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    Lee Hagey

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address200 W. Arbor Drive #8200
    CA San Diego 92103
    Phone619-543-2281
    vCardDownload vCard

      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kurogi K, Yoshihama M, Horton A, Schiefer IT, Krasowski MD, Hagey L, Williams FE, Sakakibara Y, Kenmochi N, Suiko M, Liu MC. Identification and characterization of 5a-cyprinol-sulfating cytosolic sulfotransferases (Sults) in the zebrafish (Danio rerio). J Steroid Biochem Mol Biol. 2017 Aug 12. PMID: 28807679.
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      2. Kulkarni SR, Soroka CJ, Hagey L, Boyer JL. Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid-fed mouse model of cholestasis. Hepatology. 2016 Sep 17. PMID: 27639250.
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      3. Satoh R, Ogata H, Saito T, Zhou B, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Hagey L, Hofmann AF, Iida T. Two Major Bile Acids in the Hornbills, (24R,25S)-3a,7a,24-Trihydroxy-5ß-cholestan-27-oyl Taurine and Its 12a-Hydroxy Derivative. Lipids. 2016 Jun; 51(6):757-68. PMID: 27108034.
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      4. Sato née Okihara R, Saito T, Ogata H, Nakane N, Namegawa K, Sekiguchi S, Omura K, Kurabuchi S, Mitamura K, Ikegawa S, Raines J, Hagey L, Hofmann AF, Iida T. Novel, major 2a- and 2ß-hydroxy bile alcohols and bile acids in the bile of Arapaima gigas, a large South American river fish. Steroids. 2016 Mar; 107:112-20. PMID: 26768415.
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      5. Li M, Mennone A, Soroka CJ, Hagey L, Ouyang X, Weinman EJ, Boyer JL. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 62(4):1227-36. PMID: 26108984; PMCID: PMC4589453 [Available on 10/01/16].
      6. Tabibian JH, O'Hara SP, Trussoni CE, Tietz PS, Splinter PL, Mounajjed T, Hagey L, LaRusso NF. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis. Hepatology. 2016 Jan; 63(1):185-96. PMID: 26044703; PMCID: PMC4670294 [Available on 01/01/17].
      7. de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey L, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 03; 21(2):298-310. PMID: 25651182; PMCID: PMC4317590.
      8. Spriggs M, Thompson KA, Barton D, Talley J, Volle K, Stasiak I, Beyea L, Guthrie A, Roda A, Camborata C, Hofmann AF, Hagey L. Gastrolithiasis in prehensile-tailed porcupines (Coendou prehensilis): nine cases and pathogenesis of stone formation. J Zoo Wildl Med. 2014 Dec; 45(4):883-91. PMID: 25632677.
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      9. Omura K, Ohsaki A, Zhou B, Kushida M, Mitsuma T, Kobayashi A, Hagey L, Hofmann AF, Iida T. Improved chemical synthesis, X-ray crystallographic analysis, and NMR characterization of (22R)-/(22S)-hydroxy epimers of bile acids. Lipids. 2014 Nov; 49(11):1169-80. PMID: 25319478.
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      10. Hofmann AF, Hagey L. Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades. J Lipid Res. 2014 Aug; 55(8):1553-95. PMID: 24838141; PMCID: PMC4109754.
      11. Satoh Née Okihara R, Saito T, Ogata H, Ohsaki A, Iida T, Asahina K, Mitamura K, Ikegawa S, Hofmann AF, Hagey L. N-Methyltaurine N-acyl amidated bile acids and deoxycholic acid in the bile of angelfish (Pomacanthidae): a novel bile acid profile in Perciform fish. Steroids. 2014 Feb; 80:15-23. PMID: 24291417.
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      12. Jones KL, Weiss LA, Hagey L, Gonzalez V, Benirschke K, Chambers CD. Altered lipid metabolism in gastroschisis: a novel hypothesis. Am J Med Genet A. 2013 Aug; 161A(8):1860-5. PMID: 23794282.
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      13. Wang R, Liu L, Sheps JA, Forrest D, Hofmann AF, Hagey L, Ling V. Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15; 305(4):G286-94. PMID: 23764895.
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      14. Cai SY, Lionarons DA, Hagey L, Soroka CJ, Mennone A, Boyer JL. Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion. Hepatology. 2013 Jun; 57(6):2418-26. PMID: 23175353; PMCID: PMC3604052.
      15. Ogawa S, Zhou B, Kimoto Y, Omura K, Kobayashi A, Higashi T, Mitamura K, Ikegawa S, Hagey L, Hofmann AF, Iida T. An efficient synthesis of 7a,12a-dihydroxy-4-cholesten-3-one and its biological precursor 7a-hydroxy-4-cholesten-3-one: Key intermediates in bile acid biosynthesis. Steroids. 2013 Sep; 78(9):927-37. PMID: 23707572.
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      16. Kuo SM, Merhige PM, Hagey L. The effect of dietary prebiotics and probiotics on body weight, large intestine indices, and fecal bile acid profile in wild type and IL10-/- mice. PLoS One. 2013; 8(3):e60270. PMID: 23555939; PMCID: PMC3605333.
      17. Hagey L, Krasowski MD. Microbial biotransformations of bile acids as detected by electrospray mass spectrometry. Adv Nutr. 2013 Jan 01; 4(1):29-35. PMID: 23319120; PMCID: PMC3648736.
      18. Hiller M, Schaar BT, Indjeian VB, Kingsley DM, Hagey L, Bejerano G. A "forward genomics" approach links genotype to phenotype using independent phenotypic losses among related species. Cell Rep. 2012 Oct 25; 2(4):817-23. PMID: 23022484; PMCID: PMC3572205.
      19. Hagey L, Ogawa S, Kato N, Satoh née Okihara R, Une M, Mitamura K, Ikegawa S, Hofmann AF, Iida T. A novel varanic acid epimer--(24R,25S)-3a,7a,12a,24-tetrahydroxy-5ß-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster. Steroids. 2012 Nov; 77(13):1510-21. PMID: 22986074.
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      20. Muto A, Takei H, Unno A, Murai T, Kurosawa T, Ogawa S, Iida T, Ikegawa S, Mori J, Ohtake A, Hoshina T, Mizuochi T, Kimura A, Hofmann AF, Hagey L, Nittono H. Detection of ?4-3-oxo-steroid 5ß-reductase deficiency by LC-ESI-MS/MS measurement of urinary bile acids. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 01; 900:24-31. PMID: 22695323.
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      21. Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey L, Kensler TW, Boyer JL. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. Am J Physiol Gastrointest Liver Physiol. 2012 May 01; 302(9):G925-36. PMID: 22345550; PMCID: PMC3362073.
      22. Weiss LA, Chambers CD, Gonzalez V, Hagey L, Jones KL. The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. Am J Med Genet A. 2012 Apr; 158A(4):803-7. PMID: 22315197.
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      23. Hagey L, Iida T, Ogawa S, Adachi Y, Une M, Mushiake K, Maekawa M, Shimada M, Mano N, Hofmann AF. Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3a,7a,24-trihydroxy-5ß-cholestan-27-oic acid and two epimers (25R and 25S) of 3a,7a-dihydroxy-5ß-cholestan-27-oic acid. Steroids. 2011 Sep-Oct; 76(10-11):1126-35. PMID: 21600907.
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      24. Ogawa S, Mitamura K, Ikegawa S, Krasowski MD, Hagey L, Hofmann AF, Iida T. Chemical synthesis of the (25R)- and (25S)-epimers of 3a,7a,12a-trihydroxy-5a-cholestan-27-oic acid as well as their corresponding glycine and taurine conjugates. Chem Phys Lipids. 2011 Jul; 164(5):368-77. PMID: 21554864.
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      25. Krasowski MD, Ai N, Hagey L, Kollitz EM, Kullman SW, Reschly EJ, Ekins S. The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species. BMC Biochem. 2011 Feb 03; 12:5. PMID: 21291553; PMCID: PMC3042382.
      26. Hagey L, Vidal N, Hofmann AF, Krasowski MD. COMPLEX EVOLUTION OF BILE SALTS IN BIRDS. Auk. 2010 Oct; 127(4):820-831. PMID: 21113274.
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      27. Krasowski MD, Ni A, Hagey L, Ekins S. Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CAR. Mol Cell Endocrinol. 2011 Mar 01; 334(1-2):39-48. PMID: 20615451; PMCID: PMC3033471.
      28. Hagey L, Lida T, Tamegai H, Ogawa S, Une M, Asahina K, Mushiake K, Goto T, Mano N, Goto J, Krasowski MD, Hofmann AF. Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid. Zoolog Sci. 2010 Jul; 27(7):565-73. PMID: 20608845; PMCID: PMC2901895.
      29. Hagey L, Vidal N, Hofmann AF, Krasowski MD. Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites. BMC Evol Biol. 2010 May 06; 10:133. PMID: 20444292; PMCID: PMC2886068.
      30. Howarth DL, Hagey L, Law SH, Ai N, Krasowski MD, Ekins S, Moore JT, Kollitz EM, Hinton DE, Kullman SW. Two farnesoid X receptor alpha isoforms in Japanese medaka (Oryzias latipes) are differentially activated in vitro. Aquat Toxicol. 2010 Jul 01; 98(3):245-55. PMID: 20430454; PMCID: PMC2874645.
      31. Hagey L, Møller PR, Hofmann AF, Krasowski MD. Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway. Physiol Biochem Zool. 2010 Mar-Apr; 83(2):308-21. PMID: 20113173; PMCID: PMC2845723.
      32. Huertas M, Hagey L, Hofmann AF, Cerdà J, Canário AV, Hubbard PC. Olfactory sensitivity to bile fluid and bile salts in the European eel (Anguilla anguilla), goldfish (Carassius auratus) and Mozambique tilapia (Oreochromis mossambicus) suggests a 'broad range' sensitivity not confined to those produced by conspecifics alone. J Exp Biol. 2010 Jan 15; 213(2):308-17. PMID: 20038666.
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      33. Soroka CJ, Mennone A, Hagey L, Ballatori N, Boyer JL. Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology. 2010 Jan; 51(1):181-90. PMID: 19902485; PMCID: PMC2819820.
      34. Hofmann AF, Hagey L, Krasowski MD. Bile salts of vertebrates: structural variation and possible evolutionary significance. J Lipid Res. 2010 Feb; 51(2):226-46. PMID: 19638645; PMCID: PMC2803226.
      35. Money ME, Hofmann AF, Hagey L, Walkowiak J, Talley NJ. Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. Pancreas. 2009 Mar; 38(2):232-3. PMID: 19238028.
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      36. Hagey L, Kakiyama G, Muto A, Iida T, Mushiake K, Goto T, Mano N, Goto J, Oliveira CA, Hofmann AF. A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid. J Lipid Res. 2009 Apr; 50(4):651-7. PMID: 19011113; PMCID: PMC2656658.
      37. Hofmann AF, Loening-Baucke V, Lavine JE, Hagey L, Steinbach JH, Packard CA, Griffin TL, Chatfield DA. Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients. J Pediatr Gastroenterol Nutr. 2008 Nov; 47(5):598-606. PMID: 18955863.
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      38. Hofmann AF, Hagey L. Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics. Cell Mol Life Sci. 2008 Aug; 65(16):2461-83. PMID: 18488143.
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      39. Ekins S, Reschly EJ, Hagey L, Krasowski MD. Evolution of pharmacologic specificity in the pregnane X receptor. BMC Evol Biol. 2008 Apr 02; 8:103. PMID: 18384689; PMCID: PMC2358886.
      40. Reschly EJ, Ai N, Ekins S, Welsh WJ, Hagey L, Hofmann AF, Krasowski MD. Evolution of the bile salt nuclear receptor FXR in vertebrates. J Lipid Res. 2008 Jul; 49(7):1577-87. PMID: 18362391; PMCID: PMC2431107.
      41. Reschly EJ, Ai N, Welsh WJ, Ekins S, Hagey L, Krasowski MD. Ligand specificity and evolution of liver X receptors. J Steroid Biochem Mol Biol. 2008 May; 110(1-2):83-94. PMID: 18395439; PMCID: PMC2519238.
      42. Macdonald EA, Fernandez-Duque E, Evans S, Hagey L. Sex, age, and family differences in the chemical composition of owl monkey (Aotus nancymaae) subcaudal scent secretions. Am J Primatol. 2008 Jan; 70(1):12-8. PMID: 17577212.
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      43. Reschly EJ, Bainy AC, Mattos JJ, Hagey L, Bahary N, Mada SR, Ou J, Venkataramanan R, Krasowski MD. Functional evolution of the vitamin D and pregnane X receptors. BMC Evol Biol. 2007 Nov 12; 7:222. PMID: 17997857; PMCID: PMC2263054.
      44. Kakiyama G, Tamegai H, Iida T, Mitamura K, Ikegawa S, Goto T, Mano N, Goto J, Holz P, Hagey L, Hofmann AF. Isolation and chemical synthesis of a major, novel biliary bile acid in the common wombat (Vombatus ursinus): 15alpha-hydroxylithocholic acid. J Lipid Res. 2007 Dec; 48(12):2682-92. PMID: 17785716.
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      45. Hamilton JP, Xie G, Raufman JP, Hogan S, Griffin TL, Packard CA, Chatfield DA, Hagey L, Steinbach JH, Hofmann AF. Human cecal bile acids: concentration and spectrum. Am J Physiol Gastrointest Liver Physiol. 2007 Jul; 293(1):G256-63. PMID: 17412828.
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      46. Keely SJ, Scharl MM, Bertelsen LS, Hagey L, Barrett KE, Hofmann AF. Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships. Am J Physiol Gastrointest Liver Physiol. 2007 Jan; 292(1):G290-7. PMID: 16901996.
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      47. Sehayek E, Hagey L, Fung YY, Duncan EM, Yu HJ, Eggertsen G, Björkhem I, Hofmann AF, Breslow JL. Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit. J Lipid Res. 2006 Sep; 47(9):2020-7. PMID: 16763287.
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      48. Mennone A, Soroka CJ, Cai SY, Harry K, Adachi M, Hagey L, Schuetz JD, Boyer JL. Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis. Hepatology. 2006 May; 43(5):1013-21. PMID: 16628672.
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      49. Kakiyama G, Iida T, Goto T, Mano N, Goto J, Nambara T, Hagey L, Schteingart CD, Hofmann AF. Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid. J Lipid Res. 2006 Jul; 47(7):1551-8. PMID: 16648547.
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      50. Agnew DW, Hagey L, Shoshani J. The elephants of Zoba Gash Barka, Eritrea: part 4. Cholelithiasis in a wild African elephant (Loxodonta africana). J Zoo Wildl Med. 2005 Dec; 36(4):677-83. PMID: 17312726.
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      51. Hofmann AF, Zakko SF, Lira M, Clerici C, Hagey L, Lambert KK, Steinbach JH, Schteingart CD, Olinga P, Groothuis GM. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology. 2005 Dec; 42(6):1391-8. PMID: 16317695.
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      52. Krasowski MD, Yasuda K, Hagey L, Schuetz EG. Evolutionary selection across the nuclear hormone receptor superfamily with a focus on the NR1I subfamily (vitamin D, pregnane X, and constitutive androstane receptors). Nucl Recept. 2005 Sep 30; 3:2. PMID: 16197547; PMCID: PMC1262763.
      53. Moschetta A, Xu F, Hagey L, van Berge-Henegouwen GP, van Erpecum KJ, Brouwers JF, Cohen JC, Bierman M, Hobbs HH, Steinbach JH, Hofmann AF. A phylogenetic survey of biliary lipids in vertebrates. J Lipid Res. 2005 Oct; 46(10):2221-32. PMID: 16061950.
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      54. Krasowski MD, Yasuda K, Hagey L, Schuetz EG. Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts. Mol Endocrinol. 2005 Jul; 19(7):1720-39. PMID: 15718292; PMCID: PMC2238640.
      55. Kakiyama G, Iida T, Yoshimoto A, Goto T, Mano N, Goto J, Nambara T, Hagey L, Hofmann AF. Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat. J Lipid Res. 2004 Mar; 45(3):567-73. PMID: 14657194.
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      56. Goto T, Holzinger F, Hagey L, Cerrè C, Ton-Nu HT, Schteingart CD, Steinbach JH, Shneider BL, Hofmann AF. Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fish. J Lipid Res. 2003 Sep; 44(9):1643-51. PMID: 12810826.
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      57. Porter JL, Fordtran JS, Santa Ana CA, Emmett M, Hagey L, Macdonald EA, Hofmann AF. Accurate enzymatic measurement of fecal bile acids in patients with malabsorption. J Lab Clin Med. 2003 Jun; 141(6):411-8. PMID: 12819639.
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      58. Hagey L, MacDonald E. Chemical cues identify gender and individuality in Giant pandas (Ailuropoda melanoleuca). J Chem Ecol. 2003 Jun; 29(6):1479-88. PMID: 12918929.
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      59. Lorenzo-Zúñiga V, Bartolí R, Planas R, Hofmann AF, Viñado B, Hagey L, Hernández JM, Mañé J, Alvarez MA, Ausina V, Gassull MA. Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats. Hepatology. 2003 Mar; 37(3):551-7. PMID: 12601352.
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      60. Hagey L, Czekala NM. Comparative urinary androstanes in the great apes. Gen Comp Endocrinol. 2003 Jan; 130(1):64-9. PMID: 12535626.
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      61. Zeh N, Rossi SS, Hofmann AF, Steinbach JH, Hagey L, Oliver D, Stange J, Hassanein T. The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease. Liver Int. 2003; 23 Suppl 3:34-8. PMID: 12950959.
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      62. Iida T, Hikosaka M, Kakiyama G, Shiraishi K, Schteingart CD, Hagey L, Ton-Nu HT, Hofmann AF, Mano N, Goto J, Nambara T. Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids. Chem Pharm Bull (Tokyo). 2002 Oct; 50(10):1327-34. PMID: 12372858.
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      63. Hagey L, Schteingart CD, Ton-Nu HT, Hofmann AF. A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significance. J Lipid Res. 2002 May; 43(5):685-90. PMID: 11971938.
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      64. Lance VA, Patton ML, Hagey L. Identification of a series of C(21)O(2) pregnanes from fecal extracts of a pregnant black rhinoceros (Diceros bicornis minor). Steroids. 2001 Dec; 66(12):875-81. PMID: 11711115.
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      65. Teixeira FV, Hofmann AF, Hagey L, Pera M, Kelly KA. Bile acid absorption after near-total proctocolectomy in dogs: ileal pouch vs. jejunal pouch-distal rectal anastomosis. J Gastrointest Surg. 2001 Sep-Oct; 5(5):540-5. PMID: 11986006.
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      66. Bolder U, Trang NV, Hagey L, Schteingart CD, Ton-Nu HT, Cerrè C, Elferink RP, Hofmann AF. Sulindac is excreted into bile by a canalicular bile salt pump and undergoes a cholehepatic circulation in rats. Gastroenterology. 1999 Oct; 117(4):962-71. PMID: 10500080.
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      67. Chatman K, Hollenbeck T, Hagey L, Vallee M, Purdy R, Weiss F, Siuzdak G. Nanoelectrospray mass spectrometry and precursor ion monitoring for quantitative steroid analysis and attomole sensitivity. Anal Chem. 1999 Jul 01; 71(13):2358-63. PMID: 10405603.
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      68. Gruy-Kapral C, Little KH, Fordtran JS, Meziere TL, Hagey L, Hofmann AF. Conjugated bile acid replacement therapy for short-bowel syndrome. Gastroenterology. 1999 Jan; 116(1):15-21. PMID: 9869597.
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      69. Hagey L, Schteingart CD, Rossi SS, Ton-Nu HT, Hofmann AF. An N-acyl glycyltaurine conjugate of deoxycholic acid in the biliary bile acids of the rabbit. J Lipid Res. 1998 Nov; 39(11):2119-24. PMID: 9799797.
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      70. Ricci P, Hofmann AF, Hagey L, Jorgensen RA, Rolland Dickson E, Lindor KD. Adjuvant cholylsarcosine during ursodeoxycholic acid treatment of primary biliary cirrhosis. Dig Dis Sci. 1998 Jun; 43(6):1292-5. PMID: 9635620.
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      71. Jurke MH, Czekala NM, Jurke S, Hagey L, Lance VA, Conley AJ, Fitch-Snyder H. Monitoring pregnancy in twinning pygmy loris (Nycticebus pygmaeus) using fecal estrogen metabolites. Am J Primatol. 1998; 46(2):173-83. PMID: 9773680.
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      72. Holzinger F, Schteingart CD, Ton-Nu HT, Eming SA, Monte MJ, Hagey L, Hofmann AF. Fluorescent bile acid derivatives: relationship between chemical structure and hepatic and intestinal transport in the rat. Hepatology. 1997 Nov; 26(5):1263-71. PMID: 9362371.
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      73. Yeh HZ, Schteingart CD, Hagey L, Ton-Nu HT, Bolder U, Gavrilkina MA, Steinbach JH, Hofmann AF. Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid. Hepatology. 1997 Aug; 26(2):374-85. PMID: 9252148.
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      74. Rossi SS, Moore AC, Hagey L, Yaksh TL, Chaplan SR. An improved method for the measurement of lidocaine and its metabolites in rat plasma. Ther Drug Monit. 1997 Apr; 19(2):179-84. PMID: 9108647.
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      75. Merrill JR, Schteingart CD, Hagey L, Peng Y, Ton-Nu HT, Frick E, Jirsa M, Hofmann AF. Hepatic biotransformation in rodents and physicochemical properties of 23(R)-hydroxychenodeoxycholic acid, a natural alpha-hydroxy bile acid. J Lipid Res. 1996 Jan; 37(1):98-112. PMID: 8820106.
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      76. Hagey L, Schteingart CD, Ton-Nu HT, Hofmann AF. Biliary bile acids of fruit pigeons and doves (Columbiformes): presence of 1-beta-hydroxychenodeoxycholic acid and conjugation with glycine as well as taurine. J Lipid Res. 1994 Nov; 35(11):2041-8. PMID: 7868982.
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      77. Espinoza EO, Shafer JA, Hagey L. International trade in bear gall bladders: forensic source inference. J Forensic Sci. 1993 Nov; 38(6):1363-71. PMID: 8263479.
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      78. Hagey L, Crombie DL, Espinosa E, Carey MC, Igimi H, Hofmann AF. Ursodeoxycholic acid in the Ursidae: biliary bile acids of bears, pandas, and related carnivores. J Lipid Res. 1993 Nov; 34(11):1911-7. PMID: 8263415.
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      79. Stravitz RT, Hylemon PB, Heuman DM, Hagey L, Schteingart CD, Ton-Nu HT, Hofmann AF, Vlahcevic ZR. Transcriptional regulation of cholesterol 7 alpha-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes. J Biol Chem. 1993 Jul 05; 268(19):13987-93. PMID: 8314765.
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      80. Schteingart CD, Hagey L, Setchell KD, Hofmann AF. 5 beta-hydroxylation by the liver. Identification of 3,5,7-trihydroxy nor-bile acids as new major biotransformation products of 3,7-dihydroxy nor-bile acids in rodents. J Biol Chem. 1993 May 25; 268(15):11239-46. PMID: 8496179.
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      81. Lillienau J, Crombie DL, Munoz J, Longmire-Cook SJ, Hagey L, Hofmann AF. Negative feedback regulation of the ileal bile acid transport system in rodents. Gastroenterology. 1993 Jan; 104(1):38-46. PMID: 8419260.
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      82. Lillienau J, Hagey L, Borgström B. Hepatic and ileal transport and effect on biliary secretion of norursocholic acid and its conjugates in rats. Am J Physiol. 1991 Dec; 261(6 Pt 1):G1057-64. PMID: 1767847.
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      83. Yoshii M, Mosbach EH, Schteingart CD, Hagey L, Hofmann AF, Cohen BI, McSherry CK. Chemical synthesis and hepatic biotransformation of 3 alpha,7 alpha-dihydroxy-7 beta-methyl-24-nor-5 beta-cholan-23-oic acid, a 7-methyl derivative of norchenodeoxycholic acid: studies in the hamster. J Lipid Res. 1991 Nov; 32(11):1729-40. PMID: 1770293.
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      84. Gurantz D, Schteingart CD, Hagey L, Steinbach JH, Grotmol T, Hofmann AF. Hypercholeresis induced by unconjugated bile acid infusion correlates with recovery in bile of unconjugated bile acids. Hepatology. 1991 Mar; 13(3):540-50. PMID: 1999323.
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      85. Schmassmann A, Angellotti MA, Clerici C, Hofmann AF, Ton-Nu HT, Schteingart CD, Marcus SN, Hagey L, Rossi SS, Aigner A. Transport, metabolism, and effect of chronic feeding of lagodeoxycholic acid. A new, natural bile acid. Gastroenterology. 1990 Oct; 99(4):1092-104. PMID: 2394330.
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      86. Elkin RG, Wood KV, Hagey L. Biliary bile acid profiles of domestic fowl as determined by high performance liquid chromatography and fast atom bombardment mass spectrometry. Comp Biochem Physiol B. 1990; 96(1):157-61. PMID: 2364668.
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      87. Oude Elferink RP, de Haan J, Lambert KJ, Hagey L, Hofmann AF, Jansen PL. Selective hepatobiliary transport of nordeoxycholate side chain conjugates in mutant rats with a canalicular transport defect. Hepatology. 1989 Jun; 9(6):861-5. PMID: 2714736.
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      88. Clayton LM, Gurantz D, Hofmann AF, Hagey L, Schteingart CD. Role of bile acid conjugation in hepatic transport of dihydroxy bile acids. J Pharmacol Exp Ther. 1989 Mar; 248(3):1130-7. PMID: 2703966.
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      89. Kanter JR, Hagey L, Brunton LL. Inhibition of cyclic AMP efflux by insect pheromones and fatty acids. FEBS Lett. 1989 Feb 13; 244(1):149-53. PMID: 2538347.
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      90. Lake JR, Renner EL, Scharschmidt BF, Cragoe EJ, Hagey L, Lambert KJ, Gurantz D, Hofmann AF. Inhibition of Na+/H+ exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated urodeoxycholate, and increased ursodeoxycholate glucuronidation. Gastroenterology. 1988 Aug; 95(2):454-63. PMID: 2455672.
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      91. Kuroki S, Schteingart CD, Hagey L, Cohen BI, Mosbach EH, Rossi SS, Hofmann AF, Matoba N, Une M, Hoshita T. Bile salts of the West Indian manatee, Trichechus manatus latirostris: novel bile alcohol sulfates and absence of bile acids. J Lipid Res. 1988 Apr; 29(4):509-22. PMID: 3392467.
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      92. Kirkpatrick RB, Green MD, Hagey L, Hofmann AF, Tephly TR. Effect of side chain length on bile acid conjugation: glucuronidation, sulfation and coenzyme A formation of nor-bile acids and their natural C24 homologs by human and rat liver fractions. Hepatology. 1988 Mar-Apr; 8(2):353-7. PMID: 3356416.
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      93. Palmer KR, Gurantz D, Hofmann AF, Clayton LM, Hagey L, Cecchetti S. Hypercholeresis induced by norchenodeoxycholate in biliary fistula rodent. Am J Physiol. 1987 Feb; 252(2 Pt 1):G219-28. PMID: 3826349.
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      94. Cohen BI, Hofmann AF, Mosbach EH, Stenger RJ, Rothschild MA, Hagey L, Yoon YB. Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit. Gastroenterology. 1986 Jul; 91(1):189-97. PMID: 3710068.
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      95. Yoon YB, Hagey L, Hofmann AF, Gurantz D, Michelotti EL, Steinbach JH. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology. 1986 Apr; 90(4):837-52. PMID: 3949115.
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      96. Hagey L, Krisans SK. Degradation of cholesterol to propionic acid by rat liver peroxisomes. Biochem Biophys Res Commun. 1982 Aug; 107(3):834-41. PMID: 7138522.
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