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    Lin Chao

    SchoolUniversity of California, San Diego
    DepartmentEcology, Behavior, and Evolution
    Address9500 Gilman Drive #0116
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      NIH/NIGMS R01GM060916Aug 1, 1999 - Jul 31, 2004
      Role: Principal Investigator
      NIH/NIGMS R01GM041005Jan 1, 1989 - Dec 31, 1993
      Role: Principal Investigator
      NIH/NIGMS R01GM031990Apr 1, 1983 - Mar 31, 1986
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Parthasarathy V, Frazier DT, Bettcher BM, Jastrzab L, Chao L, Reed B, Mungas D, Weiner M, DeCarli C, Chui H, Kramer JH. Triglycerides are negatively correlated with cognitive function in nondemented aging adults. Neuropsychology. 2017 Sep; 31(6):682-688. PMID: 28604016.
        View in: PubMed
      2. Chao L, Elena SF. Nonlinear trade-offs allow the cooperation game to evolve from Prisoner's Dilemma to Snowdrift. Proc Biol Sci. 2017 May 17; 284(1854). PMID: 28490625.
        View in: PubMed
      3. Chao L, Reeb R, Esparza IL, Abadjian LR. Associations between the self-reported frequency of hearing chemical alarms in theater and regional brain volume in Gulf War Veterans. Neurotoxicology. 2016 Mar; 53:246-56. PMID: 26920621.
        View in: PubMed
      4. Chao L, Rang CU, Proenca AM, Chao JU. Asymmetrical Damage Partitioning in Bacteria: A Model for the Evolution of Stochasticity, Determinism, and Genetic Assimilation. PLoS Comput Biol. 2016 Jan; 12(1):e1004700. PMID: 26761487; PMCID: PMC4711911.
      5. Chao L, Tosun D, Woodward SH, Kaufer D, Neylan TC. Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. Front Behav Neurosci. 2015; 9:333. PMID: 26696852; PMCID: PMC4667092.
      6. Chao L, Zhang Y, Buckley S. Effects of low-level sarin and cyclosarin exposure on white matter integrity in Gulf War Veterans. Neurotoxicology. 2015 May; 48:239-48. PMID: 25929683.
        View in: PubMed
      7. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Stud Health Technol Inform. 2015; 216:736-40. PMID: 26262149.
        View in: PubMed
      8. Chao L, Kriger S, Buckley S, Ng P, Mueller SG. Effects of low-level sarin and cyclosarin exposure on hippocampal subfields in Gulf War Veterans. Neurotoxicology. 2014 Sep; 44:263-9. PMID: 25058901.
        View in: PubMed
      9. Mohlenhoff BS, Chao L, Buckley ST, Weiner MW, Neylan TC. Are hippocampal size differences in posttraumatic stress disorder mediated by sleep pathology? Alzheimers Dement. 2014 Jun; 10(3 Suppl):S146-54. PMID: 24924666; PMCID: PMC4111235.
      10. Chao L, Yaffe K, Samuelson K, Neylan TC. Hippocampal volume is inversely related to PTSD duration. Psychiatry Res. 2014 Jun 30; 222(3):119-23. PMID: 24742925.
        View in: PubMed
      11. Chao L, Mohlenhoff BS, Weiner MW, Neylan TC. Associations between subjective sleep quality and brain volume in Gulf War veterans. Sleep. 2014 Mar 01; 37(3):445-52. PMID: 24587566; PMCID: PMC3920309.
      12. Campbell EM, Chao L. A population model evaluating the consequences of the evolution of double-resistance and tradeoffs on the benefits of two-drug antibiotic treatments. PLoS One. 2014; 9(1):e86971. PMID: 24498003; PMCID: PMC3909004.
      13. Díaz-Muñoz SL, Tenaillon O, Goldhill D, Brao K, Turner PE, Chao L. Electrophoretic mobility confirms reassortment bias among geographic isolates of segmented RNA phages. BMC Evol Biol. 2013 Sep 24; 13:206. PMID: 24059872; PMCID: PMC3848951.
      14. Chao L, Weiner M, Neylan T. Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Res. 2013 Sep 30; 213(3):193-201. PMID: 23816189.
        View in: PubMed
      15. Chao L, Decarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack WJ, Chui HC, Weiner MW. Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One. 2013; 8(6):e65175. PMID: 23762308; PMCID: PMC3675157.
      16. Zhang Y, Schuff N, Camacho M, Chao L, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW. MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS One. 2013; 8(6):e66367. PMID: 23762488; PMCID: PMC3675142.
      17. Cardenas VA, Tosun D, Chao L, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43. PMID: 23421601; PMCID: PMC3951683.
      18. Cardenas VA, Reed B, Chao L, Chui H, Sanossian N, DeCarli CC, Mack W, Kramer J, Hodis HN, Yan M, Buonocore MH, Carmichael O, Jagust WJ, Weiner MW. Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults. Stroke. 2012 Nov; 43(11):2865-70. PMID: 22984010; PMCID: PMC3732460.
      19. Rang CU, Peng AY, Poon AF, Chao L. Ageing in Escherichia coli requires damage by an extrinsic agent. Microbiology. 2012 Jun; 158(Pt 6):1553-9. PMID: 22422756.
        View in: PubMed
      20. Rang CU, Peng AY, Chao L. Temporal dynamics of bacterial aging and rejuvenation. Curr Biol. 2011 Nov 08; 21(21):1813-6. PMID: 22036179.
        View in: PubMed
      21. Chao L, Abadjian L, Hlavin J, Meyerhoff DJ, Weiner MW. Effects of low-level sarin and cyclosarin exposure and Gulf War Illness on brain structure and function: a study at 4T. Neurotoxicology. 2011 Dec; 32(6):814-22. PMID: 21741405.
        View in: PubMed
      22. Chao L. A model for damage load and its implications for the evolution of bacterial aging. PLoS Genet. 2010 Aug 26; 6(8). PMID: 20865171; PMCID: PMC2928801.
      23. Chao L, Rothlind JC, Cardenas VA, Meyerhoff DJ, Weiner MW. Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans. Neurotoxicology. 2010 Sep; 31(5):493-501. PMID: 20580739; PMCID: PMC2934883.
      24. Chao L, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):19-27. PMID: 20220321; PMCID: PMC2865220.
      25. Chao L, Pa J, Duarte A, Schuff N, Weiner MW, Kramer JH, Miller BL, Freeman KM, Johnson JK. Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):245-52. PMID: 19812467; PMCID: PMC2760039.
      26. Pa J, Boxer A, Chao L, Gazzaley A, Freeman K, Kramer J, Miller BL, Weiner MW, Neuhaus J, Johnson JK. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Ann Neurol. 2009 Apr; 65(4):414-23. PMID: 19399879; PMCID: PMC2680500.
      27. Chao L, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW. Patterns of white matter atrophy in frontotemporal lobar degeneration. Arch Neurol. 2007 Nov; 64(11):1619-24. PMID: 17998444; PMCID: PMC2443735.
      28. Cardenas VA, Boxer AL, Chao L, Gorno-Tempini ML, Miller BL, Weiner MW, Studholme C. Deformation-based morphometry reveals brain atrophy in frontotemporal dementia. Arch Neurol. 2007 Jun; 64(6):873-7. PMID: 17562936; PMCID: PMC2733361.
      29. Silander OK, Tenaillon O, Chao L. Understanding the evolutionary fate of finite populations: the dynamics of mutational effects. PLoS Biol. 2007 Apr; 5(4):e94. PMID: 17407380; PMCID: PMC1845161.
      30. Poon AF, Chao L. Functional origins of fitness effect-sizes of compensatory mutations in the DNA bacteriophage phiX174. Evolution. 2006 Oct; 60(10):2032-43. PMID: 17133860.
        View in: PubMed
      31. Ackermann M, Chao L. DNA sequences shaped by selection for stability. PLoS Genet. 2006 Feb; 2(2):e22. PMID: 16518467; PMCID: PMC1378130.
      32. Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv Exp Med Biol. 2006; 576:241-62; discussion 361-3. PMID: 16802717; PMCID: PMC1779762.
      33. Silander OK, Weinreich DM, Wright KM, O'Keefe KJ, Rang CU, Turner PE, Chao L. Widespread genetic exchange among terrestrial bacteriophages. Proc Natl Acad Sci U S A. 2005 Dec 27; 102(52):19009-14. PMID: 16365305; PMCID: PMC1323146.
      34. Cardenas VA, Chao L, Blumenfeld R, Song E, Meyerhoff DJ, Weiner MW, Studholme C. Using automated morphometry to detect associations between ERP latency and structural brain MRI in normal adults. Hum Brain Mapp. 2005 Jul; 25(3):317-27. PMID: 15834860; PMCID: PMC2443725.
      35. Du AT, Schuff N, Chao L, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40. PMID: 15961190; PMCID: PMC1779763.
      36. Poon A, Chao L. The rate of compensatory mutation in the DNA bacteriophage phiX174. Genetics. 2005 Jul; 170(3):989-99. PMID: 15911582; PMCID: PMC1451187.
      37. Poon A, Davis BH, Chao L. The coupon collector and the suppressor mutation: estimating the number of compensatory mutations by maximum likelihood. Genetics. 2005 Jul; 170(3):1323-32. PMID: 15879511; PMCID: PMC1451182.
      38. Du AT, Schuff N, Chao L, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9. PMID: 15653183.
        View in: PubMed
      39. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. PMID: 15592130; PMCID: PMC1820853.
      40. Chao L, Lindgren JA, Flenniken DL, Weiner MW. ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy. Clin Neurophysiol. 2004 Jul; 115(7):1583-91. PMID: 15203059; PMCID: PMC2367143.
      41. Ackermann M, Chao L. Evolution of cooperation: two for one? Curr Biol. 2004 Jan 20; 14(2):R73-4. PMID: 14738754.
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      42. Poon A, Chao L. Drift increases the advantage of sex in RNA bacteriophage Phi6. Genetics. 2004 Jan; 166(1):19-24. PMID: 15020402; PMCID: PMC1470714.
      43. Dahlberg C, Chao L. Amelioration of the cost of conjugative plasmid carriage in Eschericha coli K12. Genetics. 2003 Dec; 165(4):1641-9. PMID: 14704155; PMCID: PMC1462891.
      44. Chao L, Cardenas VA, Meyerhoff DJ, Rothlind JC, Flenniken DL, Lindgren JA, Weiner MW. Abnormal contingent negative variation in HIV patients receiving antiretroviral therapy. Neuroreport. 2003 Nov 14; 14(16):2111-5. PMID: 14600507; PMCID: PMC2733942.
      45. Chao L, Meyerhoff DJ, Cardenas VA, Rothlind JC, Weiner MW. Abnormal CNV in chronic heavy drinkers. Clin Neurophysiol. 2003 Nov; 114(11):2081-95. PMID: 14580606.
        View in: PubMed
      46. Rang C, Galen JE, Kaper JB, Chao L. Fitness cost of the green fluorescent protein in gastrointestinal bacteria. Can J Microbiol. 2003 Sep; 49(9):531-7. PMID: 14608419.
        View in: PubMed
      47. Chao L, Rang CU, Wong LE. Distribution of spontaneous mutants and inferences about the replication mode of the RNA bacteriophage phi6. J Virol. 2002 Apr; 76(7):3276-81. PMID: 11884552; PMCID: PMC136006.
      48. Rang C, Midtvedt T, Molin S, Chao L. Chemostat modeling of Escherichia coli persistence in conventionalized mono-associated and streptomycin-treated mice. Can J Microbiol. 2001 Jan; 47(1):86-90. PMID: 15049455.
        View in: PubMed
      49. Chao L, Hanley KA, Burch CL, Dahlberg C, Turner PE. Kin selection and parasite evolution: higher and lower virulence with hard and soft selection. Q Rev Biol. 2000 Sep; 75(3):261-75. PMID: 11008699.
        View in: PubMed
      50. Burch CL, Chao L. Evolvability of an RNA virus is determined by its mutational neighbourhood. Nature. 2000 Aug 10; 406(6796):625-8. PMID: 10949302.
        View in: PubMed
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