID: 27748054; PMCID: PMC5538189.

View in: PubMed Mentions: 12 Fields:
Rhe Rheumatology
Translation:Humans
The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 07; 138(1):3-14. Hoffman HM, Broderick L. PMID: 27373321.

View in: PubMed Mentions: 40 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2. Broderick L. PMID: 26707379.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology Pul Pulmonary Medicine
Translation:Humans
NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms. FASEB J. 2015 Apr; 29(4):1269-79. Qu C, Bonar SL, Hickman-Brecks CL, Abu-Amer S, McGeough MD, Peña CA, Broderick L, Yang C, Grimston SK, Kading J, Abu-Amer Y, Novack DV, Hoffman HM, Civitelli R, Mbalaviele G. PMID: 25477279; PMCID: PMC4396608.

View in: PubMed Mentions: 37 Fields:
Bio Biology Phy Physiology
Translation:Humans Animals Cells
cASCading specks. Nat Immunol. 2014 Aug; 15(8):698-700. Broderick L, Hoffman HM. PMID: 25045869.

View in: PubMed Mentions: 9 Fields:
All Allergy and Immunology
Translation:Humans
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. PMID: 23958599.

View in: PubMed Mentions: 257 Fields:
Gas Gastroenterology
Translation:Humans
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. PMID: 22926405; PMCID: PMC3540165.

View in: PubMed Mentions: 16 Fields:
All Allergy and Immunology
Translation:Humans Cells
Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. PMID: 22904305; PMCID: PMC3495128.

View in: PubMed Mentions: 41 Fields:
All Allergy and Immunology
Translation:Animals
Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. PMID: 22584197; PMCID: PMC3490505.

View in: PubMed Mentions: 1 Fields:
All Allergy and Immunology Pul Pulmonary Medicine
Translation:Humans
Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. PMID: 21659854; PMCID: PMC3154953.

View in: PubMed Mentions: 2 Fields:
All Allergy and Immunology
Translation:Humans
Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. PMID: 21220401; PMCID: PMC3025426.

View in: PubMed Mentions: 9 Fields:
Ped Pediatrics
Translation:Humans