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    Kun-liang Guan

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0695
    CA La Jolla 92093
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      Collapse Biography 
      Collapse Education and Training
      Ph.D.Purdue University

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Mechanism and Therapy for Ocular Melanoma
      NIH/NCI R01CA217642Mar 14, 2017 - Feb 28, 2022
      Role: Co-Principal Investigator
      The mTOR and Hippo pathway in cell growth and cancer
      NIH/NCI R35CA196878Aug 5, 2015 - Jul 31, 2022
      Role: Principal Investigator
      Regulation of the Hippo pathway and its role in uveal melanoma
      NIH/NEI R01EY022611Sep 1, 2012 - Aug 31, 2016
      Role: Principal Investigator
      Regulation and function of the YAP transcription co-activator oncoprotein
      NIH/NCI R01CA132809Apr 8, 2008 - Feb 28, 2018
      Role: Principal Investigator
      Rag GTPases in mTOR regulation and physiological functions
      NIH/NCI R01CA108941Sep 3, 2004 - Jun 30, 2019
      Role: Principal Investigator
      S6K and mTOR as targets for tuberous sclerosis
      NIH/NCI R41CA101611Jul 1, 2003 - Jun 30, 2004
      Role: Principal Investigator
      Regulation of Ras and Rheb modification by GCN2
      NIH/NIGMS R01GM062694Jul 1, 2000 - Jun 30, 2012
      Role: Principal Investigator
      NIH/NIGMS R01GM055642May 1, 1997 - Apr 30, 2001
      Role: Principal Investigator
      Protein phosphorylation and growth factor function
      NIH/NIGMS R01GM051586Aug 1, 1994 - Nov 30, 2019
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lin KC, Moroishi T, Meng Z, Jeong HS, Plouffe SW, Sekido Y, Han J, Park HW, Guan K. Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation. Nat Cell Biol. 2017 Jul 28; 19(8):996-1002. PMID: 28752853.
        View in: PubMed
      2. Jin Y, Chen Y, Zhao S, Guan K, Zhuang Y, Zhou W, Wu X, Xu T. DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. Proc Natl Acad Sci U S A. 2017 Jul 11; 114(28):7408-7413. PMID: 28645898.
        View in: PubMed
      3. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan K, Mischel PS. mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Mol Cell. 2017 Jul 06; 67(1):128-138.e7. PMID: 28648777.
        View in: PubMed
      4. Diao Y, Fang R, Li B, Meng Z, Yu J, Qiu Y, Lin KC, Huang H, Liu T, Marina RJ, Jung I, Shen Y, Guan K, Ren B. A tiling-deletion-based genetic screen for cis-regulatory element identification in mammalian cells. Nat Methods. 2017 Jun; 14(6):629-635. PMID: 28417999.
        View in: PubMed
      5. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan K, Klemke RL. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017 Apr 15; 77(8):1997-2007. PMID: 28381547.
        View in: PubMed
      6. Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z, Ye D, Guan K. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017 Apr 15; 37(8). PMID: 28137912.
        View in: PubMed
      7. Zhang Q, Meng F, Chen S, Plouffe SW, Wu S, Liu S, Li X, Zhou R, Wang J, Zhao B, Liu J, Qin J, Zou J, Feng XH, Guan K, Xu P. Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 Apr; 19(4):362-374. PMID: 28346439.
        View in: PubMed
      8. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y, Yuan HX, Guan K. Endothelin Promotes Colorectal Tumorigenesis by Activating YAP/TAZ. Cancer Res. 2017 May 01; 77(9):2413-2423. PMID: 28249901.
        View in: PubMed
      9. Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan K, Haybaeck J, Datz C, Zhang K, Karin M. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1643-1648. PMID: 28130546.
        View in: PubMed
      10. Ma X, Zhang S, He L, Rong Y, Brier LW, Sun Q, Liu R, Fan W, Chen S, Yue Z, Kim J, Guan K, Li D, Zhong Q. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017 Mar 04; 13(3):592-607. PMID: 28059666.
        View in: PubMed
      11. Hong AW, Meng Z, Yuan HX, Plouffe SW, Moon S, Kim W, Jho EH, Guan K. Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP. EMBO Rep. 2017 Jan; 18(1):72-86. PMID: 27979971.
        View in: PubMed
      12. Moroishi T, Hayashi T, Pan WW, Fujita Y, Holt MV, Qin J, Carson DA, Guan K. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016 Dec 01; 167(6):1525-1539.e17. PMID: 27912060.
        View in: PubMed
      13. Plouffe SW, Meng Z, Lin KC, Lin B, Hong AW, Chun JV, Guan K. Characterization of Hippo Pathway Components by Gene Inactivation. Mol Cell. 2016 Dec 01; 64(5):993-1008. PMID: 27912098.
        View in: PubMed
      14. Lin HP, Cheng ZL, He RY, Song L, Tian MX, Zhou LS, Groh BS, Liu WR, Ji MB, Ding C, Shi YH, Guan K, Ye D, Xiong Y. Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth. Cancer Res. 2016 Dec 01; 76(23):6924-6936. PMID: 27758890.
        View in: PubMed
      15. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng Z, Sun YP, Yu Y, Xiong Y, Yuan HX, Guan K. Thromboxane A2 Activates YAP/TAZ Protein to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016 Sep 02; 291(36):18947-58. PMID: 27382053; PMCID: PMC5009267 [Available on 09/02/17].
      16. Hong AW, Meng Z, Guan K. The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol. 2016 Jun; 13(6):324-37. PMID: 27147489.
        View in: PubMed
      17. Meng F, Zhou R, Wu S, Zhang Q, Jin Q, Zhou Y, Plouffe SW, Liu S, Song H, Xia Z, Zhao B, Ye S, Feng XH, Guan K, Zou J, Xu P. Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation. Genes Dev. 2016 05 01; 30(9):1086-100. PMID: 27125670; PMCID: PMC4863739 [Available on 11/01/16].
      18. Zha Z, Han XR, Smith MD, Lei QY, Guan K, Xiong Y. Hypertension-associated C825T polymorphism impairs the function of Gß3 to target GRK2 ubiquitination. Cell Discov. 2016; 2:16005. PMID: 27462452; PMCID: PMC4849471.
      19. Fu V, Moroishi T, Guan K. Glycoholics Anonymous: Cancer Sobers Up with mTORC1. Cancer Cell. 2016 Apr 11; 29(4):432-434. PMID: 27070696.
        View in: PubMed
      20. Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan K, Yang P, Yu H, Ye D. SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. EMBO Rep. 2016 Jun; 17(6):811-22. PMID: 27113762.
        View in: PubMed
      21. Diao Y, Li B, Meng Z, Jung I, Lee AY, Dixon J, Maliskova L, Guan K, Shen Y, Ren B. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening. Genome Res. 2016 Mar; 26(3):397-405. PMID: 26813977; PMCID: PMC4772021.
      22. Yuan HX, Guan K. Structural insights of mTOR complex 1. Cell Res. 2016 Mar; 26(3):267-8. PMID: 26794870; PMCID: PMC4783463 [Available on 03/01/17].
      23. Meng Z, Moroishi T, Guan K. Mechanisms of Hippo pathway regulation. Genes Dev. 2016 Jan 01; 30(1):1-17. PMID: 26728553; PMCID: PMC4701972.
      24. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977 [Available on 01/21/17].
      25. Wang P, Wu J, Ma S, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K, Ye D, Xiong Y. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22; 13(11):2353-61. PMID: 26686626; PMCID: PMC4694633.
      26. Hansen CG, Ng YL, Lam WL, Plouffe SW, Guan K. The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1. Cell Res. 2015 Dec; 25(12):1299-313. PMID: 26611634; PMCID: PMC4670996 [Available on 12/01/16].
      27. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, Guan K. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Genes Dev. 2015 Nov 15; 29(22):2362-76. PMID: 26588989; PMCID: PMC4691891.
      28. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan K. Correction: Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015 Nov; 13(11):e1002287. PMID: 26539968; PMCID: PMC4634850.
      29. Yu FX, Zhao B, Guan K. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell. 2015 Nov 05; 163(4):811-28. PMID: 26544935; PMCID: PMC4638384 [Available on 11/05/16].
      30. Yuan HX, Guan K. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015 Nov; 5(11):1127-9. PMID: 26526694; PMCID: PMC4638136.
      31. Ma T, Li J, Xu Y, Yu C, Xu T, Wang H, Liu K, Cao N, Nie BM, Zhu SY, Xu S, Li K, Wei WG, Wu Y, Guan K, Ding S. Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nat Cell Biol. 2015 Nov; 17(11):1379-87. PMID: 26502054.
        View in: PubMed
      32. Meng Z, Moroishi T, Mottier-Pavie V, Plouffe SW, Hansen CG, Hong AW, Park HW, Mo JS, Lu W, Lu S, Flores F, Yu FX, Halder G, Guan K. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway. Nat Commun. 2015 Oct 05; 6:8357. PMID: 26437443; PMCID: PMC4600732.
      33. Nemazanyy I, Montagnac G, Russell RC, Morzyglod L, Burnol AF, Guan K, Pende M, Panasyuk G. Class III PI3K regulates organismal glucose homeostasis by providing negative feedback on hepatic insulin signalling. Nat Commun. 2015 Sep 21; 6:8283. PMID: 26387534; PMCID: PMC4579570.
      34. Wang S, Jiang B, Zhang T, Liu L, Wang Y, Wang Y, Chen X, Lin H, Zhou L, Xia Y, Chen L, Yang C, Xiong Y, Ye D, Guan K. Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1. PLoS Biol. 2015; 13(9):e1002243. PMID: 26356530; PMCID: PMC4565669.
      35. Ha J, Guan K, Kim J. AMPK and autophagy in glucose/glycogen metabolism. Mol Aspects Med. 2015 Dec; 46:46-62. PMID: 26297963.
        View in: PubMed
      36. Park HW, Kim YC, Yu B, Moroishi T, Mo JS, Plouffe SW, Meng Z, Lin KC, Yu FX, Alexander CM, Wang CY, Guan K. Alternative Wnt Signaling Activates YAP/TAZ. Cell. 2015 Aug 13; 162(4):780-94. PMID: 26276632; PMCID: PMC4538707.
      37. Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX, Xu Y, Guan K. Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation. Cell Res. 2015 Aug; 25(8):985-8. PMID: 26206313; PMCID: PMC4528059.
      38. Lv XB, Liu CY, Wang Z, Sun YP, Xiong Y, Lei QY, Guan K. PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction. EMBO Rep. 2015 Aug; 16(8):975-85. PMID: 26116754; PMCID: PMC4552490.
      39. Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan K. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes Dev. 2015 Jun 15; 29(12):1271-84. PMID: 26109050; PMCID: PMC4495398.
      40. Hansen CG, Moroishi T, Guan K. YAP and TAZ: a nexus for Hippo signaling and beyond. Trends Cell Biol. 2015 Sep; 25(9):499-513. PMID: 26045258; PMCID: PMC4554827.
      41. Qi Q, Li DY, Luo HR, Guan K, Ye K. Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7255-60. PMID: 26039999; PMCID: PMC4466726.
      42. Zha Z, Han X, Smith MD, Liu Y, Giguère PM, Kopanja D, Raychaudhuri P, Siderovski DP, Guan K, Lei QY, Xiong Y. A Non-Canonical Function of Gß as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation. Mol Cell. 2015 Jun 04; 58(5):794-803. PMID: 25982117; PMCID: PMC4458238.
      43. Zhou X, Wang S, Wang Z, Feng X, Liu P, Lv XB, Li F, Yu FX, Sun Y, Yuan H, Zhu H, Xiong Y, Lei QY, Guan K. Estrogen regulates Hippo signaling via GPER in breast cancer. J Clin Invest. 2015 May; 125(5):2123-35. PMID: 25893606; PMCID: PMC4463207.
      44. Ma S, Jiang B, Deng W, Gu ZK, Wu FZ, Li T, Xia Y, Yang H, Ye D, Xiong Y, Guan K. D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 2015 Apr 20; 6(11):8606-20. PMID: 25825982; PMCID: PMC4496170.
      45. Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan K. Corrigendum: inhibition of a-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 2015 Apr 15; 29(8):887. PMID: 25877923; PMCID: PMC4403263.
      46. Zhou Q, Li L, Zhao B, Guan K. The hippo pathway in heart development, regeneration, and diseases. Circ Res. 2015 Apr 10; 116(8):1431-47. PMID: 25858067; PMCID: PMC4394208.
      47. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan K, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Sci Rep. 2015 Mar 30; 5:9502. PMID: 25819761; PMCID: PMC4377584.
      48. Yang H, Zhou L, Shi Q, Zhao Y, Lin H, Zhang M, Zhao S, Yang Y, Ling ZQ, Guan K, Xiong Y, Ye D. SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth. EMBO J. 2015 Apr 15; 34(8):1110-25. PMID: 25755250; PMCID: PMC4406655.
      49. Mo JS, Meng Z, Kim YC, Park HW, Hansen CG, Kim S, Lim DS, Guan K. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015 Apr; 17(4):500-10. PMID: 25751140; PMCID: PMC4380774.
      50. Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, Zucman-Rossi J, Guan K, Karin M. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 2015 Mar 05; 519(7541):57-62. PMID: 25731159; PMCID: PMC4447318.
      51. Jewell JL, Flores F, Guan K. Micro(RNA) managing by mTORC1. Mol Cell. 2015 Feb 19; 57(4):575-6. PMID: 25699705; PMCID: PMC4378617.
      52. Plouffe SW, Hong AW, Guan K. Disease implications of the Hippo/YAP pathway. Trends Mol Med. 2015 Apr; 21(4):212-22. PMID: 25702974; PMCID: PMC4385444.
      53. Moroishi T, Hansen CG, Guan K. The emerging roles of YAP and TAZ in cancer. Nat Rev Cancer. 2015 Feb; 15(2):73-79. PMID: 25592648; PMCID: PMC4562315.
      54. Wang Y, Xiao M, Chen X, Chen L, Xu Y, Lv L, Wang P, Yang H, Ma S, Lin H, Jiao B, Ren R, Ye D, Guan K, Xiong Y. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. Mol Cell. 2015 Feb 19; 57(4):662-73. PMID: 25601757; PMCID: PMC4336627.
      55. Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan K. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science. 2015 Jan 09; 347(6218):194-8. PMID: 25567907; PMCID: PMC4384888.
      56. Kim YC, Guan K. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015 Jan; 125(1):25-32. PMID: 25654547; PMCID: PMC4382265.
      57. Lyubasyuk V, Ouyang H, Yu FX, Guan K, Zhang K. YAP inhibition blocks uveal melanogenesis driven by GNAQ or GNA11 mutations. Mol Cell Oncol. 2015 Jan-Mar; 2(1):e970957. PMID: 27308390; PMCID: PMC4905245.
      58. Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan K, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Rep. 2014 Nov 20; 9(4):1281-91. PMID: 25457612; PMCID: PMC4303546.
      59. Zhao D, Mo Y, Li MT, Zou SW, Cheng ZL, Sun YP, Xiong Y, Guan K, Lei QY. NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. J Clin Invest. 2014 Dec; 124(12):5453-65. PMID: 25384215; PMCID: PMC4348941.
      60. Yu FX, Meng Z, Plouffe SW, Guan K. Hippo pathway regulation of gastrointestinal tissues. Annu Rev Physiol. 2015; 77:201-27. PMID: 25293527.
        View in: PubMed
      61. Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, Chen H, Zhang L, Ji H. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression. Nat Commun. 2014 Aug 13; 5:4629. PMID: 25115923.
        View in: PubMed
      62. Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan K. Rag GTPases are cardioprotective by regulating lysosomal function. Nat Commun. 2014 Jul 01; 5:4241. PMID: 24980141; PMCID: PMC4100214.
      63. Yang H, Lin H, Xu H, Zhang L, Cheng L, Wen B, Shou J, Guan K, Xiong Y, Ye D. TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites. Cell Res. 2014 Aug; 24(8):1017-20. PMID: 24971736; PMCID: PMC4123294.
      64. Yu FX, Zhang K, Guan K. YAP as oncotarget in uveal melanoma. Oncoscience. 2014; 1(7):480-1. PMID: 25594048; PMCID: PMC4278320.
      65. Luk JM, Guan K. An alternative DNA damage pathway to apoptosis in hematological cancers. Nat Med. 2014 Jun; 20(6):587-8. PMID: 24901566.
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      155. Inoki K, Guan K. Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment. Hum Mol Genet. 2009 Apr 15; 18(R1):R94-100. PMID: 19297407; PMCID: PMC2657945.
      156. Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan K, Xiong Y. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009 Apr 10; 324(5924):261-5. PMID: 19359588; PMCID: PMC3251015.
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      159. Zhang H, Liu CY, Zha ZY, Zhao B, Yao J, Zhao S, Xiong Y, Lei QY, Guan K. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J Biol Chem. 2009 May 15; 284(20):13355-62. PMID: 19324877; PMCID: PMC2679435.
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      162. Zhao B, Kim J, Ye X, Lai ZC, Guan K. Both TEAD-binding and WW domains are required for the growth stimulation and oncogenic transformation activity of yes-associated protein. Cancer Res. 2009 Feb 01; 69(3):1089-98. PMID: 19141641.
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      165. Ikenoue T, Inoki K, Zhao B, Guan K. PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 2008 Sep 01; 68(17):6908-12. PMID: 18757404.
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      166. Buller CL, Loberg RD, Fan MH, Zhu Q, Park JL, Vesely E, Inoki K, Guan K, Brosius FC. A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C836-43. PMID: 18650261; PMCID: PMC2544442.
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      176. Wang C, Mao X, Wang L, Liu M, Wetzel MD, Guan K, Dong LQ, Liu F. Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1. J Biol Chem. 2007 Mar 16; 282(11):7991-6. PMID: 17244624.
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      185. Gan B, Melkoumian ZK, Wu X, Guan K, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol. 2005 Aug 01; 170(3):379-89. PMID: 16043512; PMCID: PMC2171462.
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      188. Corradetti MN, Inoki K, Guan K. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem. 2005 Mar 18; 280(11):9769-72. PMID: 15632201.
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      189. Inoki K, Corradetti MN, Guan K. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet. 2005 Jan; 37(1):19-24. PMID: 15624019.
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      190. Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan K. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci. 2004 Nov; 7(11):1213-21. PMID: 15494734; PMCID: PMC2373267.
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      195. Inoki K, Zhu T, Guan K. TSC2 mediates cellular energy response to control cell growth and survival. Cell. 2003 Nov 26; 115(5):577-90. PMID: 14651849.
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      197. Tang ED, Wang CY, Xiong Y, Guan K. A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem. 2003 Sep 26; 278(39):37297-305. PMID: 12867425.
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      198. Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol. 2003 Jun 01; 170(11):5630-5. PMID: 12759443.
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      199. Li Y, Inoki K, Vacratsis P, Guan K. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem. 2003 Apr 18; 278(16):13663-71. PMID: 12582162.
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      200. Li Y, Inoki K, Yeung R, Guan K. Regulation of TSC2 by 14-3-3 binding. J Biol Chem. 2002 Nov 22; 277(47):44593-6. PMID: 12364343.
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      202. You Z, Saims D, Chen S, Zhang Z, Guttridge DC, Guan K, MacDougald OA, Brown AM, Evan G, Kitajewski J, Wang CY. Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. J Cell Biol. 2002 Apr 29; 157(3):429-40. PMID: 11980918; PMCID: PMC2173296.