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    Julie Law

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Establishment and Modulation of DNA Methylation Patterns in Arabidopsis
      NIH/NIGMS R01GM112966Feb 15, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Genetic Analysis of RNA-directed DNA Methylation
      NIH/NIGMS F32GM082045Sep 1, 2007 - Aug 31, 2010
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Li D, Palanca AMS, Won SY, Gao L, Feng Y, Vashisht AA, Liu L, Zhao Y, Liu X, Wu X, Li S, Le B, Kim YJ, Yang G, Li S, Liu J, Wohlschlegel JA, Guo H, Mo B, Chen X, Law J. The MBD7 complex promotes expression of methylated transgenes without significantly altering their methylation status. Elife. 2017 Apr 28; 6. PMID: 28452714.
        View in: PubMed
      2. Zhou M, Law J. RNA Pol IV and V in gene silencing: Rebel polymerases evolving away from Pol II's rules. Curr Opin Plant Biol. 2015 Oct; 27:154-64. PMID: 26344361; PMCID: PMC4618083 [Available on 10/01/16].
      3. Law J, Du J, Hale CJ, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE. Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 2013 Jun 20; 498(7454):385-9. PMID: 23636332; PMCID: PMC4119789.
      4. Zhong X, Hale CJ, Law J, Johnson LM, Feng S, Tu A, Jacobsen SE. DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. Nat Struct Mol Biol. 2012 Sep; 19(9):870-5. PMID: 22864289; PMCID: PMC3443314.
      5. Kapella MC, Herdegen JJ, Perlis ML, Shaver JL, Larson JL, Law J, Carley DW. Cognitive behavioral therapy for insomnia comorbid with COPD is feasible with preliminary evidence of positive sleep and fatigue effects. Int J Chron Obstruct Pulmon Dis. 2011; 6:625-35. PMID: 22162648; PMCID: PMC3232169.
      6. Law J, Vashisht AA, Wohlschlegel JA, Jacobsen SE. SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet. 2011 Jul; 7(7):e1002195. PMID: 21811420; PMCID: PMC3141008.
      7. Greenberg MV, Ausin I, Chan SW, Cokus SJ, Cuperus JT, Feng S, Law J, Chu C, Pellegrini M, Carrington JC, Jacobsen SE. Identification of genes required for de novo DNA methylation in Arabidopsis. Epigenetics. 2011 Mar; 6(3):344-54. PMID: 21150311; PMCID: PMC3092683.
      8. Rajakumara E, Law J, Simanshu DK, Voigt P, Johnson LM, Reinberg D, Patel DJ, Jacobsen SE. A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev. 2011 Jan 15; 25(2):137-52. PMID: 21245167; PMCID: PMC3022260.
      9. Guo L, Yu Y, Law J, Zhang X. SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18557-62. PMID: 20937886; PMCID: PMC2972934.
      10. Law J, Ausin I, Johnson LM, Vashisht AA, Zhu JK, Wohlschlegel JA, Jacobsen SE. A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol. 2010 May 25; 20(10):951-6. PMID: 20409711; PMCID: PMC2972704.
      11. Law J, Jacobsen SE. Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet. 2010 Mar; 11(3):204-20. PMID: 20142834; PMCID: PMC3034103.
      12. Law J, Jacobsen SE. Molecular biology. Dynamic DNA methylation. Science. 2009 Mar 20; 323(5921):1568-9. PMID: 19299607.
        View in: PubMed
      13. Johnson LM, Law J, Khattar A, Henderson IR, Jacobsen SE. SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet. 2008 Nov; 4(11):e1000280. PMID: 19043555; PMCID: PMC2582956.
      14. Law J, O'Hearn SF, Sollner-Webb B. Trypanosoma brucei RNA editing protein TbMP42 (band VI) is crucial for the endonucleolytic cleavages but not the subsequent steps of U-deletion and U-insertion. RNA. 2008 Jun; 14(6):1187-200. PMID: 18441050; PMCID: PMC2390806.
      15. Law J, O'Hearn S, Sollner-Webb B. In Trypanosoma brucei RNA editing, TbMP18 (band VII) is critical for editosome integrity and for both insertional and deletional cleavages. Mol Cell Biol. 2007 Jan; 27(2):777-87. PMID: 17101787; PMCID: PMC1800803.
      16. Zhelonkina AG, O'Hearn SF, Law J, Cruz-Reyes J, Huang CE, Alatortsev VS, Sollner-Webb B. T. brucei RNA editing: action of the U-insertional TUTase within a U-deletion cycle. RNA. 2006 Mar; 12(3):476-87. PMID: 16495238; PMCID: PMC1383585.
      17. Law J, Huang CE, O'Hearn SF, Sollner-Webb B. In Trypanosoma brucei RNA editing, band II enables recognition specifically at each step of the U insertion cycle. Mol Cell Biol. 2005 Apr; 25(7):2785-94. PMID: 15767682; PMCID: PMC1061641.