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    Joshua Rychak

    Address9500 Gilman Drive #0412
    CA La Jolla 92093
    Phone877-290-4043
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Scalable Transfection Technology for Lymphocytes
      NIH/NIAID R43AI120426Jun 15, 2015 - Nov 30, 2015
      Role: Principal Investigator
      Molecular Imaging of Macrophage Infiltration in Solid Cancers
      NIH/NCI R43CA183149Jul 1, 2014 - Jun 30, 2015
      Role: Principal Investigator
      Contrast agents for high-sensitivity ultrasound molecular imaging of tumor angiog
      NIH/NCI R43CA153618Sep 26, 2011 - Aug 31, 2012
      Role: Principal Investigator
      Selectin targeted ultrasound contrast agents for detection of acute coronary synd
      NIH/NHLBI R44HL110496Sep 1, 2011 - Jul 31, 2015
      Role: Principal Investigator
      Ultrasound-based molecular imaging probe for imaging acute myocardial syndromes
      NIH/NHLBI R43HL110496Sep 1, 2011 - Nov 30, 2012
      Role: Principal Investigator
      Novel Microparticle Contrast Agent for Near Infrared Molecular Imaging
      NIH/NIBIB R43EB011863May 17, 2010 - Apr 30, 2011
      Role: Principal Investigator
      Ultrasound-triggered delivery of siRNA as treatment for diabetic kidney disease
      NIH/NIDDK R44DK083142Feb 1, 2009 - Jan 31, 2014
      Role: Principal Investigator
      Ultrasound mediated targeted therapy for kidney disease
      NIH/NIDDK R43DK083142Feb 1, 2009 - May 31, 2011
      Role: Principal Investigator
      Ultrasound Contrast Agents for Inflammation and Angiogenesis
      NIH/NIBIB R43EB007857Feb 1, 2008 - Jul 31, 2008
      Role: Principal Investigator
      Gene Delivery Agents for Ultrasound-Mediated Transfection
      NIH/NIDDK R43DK079406Sep 1, 2007 - Jul 31, 2008
      Role: Principal Investigator
      Ultrasound Contrast Agents for Inflammation and Angiogenesis
      NIH/NIBIB R44EB007857Jul 1, 2007 - Aug 31, 2011
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Wei S, Xu C, Rychak J, Luong A, Sun Y, Yang Z, Li M, Liu C, Fu N, Yang B. Short Hairpin RNA Knockdown of Connective Tissue Growth Factor by Ultrasound-Targeted Microbubble Destruction Improves Renal Fibrosis. Ultrasound Med Biol. 2016 Dec; 42(12):2926-2937. PMID: 27597128.
        View in: PubMed
      2. Shekhar H, Awuor I, Thomas K, Rychak J, Doyley MM. The delayed onset of subharmonic and ultraharmonic emissions from a phospholipid-shelled microbubble contrast agent. Ultrasound Med Biol. 2014 Apr; 40(4):727-38. PMID: 24582298.
        View in: PubMed
      3. Kilroy J, Patil A, Rychak J, Hossack J. An IVUS transducer for microbubble therapies. IEEE Trans Ultrason Ferroelectr Freq Control. 2014 Mar; 61(3):441-9. PMID: 24569249.
        View in: PubMed
      4. Rychak J, Klibanov AL. Nucleic acid delivery with microbubbles and ultrasound. Adv Drug Deliv Rev. 2014 Jun; 72:82-93. PMID: 24486388.
        View in: PubMed
      5. Declèves AE, Rychak J, Smith DJ, Sharma K. Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging. Am J Physiol Renal Physiol. 2013 Nov; 305(9):F1343-51. PMID: 24049144.
        View in: PubMed
      6. Shekhar H, Rychak J, Doyley MM. Modifying the size distribution of microbubble contrast agents for high-frequency subharmonic imaging. Med Phys. 2013 Aug; 40(8):082903. PMID: 23927358.
        View in: PubMed
      7. Hu X, Caskey CF, Mahakian LM, Kruse DE, Beegle JR, Declèves AE, Rychak J, Sutcliffe PL, Sharma K, Ferrara KW. In vivo validation and 3D visualization of broadband ultrasound molecular imaging. Am J Nucl Med Mol Imaging. 2013; 3(4):336-49. PMID: 23901359.
        View in: PubMed
      8. Yuan B, Rychak J. Tumor functional and molecular imaging utilizing ultrasound and ultrasound-mediated optical techniques. Am J Pathol. 2013 Feb; 182(2):305-11. PMID: 23219728.
        View in: PubMed
      9. Tlaxca JL, Rychak J, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizzaro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB. Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease. J Control Release. 2013 Feb 10; 165(3):216-25. PMID: 23142578.
        View in: PubMed
      10. Patil AV, Rychak J, Klibanov AL, Hossack JA. Real-time technique for improving molecular imaging and guiding drug delivery in large blood vessels: in vitro and ex vivo results. Mol Imaging. 2011 Aug; 10(4):238-47. PMID: 21521555.
        View in: PubMed
      11. Anderson CR, Hu X, Zhang H, Tlaxca J, Declèves AE, Houghtaling R, Sharma K, Lawrence M, Ferrara KW, Rychak J. Ultrasound molecular imaging of tumor angiogenesis with an integrin targeted microbubble contrast agent. Invest Radiol. 2011 Apr; 46(4):215-24. PMID: 21343825.
        View in: PubMed
      12. Tlaxca JL, Anderson CR, Klibanov AL, Lowrey B, Hossack JA, Alexander JS, Lawrence MB, Rychak J. Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles. Ultrasound Med Biol. 2010 Nov; 36(11):1907-18. PMID: 20800945.
        View in: PubMed
      13. Deelman LE, Declèves AE, Rychak J, Sharma K. Targeted renal therapies through microbubbles and ultrasound. Adv Drug Deliv Rev. 2010 Nov 30; 62(14):1369-77. PMID: 20946925.
        View in: PubMed
      14. Anderson CR, Rychak J, Backer M, Backer J, Ley K, Klibanov AL. scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis. Invest Radiol. 2010 Oct; 45(10):579-85. PMID: 20733505.
        View in: PubMed
      15. Patil AV, Rychak J, Allen JS, Klibanov AL, Hossack JA. Dual frequency method for simultaneous translation and real-time imaging of ultrasound contrast agents within large blood vessels. Ultrasound Med Biol. 2009 Dec; 35(12):2021-30. PMID: 19828229.
        View in: PubMed
      16. Ferrante EA, Pickard JE, Rychak J, Klibanov A, Ley K. Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow. J Control Release. 2009 Dec 3; 140(2):100-7. PMID: 19666063.
        View in: PubMed
      17. Rychak J, Graba J, Cheung AM, Mystry BS, Lindner JR, Kerbel RS, Foster FS. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imaging. 2007 Sep-Oct; 6(5):289-96. PMID: 18092513.
        View in: PubMed
      18. Dayton PA, Rychak J. Molecular ultrasound imaging using microbubble contrast agents. Front Biosci. 2007; 12:5124-42. PMID: 17569635.
        View in: PubMed
      19. Rychak J, Klibanov AL, Ley KF, Hossack JA. Enhanced targeting of ultrasound contrast agents using acoustic radiation force. Ultrasound Med Biol. 2007 Jul; 33(7):1132-9. PMID: 17445966.
        View in: PubMed
      20. Klibanov AL, Rychak J, Yang WC, Alikhani S, Li B, Acton S, Lindner JR, Ley K, Kaul S. Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow. Contrast Media Mol Imaging. 2006 Nov-Dec; 1(6):259-66. PMID: 17191766.
        View in: PubMed
      21. Rychak J, Li B, Acton ST, Leppänen A, Cummings RD, Ley K, Klibanov AL. Selectin ligands promote ultrasound contrast agent adhesion under shear flow. Mol Pharm. 2006 Sep-Oct; 3(5):516-24. PMID: 17009850.
        View in: PubMed
      22. Rychak J, Lindner JR, Ley K, Klibanov AL. Deformable gas-filled microbubbles targeted to P-selectin. J Control Release. 2006 Sep 12; 114(3):288-99. PMID: 16887229.
        View in: PubMed
      23. Rychak J, Klibanov AL, Hossack JA. Acoustic radiation force enhances targeted delivery of ultrasound contrast microbubbles: in vitro verification. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):421-33. PMID: 15857050.
        View in: PubMed
      24. Takalkar AM, Klibanov AL, Rychak J, Lindner JR, Ley K. Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow. J Control Release. 2004 May 18; 96(3):473-82. PMID: 15120903.
        View in: PubMed
      25. Davis CE, Rychak J, Hosticka B, Davis SC, John JE, Tucker AL, Norris PM, Moorman JR. A novel method for measuring dynamic changes in cell volume. J Appl Physiol (1985). 2004 May; 96(5):1886-93. PMID: 14594867.
        View in: PubMed
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