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Olezarsen, Acute Pancreatitis, and Familial Chylomicronemia Syndrome. N Engl J Med. 2024 Apr 07.
Stroes ESG, Alexander VJ, Karwatowska-Prokopczuk E, Hegele RA, Arca M, Ballantyne CM, Soran H, Prohaska TA, Xia S, Ginsberg HN, Witztum JL, Tsimikas S, Balance Investigators. PMID: 38587247.
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PubMed Mentions:
-
Volanesorsen to Prevent Acute Pancreatitis in Hypertriglyceridemia. N Engl J Med. 2024 Feb 01; 390(5):476-477.
Alexander VJ, Karwatowska-Prokopczuk E, Prohaska TA, Li L, Geary RS, Gouni-Berthold I, Oral EA, Hegele RA, Stroes ESG, Witztum JL, Tsimikas S. PMID: 38294982.
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PubMed Mentions: Fields:
Translation:
Humans
-
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter. bioRxiv. 2023 Nov 21.
Gioia MD, Poli V, Tan PJ, Spreafico R, Chu A, Cuenca AG, Gordts PL, Pandolfi L, Meloni F, Witztum JL, Chou J, Springstead JR, Zanoni I. PMID: 38045410; PMCID: PMC10690175.
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PubMed Mentions:
-
Oxidized phospholipids in cardiovascular disease. Nat Rev Cardiol. 2024 Mar; 21(3):170-191.
Tsimikas S, Witztum JL. PMID: 37848630.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Corrigendum to "Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial" [Journal of Clinical Lipidology, Volume 17, Issue 3, May-June 2023, Pages 342-355]. J Clin Lipidol. 2023 Oct 13.
Witztum JL, Gaudet D, Arca M, Jones A, Soran H, Gouni-Berthold I, Stroes ESG, Alexander VJ, Jones R, Watts L, Xia S, Tsimikas S. PMID: 38565460.
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PubMed Mentions: Fields:
-
On-treatment platelet reactivity through the thromboxane A2 or P2Y12 platelet receptor pathways is not affected by pelacarsen. J Thromb Thrombolysis. 2023 Aug; 56(2):226-232.
Karwatowska-Prokopczuk E, Li L, Yang J, Witztum JL, Tsimikas S. PMID: 37338713.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
High immunoglobulin-M levels to oxidation-specific epitopes are associated with lower risk of acute myocardial infarction. J Lipid Res. 2023 06; 64(6):100391.
Taleb A, Willeit P, Amir S, Perkmann T, Kozma MO, Watzenböck ML, Binder CJ, Witztum JL, Tsimikas S. PMID: 37211249; PMCID: PMC10275726.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
APOC3 inhibition with volanesorsen reduces hepatic steatosis in patients with severe hypertriglyceridemia. J Clin Lipidol. 2023 May-Jun; 17(3):406-411.
Prohaska TA, Alexander VJ, Karwatowska-Prokopczuk E, Tami J, Xia S, Witztum JL, Tsimikas S. PMID: 37164837.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Volanesorsen and triglyceride levels in familial chylomicronemia syndrome: Long-term efficacy and safety data from patients in an open-label extension trial. J Clin Lipidol. 2023 May-Jun; 17(3):342-355.
Witztum JL, Gaudet D, Arca M, Jones A, Soran H, Gouni-Berthold I, Stroes ESG, Alexander VJ, Jones R, Watts L, Xia S, Tsimikas S. PMID: 37100699.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Apolipoprotein C3 induces inflammasome activation only in its delipidated form. Nat Immunol. 2023 03; 24(3):408-411.
Hsu CC, Shao B, Kanter JE, He Y, Vaisar T, Witztum JL, Snell-Bergeon J, McInnes G, Bruse S, Gottesman O, Mullick AE, Bornfeldt KE. PMID: 36781985; PMCID: PMC9992333.
View in:
PubMed Mentions:
6 Fields:
-
Assessment of efficacy and safety of volanesorsen for treatment of metabolic complications in patients with familial partial lipodystrophy: Results of the BROADEN study: Volanesorsen in FPLD; The BROADEN Study. J Clin Lipidol. 2022 Sep 22.
Oral EA, Garg A, Tami J, Huang EA, O'Dea LSL, Schmidt H, Tiulpakov A, Mertens A, Alexander VJ, Watts L, Hurh E, Witztum JL, Geary RS, Tsimikas S. PMID: 36402670.
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PubMed Mentions:
8 Fields:
-
The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. JCI Insight. 2022 09 08; 7(17).
Zhao P, Sun X, Liao Z, Yu H, Li D, Shen Z, Glass CK, Witztum JL, Saltiel AR. PMID: 35917178; PMCID: PMC9536260.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Shared Mechanisms between Cardiovascular Disease and NAFLD. Semin Liver Dis. 2022 Nov; 42(4):455-464.
Huang DQ, Downes M, Evans RM, Witztum JL, Glass CK, Loomba R. PMID: 36008083.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis. Front Immunol. 2022; 13:909475.
Srikakulapu P, Pattarabanjird T, Upadhye A, Bontha SV, Osinski V, Marshall MA, Garmey J, Deroissart J, Prohaska TA, Witztum JL, Binder CJ, Holodick NE, Rothstein TL, McNamara CA. PMID: 35935999; PMCID: PMC9353528.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
-
Interventional hepatic apoC-III knockdown improves atherosclerotic plaque stability and remodeling by triglyceride lowering. JCI Insight. 2022 07 08; 7(13).
Ramms B, Patel S, Sun X, Pessentheiner AR, Ducasa GM, Mullick AE, Lee RG, Crooke RM, Tsimikas S, Witztum JL, Gordts PL. PMID: 35653195; PMCID: PMC9310539.
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PubMed Mentions:
4 Fields:
Translation:
Animals
-
Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia. J Clin Lipidol. 2022 Sep-Oct; 16(5):617-625.
Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, Ballantyne CM, Shapiro MD, Moriarty PM, Baum SJ, Amour ES, Alexander VJ, Xia S, Otvos JD, Witztum JL, Tsimikas S, Olezarsen Trial Investigators. PMID: 35902351.
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PubMed Mentions:
8 Fields:
Translation:
Humans
-
Development and validation of an isoform-independent monoclonal antibody-based ELISA for measurement of lipoprotein(a). J Lipid Res. 2022 08; 63(8):100239.
Marcovina SM, Navabi N, Allen S, Gonen A, Witztum JL, Tsimikas S. PMID: 35688187; PMCID: PMC9352967.
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PubMed Mentions:
3 Fields:
Translation:
Humans
-
Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022 04 06; 43(14):1401-1412.
Tardif JC, Karwatowska-Prokopczuk E, Amour ES, Ballantyne CM, Shapiro MD, Moriarty PM, Baum SJ, Hurh E, Bartlett VJ, Kingsbury J, Figueroa AL, Alexander VJ, Tami J, Witztum JL, Geary RS, O'Dea LSL, Tsimikas S, Gaudet D. PMID: 35025993; PMCID: PMC8986458.
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PubMed Mentions:
34 Fields:
Translation:
Humans
-
Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 03 22; 79(11):1035-1046.
Yeang C, Karwatowska-Prokopczuk E, Su F, Dinh B, Xia S, Witztum JL, Tsimikas S. PMID: 35300814; PMCID: PMC8972555.
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PubMed Mentions:
23 Fields:
Translation:
Humans
-
Generation of cardio-protective antibodies after pneumococcal polysaccharide vaccine: Early results from a randomised controlled trial. Atherosclerosis. 2022 04; 346:68-74.
Ren S, Hansbro PM, Srikusalanukul W, Horvat JC, Hunter T, Brown AC, Peel R, Faulkner J, Evans TJ, Li SC, Newby D, Hure A, Abhayaratna WP, Tsimikas S, Gonen A, Witztum JL, Attia J, AUSPICE investigators. PMID: 35290813.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Bioactive lipids and metabolic syndrome-a symposium report. Ann N Y Acad Sci. 2022 05; 1511(1):87-106.
DeVito LM, Dennis EA, Kahn BB, Shulman GI, Witztum JL, Sadhu S, Nickels J, Spite M, Smyth S, Spiegel S. PMID: 35218041; PMCID: PMC9219555.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency. Circulation. 2021 12 14; 144(24):1940-1954.
Dou H, Kotini A, Liu W, Fidler T, Endo-Umeda K, Sun X, Olszewska M, Xiao T, Abramowicz S, Yalcinkaya M, Hardaway B, Tsimikas S, Que X, Bick A, Emdin C, Natarajan P, Papapetrou EP, Witztum JL, Wang N, Tall AR. PMID: 34846914; PMCID: PMC8663540.
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PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
Longitudinal Assessment of Lipoprotein(a) Levels in Perinatally HIV-Infected Children and Adolescents. Viruses. 2021 10 14; 13(10).
van Genderen JG, Van den Hof M, de Boer CG, Jansen HPG, van Deventer SJH, Tsimikas S, Witztum JL, Kastelein JJP, Pajkrt D. PMID: 34696496; PMCID: PMC8539147.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
-
Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell. 2021 08; 20(8):e13442.
Palmieri M, Almeida M, Nookaew I, Gomez-Acevedo H, Joseph TE, Que X, Tsimikas S, Sun X, Manolagas SC, Witztum JL, Ambrogini E. PMID: 34278710; PMCID: PMC8373359.
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PubMed Mentions:
13 Fields:
Translation:
Animals
-
Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors. Immunity. 2021 07 13; 54(7):1561-1577.e7.
Xu S, Chaudhary O, Rodríguez-Morales P, Sun X, Chen D, Zappasodi R, Xu Z, Pinto AFM, Williams A, Schulze I, Farsakoglu Y, Varanasi SK, Low JS, Tang W, Wang H, McDonald B, Tripple V, Downes M, Evans RM, Abumrad NA, Merghoub T, Wolchok JD, Shokhirev MN, Ho PC, Witztum JL, Emu B, Cui G, Kaech SM. PMID: 34102100; PMCID: PMC9273026.
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PubMed Mentions:
150 Fields:
Translation:
HumansAnimalsCells
-
Efficacy and safety of volanesorsen in patients with multifactorial chylomicronaemia (COMPASS): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Diabetes Endocrinol. 2021 05; 9(5):264-275.
Gouni-Berthold I, Alexander VJ, Yang Q, Hurh E, Steinhagen-Thiessen E, Moriarty PM, Hughes SG, Gaudet D, Hegele RA, O'Dea LSL, Stroes ESG, Tsimikas S, Witztum JL, COMPASS study group. PMID: 33798466.
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PubMed Mentions:
45 Fields:
Translation:
HumansCTClinical Trials
-
Prevalence and influence of LPA gene variants and isoform size on the Lp(a)-lowering effect of pelacarsen. Atherosclerosis. 2021 05; 324:102-108.
Karwatowska-Prokopczuk E, Clouet-Foraison N, Xia S, Viney NJ, Witztum JL, Marcovina SM, Tsimikas S. PMID: 33872986.
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PubMed Mentions:
7 Fields:
Translation:
Humans
-
Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements. J Lipid Res. 2021; 62:100053.
Yeang C, Witztum JL, Tsimikas S. PMID: 33636163; PMCID: PMC8042377.
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PubMed Mentions:
22 Fields:
-
Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia. Eur Heart J. 2020 10 21; 41(40):3936-3945.
Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, Hurh E, Kingsbury J, Bartlett VJ, Figueroa AL, Piscitelli P, Singleton W, Witztum JL, Geary RS, Tsimikas S, O'Dea LSL, Vupanorsen Study Investigators. PMID: 32860031; PMCID: PMC7750927.
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PubMed Mentions:
88 Fields:
Translation:
HumansCTClinical Trials
-
A Neutralizing Antibody Targeting Oxidized Phospholipids Promotes Bone Anabolism in Chow-Fed Young Adult Mice. J Bone Miner Res. 2021 01; 36(1):170-185.
Palmieri M, Kim HN, Gomez-Acevedo H, Que X, Tsimikas S, Jilka RL, Manolagas SC, Witztum JL, Ambrogini E. PMID: 32990984; PMCID: PMC7855899.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a). J Lipid Res. 2020 09; 61(9):1263-1270.
Gonen A, Yang X, Yeang C, Alekseeva E, Koschinsky M, Witztum JL, Boffa M, Tsimikas S. PMID: 32641432; PMCID: PMC7469883.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCellsPHPublic Health
-
CD1d Selectively Down Regulates the Expression of the Oxidized Phospholipid-Specific E06 IgM Natural Antibody in Ldlr-/- Mice. Antibodies (Basel). 2020 Jul 03; 9(3).
Biswas TK, VanderLaan PA, Que X, Gonen A, Krishack P, Binder CJ, Witztum JL, Getz GS, Reardon CA. PMID: 32635160; PMCID: PMC7551411.
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PubMed Mentions:
2
-
Statin therapy increases lipoprotein(a) levels. Eur Heart J. 2020 06 21; 41(24):2275-2284.
Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31111151.
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PubMed Mentions:
122 Fields:
Translation:
Humans
-
Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis. Immunity. 2020 06 16; 52(6):1057-1074.e7.
Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK. PMID: 32362324; PMCID: PMC7305990.
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PubMed Mentions:
139 Fields:
Translation:
AnimalsCells
-
Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circ Res. 2020 05 08; 126(10):1346-1359.
Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J. PMID: 32160811; PMCID: PMC7208285.
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PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
-
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis. Heart. 2020 05; 106(10):738-745.
Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S. PMID: 32054669.
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PubMed Mentions:
16 Fields:
Translation:
Humans
-
Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia. Nucleic Acid Ther. 2020 04; 30(2):94-103.
Narayanan P, Curtis BR, Shen L, Schneider E, Tami JA, Paz S, Burel SA, Tai LJ, Machemer T, Kwoh TJ, Xia S, Shattil SJ, Witztum JL, Engelhardt JA, Henry SP, Monia BP, Hughes SG. PMID: 32043907.
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PubMed Mentions:
8 Fields:
Translation:
HumansCTClinical Trials
-
An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660.
Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622; PMCID: PMC8012106.
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PubMed Mentions:
100 Fields:
Translation:
HumansAnimalsCells
-
Statins and increases in Lp(a): an inconvenient truth that needs attention. Eur Heart J. 2020 01 01; 41(1):192-193.
Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31893480.
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PubMed Mentions:
11 Fields:
-
Lipoprotein(a) Reduction in Persons with Cardiovascular Disease. N Engl J Med. 2020 01 16; 382(3):244-255.
Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, Tardif JC, Baum SJ, Steinhagen-Thiessen E, Shapiro MD, Stroes ES, Moriarty PM, Nordestgaard BG, Xia S, Guerriero J, Viney NJ, O'Dea L, Witztum JL, AKCEA-APO(a)-LRx Study Investigators. PMID: 31893580.
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PubMed Mentions:
215 Fields:
Translation:
HumansCTClinical Trials
-
Volanesorsen, Familial Chylomicronemia Syndrome, and Thrombocytopenia. Reply. N Engl J Med. 2019 12 26; 381(26):2584.
Witztum JL, Geary RS, O'Dea L. PMID: 31881148.
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PubMed Mentions:
1 Fields:
Translation:
Humans
-
Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 01 07; 31(1):189-206.e8.
Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566; PMCID: PMC7028360.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
-
Erratum: A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 Nov; 60(11):1979.
Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. PMID: 31676683; PMCID: PMC6824499.
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PubMed Mentions: Fields:
-
Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles. J Endocr Soc. 2019 Dec 01; 3(12):2397-2410.
O'Dea LSL, MacDougall J, Alexander VJ, Digenio A, Hubbard B, Arca M, Moriarty PM, Kastelein JJP, Bruckert E, Soran H, Witztum JL, Hegele RA, Gaudet D. PMID: 31777768; PMCID: PMC6864364.
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PubMed Mentions:
10
-
Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis. Circ Res. 2019 10 25; 125(10):e55-e70.
Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen A, McSkimming C, Marshall MA, Garmey JC, Taylor AM, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA. PMID: 31549940; PMCID: PMC6830526.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
-
Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis. J Lipid Res. 2019 12; 60(12):2082-2089.
Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas S. PMID: 31551368; PMCID: PMC6889713.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCTClinical Trials
-
N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels. Eur Heart J. 2019 09 01; 40(33):2785-2796.
Alexander VJ, Xia S, Hurh E, Hughes SG, O'Dea L, Geary RS, Witztum JL, Tsimikas S. PMID: 31329855; PMCID: PMC6736334.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansCTClinical Trials
-
Volanesorsen and Triglyceride Levels in Familial Chylomicronemia Syndrome. N Engl J Med. 2019 08 08; 381(6):531-542.
Witztum JL, Gaudet D, Freedman SD, Alexander VJ, Digenio A, Williams KR, Yang Q, Hughes SG, Geary RS, Arca M, Stroes ESG, Bergeron J, Soran H, Civeira F, Hemphill L, Tsimikas S, Blom DJ, O'Dea L, Bruckert E. PMID: 31390500.
View in:
PubMed Mentions:
137 Fields:
Translation:
HumansCTClinical Trials
-
ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance. J Lipid Res. 2019 08; 60(8):1379-1395.
Ramms B, Patel S, Nora C, Pessentheiner AR, Chang MW, Green CR, Golden GJ, Secrest P, Krauss RM, Metallo CM, Benner C, Alexander VJ, Witztum JL, Tsimikas S, Esko JD, Gordts PLSM. PMID: 31092690; PMCID: PMC6672034.
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PubMed Mentions:
25 Fields:
Translation:
Animals
-
Lipoprotein(a) and Oxidized Phospholipids Promote Valve Calcification in Patients With Aortic Stenosis. J Am Coll Cardiol. 2019 05 07; 73(17):2150-2162.
Zheng KH, Tsimikas S, Pawade T, Kroon J, Jenkins WSA, Doris MK, White AC, Timmers NKLM, Hjortnaes J, Rogers MA, Aikawa E, Arsenault BJ, Witztum JL, Newby DE, Koschinsky ML, Fayad ZA, Stroes ESG, Boekholdt SM, Dweck MR. PMID: 31047003; PMCID: PMC6494952.
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PubMed Mentions:
88 Fields:
Translation:
Humans
-
Apolipoprotein Profiles in Very Preterm and Term-Born Preschool Children. J Am Heart Assoc. 2019 04 16; 8(8):e011199.
Posod A, Pechlaner R, Yin X, Burnap SA, Kiechl SJ, Willeit J, Witztum JL, Mayr M, Kiechl S, Kiechl-Kohlendorfer U. PMID: 30968745; PMCID: PMC6507182.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
Lipoprotein(a), Oxidized Phospholipids, and Aortic Valve Microcalcification Assessed by 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography. CJC Open. 2019 May; 1(3):131-140.
Després AA, Perrot N, Poulin A, Tastet L, Shen M, Chen HY, Bourgeois R, Trottier M, Tessier M, Guimond J, Nadeau M, Engert JC, Thériault S, Bossé Y, Witztum JL, Couture P, Mathieu P, Dweck MR, Tsimikas S, Thanassoulis G, Pibarot P, Clavel MA, Arsenault BJ. PMID: 32159096; PMCID: PMC7063623.
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PubMed Mentions:
21
-
RNA-Targeted Therapeutics. Cell Metab. 2019 Feb 05; 29(2):501.
Crooke ST, Witztum JL, Bennett CF, Baker BF. PMID: 30726759.
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PubMed Mentions:
19 Fields:
-
Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 01 01; 115(1):179-189.
Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. PMID: 29850765; PMCID: PMC6302283.
View in:
PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
-
A monoclonal antibody to assess oxidized cholesteryl esters associated with apoAI and apoB-100 lipoproteins in human plasma. J Lipid Res. 2019 02; 60(2):436-445.
Gonen A, Choi SH, Miu P, Agatisa-Boyle C, Acks D, Taylor AM, McNamara CA, Tsimikas S, Witztum JL, Miller YI. PMID: 30563909; PMCID: PMC6358287.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
-
CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice. Mol Metab. 2019 02; 20:89-101.
Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS. PMID: 30553772; PMCID: PMC6358552.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43.
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.
View in:
PubMed Mentions:
4 Fields:
-
Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study. J Clin Lipidol. 2018 Nov - Dec; 12(6):1493-1501.e11.
van Capelleveen JC, Lee SR, Verbeek R, Kastelein JJP, Wareham NJ, Stroes ESG, Hovingh GK, Khaw KT, Boekholdt SM, Witztum JL, Tsimikas S. PMID: 30249512; PMCID: PMC6970616.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Relationship of lipoprotein(a) molar concentrations and mass according to lipoprotein(a) thresholds and apolipoprotein(a) isoform size. J Clin Lipidol. 2018 Sep - Oct; 12(5):1313-1323.
Tsimikas S, Fazio S, Viney NJ, Xia S, Witztum JL, Marcovina SM. PMID: 30100157.
View in:
PubMed Mentions:
26 Fields:
Translation:
Humans
-
Oxidation-specific epitopes restrain bone formation. Nat Commun. 2018 06 06; 9(1):2193.
Ambrogini E, Que X, Wang S, Yamaguchi F, Weinstein RS, Tsimikas S, Manolagas SC, Witztum JL, Jilka RL. PMID: 29875355; PMCID: PMC5990540.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
-
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306.
Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.
View in:
PubMed Mentions:
183 Fields:
Translation:
AnimalsCells
-
Characterizing familial chylomicronemia syndrome: Baseline data of the APPROACH study. J Clin Lipidol. 2018 Sep - Oct; 12(5):1234-1243.e5.
Blom DJ, O'Dea L, Digenio A, Alexander VJ, Karwatowska-Prokopczuk E, Williams KR, Hemphill L, Muñiz-Grijalvo O, Santos RD, Baum S, Witztum JL. PMID: 30318066.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCTClinical Trials
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The burden of familial chylomicronemia syndrome: Results from the global IN-FOCUS study. J Clin Lipidol. 2018 Jul - Aug; 12(4):898-907.e2.
Davidson M, Stevenson M, Hsieh A, Ahmad Z, Roeters van Lennep J, Crowson C, Witztum JL. PMID: 29784572.
View in:
PubMed Mentions:
23 Fields:
Translation:
Humans
-
Clinical and biochemical features of different molecular etiologies of familial chylomicronemia. J Clin Lipidol. 2018 Jul - Aug; 12(4):920-927.e4.
Hegele RA, Berberich AJ, Ban MR, Wang J, Digenio A, Alexander VJ, D'Erasmo L, Arca M, Jones A, Bruckert E, Stroes ES, Bergeron J, Civeira F, Witztum JL, Gaudet D. PMID: 29748148.
View in:
PubMed Mentions:
30 Fields:
Translation:
Humans
-
RNA-Targeted Therapeutics. Cell Metab. 2018 04 03; 27(4):714-739.
Crooke ST, Witztum JL, Bennett CF, Baker BF. PMID: 29617640.
View in:
PubMed Mentions:
276 Fields:
Translation:
HumansAnimals
-
Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide. J Clin Lipidol. 2018 May - Jun; 12(3):702-710.
Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S. PMID: 29574075.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCTClinical Trials
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Massively Parallel Sequencing of Peritoneal and Splenic B Cell Repertoires Highlights Unique Properties of B-1 Cell Antibodies. J Immunol. 2018 03 01; 200(5):1702-1717.
Prohaska TA, Que X, Diehl CJ, Hendrikx S, Chang MW, Jepsen K, Glass CK, Benner C, Witztum JL. PMID: 29378911; PMCID: PMC5821571.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol. 2018 01 23; 71(3):321-335.
Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S. PMID: 29348025; PMCID: PMC5995462.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
-
NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. J Am Coll Cardiol. 2018 01 16; 71(2):177-192.
Tsimikas S, Fazio S, Ferdinand KC, Ginsberg HN, Koschinsky ML, Marcovina SM, Moriarty PM, Rader DJ, Remaley AT, Reyes-Soffer G, Santos RD, Thanassoulis G, Witztum JL, Danthi S, Olive M, Liu L. PMID: 29325642; PMCID: PMC5868960.
View in:
PubMed Mentions:
126 Fields:
Translation:
Humans
-
Interleukin-1 genotypes modulate the long-term effect of lipoprotein(a) on cardiovascular events: The Ioannina Study. J Clin Lipidol. 2018 Mar - Apr; 12(2):338-347.
Naka KK, Bechlioullis A, Marini A, Sionis D, Vakalis K, Triantis G, Wilkins L, Rogus J, Kornman KS, Witztum JL, Doucette-Stamm L, Michalis LK, Tsimikas S. PMID: 29310992.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Plasma Proteomics for Epidemiology: Increasing Throughput With Standard-Flow Rates. Circ Cardiovasc Genet. 2017 Dec; 10(6).
Yin X, Baig F, Haudebourg E, Blankley RT, Gandhi T, Müller S, Reiter L, Hinterwirth H, Pechlaner R, Tsimikas S, Santer P, Willeit J, Kiechl S, Witztum JL, Sullivan A, Mayr M. PMID: 29237681.
View in:
PubMed Mentions:
8 Fields:
Translation:
Humans
-
Temporal variability in lipoprotein(a) levels in patients enrolled in the placebo arms of IONIS-APO(a)Rx and IONIS-APO(a)-LRx antisense oligonucleotide clinical trials. J Clin Lipidol. 2018 Jan - Feb; 12(1):122-129.e2.
Marcovina SM, Viney NJ, Hughes SG, Xia S, Witztum JL, Tsimikas S. PMID: 29174389.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansCTClinical Trials
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Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up. Eur Heart J. 2017 Sep 01; 38(33):2547-2555.
Hartikainen J, Hassinen I, Hedman A, Kivelä A, Saraste A, Knuuti J, Husso M, Mussalo H, Hedman M, Rissanen TT, Toivanen P, Heikura T, Witztum JL, Tsimikas S, Ylä-Herttuala S. PMID: 28903476; PMCID: PMC5837555.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCellsCTClinical Trials
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Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017 Jun; 2(3):229-240.
Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S. PMID: 29147686; PMCID: PMC5685511.
View in:
PubMed Mentions:
38
-
Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study. Arterioscler Thromb Vasc Biol. 2017 08; 37(8):1570-1578.
Kamstrup PR, Hung MY, Witztum JL, Tsimikas S, Nordestgaard BG. PMID: 28572160; PMCID: PMC5551411.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCells
-
Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides. N Engl J Med. 2017 07 20; 377(3):222-232.
Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, Witztum JL, Crooke RM, Tsimikas S. PMID: 28538111.
View in:
PubMed Mentions:
221 Fields:
Translation:
HumansAnimalsCTClinical Trials
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Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2017 06; 37(6):1206-1212.
van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum JL, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S. PMID: 28473441; PMCID: PMC5484077.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
-
Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arterioscler Thromb Vasc Biol. 2017 06; 37(6):1213-1221.
Prasad A, Clopton P, Ayers C, Khera A, de Lemos JA, Witztum JL, Tsimikas S. PMID: 28473443; PMCID: PMC5500201.
View in:
PubMed Mentions:
16 Fields:
Translation:
Humans
-
Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. Lancet Diabetes Endocrinol. 2017 07; 5(7):524-533.
Saleheen D, Haycock PC, Zhao W, Rasheed A, Taleb A, Imran A, Abbas S, Majeed F, Akhtar S, Qamar N, Zaman KS, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Mallick NH, Ishaq M, Rasheed SZ, Memon FU, Mahmood K, Ahmed N, Frossard P, Tsimikas S, Witztum JL, Marcovina S, Sandhu M, Rader DJ, Danesh J. PMID: 28408323; PMCID: PMC5483508.
View in:
PubMed Mentions:
67 Fields:
Translation:
Humans
-
The burden of familial chylomicronemia syndrome: interim results from the IN-FOCUS study. Expert Rev Cardiovasc Ther. 2017 May; 15(5):415-423.
Davidson M, Stevenson M, Hsieh A, Ahmad Z, Crowson C, Witztum JL. PMID: 28338353.
View in:
PubMed Mentions:
14 Fields:
Translation:
Humans
-
Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial. Atherosclerosis. 2017 05; 260:1-7.
Capoulade R, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. PMID: 28319871.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Very-Low-Density Lipoprotein-Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III. J Am Coll Cardiol. 2017 Feb 21; 69(7):789-800.
Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P, Oberhollenzer F, Egger G, Witztum JL, Alexander VJ, Willeit J, Kiechl S, Mayr M. PMID: 28209220; PMCID: PMC5314136.
View in:
PubMed Mentions:
79 Fields:
Translation:
Humans
-
The Effects of 2'-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials. Nucleic Acid Ther. 2017 Jun; 27(3):121-129.
Crooke ST, Baker BF, Witztum JL, Kwoh TJ, Pham NC, Salgado N, McEvoy BW, Cheng W, Hughes SG, Bhanot S, Geary RS. PMID: 28145801; PMCID: PMC5467133.
View in:
PubMed Mentions:
51 Fields:
Translation:
HumansCells
-
Oxidized Phospholipids on Apolipoprotein B-100 and Recurrent Ischemic Events Following Stroke or Transient Ischemic Attack. J Am Coll Cardiol. 2017 Jan 17; 69(2):147-158.
Byun YS, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S, SPARCL Trial Investigators. PMID: 28081824.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansPHPublic Health
-
Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326.
Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Diaz M, Castrillo A, Bensinger SJ, Chan L, Tontonoz P. PMID: 28002731; PMCID: PMC5181791.
View in:
PubMed Mentions:
53 Fields:
Translation:
AnimalsCells
-
LPA Gene, Ethnicity, and Cardiovascular Events. Circulation. 2017 Jan 17; 135(3):251-263.
Lee SR, Prasad A, Choi YS, Xing C, Clopton P, Witztum JL, Tsimikas S. PMID: 27831500; PMCID: PMC5241172.
View in:
PubMed Mentions:
40 Fields:
Translation:
Humans
-
Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet. 2016 11 05; 388(10057):2239-2253.
Viney NJ, van Capelleveen JC, Geary RS, Xia S, Tami JA, Yu RZ, Marcovina SM, Hughes SG, Graham MJ, Crooke RM, Crooke ST, Witztum JL, Stroes ES, Tsimikas S. PMID: 27665230.
View in:
PubMed Mentions:
237 Fields:
Translation:
HumansCTClinical Trials
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Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016 Aug 23; 134(8):611-24.
van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES. PMID: 27496857; PMCID: PMC4995139.
View in:
PubMed Mentions:
183 Fields:
Translation:
HumansCellsCTClinical Trials
-
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 08 01; 126(8):2855-66.
Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum JL, Esko JD. PMID: 27400128; PMCID: PMC4966320.
View in:
PubMed Mentions:
100 Fields:
Translation:
AnimalsCells
-
Innate sensing of oxidation-specific epitopes in health and disease. Nat Rev Immunol. 2016 08; 16(8):485-97.
Binder CJ, Papac-Milicevic N, Witztum JL. PMID: 27346802; PMCID: PMC7097710.
View in:
PubMed Mentions:
146 Fields:
Translation:
HumansAnimalsCells
-
Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia. J Clin Lipidol. 2016 Jul-Aug; 10(4):1011-1021.
Duell PB, Santos RD, Kirwan BA, Witztum JL, Tsimikas S, Kastelein JJP. PMID: 27578134.
View in:
PubMed Mentions:
41 Fields:
Translation:
Humans
-
Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). J Clin Lipidol. 2016 May-Jun; 10(3):594-603.
Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum JL, Tsimikas S. PMID: 27206947.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
-
Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep. 2016 Mar 15; 14(10):2348-61.
Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum JL, Shiri-Sverdlov R, Nitschke L, Binder CJ. PMID: 26947073; PMCID: PMC4802221.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):682-91.
Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum JL, McNamara CA. PMID: 26868208; PMCID: PMC4808436.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
-
Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results. J Lipid Res. 2016 Apr; 57(4):706-13.
Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller YI, Witztum JL, Tsimikas S. PMID: 26848137; PMCID: PMC4808774.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCTClinical Trials
-
Lipoprotein (a): Coming of Age at Last. J Lipid Res. 2016 Mar; 57(3):336-9.
Witztum JL, Ginsberg HN. PMID: 26839334; PMCID: PMC4766984.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study. J Lipid Res. 2016 Apr; 57(4):697-705.
Verbeek R, Boekholdt SM, Stoekenbroek RM, Hovingh GK, Witztum JL, Wareham NJ, Sandhu MS, Khaw KT, Tsimikas S. PMID: 26828068; PMCID: PMC4808778.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):456-65.
Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum JL, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH. PMID: 26821944; PMCID: PMC4853762.
View in:
PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
-
Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis. J Am Coll Cardiol. 2015 Sep 15; 66(11):1236-1246.
Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. PMID: 26361154.
View in:
PubMed Mentions:
130 Fields:
Translation:
HumansCells
-
CEP Is an Important and Ubiquitous Oxidation Specific Epitope Recognized by Innate Pattern Recognition Receptors. Circ Res. 2015 Jul 31; 117(4):305-8.
Witztum JL. PMID: 26227873; PMCID: PMC4816067.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. N Engl J Med. 2015 Jul 30; 373(5):438-47.
Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum JL, Brunzell JD, Kastelein JJ. PMID: 26222559.
View in:
PubMed Mentions:
189 Fields:
Translation:
HumansCTClinical Trials
-
Daniel Steinberg, 1922-2015. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9791-2.
Glass CK, Witztum JL. PMID: 26209653; PMCID: PMC4538637.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimals
-
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet. 2015 Oct 10; 386(10002):1472-83.
Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL. PMID: 26210642.
View in:
PubMed Mentions:
160 Fields:
Translation:
HumansCellsCTClinical Trials
-
B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17; 117(3):e28-39.
Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA. PMID: 26082558; PMCID: PMC4527334.
View in:
PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
-
Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Dis Model Mech. 2015 Aug 01; 8(8):989-98.
Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum JL, Remaley AT, Dong PD, Miller YI. PMID: 26044956; PMCID: PMC4527288.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
-
'LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol. 2015 Jun; 26(3):169-78.
Yeang C, Witztum JL, Tsimikas S. PMID: 25943842.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimals
-
Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1704-11.
Rao F, Schork AJ, Maihofer AX, Nievergelt CM, Marcovina SM, Miller ER, Witztum JL, O'Connor DT, Tsimikas S. PMID: 25953646; PMCID: PMC4483152.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
-
Relationship of oxidized phospholipids on apolipoprotein B-100 to cardiovascular outcomes in patients treated with intensive versus moderate atorvastatin therapy: the TNT trial. J Am Coll Cardiol. 2015 Apr 07; 65(13):1286-1295.
Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum JL, Tsimikas S, TNT Trial Investigators. PMID: 25835440; PMCID: PMC4386070.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):689-99.
Santos RD, Raal FJ, Catapano AL, Witztum JL, Steinhagen-Thiessen E, Tsimikas S. PMID: 25614280; PMCID: PMC4344404.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
-
Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-736.
Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. PMID: 25598080; PMCID: PMC4340319.
View in:
PubMed Mentions:
152 Fields:
Translation:
HumansCTClinical Trials
-
SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL. Autophagy. 2015; 11(5):785-95.
Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum JL, Miller YI. PMID: 25946330; PMCID: PMC4509444.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Lipoprotein(A) with An Intact Lysine Binding Site Protects the Retina From an Age-Related Macular Degeneration Phenotype in Mice (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc. 2015; 113:T5.
Handa JT, Tagami M, Ebrahimi K, Leibundgut G, Janiak A, Witztum JL, Tsimikas S. PMID: 26538774; PMCID: PMC4601905.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):570-2.
Fernandez JA, Deguchi H, Banka CL, Witztum JL, Griffin JH. PMID: 25550205; PMCID: PMC4344393.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015 Feb; 56(2):440-8.
Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum JL, Lang IM, Binder CJ. PMID: 25525116; PMCID: PMC4306697.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansCells
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Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014 Dec 04; 371(23):2200-6.
Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum JL. PMID: 25470695.
View in:
PubMed Mentions:
165 Fields:
Translation:
Humans
-
Leucocyte telomere length and risk of type 2 diabetes mellitus: new prospective cohort study and literature-based meta-analysis. PLoS One. 2014; 9(11):e112483.
Willeit P, Raschenberger J, Heydon EE, Tsimikas S, Haun M, Mayr A, Weger S, Witztum JL, Butterworth AS, Willeit J, Kronenberg F, Kiechl S. PMID: 25390655; PMCID: PMC4229188.
View in:
PubMed Mentions:
91 Fields:
Translation:
HumansCells
-
Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014 Nov 04; 20(5):813-826.
Gordts PLSM, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum JL, Esko JD. PMID: 25440058; PMCID: PMC4254584.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):229-36.
Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum JL, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, Meisinger C, Gieger C, Müller-Nurasyid M, Peters A, Willeit J, Kiechl S. PMID: 25359861; PMCID: PMC4317265.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
-
ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol. 2014 Dec 01; 193(11):5637-48.
Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum JL, Tarling EJ. PMID: 25339664; PMCID: PMC4239162.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. J Cardiovasc Transl Res. 2014 Nov; 7(8):719-36.
Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S. PMID: 25297940; PMCID: PMC4233166.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
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Discrimination and net reclassification of cardiovascular risk with lipoprotein(a): prospective 15-year outcomes in the Bruneck Study. J Am Coll Cardiol. 2014 Sep 02; 64(9):851-60.
Willeit P, Kiechl S, Kronenberg F, Witztum JL, Santer P, Mayr M, Xu Q, Mayr A, Willeit J, Tsimikas S. PMID: 25169167.
View in:
PubMed Mentions:
91 Fields:
Translation:
Humans
-
Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. J Lipid Res. 2014 Oct; 55(10):2137-55.
Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K. PMID: 25143462; PMCID: PMC4174006.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
-
B cells and humoral immunity in atherosclerosis. Circ Res. 2014 May 23; 114(11):1743-56.
Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ. PMID: 24855199; PMCID: PMC4066414.
View in:
PubMed Mentions:
125 Fields:
Translation:
HumansAnimalsCells
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Interleukin-3/granulocyte macrophage colony-stimulating factor receptor promotes stem cell expansion, monocytosis, and atheroma macrophage burden in mice with hematopoietic ApoE deficiency. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):976-84.
Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR. PMID: 24651678; PMCID: PMC4091799.
View in:
PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
-
Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71.
Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. PMID: 24613321; PMCID: PMC4629781.
View in:
PubMed Mentions:
46 Fields:
Translation:
HumansCells
-
Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a). J Am Coll Cardiol. 2014 May 06; 63(17):1724-34.
Tsimikas S, Duff GW, Berger PB, Rogus J, Huttner K, Clopton P, Brilakis E, Kornman KS, Witztum JL. PMID: 24530664; PMCID: PMC4008715.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansCells
-
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014 Apr 22; 129(16):1677-87.
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. PMID: 24488984; PMCID: PMC3997655.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100. Front Immunol. 2013; 4:493.
Tse K, Gonen A, Sidney J, Ouyang H, Witztum JL, Sette A, Tse H, Ley K. PMID: 24416033; PMCID: PMC3873602.
View in:
PubMed Mentions:
49 Fields:
-
Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. PLoS One. 2013; 8(12):e83145.
Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. PMID: 24376657; PMCID: PMC3871536.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis. J Am Coll Cardiol. 2014 Feb 11; 63(5):478-80.
Hung MY, Witztum JL, Tsimikas S. PMID: 24161316; PMCID: PMC5928500.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansPHPublic Health
-
Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2771-9.
Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum JL, Bender TP, McNamara CA. PMID: 24115031; PMCID: PMC4003558.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res. 2013 Nov; 54(11):3206-14.
Montano EN, Boullier A, Almazan F, Binder CJ, Witztum JL, Hartvigsen K. PMID: 23997238; PMCID: PMC3793625.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704.
Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC. PMID: 23990245; PMCID: PMC3882740.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol. 2014; 9:73-102.
Witztum JL, Lichtman AH. PMID: 23937439; PMCID: PMC3988528.
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PubMed Mentions:
123 Fields:
Translation:
HumansAnimalsCells
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Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res. 2013 Oct; 54(10):2815-30.
Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum JL, Koschinsky ML, Tsimikas S. PMID: 23828779; PMCID: PMC3770094.
View in:
PubMed Mentions:
82 Fields:
Translation:
HumansAnimalsCells
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IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS One. 2013; 8(6):e65203.
Que X, Widhopf GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum JL. PMID: 23840319; PMCID: PMC3688726.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83.
Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. PMID: 23667177; PMCID: PMC3679389.
View in:
PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
-
Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis. Curr Opin Pharmacol. 2013 Apr; 13(2):168-79.
Leibundgut G, Witztum JL, Tsimikas S. PMID: 23541680; PMCID: PMC3844667.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Oxidation-specific biomarkers and risk of peripheral artery disease. J Am Coll Cardiol. 2013 May 28; 61(21):2169-79.
Bertoia ML, Pai JK, Lee JH, Taleb A, Joosten MM, Mittleman MA, Yang X, Witztum JL, Rimm EB, Tsimikas S, Mukamal KJ. PMID: 23541965; PMCID: PMC3756816.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Adaptive immunity in atherogenesis: new insights and therapeutic approaches. J Clin Invest. 2013 Jan; 123(1):27-36.
Lichtman AH, Binder CJ, Tsimikas S, Witztum JL. PMID: 23281407; PMCID: PMC3533280.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansAnimalsCells
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Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35.
Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. PMID: 23192915; PMCID: PMC3563836.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansAnimals
-
Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia. Atherosclerosis. 2013 Jan; 226(1):161-4.
Yoshida H, Shoda T, Yanai H, Ikewaki K, Kurata H, Ito K, Furutani N, Tada N, Witztum JL, Tsimikas S. PMID: 23174369.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol. 2012 Nov 20; 60(21):2218-29.
Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum JL, Kiechl S. PMID: 23122790.
View in:
PubMed Mentions:
84 Fields:
Translation:
HumansCells
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Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations. Arterioscler Thromb Vasc Biol. 2012 Dec; 32(12):3066-75.
Holleboom AG, Daniil G, Fu X, Zhang R, Hovingh GK, Schimmel AW, Kastelein JJ, Stroes ES, Witztum JL, Hutten BA, Tsimikas S, Hazen SL, Chroni A, Kuivenhoven JA. PMID: 23023370; PMCID: PMC3610418.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. J Lipid Res. 2012 Dec; 53(12):2773-90.
van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum JL, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. PMID: 22969153; PMCID: PMC3494262.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. J Med Chem. 2012 Sep 27; 55(18):8178-82.
Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum JL, VanNieuwenhze MS. PMID: 22934615; PMCID: PMC3465084.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke. Biochem Biophys Res Commun. 2012 Sep 21; 426(2):253-9.
Thimmulappa RK, Gang X, Kim JH, Sussan TE, Witztum JL, Biswal S. PMID: 22935414; PMCID: PMC3495329.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCellsPHPublic Health
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Increased expression of oxidation-specific epitopes and apoptosis are associated with haptoglobin genotype: possible implications for plaque progression in human atherosclerosis. J Am Coll Cardiol. 2012 Jul 10; 60(2):112-9.
Purushothaman KR, Purushothaman M, Levy AP, Lento PA, Evrard S, Kovacic JC, Briley-Saebo KC, Tsimikas S, Witztum JL, Krishnan P, Kini A, Fayad ZA, Fuster V, Sharma SK, Moreno PR. PMID: 22766337.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCells
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Antisense oligonucleotides for the treatment of dyslipidaemia. Eur Heart J. 2012 Jun; 33(12):1451-8.
Visser ME, Witztum JL, Stroes ES, Kastelein JJ. PMID: 22634577.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimals
-
Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia. J Lipid Res. 2012 Aug; 53(8):1670-8.
Arai K, Orsoni A, Mallat Z, Tedgui A, Witztum JL, Bruckert E, Tselepis AD, Chapman MJ, Tsimikas S. PMID: 22628616; PMCID: PMC3540845.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
-
Oxidized phospholipids are present on plasminogen, affect fibrinolysis, and increase following acute myocardial infarction. J Am Coll Cardiol. 2012 Apr 17; 59(16):1426-37.
Leibundgut G, Arai K, Orsoni A, Yin H, Scipione C, Miller ER, Koschinsky ML, Chapman MJ, Witztum JL, Tsimikas S. PMID: 22497821; PMCID: PMC3333481.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
-
Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res. 2012 Jul; 53(7):1316-26.
Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum JL, Binder CJ. PMID: 22508944; PMCID: PMC3371243.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
-
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012 Apr 04; 15(4):554-62.
Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum JL, Melnick AM, Dent AL, Tangirala RK, Evans RM. PMID: 22465074; PMCID: PMC3367511.
View in:
PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
-
In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probes. J Am Coll Cardiol. 2012 Feb 07; 59(6):616-26.
Briley-Saebo KC, Nguyen TH, Saeboe AM, Cho YS, Ryu SK, Volkova ER, Volkava E, Dickson S, Leibundgut G, Wiesner P, Weisner P, Green S, Casanada F, Miller YI, Shaw W, Witztum JL, Fayad ZA, Tsimikas S. PMID: 22300697; PMCID: PMC3333483.
View in:
PubMed Mentions:
24 Fields:
Translation:
AnimalsCells
-
In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J Clin Invest. 2011 Dec; 121(12):4861-9.
Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum JL, Tsimikas S, Miller YI. PMID: 22105168; PMCID: PMC3225997.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
-
Is atherosclerosis an allergic disease? Circ Res. 2011 Oct 28; 109(10):1103-4.
Binder CJ, Witztum JL. PMID: 22034478.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
-
B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012 Jan 06; 110(1):e1-12.
Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum JL, Tsimikas S, Bender TP, McNamara CA. PMID: 22034493; PMCID: PMC3253259.
View in:
PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
-
Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27.
Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL. PMID: 21982317; PMCID: PMC3230644.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
-
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011 Oct 05; 478(7367):76-81.
Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ. PMID: 21979047; PMCID: PMC4826616.
View in:
PubMed Mentions:
260 Fields:
Translation:
HumansAnimalsCells
-
Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events. Biomark Med. 2011 Oct; 5(5):673-94.
Taleb A, Witztum JL, Tsimikas S. PMID: 22003918; PMCID: PMC3230643.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansCells
-
Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study. J Lipid Res. 2011 Oct; 52(10):1829-36.
Ravandi A, Boekholdt SM, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Tsimikas S. PMID: 21821825; PMCID: PMC3173004.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansCells
-
High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis. 2011 Sep; 70(9):1619-24.
McMahon M, Skaggs BJ, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, Charles-Schoeman C, Chernishof M, Gorn A, Witztum JL, Wong WK, Weisman M, Wallace DJ, La Cava A, Hahn BH. PMID: 21670088; PMCID: PMC3147230.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCells
-
Oxidative damage in multiple sclerosis lesions. Brain. 2011 Jul; 134(Pt 7):1914-24.
Haider L, Fischer MT, Frischer JM, Bauer J, Höftberger R, Botond G, Esterbauer H, Binder CJ, Witztum JL, Lassmann H. PMID: 21653539; PMCID: PMC3122372.
View in:
PubMed Mentions:
282 Fields:
Translation:
HumansCells
-
Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation. J Am Coll Cardiol. 2011 May 24; 57(21):2194-204.
von Vietinghoff S, Koltsova EK, Mestas J, Diehl CJ, Witztum JL, Ley K. PMID: 21596236; PMCID: PMC3378670.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. J Am Coll Cardiol. 2011 Apr 12; 57(15):1611-21.
Merki E, Graham M, Taleb A, Leibundgut G, Yang X, Miller ER, Fu W, Mullick AE, Lee R, Willeit P, Crooke RM, Witztum JL, Tsimikas S. PMID: 21474042.
View in:
PubMed Mentions:
46 Fields:
Translation:
AnimalsCells
-
Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol. 2011 Mar; 25(3):529-45.
Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass CK, Evans RM, Witztum JL. PMID: 21273443; PMCID: PMC3045740.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48.
Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 21252151; PMCID: PMC3075542.
View in:
PubMed Mentions:
301 Fields:
Translation:
HumansAnimalsCells
-
Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2311-6.
Steinberg D, Witztum JL. PMID: 21084697.
View in:
PubMed Mentions:
173 Fields:
Translation:
HumansAnimalsCells
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Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010 Nov 10; 5(11):e13919.
Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum JL, Esko JD, Moulton KS. PMID: 21085708; PMCID: PMC2978080.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
-
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010 Nov 03; 12(5):467-82.
Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum JL, Tsimikas S, Golenbock D, Moore KJ, Tabas I. PMID: 21035758; PMCID: PMC2991104.
View in:
PubMed Mentions:
206 Fields:
Translation:
AnimalsCells
-
The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) mice. Atherosclerosis. 2011 Jan; 214(1):73-80.
Mendez-Fernandez YV, Stevenson BG, Diehl CJ, Braun NA, Wade NS, Covarrubias R, van Leuven S, Witztum JL, Major AS. PMID: 21084088; PMCID: PMC3052995.
View in:
PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
-
4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan; 25(1):290-300.
Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum JL, Reardon CA, Getz GS. PMID: 20876212; PMCID: PMC3005429.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. J Am Coll Cardiol. 2010 Sep 14; 56(12):946-55.
Tsimikas S, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Sandhu MS, Miller ER, Benessiano J, Tedgui A, Witztum JL, Khaw KT, Boekholdt SM. PMID: 20828647.
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PubMed Mentions:
60 Fields:
Translation:
HumansCells
-
Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. J Lipid Res. 2010 Nov; 51(11):3324-30.
Faghihnia N, Tsimikas S, Miller ER, Witztum JL, Krauss RM. PMID: 20713651; PMCID: PMC2952573.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansCells
-
Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51.
Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. PMID: 20710028; PMCID: PMC2952235.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
-
Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20.
Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. PMID: 20697023; PMCID: PMC2927799.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCellsPHPublic Health
-
Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 09; 107(1):56-65.
Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum JL, Glass CK, Miller YI. PMID: 20489162; PMCID: PMC2904601.
View in:
PubMed Mentions:
93 Fields:
Translation:
AnimalsCells
-
ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010 Jun 25; 106(12):1861-9.
Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum JL, Tabas I, Tall AR. PMID: 20431058; PMCID: PMC2995809.
View in:
PubMed Mentions:
92 Fields:
Translation:
AnimalsCells
-
When monocytes come (too) close to our hearts. J Am Coll Cardiol. 2010 Apr 13; 55(15):1639-41.
Cardilo-Reis L, Witztum JL, Binder CJ. PMID: 20378084.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem. 2010 Jun 11; 285(24):18473-84.
Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. PMID: 20378541; PMCID: PMC2881773.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
-
Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovasc Res. 2010 Jan 01; 85(1):224-31.
Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum JL, Morganelli PM. PMID: 19720605; PMCID: PMC2791057.
View in:
PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
-
Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35.
Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum JL, Varki NM, Varki A. PMID: 19828701; PMCID: PMC2792214.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
-
Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol. 2009 Nov 01; 183(9):5673-84.
Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum JL, Puri KD, Gold MR. PMID: 19843950.
View in:
PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
-
The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 2010 Apr; 209(2):498-503.
Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum JL, Kane JP, Tsimikas S. PMID: 19880117.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest. 2009 Nov; 119(11):3236-45.
Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum JL, Esko JD. PMID: 19805913; PMCID: PMC2769193.
View in:
PubMed Mentions:
114 Fields:
Translation:
HumansAnimalsCells
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Critical role of IL-17RA in immunopathology of influenza infection. J Immunol. 2009 Oct 15; 183(8):5301-10.
Crowe CR, Chen K, Pociask DA, Alcorn JF, Krivich C, Enelow RI, Ross TM, Witztum JL, Kolls JK. PMID: 19783685; PMCID: PMC3638739.
View in:
PubMed Mentions:
212 Fields:
Translation:
HumansAnimalsCells
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Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol. 2009 Jun 09; 53(23):2186-96.
Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum JL, Tsimikas S, MIRACL Study Investigators. PMID: 19497447.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansCells
-
Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9546-7.
Steinberg D, Witztum JL. PMID: 19506257; PMCID: PMC2701045.
View in:
PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
-
Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res. 2009 Jun 19; 104(12):1355-63.
Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum JL, Bae YS, Miller YI. PMID: 19461045; PMCID: PMC2741301.
View in:
PubMed Mentions:
104 Fields:
Translation:
HumansAnimalsCells
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Conventional dendritic cells at the crossroads between immunity and cholesterol homeostasis in atherosclerosis. Circulation. 2009 May 05; 119(17):2367-75.
Gautier EL, Huby T, Saint-Charles F, Ouzilleau B, Pirault J, Deswaerte V, Ginhoux F, Miller ER, Witztum JL, Chapman MJ, Lesnik P. PMID: 19380622.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49.
Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum JL, Binder CJ. PMID: 19363291; PMCID: PMC2673862.
View in:
PubMed Mentions:
246 Fields:
Translation:
AnimalsCells
-
Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1.
Dennis EA, Witztum JL. PMID: 19346336; PMCID: PMC2674715.
View in:
PubMed Mentions:
1 Fields:
-
Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation. 2009 Apr 07; 119(13):1711-9.
Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum JL. PMID: 19307470; PMCID: PMC2782388.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation. 2009 Apr 07; 119(13):1795-804.
Gautier EL, Huby T, Witztum JL, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P. PMID: 19307478.
View in:
PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
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Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60.
Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. PMID: 19265037; PMCID: PMC2834250.
View in:
PubMed Mentions:
112 Fields:
Translation:
HumansAnimalsCells
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The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr; 50 Suppl:S388-93.
Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum JL. PMID: 19106070; PMCID: PMC2674727.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
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Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009 Jan 30; 104(2):210-8, 21p following 218.
Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum JL, Miller YI. PMID: 19096031; PMCID: PMC2720065.
View in:
PubMed Mentions:
176 Fields:
Translation:
AnimalsCells
-
Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study. Eur Heart J. 2009 Jan; 30(1):107-15.
Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum JL, Wiedermann CJ, Xu Q, Kiechl S. PMID: 19019993.
View in:
PubMed Mentions:
35 Fields:
Translation:
Humans
-
In memoriam: Roger A. Davis (1945-2008). J Lipid Res. 2008 Nov; 49(11):2279-80.
Attie AD, Witztum JL, Edwards PA, Lusis JA. PMID: 19123270.
View in:
PubMed Mentions: Fields:
Translation:
Animals
-
Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 2008 Aug 05; 118(6):672-7.
Steinberg D, Glass CK, Witztum JL. PMID: 18678783.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28.
Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118; PMCID: PMC2467381.
View in:
PubMed Mentions:
84 Fields:
Translation:
HumansCells
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The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Curr Opin Lipidol. 2008 Aug; 19(4):369-77.
Tsimikas S, Witztum JL. PMID: 18607184.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12; 118(7):743-53.
Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum JL, Tsimikas S. PMID: 18663084.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res. 2008 Oct; 49(10):2230-9.
Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum JL, Tsimikas S. PMID: 18594118.
View in:
PubMed Mentions:
132 Fields:
Translation:
HumansCells
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Relationship between biomarkers of oxidized low-density lipoprotein, statin therapy, quantitative coronary angiography, and atheroma: volume observations from the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) study. J Am Coll Cardiol. 2008 Jul 01; 52(1):24-32.
Choi SH, Chae A, Miller E, Messig M, Ntanios F, DeMaria AN, Nissen SE, Witztum JL, Tsimikas S. PMID: 18582631.
View in:
PubMed Mentions:
26 Fields:
Translation:
Humans
-
Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15.
Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum JL, Fuster V, Tsimikas S, Fayad ZA. PMID: 18541740; PMCID: PMC4492476.
View in:
PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. J Am Coll Cardiol. 2008 Apr 29; 51(17):1653-62.
Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. PMID: 18436117.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCTClinical Trials
-
Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2008 Apr 15; 51(15):1512-24.
Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL. PMID: 18402913.
View in:
PubMed Mentions:
164 Fields:
Translation:
Humans
-
Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 2008 Apr; 31(4):811-22.
Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum JL, American Diabetes Association, American College of Cardiology Foundation. PMID: 18375431.
View in:
PubMed Mentions:
153 Fields:
Translation:
Humans
-
Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar; 9(3):190-5.
Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum JL. PMID: 18336236.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
-
Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51.
Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. PMID: 18263582; PMCID: PMC2447632.
View in:
PubMed Mentions:
52 Fields:
Translation:
AnimalsCells
-
Promise of immune modulation to inhibit atherogenesis. J Am Coll Cardiol. 2007 Aug 07; 50(6):547-50.
Binder CJ, Hartvigsen K, Witztum JL. PMID: 17678739.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsPHPublic Health
-
Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007 Aug; 27(8):1788-95.
Kiechl S, Willeit J, Mayr M, Viehweider B, Oberhollenzer M, Kronenberg F, Wiedermann CJ, Oberthaler S, Xu Q, Witztum JL, Tsimikas S. PMID: 17541022.
View in:
PubMed Mentions:
86 Fields:
Translation:
HumansPHPublic Health
-
Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1080-6.
Bro S, Binder CJ, Witztum JL, Olgaard K, Nielsen LB. PMID: 17347482.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
-
C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43.
Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. PMID: 17211240.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansCells
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ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res. 2007 Apr; 48(4):794-805.
Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum JL, Lusis AJ, Tsao BP. PMID: 17259598.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
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A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):878-85.
Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum JL, Li AC. PMID: 17255537.
View in:
PubMed Mentions:
42 Fields:
Translation:
Animals
-
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest. 2007 Jan; 117(1):153-64.
MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum JL, Esko JD. PMID: 17200715; PMCID: PMC1716206.
View in:
PubMed Mentions:
97 Fields:
Translation:
HumansCells
-
Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J Lipid Res. 2007 Feb; 48(2):425-33.
Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum JL, McConnell JP, Kornman KS, Berger PB. PMID: 17093289.
View in:
PubMed Mentions:
117 Fields:
Translation:
Humans
-
Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81.
Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum JL. PMID: 17082490.
View in:
PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 07; 114(19):2047-55.
Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. PMID: 17060381.
View in:
PubMed Mentions:
92 Fields:
Translation:
AnimalsCells
-
A natural antibody to oxidized cardiolipin binds to oxidized low-density lipoprotein, apoptotic cells, and atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2096-102.
Tuominen A, Miller YI, Hansen LF, Kesäniemi YA, Witztum JL, Hörkkö S. PMID: 16794225.
View in:
PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Rosuvastatin: an independent analysis of risks and benefits. MedGenMed. 2006 Jun 14; 8(2):73.
Zipes DP, Zvaifler NJ, Glassock RJ, Gilman S, Muñoz A, Gogolak V, Gordis L, Dedon PC, Guengerich FP, Wasserman SI, Witztum JL, Wogan GN. PMID: 16926812; PMCID: PMC1785157.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Oxidized low-density lipoprotein autoantibodies, chronic infections, and carotid atherosclerosis in a population-based study. J Am Coll Cardiol. 2006 Jun 20; 47(12):2436-43.
Mayr M, Kiechl S, Tsimikas S, Miller E, Sheldon J, Willeit J, Witztum JL, Xu Q. PMID: 16781371.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol. 2006 Jun 06; 47(11):2219-28.
Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum JL. PMID: 16750687.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansCells
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Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin. J Am Coll Cardiol. 2006 May 02; 47(9):1803-10.
Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJ, Tsimikas S. PMID: 16682304.
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PubMed Mentions:
19 Fields:
Translation:
Humans
-
Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1169-76.
Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum JL, Miller YI. PMID: 16484596.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Autoantibodies to oxidized LDL and cardiovascular risk: the Framingham Offspring Study. Atherosclerosis. 2006 Dec; 189(2):364-8.
Wilson PW, Ben-Yehuda O, McNamara J, Massaro J, Witztum J, Reaven PD. PMID: 16476434.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans
-
Relationship of a comprehensive panel of plasma oxidized low-density lipoprotein markers to angiographic restenosis in patients undergoing percutaneous coronary intervention for stable angina. Am Heart J. 2005 Nov; 150(5):1007-14.
Segev A, Strauss BH, Witztum JL, Lau HK, Tsimikas S. PMID: 16290986.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
You are right too! J Clin Invest. 2005 Aug; 115(8):2072-5.
Witztum JL. PMID: 16075051; PMCID: PMC1180570.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med. 2005 Jul 07; 353(1):46-57.
Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS, Witztum JL, Berger PB. PMID: 16000355.
View in:
PubMed Mentions:
192 Fields:
Translation:
HumansCells
-
Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits. Circulation. 2005 Jun 21; 111(24):3302-9.
Arakawa H, Qian JY, Baatar D, Karasawa K, Asada Y, Sasaguri Y, Miller ER, Witztum JL, Ueno H. PMID: 15956136.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63.
Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum JL. PMID: 15897601.
View in:
PubMed Mentions:
84 Fields:
Translation:
HumansAnimalsCells
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Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1213-9.
Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum JL. PMID: 15718493.
View in:
PubMed Mentions:
111 Fields:
Translation:
AnimalsCells
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A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61.
Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. PMID: 15722563.
View in:
PubMed Mentions:
507 Fields:
Translation:
Cells
-
Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76.
Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. PMID: 15722561.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
-
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A. 2005 Feb 01; 102(5):1596-601.
Buono C, Binder CJ, Stavrakis G, Witztum JL, Glimcher LH, Lichtman AH. PMID: 15665085; PMCID: PMC547865.
View in:
PubMed Mentions:
142 Fields:
Translation:
AnimalsCells
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High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 2005 Apr; 46(4):769-78.
Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. PMID: 15654123.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum. 2005 Jan; 52(1):192-200.
Frostegård J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Hörkkö S, Witztum JL. PMID: 15641060.
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PubMed Mentions:
98 Fields:
Translation:
HumansCells
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Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 06; 200(11):1359-70.
Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. PMID: 15583011; PMCID: PMC2211955.
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PubMed Mentions:
139 Fields:
Translation:
AnimalsCells
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Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest. 2004 Dec; 114(11):1564-76.
Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK. PMID: 15578089; PMCID: PMC529277.
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PubMed Mentions:
202 Fields:
Translation:
HumansAnimalsCells
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Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12.
Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum JL, Palinski W, Tsimikas S. PMID: 15528482.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Alterations in plasma vitamin E distribution in type 2 diabetic patients with elevated plasma phospholipid transfer protein activity. Diabetes. 2004 Oct; 53(10):2633-9.
Schneider M, Vergès B, Klein A, Miller ER, Deckert V, Desrumaux C, Masson D, Gambert P, Brun JM, Fruchart-Najib J, Blache D, Witztum JL, Lagrost L. PMID: 15448094.
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PubMed Mentions:
10 Fields:
Translation:
Humans
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Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Oct 05; 110(14):2024-31.
Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum JL, Nadler JL, Funk CD, Ley K. PMID: 15451785.
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PubMed Mentions:
76 Fields:
Translation:
AnimalsCells
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High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation. 2004 Sep 14; 110(11):1406-12.
Tsimikas S, Witztum JL, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG, Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. PMID: 15353498.
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PubMed Mentions:
54 Fields:
Translation:
HumansCellsCTClinical Trials
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High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1904-9.
Choudhury RP, Rong JX, Trogan E, Elmalem VI, Dansky HM, Breslow JL, Witztum JL, Fallon JT, Fisher EA. PMID: 15319266.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004 Aug 03; 110(5):637-41.
Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL, Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and M. PMID: 15289389.
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PubMed Mentions:
102 Fields:
Translation:
HumansPHPublic Health
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IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest. 2004 Aug; 114(3):427-37.
Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum JL. PMID: 15286809; PMCID: PMC484976.
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PubMed Mentions:
169 Fields:
Translation:
AnimalsCells
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Assessment of atherosclerotic risk factors and endothelial function in children and young adults with pediatric-onset systemic lupus erythematosus. Arthritis Rheum. 2004 Jun 15; 51(3):451-7.
Soep JB, Mietus-Snyder M, Malloy MJ, Witztum JL, von Scheven E. PMID: 15188333.
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PubMed Mentions:
23 Fields:
Translation:
Humans
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Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 2004 Jun 29; 109(25):3164-70.
Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum JL, Strauss BH. PMID: 15184281.
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PubMed Mentions:
77 Fields:
Translation:
HumansCells
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Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. J Lipid Res. 2004 Jul; 45(7):1347-54.
Reardon CA, Miller ER, Blachowicz L, Lukens J, Binder CJ, Witztum JL, Getz GS. PMID: 15102879.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function. J Am Coll Cardiol. 2004 Feb 18; 43(4):629-34.
Kinlay S, Behrendt D, Fang JC, Delagrange D, Morrow J, Witztum JL, Rifai N, Selwyn AP, Creager MA, Ganz P. PMID: 14975474.
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PubMed Mentions:
22 Fields:
Translation:
HumansCTClinical Trials
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Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. J Nutr. 2004 Feb; 134(2):342-7.
Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Pierce JP, Chang RJ, Witztum JL, Women's Healthy Eating and Living (WHEL) Study Group. PMID: 14747670.
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PubMed Mentions:
15 Fields:
Translation:
HumansCTClinical Trials
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Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004 Mar; 24(3):498-503.
Silaste ML, Rantala M, Alfthan G, Aro A, Witztum JL, Kesäniemi YA, Hörkkö S. PMID: 14739118.
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PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
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Circulating oxidized low-density lipoprotein is increased in hypertension. Clin Sci (Lond). 2003 Nov; 105(5):615-20.
Frostegård J, Wu R, Lemne C, Thulin T, Witztum JL, de Faire U. PMID: 12837127.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Lysine-phosphatidylcholine adducts in kringle V impart unique immunological and potential pro-inflammatory properties to human apolipoprotein(a). J Biol Chem. 2003 Dec 26; 278(52):52841-7.
Edelstein C, Pfaffinger D, Hinman J, Miller E, Lipkind G, Tsimikas S, Bergmark C, Getz GS, Witztum JL, Scanu AM. PMID: 14557258.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45.
Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum JL. PMID: 14501582.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimals
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Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? FEBS Lett. 2003 Sep 11; 551(1-3):104-6.
Russell AP, Gastaldi G, Bobbioni-Harsch E, Arboit P, Gobelet C, Dériaz O, Golay A, Witztum JL, Giacobino JP. PMID: 12965212.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 2003 Sep 02; 108(9):1059-63.
Engler MM, Engler MB, Malloy MJ, Chiu EY, Schloetter MC, Paul SM, Stuehlinger M, Lin KY, Cooke JP, Morrow JD, Ridker PM, Rifai N, Miller E, Witztum JL, Mietus-Snyder M. PMID: 12912807.
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PubMed Mentions:
50 Fields:
Translation:
HumansCTClinical Trials
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Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003 Oct; 14(10):4196-206.
Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum JL. PMID: 14517329; PMCID: PMC207011.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7.
Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. PMID: 12794145.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43.
Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ. PMID: 12740573.
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Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906.
Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. PMID: 12639996; PMCID: PMC153760.
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PubMed Mentions:
140 Fields:
Translation:
AnimalsCells
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Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol. 2003 Feb 05; 41(3):360-70.
Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum JL. PMID: 12575961.
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PubMed Mentions:
98 Fields:
Translation:
Humans
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Shifting the diagnosis and treatment of atherosclerosis to children and young adults: a new paradigm for the 21st century. J Am Coll Cardiol. 2002 Dec 18; 40(12):2122-4.
Tsimikas S, Witztum JL. PMID: 12505223.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Circulating autoantibodies to oxidized LDL correlate with impaired coronary endothelial function after cardiac transplantation. Arterioscler Thromb Vasc Biol. 2002 Dec 01; 22(12):2044-8.
Fang JC, Kinlay S, Behrendt D, Hikita H, Witztum JL, Selwyn AP, Ganz P. PMID: 12482832.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26.
Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum JL. PMID: 12411948.
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PubMed Mentions:
187 Fields:
Translation:
HumansAnimalsCells
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Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6.
Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum JL, Libby P. PMID: 12221058.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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Mechanical aortic injury in apoE-deficient mice as a model for development of atherosclerosis: demonstration of leukocyte rolling early after injury. Ultrastruct Pathol. 2002 Jul-Aug; 26(4):251-60.
Bannykh SI, Witztum JL, Bergmark C. PMID: 12227951.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Influence of C3 deficiency on atherosclerosis. Circulation. 2002 Jun 25; 105(25):3025-31.
Buono C, Come CE, Witztum JL, Maguire GF, Connelly PW, Carroll M, Lichtman AH. PMID: 12081998.
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PubMed Mentions:
59 Fields:
Translation:
Animals
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Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002 Aug 30; 277(35):31850-6.
Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum JL, Lagrost L. PMID: 12105225.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation. 2002 Apr 30; 105(17):2107-11.
Steinberg D, Witztum JL. PMID: 11980692.
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PubMed Mentions:
109 Fields:
Translation:
HumansAnimalsCells
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Splenic immunity and atherosclerosis: a glimpse into a novel paradigm? J Clin Invest. 2002 Mar; 109(6):721-4.
Witztum JL. PMID: 11901180; PMCID: PMC150921.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Oxidized membrane vesicles and blebs from apoptotic cells contain biologically active oxidized phospholipids that induce monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):101-7.
Huber J, Vales A, Mitulovic G, Blumer M, Schmid R, Witztum JL, Binder BR, Leitinger N. PMID: 11788468.
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PubMed Mentions:
104 Fields:
Translation:
HumansCells
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Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta. J Biol Chem. 2002 Mar 01; 277(9):7271-81.
Subbanagounder G, Wong JW, Lee H, Faull KF, Miller E, Witztum JL, Berliner JA. PMID: 11751881.
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PubMed Mentions:
51 Fields:
Translation:
HumansCells
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Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 01; 277(9):7010-20.
Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. PMID: 11744722.
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PubMed Mentions:
92 Fields:
Translation:
Cells