Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Kevin Bush

    TitleProject Scientist
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0693
    CA La Jolla 92093
    Phone858-822-3478
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Wu W, Bush K, Nigam SK. Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes. Sci Rep. 2017 Jul 10; 7(1):4939. PMID: 28694431.
        View in: PubMed
      2. Martovetsky G, Bush K, Nigam SK. Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers. Drug Metab Dispos. 2016 Jul; 44(7):1050-60. PMID: 27044799.
        View in: PubMed
      3. Kumar N, Richter J, Cutts J, Bush K, Trujillo C, Nigam SK, Gaasterland T, Brafman D, Willert K. Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. Elife. 2015; 4. PMID: 26554899.
        View in: PubMed
      4. Zhu C, Nigam KB, Date RC, Bush K, Springer SA, Saier MH, Wu W, Nigam SK. Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence Motifs. PLoS One. 2015; 10(11):e0140569. PMID: 26536134.
        View in: PubMed
      5. Nigam SK, Wu W, Bush K, Hoenig MP, Blantz RC, Bhatnagar V. Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters. Clin J Am Soc Nephrol. 2015 Nov 6; 10(11):2039-49. PMID: 26490509.
        View in: PubMed
      6. Wu W, Bush K, Liu HC, Zhu C, Abagyan R, Nigam SK. Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors. Drug Metab Dispos. 2015 Dec; 43(12):1855-63. PMID: 26358290.
        View in: PubMed
      7. Nigam SK, Bush K, Martovetsky G, Ahn SY, Liu HC, Richard E, Bhatnagar V, Wu W. The organic anion transporter (OAT) family: a systems biology perspective. Physiol Rev. 2015 Jan; 95(1):83-123. PMID: 25540139.
        View in: PubMed
      8. Bush K, Martovetsky G, Nigam SK. Relevance of ureteric bud development and branching to tissue engineering, regeneration and repair in acute and chronic kidney disease. Curr Opin Organ Transplant. 2014 Apr; 19(2):153-61. PMID: 24503495.
        View in: PubMed
      9. Nigam SK, Bush K. Growth factor-heparan sulfate "switches" regulating stages of branching morphogenesis. Pediatr Nephrol. 2014 Apr; 29(4):727-35. PMID: 24488503.
        View in: PubMed
      10. Wu W, Jamshidi N, Eraly SA, Liu HC, Bush K, Palsson BO, Nigam SK. Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways. Drug Metab Dispos. 2013 Oct; 41(10):1825-34. PMID: 23920220.
        View in: PubMed
      11. Tee JB, Choi Y, Dnyanmote A, Decambre M, Ito C, Bush K, Nigam SK. GDNF-independent ureteric budding: role of PI3K-independent activation of AKT and FOSB/JUN/AP-1 signaling. Biol Open. 2013; 2(9):952-9. PMID: 24143282.
        View in: PubMed
      12. Bush K, Crawford BE, Garner OB, Nigam KB, Esko JD, Nigam SK. N-sulfation of heparan sulfate regulates early branching events in the developing mammary gland. J Biol Chem. 2012 Dec 7; 287(50):42064-70. PMID: 23060443.
        View in: PubMed
      13. Gallegos TF, Martovetsky G, Kouznetsova V, Bush K, Nigam SK. Organic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubule. PLoS One. 2012; 7(7):e40796. PMID: 22808265.
        View in: PubMed
      14. Gallegos TF, Kouznetsova V, Kudlicka K, Sweeney DE, Bush K, Willert K, Farquhar MG, Nigam SK. A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development. Dev Biol. 2012 Apr 1; 364(1):11-21. PMID: 22290330.
        View in: PubMed
      15. Zhang X, Bush K, Nigam SK. In vitro culture of embryonic kidney rudiments and isolated ureteric buds. Methods Mol Biol. 2012; 886:13-21. PMID: 22639247.
        View in: PubMed
      16. Ahn SY, Jamshidi N, Mo ML, Wu W, Eraly SA, Dnyanmote A, Bush K, Gallegos TF, Sweet DH, Palsson BØ, Nigam SK. Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis. J Biol Chem. 2011 Sep 9; 286(36):31522-31. PMID: 21757732.
        View in: PubMed
      17. Torres AM, Dnyanmote AV, Bush K, Wu W, Nigam SK. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem. 2011 Jul 29; 286(30):26391-5. PMID: 21652719.
        View in: PubMed
      18. Shah MM, Sakurai H, Gallegos TF, Sweeney DE, Bush K, Esko JD, Nigam SK. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol. 2011 Aug 1; 356(1):19-27. PMID: 21600196.
        View in: PubMed
      19. Garner OB, Bush K, Nigam KB, Yamaguchi Y, Xu D, Esko JD, Nigam SK. Stage-dependent regulation of mammary ductal branching by heparan sulfate and HGF-cMet signaling. Dev Biol. 2011 Jul 15; 355(2):394-403. PMID: 21586278.
        View in: PubMed
      20. Tee JB, Choi Y, Shah MM, Dnyanmote A, Sweeney DE, Gallegos TF, Johkura K, Ito C, Bush K, Nigam SK. Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol. 2010 Nov 15; 347(2):337-47. PMID: 20816800.
        View in: PubMed
      21. Rosines E, Johkura K, Zhang X, Schmidt HJ, Decambre M, Bush K, Nigam SK. Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A. 2010 Aug; 16(8):2441-55. PMID: 20214453.
        View in: PubMed
      22. Crawford BE, Garner OB, Bishop JR, Zhang DY, Bush K, Nigam SK, Esko JD. Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One. 2010; 5(5):e10691. PMID: 20502530.
        View in: PubMed
      23. Shah MM, Sakurai H, Sweeney DE, Gallegos TF, Bush K, Esko JD, Nigam SK. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol. 2010 Mar 15; 339(2):354-65. PMID: 20059993.
        View in: PubMed
      24. Choi Y, Tee JB, Gallegos TF, Shah MM, Oishi H, Sakurai H, Kitamura S, Wu W, Bush K, Nigam SK. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development. 2009 Dec; 136(24):4213-24. PMID: 19934016.
        View in: PubMed
      25. Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush K, Sakurai H, Nigam SK. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol. 2009 Nov; 297(5):F1330-41. PMID: 19726549.
        View in: PubMed
      26. Wu W, Kitamura S, Truong DM, Rieg T, Vallon V, Sakurai H, Bush K, Vera DR, Ross RS, Nigam SK. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F210-7. PMID: 19439520.
        View in: PubMed
      27. Wu W, Baker ME, Eraly SA, Bush K, Nigam SK. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Physiol Genomics. 2009 Jul 9; 38(2):116-24. PMID: 19417012.
        View in: PubMed
      28. Tsigelny IF, Kouznetsova VL, Sweeney DE, Wu W, Bush K, Nigam SK. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal. 2008; 1(49):ra16. PMID: 19066399.
        View in: PubMed
      29. Nigam SK, Wu W, Bush K. Organogenesis forum lecture: In vitro kidney development, tissue engineering and systems biology. Organogenesis. 2008 Jul; 4(3):137-43. PMID: 19279725.
        View in: PubMed
      30. Nigam SK, Bush K, Bhatnagar V. Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues. Nat Clin Pract Nephrol. 2007 Aug; 3(8):443-8. PMID: 17653123.
        View in: PubMed
      31. Monte JC, Sakurai H, Bush K, Nigam SK. The developmental nephrome: systems biology in the developing kidney. Curr Opin Nephrol Hypertens. 2007 Jan; 16(1):3-9. PMID: 17143064.
        View in: PubMed
      32. Meyer TN, Schwesinger C, Sampogna RV, Vaughn DA, Stuart RO, Steer DL, Bush K, Nigam SK. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation. 2006 Dec; 74(9-10):638-47. PMID: 17177859.
        View in: PubMed
      33. Bush K, Vaughn DA, Li X, Rosenfeld MG, Rose DW, Mendoza SA, Nigam SK. Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Dev Biol. 2006 Oct 15; 298(2):571-84. PMID: 16934795.
        View in: PubMed
      34. Sweet DH, Eraly SA, Vaughn DA, Bush K, Nigam SK. Organic anion and cation transporter expression and function during embryonic kidney development and in organ culture models. Kidney Int. 2006 Mar; 69(5):837-45. PMID: 16518343.
        View in: PubMed
      35. Sakurai H, Bush K, Nigam SK. Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. J Biol Chem. 2005 Dec 23; 280(51):42181-7. PMID: 16183643.
        View in: PubMed
      36. Meyer TN, Schwesinger C, Bush K, Stuart RO, Rose DW, Shah MM, Vaughn DA, Steer DL, Nigam SK. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol. 2004 Nov 1; 275(1):44-67. PMID: 15464572.
        View in: PubMed
      37. George SK, Meyer TN, Abdeen O, Bush K, Nigam SK. Tunicamycin preserves intercellular junctions, cytoarchitecture, and cell-substratum interactions in ATP-depleted epithelial cells. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):223-31. PMID: 15313195.
        View in: PubMed
      38. Steer DL, Shah MM, Bush K, Stuart RO, Sampogna RV, Meyer TN, Schwesinger C, Bai X, Esko JD, Nigam SK. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004 Aug 15; 272(2):310-27. PMID: 15282150.
        View in: PubMed
      39. Shah MM, Sampogna RV, Sakurai H, Bush K, Nigam SK. Branching morphogenesis and kidney disease. Development. 2004 Apr; 131(7):1449-62. PMID: 15023929.
        View in: PubMed
      40. Eraly SA, Bush K, Sampogna RV, Bhatnagar V, Nigam SK. The molecular pharmacology of organic anion transporters: from DNA to FDA? Mol Pharmacol. 2004 Mar; 65(3):479-87. PMID: 14978224.
        View in: PubMed
      41. Bush K, Sakurai H, Steer DL, Leonard MO, Sampogna RV, Meyer TN, Schwesinger C, Qiao J, Nigam SK. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol. 2004 Feb 15; 266(2):285-98. PMID: 14738877.
        View in: PubMed
      42. Stuart RO, Bush K, Nigam SK. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney Int. 2003 Dec; 64(6):1997-2008. PMID: 14633122.
        View in: PubMed
      43. Li X, Oghi KA, Zhang J, Krones A, Bush K, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20; 426(6964):247-54. PMID: 14628042.
        View in: PubMed
      44. Steer DL, Bush K, Meyer TN, Schwesinger C, Nigam SK. A strategy for in vitro propagation of rat nephrons. Kidney Int. 2002 Dec; 62(6):1958-65. PMID: 12427120.
        View in: PubMed
      45. Qiao J, Bush K, Steer DL, Stuart RO, Sakurai H, Wachsman W, Nigam SK. Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis. Mech Dev. 2001 Dec; 109(2):123-35. PMID: 11731227.
        View in: PubMed
      46. Karihaloo A, Karumanchi SA, Barasch J, Jha V, Nickel CH, Yang J, Grisaru S, Bush K, Nigam S, Rosenblum ND, Sukhatme VP, Cantley LG. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12509-14. PMID: 11606725.
        View in: PubMed
      47. Zent R, Bush K, Pohl ML, Quaranta V, Koshikawa N, Wang Z, Kreidberg JA, Sakurai H, Stuart RO, Nigám SK. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol. 2001 Oct 15; 238(2):289-302. PMID: 11784011.
        View in: PubMed
      48. Sakurai H, Bush K, Nigam SK. Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis. Development. 2001 Sep; 128(17):3283-93. PMID: 11546745.
        View in: PubMed
      49. Sweet DH, Bush K, Nigam SK. The organic anion transporter family: from physiology to ontogeny and the clinic. Am J Physiol Renal Physiol. 2001 Aug; 281(2):F197-205. PMID: 11457711.
        View in: PubMed
      50. Stuart RO, Bush K, Nigam SK. Changes in global gene expression patterns during development and maturation of the rat kidney. Proc Natl Acad Sci U S A. 2001 May 8; 98(10):5649-54. PMID: 11331749.
        View in: PubMed
      51. Yang Z, Xia Ch, Roberts EA, Bush K, Nigam SK, Goldstein LS. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3. Mol Cell Biol. 2001 Feb; 21(3):765-70. PMID: 11154264.
        View in: PubMed
      52. Pohl M, Sakurai H, Bush K, Nigam SK. Matrix metalloproteinases and their inhibitors regulate in vitro ureteric bud branching morphogenesis. Am J Physiol Renal Physiol. 2000 Nov; 279(5):F891-900. PMID: 11053050.
        View in: PubMed
      53. Bush K, Keller SH, Nigam SK. Genesis and reversal of the ischemic phenotype in epithelial cells. J Clin Invest. 2000 Sep; 106(5):621-6. PMID: 10974012.
        View in: PubMed
      54. Li Z, Stuart RO, Qiao J, Pavlova A, Bush K, Pohl M, Sakurai H, Nigam SK. A role for Timeless in epithelial morphogenesis during kidney development. Proc Natl Acad Sci U S A. 2000 Aug 29; 97(18):10038-43. PMID: 10963667.
        View in: PubMed
      55. Bush K, Tsukamoto T, Nigam SK. Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia. Am J Physiol Renal Physiol. 2000 May; 278(5):F847-52. PMID: 10807598.
        View in: PubMed
      56. Bush K, George SK, Zhang PL, Nigam SK. Pretreatment with inducers of ER molecular chaperones protects epithelial cells subjected to ATP depletion. Am J Physiol. 1999 Aug; 277(2 Pt 2):F211-8. PMID: 10444575.
        View in: PubMed
      57. Bush K, Nigam SK. Less degradation, more shock, please. Gastroenterology. 1999 Apr; 116(4):994-5. PMID: 10092324.
        View in: PubMed
      58. Bush K, Goldberg AL, Nigam SK. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem. 1997 Apr 4; 272(14):9086-92. PMID: 9083035.
        View in: PubMed
      59. Lopez-Nieto CE, You G, Bush K, Barros EJ, Beier DR, Nigam SK. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem. 1997 Mar 7; 272(10):6471-8. PMID: 9045672.
        View in: PubMed
      60. Kuznetsov G, Bush K, Zhang PL, Nigam SK. Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia. Proc Natl Acad Sci U S A. 1996 Aug 6; 93(16):8584-9. PMID: 8710914.
        View in: PubMed
      61. Stuart RO, Sun A, Bush K, Nigam SK. Dependence of epithelial intercellular junction biogenesis on thapsigargin-sensitive intracellular calcium stores. J Biol Chem. 1996 Jun 7; 271(23):13636-41. PMID: 8662885.
        View in: PubMed
      62. Bush K, Hendrickson BA, Nigam SK. Induction of the FK506-binding protein, FKBP13, under conditions which misfold proteins in the endoplasmic reticulum. Biochem J. 1994 Nov 1; 303 ( Pt 3):705-8. PMID: 7526846.
        View in: PubMed
      63. Bush K, Stuart RO, Li SH, Moura LA, Sharp AH, Ross CA, Nigam SK. Epithelial inositol 1,4,5-trisphosphate receptors. Multiplicity of localization, solubility, and isoforms. J Biol Chem. 1994 Sep 23; 269(38):23694-9. PMID: 8089140.
        View in: PubMed
      64. Gonzalez Leiza M, Perez-Diaz JC, Ayala J, Casellas JM, Martinez-Beltran J, Bush K, Baquero F. Gene sequence and biochemical characterization of FOX-1 from Klebsiella pneumoniae, a new AmpC-type plasmid-mediated beta-lactamase with two molecular variants. Antimicrob Agents Chemother. 1994 Sep; 38(9):2150-7. PMID: 7811034.
        View in: PubMed
      65. Rasmussen BA, Keeney D, Yang Y, Bush K. Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme. Antimicrob Agents Chemother. 1994 Sep; 38(9):2078-85. PMID: 7811022.
        View in: PubMed
      66. Nigam SK, Goldberg AL, Ho S, Rohde MF, Bush K. A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem. 1994 Jan 21; 269(3):1744-9. PMID: 8294423.
        View in: PubMed
      67. Nigam SK, Jin YJ, Jin MJ, Bush K, Bierer BE, Burakoff SJ. Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum. Biochem J. 1993 Sep 1; 294 ( Pt 2):511-5. PMID: 8373365.
        View in: PubMed
      Kevin's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _