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    Karl Wahlin

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentOphthalmology
    Address9500 Gilman Drive #0946
    CA La Jolla 92093
    Phone858-822-7701
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      Collapse Biography 
      Collapse Education and Training
      Johns Hopkins School of Medicine, Baltimorepost-doc2015Ophthalmology
      Johns Hopkins School of Medicine, BaltimorePh.D.2009Neuroscience

      Collapse Overview 
      Collapse Overview
      My lab leverages stem cells and genetic engineering to uncover the basic biology of eye development. It is hoped that a better understanding of how the eye forms will give us new tools to combat debilitating eye diseases like glaucoma, retinitis pigments and age-related macular degeneration.


      Collapse Research 
      Collapse Research Activities and Funding
      Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
      NIH R00EY024648Aug 1, 2016 - Jul 31, 2019
      Role: Principal Investigator
      Modeling Photoreceptor Development and Disease Using Human Pluripotent Stem Cells
      NIH K99EY024648Aug 1, 2014 - Jul 31, 2016
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Wilson DR, Routkevitch D, Rui Y, Mosenia A, Wahlin K, Quinones-Hinojosa A, Zack DJ, Green JJ. A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Mol Ther. 2017 May 03. PMID: 28479046.
        View in: PubMed
      2. Wahlin K, Maruotti JA, Sripathi SR, Ball J, Angueyra JM, Kim C, Grebe R, Li W, Jones BW, Zack DJ. Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. Sci Rep. 2017 Apr 10; 7(1):766. PMID: 28396597.
        View in: PubMed
      3. Foster JW, Wahlin K, Adams SM, Birk DE, Zack DJ, Chakravarti S. Cornea organoids from human induced pluripotent stem cells. Sci Rep. 2017 Jan 27; 7:41286. PMID: 28128337.
        View in: PubMed
      4. Maruotti J, Sripathi SR, Bharti K, Fuller J, Wahlin K, Ranganathan V, Sluch VM, Berlinicke CA, Davis J, Kim C, Zhao L, Wan J, Qian J, Corneo B, Temple S, Dubey R, Olenyuk BZ, Bhutto I, Lutty GA, Zack DJ. Small-molecule-directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells. Proc Natl Acad Sci U S A. 2015 Sep 1; 112(35):10950-5. PMID: 26269569.
        View in: PubMed
      5. Masuda T, Wahlin K, Wan J, Hu J, Maruotti J, Yang X, Iacovelli J, Wolkow N, Kist R, Dunaief JL, Qian J, Zack DJ, Esumi N. Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium. J Biol Chem. 2014 May 2; 289(18):12908-21. PMID: 24634209; PMCID: PMC4007478 [Available on 05/02/15].
      6. Wahlin K, Maruotti J, Zack DJ. Modeling retinal dystrophies using patient-derived induced pluripotent stem cells. Adv Exp Med Biol. 2014; 801:157-64. PMID: 24664693; NIHMSID: NIHMS595697.
        View in: PubMed
      7. Bhise NS, Wahlin K, Zack DJ, Green JJ. Evaluating the potential of poly(beta-amino ester) nanoparticles for reprogramming human fibroblasts to become induced pluripotent stem cells. Int J Nanomedicine. 2013; 8:4641-58. PMID: 24348039; PMCID: PMC3857166.
      8. Wahlin K, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS One. 2013; 8(11):e79140. PMID: 24244436; PMCID: PMC3823652.
      9. Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N. RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013; 19:1371-86. PMID: 23805044; PMCID: PMC3692409.
      10. Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013 May; 2(5):341-54. PMID: 23585288; PMCID: PMC3667560.
      11. Lumayag S, Haldin CE, Corbett NJ, Wahlin K, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):E507-16. PMID: 23341629; PMCID: PMC3568372.
      12. Wahlin K, Hackler L, Adler R, Zack DJ. Alternative splicing of neuroligin and its protein distribution in the outer plexiform layer of the chicken retina. J Comp Neurol. 2010 Dec 15; 518(24):4938-62. PMID: 21031560; NIHMSID: NIHMS531272.
        View in: PubMed
      13. McNally MM, Wahlin K, Canto-Soler MV. Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: relevance for the developmental biology research field. BMC Dev Biol. 2010; 10:106. PMID: 20955591; PMCID: PMC2973938.
      14. Engler C, Kelliher C, Wahlin K, Speck CL, Jun AS. Comparison of non-viral methods to genetically modify and enrich populations of primary human corneal endothelial cells. Mol Vis. 2009; 15:629-37. PMID: 19347048; PMCID: PMC2664841.
      15. Wahlin K, Moreira EF, Huang H, Yu N, Adler R. Molecular dynamics of photoreceptor synapse formation in the developing chick retina. J Comp Neurol. 2008 Feb 10; 506(5):822-37. PMID: 18076030.
        View in: PubMed
      16. Huang H, Wahlin K, McNally M, Irving ND, Adler R. Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. Dev Dyn. 2008 Jan; 237(1):286-96. PMID: 18095352.
        View in: PubMed
      17. Pasterkamp RJ, Dai HN, Terman JR, Wahlin K, Kim B, Bregman BS, Popovich PG, Kolodkin AL. MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the rat. Mol Cell Neurosci. 2006 Jan; 31(1):52-69. PMID: 16230022.
        View in: PubMed
      18. Wahlin K, Lim L, Grice EA, Campochiaro PA, Zack DJ, Adler R. A method for analysis of gene expression in isolated mouse photoreceptor and Müller cells. Mol Vis. 2004 Jun 3; 10:366-75. PMID: 15205663.
        View in: PubMed
      19. Mori K, Gehlbach P, Ando A, Wahlin K, Gunther V, McVey D, Wei L, Campochiaro PA. Intraocular adenoviral vector-mediated gene transfer in proliferative retinopathies. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1610-5. PMID: 11980881.
        View in: PubMed
      20. Wahlin K, Adler R, Zack DJ, Campochiaro PA. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001 Nov; 73(5):693-701. PMID: 11747369.
        View in: PubMed
      21. Hackett SF, Ozaki H, Strauss RW, Wahlin K, Suri C, Maisonpierre P, Yancopoulos G, Campochiaro PA. Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization. J Cell Physiol. 2000 Sep; 184(3):275-84. PMID: 10911358.
        View in: PubMed
      22. Wahlin K, Campochiaro PA, Zack DJ, Adler R. Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):927-36. PMID: 10711715.
        View in: PubMed
      23. Mathura JR, Jafari N, Chang JT, Hackett SF, Wahlin K, Della NG, Okamoto N, Zack DJ, Campochiaro PA. Bone morphogenetic proteins-2 and -4: negative growth regulators in adult retinal pigmented epithelium. Invest Ophthalmol Vis Sci. 2000 Feb; 41(2):592-600. PMID: 10670493.
        View in: PubMed