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    Lori Broderick

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0760
    CA La Jolla 92093
    Phone858-534-1703
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      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Genetics and Immunoregulatory mechanisms of PFAPA syndrome
      NIH K08HD075830May 1, 2014 - Apr 30, 2019
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Hoffman HM, Broderick L. The role of the inflammasome in patients with autoinflammatory diseases. J Allergy Clin Immunol. 2016 Jul; 138(1):3-14. PMID: 27373321.
        View in: PubMed
      2. Broderick L. Recurrent Fevers for the Pediatric Immunologist: It's Not All Immunodeficiency. Curr Allergy Asthma Rep. 2016 Jan; 16(1):2. PMID: 26707379.
        View in: PubMed
      3. Broderick L, De Nardo D, Franklin BS, Hoffman HM, Latz E. The inflammasomes and autoinflammatory syndromes. Annu Rev Pathol. 2015 Jan 24; 10:395-424. PMID: 25423351.
        View in: PubMed
      4. Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T. Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15514-9. PMID: 25313054.
        View in: PubMed
      5. Broderick L, Hoffman HM. cASCading specks. Nat Immunol. 2014 Jul 21; 15(8):698-700. PMID: 25045869.
        View in: PubMed
      6. Brydges SD, Broderick L, McGeough MD, Pena CA, Mueller JL, Hoffman HM. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. J Clin Invest. 2013 Nov 1; 123(11):4695-705. PMID: 24084736.
        View in: PubMed
      7. Scott DR, Chan S, Chang J, Broderick L, Hoffman HM. Recurrent fevers and failure to thrive in an infant. Allergy Asthma Proc. 2013 Sep-Oct; 34(5):473-9. PMID: 23998246.
        View in: PubMed
      8. Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat Rev Gastroenterol Hepatol. 2013 Nov; 10(11):627-36. PMID: 23958599.
        View in: PubMed
      9. Broderick L, Gandhi C, Mueller JL, Putnam CD, Shayan K, Giclas PC, Peterson KS, Aceves SS, Sheets RM, Peterson BM, Newbury RO, Hoffman HM, Bastian JF. Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis. J Clin Immunol. 2013 Jan; 33(1):162-71. PMID: 22926405.
        View in: PubMed
      10. McGeough MD, Pena CA, Mueller JL, Pociask DA, Broderick L, Hoffman HM, Brydges SD. Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models. J Immunol. 2012 Sep 15; 189(6):2707-11. PMID: 22904305.
        View in: PubMed
      11. Broderick L, Tremoulet AH, Burns JC, Hoffman HM. Prolonged urticaria and fever in a toddler. Allergy Asthma Proc. 2012 May-Jun; 33(3):297-301. PMID: 22584197.
        View in: PubMed
      12. Broderick L, Tourangeau LM, Kavanaugh A, Wasserman SI. Biologic modulators in allergic and autoinflammatory diseases. Curr Opin Allergy Clin Immunol. 2011 Aug; 11(4):355-60. PMID: 21659854.
        View in: PubMed
      13. Broderick L, Tremoulet AH, Burns JC, Bastian JF, Hoffman HM. Recurrent fever syndromes in patients after recovery from Kawasaki syndrome. Pediatrics. 2011 Feb; 127(2):e489-93. PMID: 21220401.
        View in: PubMed
      14. Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 1; 178(9):5552-62. PMID: 17442937.
        View in: PubMed
      15. Broderick L, Bankert RB. Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments. J Immunol. 2006 Sep 1; 177(5):3082-8. PMID: 16920945.
        View in: PubMed
      16. Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906. PMID: 15634912.
        View in: PubMed