Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Joseph Witztum

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0682
    CA La Jolla 92093
    Phone858-534-4347
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Role of Immune Mechanisms in Athersclerosis and Inflammation
      NIH/NHLBI P01HL088093Apr 1, 2007 - Apr 30, 2019
      Role: Principal Investigator
      Development of a Vaccine Approach to Inhibit Atherosclerosis
      NIH/NHLBI R01HL086559Feb 10, 2007 - Jan 31, 2013
      Role: Principal Investigator
      LIPID MAPS
      NIH/NIGMS U54GM069338Aug 12, 2003 - Jul 31, 2014
      Role: Co-Investigator
      Role of B-1 Lymphocytes in Athergenesis
      NIH/NHLBI R01HL069464Sep 30, 2001 - Jul 31, 2005
      Role: Principal Investigator
      Discovery and Development of Therapeutic Genes for CHF
      NIH P01HL066941Sep 29, 2000 - Jun 30, 2018
      Role: Co-Investigator
      B-LYMPHOCYTE MEDIATED IMMUNE MECHANISMS IN ATHEROGENESIS
      NIH/NHLBI R01HL064833Jun 1, 2000 - May 31, 2004
      Role: Principal Investigator
      SCOR in Molecular Medicine and Atherosclerosis
      NIH/NHLBI P50HL056989Apr 23, 1997 - Mar 31, 2008
      Role: Principal Investigator
      Anticardiolipin Antibodies and Oxidized Phospholipids
      NIH/NHLBI R01HL057505Jan 1, 1997 - Jul 31, 2006
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      APOLIPOPROTEIN E DEFICIENCY AND ATHEROSCLEROSIS
      NIH/NHLBI R01HL039608Jul 1, 1988 - Sep 29, 1991
      Role: Principal Investigator
      Experimental Endocrinology and Metabolism
      NIH/NIDDK T32DK007044Sep 15, 1978 - Mar 31, 2021
      Role: Principal Investigator
      SCOR IN ARTERIOSCLEROSIS
      NIH P50HL014197Dec 1, 1976 - Apr 30, 1997
      Role: Co-Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kamstrup PR, Hung MY, Witztum J, Tsimikas S, Nordestgaard BG. Oxidized Phospholipids and Risk of Calcific Aortic Valve Disease: The Copenhagen General Population Study. Arterioscler Thromb Vasc Biol. 2017 Aug; 37(8):1570-1578. PMID: 28572160.
        View in: PubMed
      2. Prasad A, Clopton P, Ayers C, Khera A, de Lemos JA, Witztum J, Tsimikas S. Relationship of Autoantibodies to MDA-LDL and ApoB-Immune Complexes to Sex, Ethnicity, Subclinical Atherosclerosis, and Cardiovascular Events. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1213-1221. PMID: 28473443.
        View in: PubMed
      3. van Capelleveen JC, Bernelot Moens SJ, Yang X, Kastelein JJP, Wareham NJ, Zwinderman AH, Stroes ESG, Witztum J, Hovingh GK, Khaw KT, Boekholdt SM, Tsimikas S. Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study. Arterioscler Thromb Vasc Biol. 2017 Jun; 37(6):1206-1212. PMID: 28473441.
        View in: PubMed
      4. Byun YS, Yang X, Bao W, DeMicco D, Laskey R, Witztum J, Tsimikas S. Oxidized Phospholipids on Apolipoprotein B-100 and Recurrent Ischemic Events Following Stroke or Transient Ischemic Attack. J Am Coll Cardiol. 2017 Jan 17; 69(2):147-158. PMID: 28081824.
        View in: PubMed
      5. Lee SR, Prasad A, Choi YS, Xing C, Clopton P, Witztum J, Tsimikas S. The LPA Gene, Ethnicity, and Cardiovascular Events. Circulation. 2016 Nov 9. PMID: 27831500.
        View in: PubMed
      6. van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum J, Tsimikas S, Riksen NP, Stroes ES. Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016 Aug 23; 134(8):611-24. PMID: 27496857.
        View in: PubMed
      7. Gordts PL, Nock R, Son NH, Ramms B, Lew I, Gonzales JC, Thacker BE, Basu D, Lee RG, Mullick AE, Graham MJ, Goldberg IJ, Crooke RM, Witztum J, Esko JD. ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors. J Clin Invest. 2016 Aug 1; 126(8):2855-2866. PMID: 27400128.
        View in: PubMed
      8. Binder CJ, Papac-Milicevic N, Witztum J. Innate sensing of oxidation-specific epitopes in health and disease. Nat Rev Immunol. 2016 Aug; 16(8):485-97. PMID: 27346802.
        View in: PubMed
      9. Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum J, Tsimikas S. Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). J Clin Lipidol. 2016 May-Jun; 10(3):594-603. PMID: 27206947.
        View in: PubMed
      10. Gruber S, Hendrikx T, Tsiantoulas D, Ozsvar-Kozma M, Göderle L, Mallat Z, Witztum J, Shiri-Sverdlov R, Nitschke L, Binder CJ. Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells. Cell Rep. 2016 Mar 15; 14(10):2348-61. PMID: 26947073; PMCID: PMC4802221.
      11. Harmon DB, Srikakulapu P, Kaplan JL, Oldham SN, McSkimming C, Garmey JC, Perry HM, Kirby JL, Prohaska TA, Gonen A, Hallowell P, Schirmer B, Tsimikas S, Taylor AM, Witztum J, McNamara CA. Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance. Arterioscler Thromb Vasc Biol. 2016 Apr; 36(4):682-91. PMID: 26868208.
        View in: PubMed
      12. Yang X, Lee SR, Choi YS, Alexander VJ, Digenio A, Yang Q, Miller YI, Witztum J, Tsimikas S. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results. J Lipid Res. 2016 Apr; 57(4):706-13. PMID: 26848137.
        View in: PubMed
      13. Witztum J, Ginsberg HN. Lipoprotein (a): Coming of Age at Last. J Lipid Res. 2016 Mar; 57(3):336-9. PMID: 26839334.
        View in: PubMed
      14. Verbeek R, Boekholdt SM, Stoekenbroek RM, Hovingh GK, Witztum J, Wareham NJ, Sandhu MS, Khaw KT, Tsimikas S. Population and assay thresholds for the predictive value of lipoprotein (a) for coronary artery disease: the EPIC-Norfolk Prospective Population Study. J Lipid Res. 2016 Apr; 57(4):697-705. PMID: 26828068.
        View in: PubMed
      15. Foks AC, Engelbertsen D, Kuperwaser F, Alberts-Grill N, Gonen A, Witztum J, Lederer J, Jarolim P, DeKruyff RH, Freeman GJ, Lichtman AH. Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):456-65. PMID: 26821944.
        View in: PubMed
      16. Witztum J. CEP Is an Important and Ubiquitous Oxidation Specific Epitope Recognized by Innate Pattern Recognition Receptors. Circ Res. 2015 Jul 31; 117(4):305-8. PMID: 26227873.
        View in: PubMed
      17. Gaudet D, Alexander VJ, Baker BF, Brisson D, Tremblay K, Singleton W, Geary RS, Hughes SG, Viney NJ, Graham MJ, Crooke RM, Witztum J, Brunzell JD, Kastelein JJ. Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. N Engl J Med. 2015 Jul 30; 373(5):438-47. PMID: 26222559.
        View in: PubMed
      18. Glass CK, Witztum J. Daniel Steinberg, 1922-2015. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9791-2. PMID: 26209653.
        View in: PubMed
      19. Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum J. Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study. Lancet. 2015 Oct 10; 386(10002):1472-83. PMID: 26210642.
        View in: PubMed
      20. Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum J, McNamara CA. B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis. Circ Res. 2015 Jul 17; 117(3):e28-39. PMID: 26082558.
        View in: PubMed
      21. Liu C, Gates KP, Fang L, Amar MJ, Schneider DA, Geng H, Huang W, Kim J, Pattison J, Zhang J, Witztum J, Remaley AT, Dong PD, Miller YI. Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Dis Model Mech. 2015 Aug 1; 8(8):989-98. PMID: 26044956.
        View in: PubMed
      22. Yeang C, Witztum J, Tsimikas S. 'LDL-C'?=?LDL-C?+?Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol. 2015 Jun; 26(3):169-78. PMID: 25943842.
        View in: PubMed
      23. Rao F, Schork AJ, Maihofer AX, Nievergelt CM, Marcovina SM, Miller ER, Witztum J, O'Connor DT, Tsimikas S. Heritability of Biomarkers of Oxidized Lipoproteins: Twin Pair Study. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1704-11. PMID: 25953646.
        View in: PubMed
      24. Choi SH, Gonen A, Diehl CJ, Kim J, Almazan F, Witztum J, Miller YI. SYK regulates macrophage MHC-II expression via activation of autophagy in response to oxidized LDL. Autophagy. 2015 May 4; 11(5):785-95. PMID: 25946330.
        View in: PubMed
      25. Byun YS, Lee JH, Arsenault BJ, Yang X, Bao W, DeMicco D, Laskey R, Witztum J, Tsimikas S. Relationship of Oxidized Phospholipids on Apolipoprotein B-100 to Cardiovascular Outcomes in Patients Treated With Intensive Versus Moderate Atorvastatin Therapy: The TNT Trial. J Am Coll Cardiol. 2015 Apr 7; 65(13):1286-95. PMID: 25835440.
        View in: PubMed
      26. Santos RD, Raal FJ, Catapano AL, Witztum J, Steinhagen-Thiessen E, Tsimikas S. Mipomersen, an Antisense Oligonucleotide to Apolipoprotein B-100, Reduces Lipoprotein(a) in Various Populations With Hypercholesterolemia: Results of 4 Phase III Trials. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):689-99. PMID: 25614280.
        View in: PubMed
      27. Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum J, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Russell DW, Subramaniam S, Brown HA. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res. 2015 Mar; 56(3):722-36. PMID: 25598080.
        View in: PubMed
      28. Fernandez JA, Deguchi H, Banka CL, Witztum J, Griffin JH. Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):570-2. PMID: 25550205.
        View in: PubMed
      29. Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold A, Prohaska TA, Papac-Milicevic N, Millischer V, Bartel C, Hörkkö S, Boulanger CM, Tsimikas S, Fischer MB, Witztum J, Lang IM, Binder CJ. Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. J Lipid Res. 2015 Feb; 56(2):440-8. PMID: 25525116.
        View in: PubMed
      30. Gaudet D, Brisson D, Tremblay K, Alexander VJ, Singleton W, Hughes SG, Geary RS, Baker BF, Graham MJ, Crooke RM, Witztum J. Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med. 2014 Dec 4; 371(23):2200-6. PMID: 25470695.
        View in: PubMed
      31. Gordts PL, Foley EM, Lawrence R, Sinha R, Lameda-Diaz C, Deng L, Nock R, Glass CK, Erbilgin A, Lusis AJ, Witztum J, Esko JD. Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling. Cell Metab. 2014 Nov 4; 20(5):813-26. PMID: 25440058.
        View in: PubMed
      32. Pechlaner R, Willeit P, Summerer M, Santer P, Egger G, Kronenberg F, Demetz E, Weiss G, Tsimikas S, Witztum J, Willeit K, Iglseder B, Paulweber B, Kedenko L, Haun M, Meisinger C, Gieger C, Müller-Nurasyid M, Peters A, Willeit J, Kiechl S. Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with progressive atherosclerosis and incident cardiovascular disease. Arterioscler Thromb Vasc Biol. 2015 Jan; 35(1):229-36. PMID: 25359861.
        View in: PubMed
      33. Baldan A, Gonen A, Choung C, Que X, Marquart TJ, Hernandez I, Bjorkhem I, Ford DA, Witztum J, Tarling EJ. ABCG1 Is Required for Pulmonary B-1 B Cell and Natural Antibody Homeostasis. J Immunol. 2014 Dec 1; 193(11):5637-48. PMID: 25339664.
        View in: PubMed
      34. Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum J, Hartvigsen K. Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine. J Lipid Res. 2014 Oct; 55(10):2137-55. PMID: 25143462.
        View in: PubMed
      35. Tsiantoulas D, Diehl CJ, Witztum J, Binder CJ. B cells and humoral immunity in atherosclerosis. Circ Res. 2014 May 23; 114(11):1743-56. PMID: 24855199.
        View in: PubMed
      36. Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M, Tall AR. Interleukin-3/Granulocyte Macrophage Colony-Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):976-84. PMID: 24651678.
        View in: PubMed
      37. Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum J, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. J Am Coll Cardiol. 2014 May 20; 63(19):1961-71. PMID: 24613321.
        View in: PubMed
      38. Tsimikas S, Duff GW, Berger PB, Rogus J, Huttner K, Clopton P, Brilakis E, Kornman KS, Witztum J. Pro-Inflammatory Interleukin-1 Genotypes Potentiate the Risk of Coronary Artery Disease and Cardiovascular Events Mediated by Oxidized Phospholipids and Lipoprotein(a). J Am Coll Cardiol. 2014 May 6; 63(17):1724-34. PMID: 24530664.
        View in: PubMed
      39. Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum J, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014 Apr 22; 129(16):1677-87. PMID: 24488984.
        View in: PubMed
      40. Tse K, Gonen A, Sidney J, Ouyang H, Witztum J, Sette A, Tse H, Ley K. Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100. Front Immunol. 2013; 4:493. PMID: 24416033.
        View in: PubMed
      41. Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum J, Miller YI. Polyoxygenated Cholesterol Ester Hydroperoxide Activates TLR4 and SYK Dependent Signaling in Macrophages. PLoS One. 2013; 8(12):e83145. PMID: 24376657.
        View in: PubMed
      42. Hung MY, Witztum J, Tsimikas S. New Therapeutic Targets for Calcific Aortic Valve Stenosis: The Lipoprotein(a)-Lipoprotein-Associated Phospholipase A2-Oxidized Phospholipid Axis. J Am Coll Cardiol. 2014 Feb 11; 63(5):478-80. PMID: 24161316.
        View in: PubMed
      43. Perry HM, Oldham SN, Fahl SP, Que X, Gonen A, Harmon DB, Tsimikas S, Witztum J, Bender TP, McNamara CA. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol. 2013 Dec; 33(12):2771-9. PMID: 24115031.
        View in: PubMed
      44. Montano EN, Boullier A, Almazan F, Binder CJ, Witztum J, Hartvigsen K. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res. 2013 Nov; 54(11):3206-14. PMID: 23997238.
        View in: PubMed
      45. Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum J, Haddad GG, Li AC. Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704. PMID: 23990245.
        View in: PubMed
      46. Witztum J, Lichtman AH. The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol. 2014 Jan 24; 9:73-102. PMID: 23937439.
        View in: PubMed
      47. Leibundgut G, Scipione C, Yin H, Schneider M, Boffa MB, Green S, Yang X, Dennis E, Witztum J, Koschinsky ML, Tsimikas S. Determinants of binding of oxidized phospholipids on apolipoprotein (a) and lipoprotein (a). J Lipid Res. 2013 Oct; 54(10):2815-30. PMID: 23828779.
        View in: PubMed
      48. Que X, Widhopf GF, Amir S, Hartvigsen K, Hansen LF, Woelkers D, Tsimikas S, Binder CJ, Kipps TJ, Witztum J. IGHV1-69-encoded antibodies expressed in chronic lymphocytic leukemia react with malondialdehyde-acetaldehyde adduct, an immunodominant oxidation-specific epitope. PLoS One. 2013; 8(6):e65203. PMID: 23840319.
        View in: PubMed
      49. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum J, Handel TM, Tsimikas S, Miller YI. MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. PMID: 23667177.
        View in: PubMed
      50. Leibundgut G, Witztum J, Tsimikas S. Oxidation-specific epitopes and immunological responses: Translational biotheranostic implications for atherosclerosis. Curr Opin Pharmacol. 2013 Apr; 13(2):168-79. PMID: 23541680.
        View in: PubMed
      51. Lichtman AH, Binder CJ, Tsimikas S, Witztum J. Adaptive immunity in atherogenesis: new insights and therapeutic approaches. J Clin Invest. 2013 Jan 2; 123(1):27-36. PMID: 23281407.
        View in: PubMed
      52. Tsimikas S, Willeit P, Willeit J, Santer P, Mayr M, Xu Q, Mayr A, Witztum J, Kiechl S. Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events. J Am Coll Cardiol. 2012 Nov 20; 60(21):2218-29. PMID: 23122790.
        View in: PubMed
      53. Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum J, VanNieuwenhze MS. Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors. J Med Chem. 2012 Sep 27; 55(18):8178-82. PMID: 22934615.
        View in: PubMed
      54. van Dijk RA, Kolodgie F, Ravandi A, Leibundgut G, Hu PP, Prasad A, Mahmud E, Dennis E, Curtiss LK, Witztum J, Wasserman BA, Otsuka F, Virmani R, Tsimikas S. Differential expression of oxidation-specific epitopes and apolipoprotein(a) in progressing and ruptured human coronary and carotid atherosclerotic lesions. J Lipid Res. 2012 Dec; 53(12):2773-90. PMID: 22969153.
        View in: PubMed
      55. Arai K, Orsoni A, Mallat Z, Tedgui A, Witztum J, Bruckert E, Tselepis AD, Chapman MJ, Tsimikas S. Acute impact of apheresis on oxidized phospholipids in patients with familial hypercholesterolemia. J Lipid Res. 2012 Aug; 53(8):1670-8. PMID: 22628616.
        View in: PubMed
      56. Amir S, Hartvigsen K, Gonen A, Leibundgut G, Que X, Jensen-Jarolim E, Wagner O, Tsimikas S, Witztum J, Binder CJ. Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease. J Lipid Res. 2012 Jul; 53(7):1316-26. PMID: 22508944.
        View in: PubMed
      57. Barish GD, Yu RT, Karunasiri MS, Becerra D, Kim J, Tseng TW, Tai LJ, Leblanc M, Diehl C, Cerchietti L, Miller YI, Witztum J, Melnick AM, Dent AL, Tangirala RK, Evans RM. The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis. Cell Metab. 2012 Apr 4; 15(4):554-62. PMID: 22465074.
        View in: PubMed
      58. Fang L, Green SR, Baek JS, Lee SH, Ellett F, Deer E, Lieschke GJ, Witztum J, Tsimikas S, Miller YI. In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish. J Clin Invest. 2011 Dec; 121(12):4861-9. PMID: 22105168.
        View in: PubMed
      59. Binder CJ, Witztum J. Is atherosclerosis an allergic disease? Circ Res. 2011 Oct 28; 109(10):1103-4. PMID: 22034478.
        View in: PubMed
      60. Doran AC, Lipinski MJ, Oldham SN, Garmey JC, Campbell KA, Skaflen MD, Cutchins A, Lee DJ, Glover DK, Kelly KA, Galkina EV, Ley K, Witztum J, Tsimikas S, Bender TP, McNamara CA. B-cell aortic homing and atheroprotection depend on Id3. Circ Res. 2012 Jan 6; 110(1):e1-12. PMID: 22034493.
        View in: PubMed
      61. Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum J. Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression. J Am Coll Cardiol. 2011 Oct 11; 58(16):1715-27. PMID: 21982317.
        View in: PubMed
      62. Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum J, Binder CJ. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011 Oct 6; 478(7367):76-81. PMID: 21979047.
        View in: PubMed
      63. Taleb A, Witztum J, Tsimikas S. Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular events. Biomark Med. 2011 Oct; 5(5):673-94. PMID: 22003918.
        View in: PubMed
      64. Ravandi A, Boekholdt SM, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Miller ER, Benessiano J, Tedgui A, Witztum J, Khaw KT, Tsimikas S. Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study. J Lipid Res. 2011 Oct; 52(10):1829-36. PMID: 21821825.
        View in: PubMed
      65. von Vietinghoff S, Koltsova EK, Mestas J, Diehl CJ, Witztum J, Ley K. Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation. J Am Coll Cardiol. 2011 May 24; 57(21):2194-204. PMID: 21596236.
        View in: PubMed
      66. Merki E, Graham M, Taleb A, Leibundgut G, Yang X, Miller ER, Fu W, Mullick AE, Lee R, Willeit P, Crooke RM, Witztum J, Tsimikas S. Antisense oligonucleotide lowers plasma levels of apolipoprotein (a) and lipoprotein (a) in transgenic mice. J Am Coll Cardiol. 2011 Apr 12; 57(15):1611-21. PMID: 21474042.
        View in: PubMed
      67. Diehl CJ, Barish GD, Downes M, Chou MY, Heinz S, Glass CK, Evans RM, Witztum J. Research resource: Comparative nuclear receptor atlas: basal and activated peritoneal B-1 and B-2 cells. Mol Endocrinol. 2011 Mar; 25(3):529-45. PMID: 21273443.
        View in: PubMed
      68. Miller YI, Choi SH, Wiesner P, Fang L, Harkewicz R, Hartvigsen K, Boullier A, Gonen A, Diehl CJ, Que X, Montano E, Shaw PX, Tsimikas S, Binder CJ, Witztum J. Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res. 2011 Jan 21; 108(2):235-48. PMID: 21252151.
        View in: PubMed
      69. Steinberg D, Witztum J. Oxidized low-density lipoprotein and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2311-6. PMID: 21084697.
        View in: PubMed
      70. Bishop JR, Passos-Bueno MR, Fong L, Stanford KI, Gonzales JC, Yeh E, Young SG, Bensadoun A, Witztum J, Esko JD, Moulton KS. Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans. PLoS One. 2010; 5(11):e13919. PMID: 21085708.
        View in: PubMed
      71. Seimon TA, Nadolski MJ, Liao X, Magallon J, Nguyen M, Feric NT, Koschinsky ML, Harkewicz R, Witztum J, Tsimikas S, Golenbock D, Moore KJ, Tabas I. Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab. 2010 Nov 3; 12(5):467-82. PMID: 21035758.
        View in: PubMed
      72. Mendez-Fernandez YV, Stevenson BG, Diehl CJ, Braun NA, Wade NS, Covarrubias R, van Leuven S, Witztum J, Major AS. The inhibitory Fc?RIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) mice. Atherosclerosis. 2011 Jan; 214(1):73-80. PMID: 21084088.
        View in: PubMed
      73. Wool GD, Cabana VG, Lukens J, Shaw PX, Binder CJ, Witztum J, Reardon CA, Getz GS. 4F Peptide reduces nascent atherosclerosis and induces natural antibody production in apolipoprotein E-null mice. FASEB J. 2011 Jan; 25(1):290-300. PMID: 20876212.
        View in: PubMed
      74. Tsimikas S, Mallat Z, Talmud PJ, Kastelein JJ, Wareham NJ, Sandhu MS, Miller ER, Benessiano J, Tedgui A, Witztum J, Khaw KT, Boekholdt SM. Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events. J Am Coll Cardiol. 2010 Sep 14; 56(12):946-55. PMID: 20828647.
        View in: PubMed
      75. Faghihnia N, Tsimikas S, Miller ER, Witztum J, Krauss RM. Changes in lipoprotein(a), oxidized phospholipids, and LDL subclasses with a low-fat high-carbohydrate diet. J Lipid Res. 2010 Nov; 51(11):3324-30. PMID: 20713651.
        View in: PubMed
      76. Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum J, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J Biol Chem. 2010 Oct 15; 285(42):32343-51. PMID: 20710028.
        View in: PubMed
      77. Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum J, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20. PMID: 20697023.
        View in: PubMed
      78. Wiesner P, Choi SH, Almazan F, Benner C, Huang W, Diehl CJ, Gonen A, Butler S, Witztum J, Glass CK, Miller YI. Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia. Circ Res. 2010 Jul 9; 107(1):56-65. PMID: 20489162.
        View in: PubMed
      79. Yvan-Charvet L, Pagler TA, Seimon TA, Thorp E, Welch CL, Witztum J, Tabas I, Tall AR. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res. 2010 Jun 25; 106(12):1861-9. PMID: 20431058.
        View in: PubMed
      80. Kelly JA, Griffin ME, Fava RA, Wood SG, Bessette KA, Miller ER, Huber SA, Binder CJ, Witztum J, Morganelli PM. Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10. Cardiovasc Res. 2010 Jan 1; 85(1):224-31. PMID: 19720605.
        View in: PubMed
      81. Pham T, Gregg CJ, Karp F, Chow R, Padler-Karavani V, Cao H, Chen X, Witztum J, Varki NM, Varki A. Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium. Blood. 2009 Dec 10; 114(25):5225-35. PMID: 19828701.
        View in: PubMed
      82. Arai K, Luke MM, Koschinsky ML, Miller ER, Pullinger CR, Witztum J, Kane JP, Tsimikas S. The I4399M variant of apolipoprotein(a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles. Atherosclerosis. 2010 Apr; 209(2):498-503. PMID: 19880117.
        View in: PubMed
      83. Stanford KI, Bishop JR, Foley EM, Gonzales JC, Niesman IR, Witztum J, Esko JD. Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice. J Clin Invest. 2009 Nov; 119(11):3236-45. PMID: 19805913.
        View in: PubMed
      84. Fraley AE, Schwartz GG, Olsson AG, Kinlay S, Szarek M, Rifai N, Libby P, Ganz P, Witztum J, Tsimikas S. Relationship of oxidized phospholipids and biomarkers of oxidized low-density lipoprotein with cardiovascular risk factors, inflammatory biomarkers, and effect of statin therapy in patients with acute coronary syndromes: Results from the MIRACL (Myocardial Ischemia Reduction With Aggressive Cholesterol Lowering) trial. J Am Coll Cardiol. 2009 Jun 9; 53(23):2186-96. PMID: 19497447.
        View in: PubMed
      85. Steinberg D, Witztum J. Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9546-7. PMID: 19506257.
        View in: PubMed
      86. Choi SH, Harkewicz R, Lee JH, Boullier A, Almazan F, Li AC, Witztum J, Bae YS, Miller YI. Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res. 2009 Jun 19; 104(12):1355-63. PMID: 19461045.
        View in: PubMed
      87. Chou MY, Fogelstrand L, Hartvigsen K, Hansen LF, Woelkers D, Shaw PX, Choi J, Perkmann T, Bäckhed F, Miller YI, Hörkkö S, Corr M, Witztum J, Binder CJ. Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest. 2009 May; 119(5):1335-49. PMID: 19363291.
        View in: PubMed
      88. Dennis EA, Witztum J. Fifty years of research on lipids. J Lipid Res. 2009 Apr; 50 Suppl:S1. PMID: 19346336.
        View in: PubMed
      89. Gautier EL, Huby T, Witztum J, Ouzilleau B, Miller ER, Saint-Charles F, Aucouturier P, Chapman MJ, Lesnik P. Macrophage apoptosis exerts divergent effects on atherogenesis as a function of lesion stage. Circulation. 2009 Apr 7; 119(13):1795-804. PMID: 19307478.
        View in: PubMed
      90. Tsimikas S, Clopton P, Brilakis ES, Marcovina SM, Khera A, Miller ER, de Lemos JA, Witztum J. Relationship of oxidized phospholipids on apolipoprotein B-100 particles to race/ethnicity, apolipoprotein(a) isoform size, and cardiovascular risk factors: results from the Dallas Heart Study. Circulation. 2009 Apr 7; 119(13):1711-9. PMID: 19307470.
        View in: PubMed
      91. Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum J, Klemke RL, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res. 2009 Apr 24; 104(8):952-60. PMID: 19265037.
        View in: PubMed
      92. Hartvigsen K, Chou MY, Hansen LF, Shaw PX, Tsimikas S, Binder CJ, Witztum J. The role of innate immunity in atherogenesis. J Lipid Res. 2009 Apr; 50 Suppl:S388-93. PMID: 19106070.
        View in: PubMed
      93. Bae YS, Lee JH, Choi SH, Kim S, Almazan F, Witztum J, Miller YI. Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res. 2009 Jan 30; 104(2):210-8, 21p following 218. PMID: 19096031.
        View in: PubMed
      94. Tsimikas S, Willeit J, Knoflach M, Mayr M, Egger G, Notdurfter M, Witztum J, Wiedermann CJ, Xu Q, Kiechl S. Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome, and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study. Eur Heart J. 2009 Jan; 30(1):107-15. PMID: 19019993.
        View in: PubMed
      95. Attie AD, Witztum J, Edwards PA, Lusis JA. In memoriam: Roger A. Davis (1945-2008). J Lipid Res. 2008 Nov; 49(11):2279-80. PMID: 19123270.
        View in: PubMed
      96. Steinberg D, Glass CK, Witztum J. Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation. 2008 Aug 5; 118(6):672-7. PMID: 18678783.
        View in: PubMed
      97. Tsimikas S, Witztum J. The role of oxidized phospholipids in mediating lipoprotein(a) atherogenicity. Curr Opin Lipidol. 2008 Aug; 19(4):369-77. PMID: 18607184.
        View in: PubMed
      98. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum J, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. PMID: 18636118.
        View in: PubMed
      99. Merki E, Graham MJ, Mullick AE, Miller ER, Crooke RM, Pitas RE, Witztum J, Tsimikas S. Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice. Circulation. 2008 Aug 12; 118(7):743-53. PMID: 18663084.
        View in: PubMed
      100. Bergmark C, Dewan A, Orsoni A, Merki E, Miller ER, Shin MJ, Binder CJ, Hörkkö S, Krauss RM, Chapman MJ, Witztum J, Tsimikas S. A novel function of lipoprotein [a] as a preferential carrier of oxidized phospholipids in human plasma. J Lipid Res. 2008 Oct; 49(10):2230-9. PMID: 18594118.
        View in: PubMed
      101. Briley-Saebo KC, Shaw PX, Mulder WJ, Choi SH, Vucic E, Aguinaldo JG, Witztum J, Fuster V, Tsimikas S, Fayad ZA. Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes. Circulation. 2008 Jun 24; 117(25):3206-15. PMID: 18541740.
        View in: PubMed
      102. Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum J. Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2008 Apr 15; 51(15):1512-24. PMID: 18402913.
        View in: PubMed
      103. Brunzell JD, Davidson M, Furberg CD, Goldberg RB, Howard BV, Stein JH, Witztum J. Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care. 2008 Apr; 31(4):811-22. PMID: 18375431.
        View in: PubMed
      104. Binder CJ, Chou MY, Fogelstrand L, Hartvigsen K, Shaw PX, Boullier A, Witztum J. Natural antibodies in murine atherosclerosis. Curr Drug Targets. 2008 Mar; 9(3):190-5. PMID: 18336236.
        View in: PubMed
      105. Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum J, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. J Biol Chem. 2008 Apr 18; 283(16):10241-51. PMID: 18263582.
        View in: PubMed
      106. Bro S, Binder CJ, Witztum J, Olgaard K, Nielsen LB. Inhibition of the renin-angiotensin system abolishes the proatherogenic effect of uremia in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1080-6. PMID: 17347482.
        View in: PubMed
      107. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton BA, Ziegler MG, Witztum J, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
        View in: PubMed
      108. Feng X, Li H, Rumbin AA, Wang X, La Cava A, Brechtelsbauer K, Castellani LW, Witztum J, Lusis AJ, Tsao BP. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res. 2007 Apr; 48(4):794-805. PMID: 17259598.
        View in: PubMed
      109. Hartvigsen K, Binder CJ, Hansen LF, Rafia A, Juliano J, Hörkkö S, Steinberg D, Palinski W, Witztum J, Li AC. A diet-induced hypercholesterolemic murine model to study atherogenesis without obesity and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2007 Apr; 27(4):878-85. PMID: 17255537.
        View in: PubMed
      110. MacArthur JM, Bishop JR, Stanford KI, Wang L, Bensadoun A, Witztum J, Esko JD. Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest. 2007 Jan; 117(1):153-64. PMID: 17200715.
        View in: PubMed
      111. Tsimikas S, Brilakis ES, Lennon RJ, Miller ER, Witztum J, McConnell JP, Kornman KS, Berger PB. Relationship of IgG and IgM autoantibodies to oxidized low density lipoprotein with coronary artery disease and cardiovascular events. J Lipid Res. 2007 Feb; 48(2):425-33. PMID: 17093289.
        View in: PubMed
      112. Tsimikas S, Aikawa M, Miller FJ, Miller ER, Torzewski M, Lentz SR, Bergmark C, Heistad DD, Libby P, Witztum J. Increased plasma oxidized phospholipid:apolipoprotein B-100 ratio with concomitant depletion of oxidized phospholipids from atherosclerotic lesions after dietary lipid-lowering: a potential biomarker of early atherosclerosis regression. Arterioscler Thromb Vasc Biol. 2007 Jan; 27(1):175-81. PMID: 17082490.
        View in: PubMed
      113. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum J, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 7; 114(19):2047-55. PMID: 17060381.
        View in: PubMed
      114. Tsimikas S, Kiechl S, Willeit J, Mayr M, Miller ER, Kronenberg F, Xu Q, Bergmark C, Weger S, Oberhollenzer F, Witztum J. Oxidized phospholipids predict the presence and progression of carotid and femoral atherosclerosis and symptomatic cardiovascular disease: five-year prospective results from the Bruneck study. J Am Coll Cardiol. 2006 Jun 6; 47(11):2219-28. PMID: 16750687.
        View in: PubMed
      115. Boullier A, Li Y, Quehenberger O, Palinski W, Tabas I, Witztum J, Miller YI. Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages. Arterioscler Thromb Vasc Biol. 2006 May; 26(5):1169-76. PMID: 16484596.
        View in: PubMed
      116. Witztum J. You are right too! J Clin Invest. 2005 Aug; 115(8):2072-5. PMID: 16075051.
        View in: PubMed
      117. Tsimikas S, Brilakis ES, Miller ER, McConnell JP, Lennon RJ, Kornman KS, Witztum J, Berger PB. Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med. 2005 Jul 7; 353(1):46-57. PMID: 16000355.
        View in: PubMed
      118. Binder CJ, Shaw PX, Chang MK, Boullier A, Hartvigsen K, Hörkkö S, Miller YI, Woelkers DA, Corr M, Witztum J. The role of natural antibodies in atherogenesis. J Lipid Res. 2005 Jul; 46(7):1353-63. PMID: 15897601.
        View in: PubMed
      119. Miller YI, Viriyakosol S, Worrall DS, Boullier A, Butler S, Witztum J. Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol. 2005 Jun; 25(6):1213-9. PMID: 15718493.
        View in: PubMed
      120. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum J, Dennis EA. A comprehensive classification system for lipids. J Lipid Res. 2005 May; 46(5):839-61. PMID: 15722563.
        View in: PubMed
      121. Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum J, Quehenberger O. Phosphocholine as a pattern recognition ligand for CD36. J Lipid Res. 2005 May; 46(5):969-76. PMID: 15722561.
        View in: PubMed
      122. Buono C, Binder CJ, Stavrakis G, Witztum J, Glimcher LH, Lichtman AH. T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1596-601. PMID: 15665085.
        View in: PubMed
      123. Schneider M, Witztum J, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J Lipid Res. 2005 Apr; 46(4):769-78. PMID: 15654123.
        View in: PubMed
      124. Frostegård J, Svenungsson E, Wu R, Gunnarsson I, Lundberg IE, Klareskog L, Hörkkö S, Witztum J. Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum. 2005 Jan; 52(1):192-200. PMID: 15641060.
        View in: PubMed
      125. Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum J. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 6; 200(11):1359-70. PMID: 15583011.
        View in: PubMed
      126. Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum J, Palinski W, Glass CK. Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest. 2004 Dec; 114(11):1564-76. PMID: 15578089.
        View in: PubMed
      127. Torzewski M, Shaw PX, Han KR, Shortal B, Lackner KJ, Witztum J, Palinski W, Tsimikas S. Reduced in vivo aortic uptake of radiolabeled oxidation-specific antibodies reflects changes in plaque composition consistent with plaque stabilization. Arterioscler Thromb Vasc Biol. 2004 Dec; 24(12):2307-12. PMID: 15528482.
        View in: PubMed
      128. Huo Y, Zhao L, Hyman MC, Shashkin P, Harry BL, Burcin T, Forlow SB, Stark MA, Smith DF, Clarke S, Srinivasan S, Hedrick CC, Praticò D, Witztum J, Nadler JL, Funk CD, Ley K. Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Oct 5; 110(14):2024-31. PMID: 15451785.
        View in: PubMed
      129. Tsimikas S, Witztum J, Miller ER, Sasiela WJ, Szarek M, Olsson AG, Schwartz GG. High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation. 2004 Sep 14; 110(11):1406-12. PMID: 15353498.
        View in: PubMed
      130. Choudhury RP, Rong JX, Trogan E, Elmalem VI, Dansky HM, Breslow JL, Witztum J, Fallon JT, Fisher EA. High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation. Arterioscler Thromb Vasc Biol. 2004 Oct; 24(10):1904-9. PMID: 15319266.
        View in: PubMed
      131. Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum J. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004 Aug 3; 110(5):637-41. PMID: 15289389.
        View in: PubMed
      132. Binder CJ, Hartvigsen K, Chang MK, Miller M, Broide D, Palinski W, Curtiss LK, Corr M, Witztum J. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest. 2004 Aug; 114(3):427-37. PMID: 15286809.
        View in: PubMed
      133. Soep JB, Mietus-Snyder M, Malloy MJ, Witztum J, von Scheven E. Assessment of atherosclerotic risk factors and endothelial function in children and young adults with pediatric-onset systemic lupus erythematosus. Arthritis Rheum. 2004 Jun 15; 51(3):451-7. PMID: 15188333.
        View in: PubMed
      134. Tsimikas S, Lau HK, Han KR, Shortal B, Miller ER, Segev A, Curtiss LK, Witztum J, Strauss BH. Percutaneous coronary intervention results in acute increases in oxidized phospholipids and lipoprotein(a): short-term and long-term immunologic responses to oxidized low-density lipoprotein. Circulation. 2004 Jun 29; 109(25):3164-70. PMID: 15184281.
        View in: PubMed
      135. Reardon CA, Miller ER, Blachowicz L, Lukens J, Binder CJ, Witztum J, Getz GS. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. J Lipid Res. 2004 Jul; 45(7):1347-54. PMID: 15102879.
        View in: PubMed
      136. Rock CL, Flatt SW, Thomson CA, Stefanick ML, Newman VA, Jones L, Natarajan L, Pierce JP, Chang RJ, Witztum J. Plasma triacylglycerol and HDL cholesterol concentrations confirm self-reported changes in carbohydrate and fat intakes in women in a diet intervention trial. J Nutr. 2004 Feb; 134(2):342-7. PMID: 14747670.
        View in: PubMed
      137. Silaste ML, Rantala M, Alfthan G, Aro A, Witztum J, Kesäniemi YA, Hörkkö S. Changes in dietary fat intake alter plasma levels of oxidized low-density lipoprotein and lipoprotein(a). Arterioscler Thromb Vasc Biol. 2004 Mar; 24(3):498-503. PMID: 14739118.
        View in: PubMed
      138. Miller YI, Chang MK, Binder CJ, Shaw PX, Witztum J. Oxidized low density lipoprotein and innate immune receptors. Curr Opin Lipidol. 2003 Oct; 14(5):437-45. PMID: 14501582.
        View in: PubMed
      139. Miller YI, Worrall DS, Funk CD, Feramisco JR, Witztum J. Actin polymerization in macrophages in response to oxidized LDL and apoptotic cells: role of 12/15-lipoxygenase and phosphoinositide 3-kinase. Mol Biol Cell. 2003 Oct; 14(10):4196-206. PMID: 14517329.
        View in: PubMed
      140. Shaw PX, Goodyear CS, Chang MK, Witztum J, Silverman GJ. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7. PMID: 12794145.
        View in: PubMed
      141. Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum J, Silverman GJ. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43. PMID: 12740573.
        View in: PubMed
      142. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum J, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906. PMID: 12639996.
        View in: PubMed
      143. Tsimikas S, Bergmark C, Beyer RW, Patel R, Pattison J, Miller E, Juliano J, Witztum J. Temporal increases in plasma markers of oxidized low-density lipoprotein strongly reflect the presence of acute coronary syndromes. J Am Coll Cardiol. 2003 Feb 5; 41(3):360-70. PMID: 12575961.
        View in: PubMed
      144. Miller YI, Viriyakosol S, Binder CJ, Feramisco JR, Kirkland TN, Witztum J. Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem. 2003 Jan 17; 278(3):1561-8. PMID: 12424240.
        View in: PubMed
      145. Binder CJ, Chang MK, Shaw PX, Miller YI, Hartvigsen K, Dewan A, Witztum J. Innate and acquired immunity in atherogenesis. Nat Med. 2002 Nov; 8(11):1218-26. PMID: 12411948.
        View in: PubMed
      146. Chang MK, Binder CJ, Torzewski M, Witztum J. C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci U S A. 2002 Oct 1; 99(20):13043-8. PMID: 12244213.
        View in: PubMed
      147. Aikawa M, Sugiyama S, Hill CC, Voglic SJ, Rabkin E, Fukumoto Y, Schoen FJ, Witztum J, Libby P. Lipid lowering reduces oxidative stress and endothelial cell activation in rabbit atheroma. Circulation. 2002 Sep 10; 106(11):1390-6. PMID: 12221058.
        View in: PubMed
      148. Bannykh SI, Witztum J, Bergmark C. Mechanical aortic injury in apoE-deficient mice as a model for development of atherosclerosis: demonstration of leukocyte rolling early after injury. Ultrastruct Pathol. 2002 Jul-Aug; 26(4):251-60. PMID: 12227951.
        View in: PubMed
      149. Buono C, Come CE, Witztum J, Maguire GF, Connelly PW, Carroll M, Lichtman AH. Influence of C3 deficiency on atherosclerosis. Circulation. 2002 Jun 25; 105(25):3025-31. PMID: 12081998.
        View in: PubMed
      150. Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum J, Lagrost L. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002 Aug 30; 277(35):31850-6. PMID: 12105225.
        View in: PubMed
      151. Steinberg D, Witztum J. Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation. 2002 Apr 30; 105(17):2107-11. PMID: 11980692.
        View in: PubMed
      152. Witztum J. Splenic immunity and atherosclerosis: a glimpse into a novel paradigm? J Clin Invest. 2002 Mar; 109(6):721-4. PMID: 11901180.
        View in: PubMed
      153. Friedman P, Horkko S, Steinberg D, Witztum J, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. J Biol Chem. 2002 Mar 1; 277(9):7010-20. PMID: 11744722.
        View in: PubMed
      154. Witztum J, Steinberg D. The oxidative modification hypothesis of atherosclerosis: does it hold for humans? Trends Cardiovasc Med. 2001 Apr-May; 11(3-4):93-102. PMID: 11686009.
        View in: PubMed
      Joseph's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _