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    Karen Oegema

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0653
    CA La Jolla 92093
    Phone858-534-9714
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      Collapse Overview 
      Collapse Overview
      The Oegema lab takes parallel approaches in mammalian cells and using the C. elegans embryo as a metazoan model system to study cell division and embryonic development.

      Research Focus Area:

    • Cell Division and Cell Cycle Control

    • Genetics and Genomics

    • Signal Transduction

    • Stem Cell Biology

    • Systems Biology



    • Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kim T, Lara-Gonzalez P, Prevo B, Meitinger F, Cheerambathur DK, Oegema K, Desai A. Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates. Genes Dev. 2017 Jun 01; 31(11):1089-1094. PMID: 28698300.
        View in: PubMed
      2. Cheerambathur DK, Prevo B, Hattersley N, Lewellyn L, Corbett KD, Oegema K, Desai A. Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex. Dev Cell. 2017 May 22; 41(4):424-437.e4. PMID: 28535376.
        View in: PubMed
      3. Ohta M, Desai A, Oegema K. How centrioles acquire the ability to reproduce. Elife. 2017 Mar 08; 6. PMID: 28271993.
        View in: PubMed
      4. Wueseke O, Zwicker D, Schwager A, Wong YL, Oegema K, Jülicher F, Hyman AA, Woodruff JB. Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation. Biol Open. 2016 Oct 15; 5(10):1431-1440. PMID: 27591191.
        View in: PubMed
      5. Xing M, Peterman MC, Davis RL, Oegema K, Shiau AK, Field SJ. GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge. Mol Biol Cell. 2016 Dec 01; 27(24):3828-3840. PMID: 27708138.
        View in: PubMed
      6. Hattersley N, Cheerambathur D, Moyle M, Stefanutti M, Richardson A, Lee KY, Dumont J, Oegema K, Desai A. A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly. Dev Cell. 2016 Sep 12; 38(5):463-77. PMID: 27623381.
        View in: PubMed
      7. Meitinger F, Anzola JV, Kaulich M, Richardson A, Stender JD, Benner C, Glass CK, Dowdy SF, Desai A, Shiau AK, Oegema K. 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. J Cell Biol. 2016 Jul 18; 214(2):155-66. PMID: 27432897; PMCID: PMC4949453 [Available on 01/18/17].
      8. Gerson-Gurwitz A, Wang S, Sathe S, Green R, Yeo GW, Oegema K, Desai A. A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. Cell. 2016 Apr 07; 165(2):396-409. PMID: 27020753; PMCID: PMC4826293 [Available on 04/07/17].
      9. Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A. Correction: Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2016 Mar 14; 212(6):737. PMID: 26953348; PMCID: PMC4792070.
      10. Wang S, Wu D, Quintin S, Green RA, Cheerambathur DK, Ochoa SD, Desai A, Oegema K. NOCA-1 functions with ?-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans. Elife. 2015 Sep 15; 4:e08649. PMID: 26371552; PMCID: PMC4608005.
      11. Kim T, Moyle MW, Lara-Gonzalez P, De Groot C, Oegema K, Desai A. Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans. J Cell Biol. 2015 May 25; 209(4):507-17. PMID: 25987605; PMCID: PMC4442812.
      12. Woodruff JB, Wueseke O, Viscardi V, Mahamid J, Ochoa SD, Bunkenborg J, Widlund PO, Pozniakovsky A, Zanin E, Bahmanyar S, Zinke A, Hong SH, Decker M, Baumeister W, Andersen JS, Oegema K, Hyman AA. Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro. Science. 2015 May 15; 348(6236):808-12. PMID: 25977552; PMCID: PMC5039038.
      13. Monen J, Hattersley N, Muroyama A, Stevens D, Oegema K, Desai A. Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans. PLoS One. 2015; 10(4):e0125382. PMID: 25919583; PMCID: PMC4412405.
      14. Folco HD, Campbell CS, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SI, Desai A. The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast. Curr Biol. 2015 Feb 02; 25(3):348-56. PMID: 25619765; PMCID: PMC4318777.
      15. Chuang M, Goncharov A, Wang S, Oegema K, Jin Y, Chisholm AD. The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans. Cell Rep. 2014 Nov 06; 9(3):874-83. PMID: 25437544; PMCID: PMC4250830.
      16. Wueseke O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA. The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix. Mol Biol Cell. 2014 Oct 01; 25(19):2984-92. PMID: 25103243; PMCID: PMC4230587.
      17. Moyle MW, Kim T, Hattersley N, Espeut J, Cheerambathur DK, Oegema K, Desai A. A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J Cell Biol. 2014 Mar 03; 204(5):647-57. PMID: 24567362; PMCID: PMC3941058.
      18. Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014 Jan 15; 28(2):121-6. PMID: 24449268; PMCID: PMC3909786.
      19. Stevens D, Oegema K, Desai A. Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline. Curr Biol. 2013 Dec 02; 23(23):2400-6. PMID: 24239117; PMCID: PMC3885542.
      20. Cheerambathur DK, Gassmann R, Cook B, Oegema K, Desai A. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Science. 2013 Dec 06; 342(6163):1239-42. PMID: 24231804; PMCID: PMC3885540.
      21. Green RA, Mayers JR, Wang S, Lewellyn L, Desai A, Audhya A, Oegema K. The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules. J Cell Biol. 2013 Nov 11; 203(3):505-20. PMID: 24217623; PMCID: PMC3824018.
      22. Zanin E, Desai A, Poser I, Toyoda Y, Andree C, Moebius C, Bickle M, Conradt B, Piekny A, Oegema K. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Dev Cell. 2013 Sep 16; 26(5):496-510. PMID: 24012485; PMCID: PMC4239416.
      23. Green RA, Paluch E, Oegema K. Cytokinesis in animal cells. Annu Rev Cell Dev Biol. 2012; 28:29-58. PMID: 22804577.
        View in: PubMed
      24. Gassmann R, Rechtsteiner A, Yuen KW, Muroyama A, Egelhofer T, Gaydos L, Barron F, Maddox P, Essex A, Monen J, Ercan S, Lieb JD, Oegema K, Strome S, Desai A. An inverse relationship to germline transcription defines centromeric chromatin in C. elegans. Nature. 2012 Apr 08; 484(7395):534-7. PMID: 22495302; PMCID: PMC3538161.
      25. Espeut J, Cheerambathur DK, Krenning L, Oegema K, Desai A. Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore. J Cell Biol. 2012 Feb 20; 196(4):469-82. PMID: 22331849; PMCID: PMC3284002.
      26. Han S, Bahmanyar S, Zhang P, Grishin N, Oegema K, Crooke R, Graham M, Reue K, Dixon JE, Goodman JM. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. J Biol Chem. 2012 Jan 27; 287(5):3123-37. PMID: 22134922; PMCID: PMC3283218.
      27. Yuen KW, Nabeshima K, Oegema K, Desai A. Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos. Curr Biol. 2011 Nov 08; 21(21):1800-7. PMID: 22018540; PMCID: PMC3249440.
      28. Carvalho A, Olson SK, Gutierrez E, Zhang K, Noble LB, Zanin E, Desai A, Groisman A, Oegema K. Acute drug treatment in the early C. elegans embryo. PLoS One. 2011; 6(9):e24656. PMID: 21935434; PMCID: PMC3173474.
      29. Stevens D, Gassmann R, Oegema K, Desai A. Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. PLoS One. 2011; 6(8):e22969. PMID: 21829677; PMCID: PMC3149067.
      30. Green RA, Kao HL, Audhya A, Arur S, Mayers JR, Fridolfsson HN, Schulman M, Schloissnig S, Niessen S, Laband K, Wang S, Starr DA, Hyman AA, Schedl T, Desai A, Piano F, Gunsalus KC, Oegema K. A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell. 2011 Apr 29; 145(3):470-82. PMID: 21529718; PMCID: PMC3086541.
      31. Lewellyn L, Carvalho A, Desai A, Maddox AS, Oegema K. The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly. J Cell Biol. 2011 Apr 04; 193(1):155-69. PMID: 21464231; PMCID: PMC3082186.
      32. Zanin E, Dumont J, Gassmann R, Cheeseman I, Maddox P, Bahmanyar S, Carvalho A, Niessen S, Yates JR, Oegema K, Desai A. Affinity purification of protein complexes in C. elegans. Methods Cell Biol. 2011; 106:289-322. PMID: 22118282; PMCID: PMC3319706.
      33. Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010 Sep; 12(9):894-901. PMID: 20729837; PMCID: PMC3052858.
      34. Gassmann R, Holland AJ, Varma D, Wan X, Civril F, Cleveland DW, Oegema K, Salmon ED, Desai A. Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 2010 May; 24(9):957-71. PMID: 20439434; PMCID: PMC2861194.
      35. Lewellyn L, Dumont J, Desai A, Oegema K. Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo. Mol Biol Cell. 2010 Jan 01; 21(1):50-62. PMID: 19889842; PMCID: PMC2801719.
      36. Dammermann A, Pemble H, Mitchell BJ, McLeod I, Yates JR, Kintner C, Desai AB, Oegema K. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation. Genes Dev. 2009 Sep 01; 23(17):2046-59. PMID: 19656802; PMCID: PMC2751977.
      37. Carvalho A, Desai A, Oegema K. Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size. Cell. 2009 May 29; 137(5):926-37. PMID: 19490897.
        View in: PubMed
      38. Essex A, Dammermann A, Lewellyn L, Oegema K, Desai A. Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell. 2009 Feb; 20(4):1252-67. PMID: 19109417; PMCID: PMC2642744.
      39. Canman JC, Lewellyn L, Laband K, Smerdon SJ, Desai A, Bowerman B, Oegema K. Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science. 2008 Dec 05; 322(5907):1543-6. PMID: 19056985; PMCID: PMC2736296.
      40. Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O'Rourke SM, Bowerman B, McLeod I, Yates JR, Oegema K, Cheeseman IM, Desai A. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008 Sep 01; 22(17):2385-99. PMID: 18765790; PMCID: PMC2532926.
      41. Dammermann A, Maddox PS, Desai A, Oegema K. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol. 2008 Feb 25; 180(4):771-85. PMID: 18299348; PMCID: PMC2265562.
      42. Green RA, Audhya A, Pozniakovsky A, Dammermann A, Pemble H, Monen J, Portier N, Hyman A, Desai A, Oegema K. Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo. Methods Cell Biol. 2008; 85:179-218. PMID: 18155464.
        View in: PubMed
      43. Audhya A, McLeod IX, Yates JR, Oegema K. MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. PLoS One. 2007 Sep 26; 2(9):e956. PMID: 17895996; PMCID: PMC1978536.
      44. Maddox AS, Lewellyn L, Desai A, Oegema K. Anillin and the septins promote asymmetric ingression of the cytokinetic furrow. Dev Cell. 2007 May; 12(5):827-35. PMID: 17488632.
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      45. Portier N, Audhya A, Maddox PS, Green RA, Dammermann A, Desai A, Oegema K. A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev Cell. 2007 Apr; 12(4):515-29. PMID: 17419991; PMCID: PMC2973840.
      46. Schlaitz AL, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, de Robillard Q, Zinke A, Yates JR, Müller-Reichert T, Shevchenko A, Oegema K, Hyman AA. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell. 2007 Jan 12; 128(1):115-27. PMID: 17218259; PMCID: PMC2987564.
      47. McNally K, Audhya A, Oegema K, McNally FJ. Katanin controls mitotic and meiotic spindle length. J Cell Biol. 2006 Dec 18; 175(6):881-91. PMID: 17178907; PMCID: PMC2064698.
      48. Sandall S, Severin F, McLeod IX, Yates JR, Oegema K, Hyman A, Desai A. A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell. 2006 Dec 15; 127(6):1179-91. PMID: 17174893; PMCID: PMC2265205.
      49. Maddox PS, Portier N, Desai A, Oegema K. Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15097-102. PMID: 17005720; PMCID: PMC1622782.
      50. Olson SK, Bishop JR, Yates JR, Oegema K, Esko JD. Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2. J Cell Biol. 2006 Jun 19; 173(6):985-94. PMID: 16785326; PMCID: PMC2063922.
      51. Oegema K, Hyman AA. Cell division. WormBook. 2006 Jan 19; 1-40. PMID: 18050484; PMCID: PMC4780891.
      52. Monen J, Maddox PS, Hyndman F, Oegema K, Desai A. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat Cell Biol. 2005 Dec; 7(12):1248-55. PMID: 16273096.
        View in: PubMed
      53. Audhya A, Hyndman F, McLeod IX, Maddox AS, Yates JR, Desai A, Oegema K. A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J Cell Biol. 2005 Oct 24; 171(2):267-79. PMID: 16247027; PMCID: PMC2171198.
      54. Maddox AS, Habermann B, Desai A, Oegema K. Distinct roles for two C. elegans anillins in the gonad and early embryo. Development. 2005 Jun; 132(12):2837-48. PMID: 15930113.
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      55. Cheeseman IM, MacLeod I, Yates JR, Oegema K, Desai A. The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation. Curr Biol. 2005 Apr 26; 15(8):771-7. PMID: 15854912.
        View in: PubMed
      56. Dammermann A, Müller-Reichert T, Pelletier L, Habermann B, Desai A, Oegema K. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004 Dec; 7(6):815-29. PMID: 15572125.
        View in: PubMed
      57. Cheeseman IM, Niessen S, Anderson S, Hyndman F, Yates JR, Oegema K, Desai A. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004 Sep 15; 18(18):2255-68. PMID: 15371340; PMCID: PMC517519.
      58. Maddox PS, Oegema K, Desai A, Cheeseman IM. "Holo"er than thou: chromosome segregation and kinetochore function in C. elegans. Chromosome Res. 2004; 12(6):641-53. PMID: 15289669.
        View in: PubMed
      59. Desai A, Rybina S, Müller-Reichert T, Shevchenko A, Shevchenko A, Hyman A, Oegema K. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 2003 Oct 01; 17(19):2421-35. PMID: 14522947; PMCID: PMC218079.
      60. Maddox AS, Oegema K. Deconstructing cytokinesis. Nat Cell Biol. 2003 Sep; 5(9):773-6. PMID: 12951607.
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      61. Maddox AS, Oegema K. Closing the GAP: a role for a RhoA GAP in cytokinesis. Mol Cell. 2003 Apr; 11(4):846-8. PMID: 12718869.
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      62. Kirkham M, Müller-Reichert T, Oegema K, Grill S, Hyman AA. SAS-4 is a C. elegans centriolar protein that controls centrosome size. Cell. 2003 Feb 21; 112(4):575-87. PMID: 12600319.
        View in: PubMed
      63. Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol. 2002 Oct 01; 12(19):1670-4. PMID: 12361570.
        View in: PubMed
      64. Hannak E, Oegema K, Kirkham M, Gönczy P, Habermann B, Hyman AA. The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol. 2002 May 13; 157(4):591-602. PMID: 12011109; PMCID: PMC2173857.