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    J. Silvio Gutkind, Ph.D.

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentPharmacology
    Address3855 Health Sciences Drive
    CA La Jolla 92093
    Phone858-534-5980
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Ph.D.University of Buenos Aires

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      NEUROPEPTIDES AND BIOGENIC AMINES IN HYPERTENSION
      NIH/FIC F05TW003778Jun 10, 1987
      Role: Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind J, Fertig EJ, Gaykalova DA, Califano J. A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers. Cancer Res. 2017 Jul 21. PMID: 28733453.
        View in: PubMed
      2. O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind J. Genetic evidence that ß-arrestins are dispensable for the initiation of ß2-adrenergic receptor signaling to ERK. Sci Signal. 2017 Jun 20; 10(484). PMID: 28634209.
        View in: PubMed
      3. Cimas FJ, Callejas-Valera JL, García-Olmo DC, Hernández-Losa J, Melgar-Rojas P, Ruiz-Hidalgo MJ, Pascual-Serra R, Ortega-Muelas M, Roche O, Marcos P, Garcia-Gil E, Fernandez-Aroca DM, Ramón Y Cajal S, Gutkind J, Sanchez-Prieto R. E1a is an exogenous in vivo tumour suppressor. Cancer Lett. 2017 Apr 15; 399:74-81. PMID: 28416454.
        View in: PubMed
      4. Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind J. Epidermal loss of Gaq confers a migratory and differentiation defect in keratinocytes. PLoS One. 2017; 12(3):e0173692. PMID: 28301547.
        View in: PubMed
      5. Carter H, Marty R, Hofree M, Gross A, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo G, Gutkind J, Ideker T. Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer. Cancer Discov. 2017 Feb 10. PMID: 28188128.
        View in: PubMed
      6. Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind J, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA. Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC. Oncotarget. 2017 Jan 27. PMID: 28146432.
        View in: PubMed
      7. Sakurai A, Doçi CL, Gutkind J. Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components. Methods Mol Biol. 2017; 1493:163-170. PMID: 27787849.
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      8. Nohata N, Goto Y, Gutkind J. Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer. J Hum Genet. 2016 Oct 13. PMID: 27734836.
        View in: PubMed
      9. Deng WW, Mao L, Yu GT, Bu LL, Ma SR, Liu B, Gutkind J, Kulkarni AB, Zhang WF, Sun ZJ. LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma. Oncoimmunology. 2016; 5(11):e1239005. PMID: 27999760.
        View in: PubMed
      10. Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind J. mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model. Carcinogenesis. 2016 Oct; 37(10):1014-25. PMID: 27538837.
        View in: PubMed
      11. Nohata N, Abba MC, Gutkind J. Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. Oral Oncol. 2016 Aug; 59:58-66. PMID: 27424183.
        View in: PubMed
      12. Arthofer E, Hot B, Petersen J, Strakova K, Jager S, Grundmann M, Kostenis E, Gutkind J, Schulte G. WNT stimulation dissociates a Frizzled 4 inactive state complex with Ga12/13. Mol Pharmacol. 2016 Jul 25. PMID: 27458145.
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      13. Porat-Shliom N, Tietgens AJ, Van Itallie CM, Vitale-Cross L, Jarnik M, Harding OJ, Anderson JM, Gutkind J, Weigert R, Arias IM. Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo. Hepatology. 2016 Jul 11. PMID: 27396550.
        View in: PubMed
      14. Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, Arnold N, Quintanilla M, Megías D, Vicente-Manzanares M, Urigüen L, Gutkind J, Guzmán M, Pérez-Gómez E, Sánchez C. Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer. Oncotarget. 2016 Jun 21. PMID: 27340777.
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      15. Alonso N, Diaz Nebreda A, Monczor F, Gutkind J, Davio C, Fernandez N, Shayo C. PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells. Biochim Biophys Acta. 2016 Sep; 1860(9):1998-2007. PMID: 27316323.
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      16. Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind J, Hedberg ML, Grandis JR, Argiris A. Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma. Head Neck. 2016 May 27. PMID: 27232378.
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      17. Zhao ZL, Zhang L, Huang CF, Ma SR, Bu LL, Liu JF, Yu GT, Liu B, Gutkind J, Kulkarni AB, Zhang WF, Sun ZJ. NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell. Sci Rep. 2016; 6:24704. PMID: 27108536; PMCID: PMC4842967.
      18. Das JR, Gutkind J, Ray PE. Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells. PLoS One. 2016; 11(4):e0153837. PMID: 27097314; PMCID: PMC4838216.
      19. Heldin CH, Lu B, Evans R, Gutkind J. Signals and Receptors. Cold Spring Harb Perspect Biol. 2016; 8(4). PMID: 27037414.
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      20. Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Wen Ng AK, Martin D, Lim KP, Kallarakkal TG, Wan Mustafa WM, Lau SH, Abraham MT, Zain RB, Abdul Rahman ZA, Molinolo A, Patel V, Gutkind J, Tan AC, Cheong SC. Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies. Oncotarget. 2016 Apr 1; 7(19):27802-18. PMID: 27050151.
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      21. Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind J. A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. Oncotarget. 2016 Mar 8; 7(10):10696-709. PMID: 26882569.
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      22. Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind J, Wang S. Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands. Oncotarget. 2016 Mar 6. PMID: 26958808.
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      23. Wang F, Yang K, Wang Z, Ma Y, Gutkind J, Hida N, Niu G, Tian J. Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter. Nanoscale. 2016 Feb 11; 8(7):3991-4000. PMID: 26818100.
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      24. Nohata N, Uchida Y, Stratman AN, Adams RH, Zheng Y, Weinstein BM, Mukouyama YS, Gutkind J. Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Dev Biol. 2016 Feb 10. PMID: 26872874.
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      25. William WN, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen EE, Lin HY, Gillenwater AM, Martin JW, Lingen MW, Boyle JO, Shin DM, Vigneswaran N, Shinn N, Heymach JV, Wistuba II, Tang X, Kim ES, Saintigny P, Blair EA, Meiller T, Gutkind J, Myers J, El-Naggar A, Lippman SM. Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial. JAMA Oncol. 2016 Feb 1; 2(2):209-16. PMID: 26540028.
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      26. Cimas FJ, Callejas-Valera JL, Pascual-Serra R, García-Cano J, Garcia-Gil E, De la Cruz-Morcillo MA, Ortega-Muelas M, Serrano-Oviedo L, Gutkind J, Sánchez-Prieto R. MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells. Oncotarget. 2015 Dec 29; 6(42):44095-107. PMID: 26689986.
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      27. Yu GT, Bu LL, Huang CF, Zhang WF, Chen WJ, Gutkind J, Kulkarni AB, Sun ZJ. PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPa axis in HPV negative head and neck squamous cell carcinoma. Oncotarget. 2015 Dec 8; 6(39):42067-80. PMID: 26573233.
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      28. O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind J. Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Ga13/RhoA axis in B cells. Oncogene. 2015 Nov 30. PMID: 26616858.
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      29. Laukkanen MO, Gutkind J, Castellone MD. Sonic Hedgehog in SCLC. Aging (Albany NY). 2015 Sep; 7(9):605-6. PMID: 26420823; PMCID: PMC4600616.
      30. House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Gutkind J, Hales TG, Lee NH. Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Sci Rep. 2015; 5:11541. PMID: 26096612; PMCID: PMC4476109.
      31. Wang Z, Wang Y, Wang Z, Zhao J, Gutkind J, Srivatsan A, Zhang G, Liao HS, Fu X, Jin A, Tong X, Niu G, Chen X. Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury. ACS Nano. 2015 Jul 28; 9(7):6683-95. PMID: 26020550.
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      32. Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind J. Inactivation of a Gas-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nat Cell Biol. 2015 Jun; 17(6):793-803. PMID: 25961504.
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      33. Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind J. Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma. Cancer Res. 2015 Jul 15; 75(14):2937-48. PMID: 25952650.
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      34. Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind J. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015; 6:6725. PMID: 25857352.
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      35. Degese MS, Tanos T, Naipauer J, Gingerich T, Chiappe D, Echeverria P, LaMarre J, Gutkind J, Coso OA. An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation. Biochem J. 2015 Apr 1; 467(1):77-90. PMID: 25588078.
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      36. Nudelman Z, Findler M, Barasch D, Nemirovski A, Pikovsky A, Kirmayer D, Basheer M, Gutkind J, Friedman M, Czerninski R. Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application. Cancer Chemother Pharmacol. 2015 May; 75(5):969-74. PMID: 25757961.
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      37. Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN, Seethala RR, Ferris RL, Gutkind J. Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3. Cancer Prev Res (Phila). 2015 Mar; 8(3):197-207. PMID: 25681087.
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      38. Deshapriya IK, Stromer BS, Pattammattel A, Kim CS, Iglesias-Bartolome R, Gonzalez-Fajardo L, Patel V, Gutkind J, Lu X, Kumar CV. Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake. Bioconjug Chem. 2015 Mar 18; 26(3):396-404. PMID: 25642999.
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      39. Wang Z, Wang Y, Wang Z, Gutkind J, Wang Z, Wang F, Lu J, Niu G, Teng G, Chen X. Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury. Stem Cells. 2015 Feb; 33(2):456-67. PMID: 25346537.
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      40. Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind J. SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gai/mTORC1 axis. FASEB J. 2015 Mar; 29(3):1056-68. PMID: 25466898.
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      41. Feng X, Chen Q, Gutkind J. Oncotargeting G proteins: The Hippo in the room. Oncotarget. 2014 Nov 30; 5(22):10997-9. PMID: 25526026.
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      42. Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind J, Molinolo AA, Crawford NP. A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes. PLoS Genet. 2014 Nov; 10(11):e1004809. PMID: 25411967.
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      43. Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind J, Cheong SC. Heterotrimeric G-protein alpha-12 (Ga12) subunit promotes oral cancer metastasis. Oncotarget. 2014 Oct 30; 5(20):9626-40. PMID: 25275299.
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      44. Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind J. The head and neck cancer cell oncogenome: A platform for the development of precision molecular therapies. Oncotarget. 2014 Oct 15; 5(19):8906-23. PMID: 25275298.
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      45. Smith JP, Cooper TK, McGovern CO, Gilius EL, Zhong Q, Liao J, Molinolo AA, Gutkind J, Matters GL. Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice. Pancreas. 2014 Oct; 43(7):1050-9. PMID: 25058882.
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      46. Qi S, O'Hayre M, Gutkind J, Hurley JH. Insights into ß2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci. 2014 Dec; 23(12):1708-16. PMID: 25220262; PMCID: PMC4253811.
      47. Liu G, Yu FX, Kim YC, Meng Z, Naipauer J, Looney DJ, Liu X, Gutkind J, Mesri EA, Guan KL. Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene. 2015 Jul; 34(27):3536-46. PMID: 25195862.
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      48. Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, Gutkind J, Bowcock AM, Streicher HZ, Patel PM, Sato T, Sossman JA, Sznol M, Welch J, Thurin M, Selig S, Flaherty KT, Carvajal RD. Biology of advanced uveal melanoma and next steps for clinical therapeutics. Pigment Cell Melanoma Res. 2015 Mar; 28(2):135-47. PMID: 25113308; NIHMSID: NIHMS621657.
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      49. Wang Z, Martin D, Molinolo AA, Patel V, Iglesias-Bartolome R, Sol Degese M, Vitale-Cross L, Chen Q, Gutkind J. mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations. J Natl Cancer Inst. 2014 Sep; 106(9). PMID: 25099740.
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      50. González FE, Ortiz C, Reyes M, Dutzan N, Patel V, Pereda C, Gleisner MA, López MN, Gutkind J, Salazar-Onfray F. Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells. Immunology. 2014 Jul; 142(3):396-405. PMID: 24673602; PMCID: PMC4080955.
      51. Adi AH, Alturkmani H, Spock T, Williams Yohannes P, Wargo S, Szabo E, Gutkind J, Van Waes C. Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: A case report. Head Neck. 2015 Jan; 37(1):E1-3. PMID: 24715579.
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      52. Feng X, Degese MS, Iglesias-Bartolome R, Vaque JP, Molinolo AA, Rodrigues M, Zaidi MR, Ksander BR, Merlino G, Sodhi A, Chen Q, Gutkind J. Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell. 2014 Jun 16; 25(6):831-45. PMID: 24882515.
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      53. Castellone MD, Laukkanen MO, Teramoto H, Bellelli R, Alì G, Fontanini G, Santoro M, Gutkind J. Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma. Oncogene. 2015 Mar 26; 34(13):1679-87. PMID: 24747971.
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      54. Prickett TD, Zerlanko BJ, Hill VK, Gartner JJ, Qutob N, Jiang J, Simaan M, Wunderlich J, Gutkind J, Rosenberg SA, Samuels Y. Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol. 2014 Sep; 134(9):2390-8. PMID: 24739903.
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      55. Bhirde AA, Chikkaveeraiah BV, Srivatsan A, Niu G, Jin AJ, Kapoor A, Wang Z, Patel S, Patel V, Gorbach AM, Leapman RD, Gutkind J, Hight Walker AR, Chen X. Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance. ACS Nano. 2014 May 27; 8(5):4177-89. PMID: 24708375.
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      56. Nudelman Z, Friedman M, Barasch D, Nemirovski A, Findler M, Pikovsky A, Gutkind J, Czerninski R. Levels of sirolimus in saliva and blood following mouthwash application. Oral Dis. 2014 Nov; 20(8):768-72. PMID: 24548545.
        View in: PubMed
      57. Homolya L, Fu D, Sengupta P, Jarnik M, Gillet JP, Vitale-Cross L, Gutkind J, Lippincott-Schwartz J, Arias IM. LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes. PLoS One. 2014; 9(3):e91921. PMID: 24643070.
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      58. Xie X, Colberg-Poley AM, Das JR, Li J, Zhang A, Tang P, Jerebtsova M, Gutkind J, Ray PE. The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy. J Am Soc Nephrol. 2014 Aug; 25(8):1800-13. PMID: 24578133; PMCID: PMC4116058.
      59. Sobral LM, Sousa LO, Coletta RD, Cabral H, Greene LJ, Tajara EH, Gutkind J, Curti C, Leopoldino AM. Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models. Mol Cancer. 2014; 13:32. PMID: 24555657.
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      60. Manavski Y, Carmona G, Bennewitz K, Tang Z, Zhang F, Sakurai A, Zeiher AM, Gutkind J, Li X, Kroll J, Dimmeler S, Chavakis E. Brag2 differentially regulates ß1- and ß3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Basic Res Cardiol. 2014 Mar; 109(2):404. PMID: 24522833.
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      61. O'Hayre M, Degese MS, Gutkind J. Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol. 2014 Apr; 27:126-35. PMID: 24508914.
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      62. Sales KU, Friis S, Konkel JE, Godiksen S, Hatakeyama M, Hansen KK, Rogatto SR, Szabo R, Vogel LK, Chen W, Gutkind J, Bugge TH. Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Oncogene. 2015 Jan 15; 34(3):346-56. PMID: 24469043.
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      63. Qi S, O'Hayre M, Gutkind J, Hurley JH. Structural and biochemical basis for ubiquitin ligase recruitment by arrestin-related domain-containing protein-3 (ARRDC3). J Biol Chem. 2014 Feb 21; 289(8):4743-52. PMID: 24379409; PMCID: PMC3931036.
      64. Abrigo M, Alvarez R, Paparella ML, Calb DE, Bal de Kier Joffe E, Gutkind J, Raimondi AR. Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. Carcinogenesis. 2014 Mar; 35(3):662-9. PMID: 24148820.
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      65. Wei JS, Johansson P, Chen L, Song YK, Tolman C, Li S, Hurd L, Patidar R, Wen X, Badgett TC, Cheuk AT, Marshall JC, Steeg PS, Vaqué Díez JP, Yu Y, Gutkind J, Khan J. Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma. PLoS One. 2013; 8(10):e77731. PMID: 24147068.
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      66. Leelahavanichkul K, Amornphimoltham P, Molinolo AA, Basile JR, Koontongkaew S, Gutkind J. A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis. Mol Oncol. 2014 Feb; 8(1):105-18. PMID: 24216180.
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      67. Artamonov MV, Momotani K, Stevenson A, Trentham DR, Derewenda U, Derewenda ZS, Read PW, Gutkind J, Somlyo AV. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. J Biol Chem. 2013 Nov 22; 288(47):34030-40. PMID: 24106280; PMCID: PMC3837142.
      68. Iglesias-Bartolome R, Martin D, Gutkind J. Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. Cancer Discov. 2013 Jul; 3(7):722-5. PMID: 23847349.
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      69. Wang Y, Lu X, Zhu L, Shen Y, Chengedza S, Feng H, Wang L, Jung JU, Gutkind JS, Gutkind JS, Feng P. IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis. Proc Natl Acad Sci U S A. 2013 Jul 2; 110(27):11139-44. PMID: 23771900; PMCID: PMC3703966.
      70. Krause CE, Otieno BA, Latus A, Faria RC, Patel V, Gutkind J, Rusling JF. Rapid microfluidic immunoassays of cancer biomarker proteins using disposable inkjet-printed gold nanoparticle arrays. ChemistryOpen. 2013 Aug; 2(4):141-5. PMID: 24482763; NIHMSID: NIHMS546805.
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      71. Coppock JD, Wieking BG, Molinolo AA, Gutkind J, Miskimins WK, Lee JH. Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition. Neoplasia. 2013 Jun; 15(6):620-30. PMID: 23730210.
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      72. Martin D, Nguyen Q, Molinolo A, Gutkind J. Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene. Oncogene. 2014 May 1; 33(18):2405-12. PMID: 23708663.
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      73. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind J. The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013 Jun; 13(6):412-24. PMID: 23640210.
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      74. Squarize CH, Castilho RM, Abrahao AC, Molinolo A, Lingen MW, Gutkind J. PTEN deficiency contributes to the development and progression of head and neck cancer. Neoplasia. 2013 May; 15(5):461-71. PMID: 23633918.
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      75. Patel SJ, Molinolo AA, Gutkind J, Crawford NP. Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma. PLoS One. 2013; 8(4):e61848. PMID: 23620793.
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      76. Blelloch R, Gutkind J. Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions. Curr Opin Cell Biol. 2013 Apr; 25(2):149-51. PMID: 23498659.
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      77. Han G, Bian L, Li F, Cotrim A, Wang D, Lu J, Deng Y, Bird G, Sowers A, Mitchell JB, Gutkind J, Zhao R, Raben D, ten Dijke P, Refaeli Y, Zhang Q, Wang XJ. Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis. Nat Med. 2013 Apr; 19(4):421-8. PMID: 23475202; NIHMSID: NIHMS442406.
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      78. Mikelis CM, Palmby TR, Simaan M, Li W, Szabo R, Lyons R, Martin D, Yagi H, Fukuhara S, Chikumi H, Galisteo R, Mukouyama YS, Bugge TH, Gutkind J. PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation. J Biol Chem. 2013 Apr 26; 288(17):12232-43. PMID: 23467409.
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      79. Alonso N, Fernandez N, Notcovich C, Monczor F, Simaan M, Baldi A, Gutkind J, Davio C, Shayo C. Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration. Mol Pharmacol. 2013 May; 83(5):1087-98. PMID: 23462507; PMCID: PMC3629830.
      80. Iglesias-Bartolome R, Callejas-Valera JL, Gutkind J. Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity. Curr Opin Cell Biol. 2013 Apr; 25(2):162-9. PMID: 23434069.
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      81. Castilho RM, Squarize CH, Gutkind J. Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing. Oral Dis. 2013 Sep; 19(6):551-8. PMID: 23379329.
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      82. Chen JJ, Mikelis CM, Zhang Y, Gutkind J, Zhang B. TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5. Oncotarget. 2013 Feb; 4(2):206-17. PMID: 23470485.
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      83. Amornphimoltham P, Rechache K, Thompson J, Masedunskas A, Leelahavanichkul K, Patel V, Molinolo A, Gutkind J, Weigert R. Rab25 regulates invasion and metastasis in head and neck cancer. Clin Cancer Res. 2013 Mar 15; 19(6):1375-88. PMID: 23340300.
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      84. Leelahavanichkul K, Gutkind J. Oral and pharyngeal epithelial keratinocyte culture. Methods Mol Biol. 2013; 945:67-79. PMID: 23097101.
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      85. Xie-Zukauskas H, Das J, Short BL, Gutkind J, Ray PE. Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways. Vascul Pharmacol. 2013 Apr; 58(4):313-8. PMID: 23268358; NIHMSID: NIHMS435566.
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      86. Almeida LO, Goto RN, Pestana CR, Uyemura SA, Gutkind J, Curti C, Leopoldino AM. SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. FEBS J. 2012 Dec; 279(24):4615-28. PMID: 23106910.
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      87. Vaqué JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind J. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell. 2013 Jan 10; 49(1):94-108. PMID: 23177739.
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      88. Saito K, Matsumoto S, Yasui H, Devasahayam N, Subramanian S, Munasinghe JP, Patel V, Gutkind J, Mitchell JB, Krishna MC. Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin. PLoS One. 2012; 7(11):e49456. PMID: 23185335.
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      89. Montaner S, Kufareva I, Abagyan R, Gutkind J. Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases. Annu Rev Pharmacol Toxicol. 2013; 53:331-54. PMID: 23092247.
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      90. Iglesias-Bartolome R, Gutkind J. Exploiting the mTOR paradox for disease prevention. Oncotarget. 2012 Oct; 3(10):1061-3. PMID: 23165441; PMCID: PMC3717954.
      91. Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, Gutkind J. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. PMID: 23010602.
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      92. Chow HY, Jubb AM, Koch JN, Jaffer ZM, Stepanova D, Campbell DA, Duron SG, O'Farrell M, Cai KQ, Klein-Szanto AJ, Gutkind J, Hoeflich KP, Chernoff J. p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model. Cancer Res. 2012 Nov 15; 72(22):5966-75. PMID: 22983922.
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      93. Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind J. mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell. 2012 Sep 7; 11(3):401-14. PMID: 22958932.
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      94. Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind J, Vogel LK, Hummler E, Camerer E, Bugge TH. Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet. 2012; 8(8):e1002937. PMID: 22952456.
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      95. Hoeben A, Martin D, Clement PM, Cools J, Gutkind J. Role of GRB2-associated binder 1 in epidermal growth factor receptor-induced signaling in head and neck squamous cell carcinoma. Int J Cancer. 2013 Mar 1; 132(5):1042-50. PMID: 22865653.
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      96. Sun ZJ, Zhang L, Hall B, Bian Y, Gutkind J, Kulkarni AB. Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model. Clin Cancer Res. 2012 Oct 1; 18(19):5304-13. PMID: 22859719.
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      97. Malhotra R, Patel V, Chikkaveeraiah BV, Munge BS, Cheong SC, Zain RB, Abraham MT, Dey DK, Gutkind J, Rusling JF. Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array. Anal Chem. 2012 Jul 17; 84(14):6249-55. PMID: 22697359; NIHMSID: NIHMS391223.
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      98. Tamburrino A, Molinolo AA, Salerno P, Chernock RD, Raffeld M, Xi L, Gutkind J, Moley JF, Wells SA, Santoro M. Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases. Clin Cancer Res. 2012 Jul 1; 18(13):3532-40. PMID: 22753663.
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      99. Pan W, Pham VN, Stratman AN, Castranova D, Kamei M, Kidd KR, Lo BD, Shaw KM, Torres-Vazquez J, Mikelis CM, Gutkind J, Davis GE, Weinstein BM. CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. Blood. 2012 Jul 12; 120(2):489-98. PMID: 22649102.
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      100. Gandini NA, Fermento ME, Salomón DG, Blasco J, Patel V, Gutkind J, Molinolo AA, Facchinetti MM, Curino AC. Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas. Exp Mol Pathol. 2012 Oct; 93(2):237-45. PMID: 22580187.
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      101. Bhirde AA, Kapoor A, Liu G, Iglesias-Bartolome R, Jin A, Zhang G, Xing R, Lee S, Leapman RD, Gutkind J, Chen X. Nuclear mapping of nanodrug delivery systems in dynamic cellular environments. ACS Nano. 2012 Jun 26; 6(6):4966-72. PMID: 22540867.
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      102. Krejci P, Aklian A, Kaucka M, Sevcikova E, Prochazkova J, Masek JK, Mikolka P, Pospisilova T, Spoustova T, Weis M, Paznekas WA, Wolf JH, Gutkind J, Wilcox WR, Kozubik A, Jabs EW, Bryja V, Salazar L, Vesela I, Balek L. Receptor tyrosine kinases activate canonical WNT/ß-catenin signaling via MAP kinase/LRP6 pathway and direct ß-catenin phosphorylation. PLoS One. 2012; 7(4):e35826. PMID: 22558232; PMCID: PMC3338780.
      103. Quijano C, Cao L, Fergusson MM, Romero H, Liu J, Gutkind J, Rovira II, Mohney RP, Karoly ED, Finkel T. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations. Cell Cycle. 2012 Apr 1; 11(7):1383-92. PMID: 22421146; PMCID: PMC3350879.
      104. Vitale-Cross L, Molinolo AA, Martin D, Younis RH, Maruyama T, Patel V, Chen W, Schneider A, Gutkind J. Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions. Cancer Prev Res (Phila). 2012 Apr; 5(4):562-73. PMID: 22467081.
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      105. Degese MS, Mendizabal JE, Gandini NA, Gutkind J, Molinolo A, Hewitt SM, Curino AC, Coso OA, Facchinetti MM. Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data. Lung Cancer. 2012 Jul; 77(1):168-75. PMID: 22418244.
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      106. Molinolo AA, Marsh C, El Dinali M, Gangane N, Jennison K, Hewitt S, Patel V, Seiwert TY, Gutkind J. mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas. Clin Cancer Res. 2012 May 1; 18(9):2558-68. PMID: 22409888.
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      107. Giulianelli S, Vaqué JP, Soldati R, Wargon V, Vanzulli SI, Martins R, Zeitlin E, Molinolo AA, Helguero LA, Lamb CA, Gutkind J, Lanari C. Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. Cancer Res. 2012 May 1; 72(9):2416-27. PMID: 22396492.
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      108. Nguyen SA, Walker D, Gillespie MB, Gutkind J, Day TA. mTOR inhibitors and its role in the treatment of head and neck squamous cell carcinoma. Curr Treat Options Oncol. 2012 Mar; 13(1):71-81. PMID: 22282394.
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      109. Wise-Draper TM, Draper DJ, Gutkind J, Molinolo AA, Wikenheiser-Brokamp KA, Wells SI. Future directions and treatment strategies for head and neck squamous cell carcinomas. Transl Res. 2012 Sep; 160(3):167-77. PMID: 22683420.
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      110. Giulianelli S, Vaqué JP, Wargon V, Soldati R, Vanzulli SI, Martins R, Zeitlin E, Helguero L, Lamb C, Molinolo AA, Gutkind J, Lanari C. [The role of estrogen receptor alpha in breast cancer cell proliferation mediated by progestins]. Medicina (B Aires). 2012; 72(4):315-20. PMID: 22892083.
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      111. Dutzan N, Vernal R, Vaque JP, García-Sesnich J, Hernandez M, Abusleme L, Dezerega A, Gutkind J, Gamonal J. Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients. J Periodontol. 2012 Jul; 83(7):948-54. PMID: 22181687.
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      112. Sakurai A, Doçi CL, Doci C, Gutkind J. Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res. 2012 Jan; 22(1):23-32. PMID: 22157652.
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      113. Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Polizello AC, Uyemura SA, Tajara EH, Gutkind J, Curti C. Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling. Mol Cell Biochem. 2012 Apr; 363(1-2):65-74. PMID: 22143534.
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      114. Bian Y, Hall B, Sun ZJ, Molinolo A, Chen W, Gutkind J, Waes CV, Kulkarni AB. Loss of TGF-ß signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. Oncogene. 2012 Jul 12; 31(28):3322-32. PMID: 22037217.
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      115. Patel V, Marsh CA, Dorsam RT, Mikelis CM, Masedunskas A, Amornphimoltham P, Nathan CA, Nathan CA, Singh B, Weigert R, Molinolo AA, Gutkind J. Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. Cancer Res. 2011 Nov 15; 71(22):7103-12. PMID: 21975930.
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      116. Berendsen AD, Fisher LW, Kilts TM, Owens RT, Robey PG, Gutkind J, Young MF. Modulation of canonical Wnt signaling by the extracellular matrix component biglycan. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17022-7. PMID: 21969569.
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      117. Yagi H, Tan W, Dillenburg-Pilla P, Armando S, Amornphimoltham P, Simaan M, Weigert R, Molinolo AA, Bouvier M, Gutkind J. A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells. Sci Signal. 2011 Sep 20; 4(191):ra60. PMID: 21934106.
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      118. Iglesias-Bartolome R, Gutkind J. Signaling circuitries controlling stem cell fate: to be or not to be. Curr Opin Cell Biol. 2011 Dec; 23(6):716-23. PMID: 21880478.
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      119. Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind J. Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein. J Biol Chem. 2011 Sep 30; 286(39):34335-45. PMID: 21795701.
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      120. Bhirde AA, Liu G, Jin A, Iglesias-Bartolome R, Sousa AA, Leapman RD, Gutkind J, Lee S, Chen X. Combining portable Raman probes with nanotubes for theranostic applications. Theranostics. 2011; 1:310-21. PMID: 21769298.
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      121. Munge BS, Coffey AL, Doucette JM, Somba BK, Malhotra R, Patel V, Gutkind J, Rusling JF. Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles. Angew Chem Int Ed Engl. 2011 Aug 16; 50(34):7915-8. PMID: 21721091; NIHMSID: NIHMS365210.
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      122. Martin D, Galisteo R, Molinolo AA, Wetzker R, Hirsch E, Gutkind J. PI3K? mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell. 2011 Jun 14; 19(6):805-13. PMID: 21665152.
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      123. Chikkaveeraiah BV, Mani V, Patel V, Gutkind J, Rusling JF. Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum. Biosens Bioelectron. 2011 Jul 15; 26(11):4477-83. PMID: 21632234; NIHMSID: NIHMS295962.
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      124. Cerliani JP, Guillardoy T, Giulianelli S, Vaque JP, Gutkind J, Vanzulli SI, Martins R, Zeitlin E, Lamb CA, Lanari C. Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. Cancer Res. 2011 May 15; 71(10):3720-31. PMID: 21464042.
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      125. Fujita M, Cha YR, Pham VN, Sakurai A, Roman BL, Gutkind J, Weinstein BM. Assembly and patterning of the vascular network of the vertebrate hindbrain. Development. 2011 May; 138(9):1705-15. PMID: 21429985.
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      126. Sansing HA, Sarkeshik A, Yates JR, Patel V, Gutkind J, Yamada KM, Berrier AL. Integrin aß1, avß, a6ß effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance. Biochem Biophys Res Commun. 2011 Mar 11; 406(2):171-6. PMID: 21291860.
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      127. Szabo R, Rasmussen AL, Moyer AB, Kosa P, Schafer JM, Molinolo AA, Gutkind J, Bugge TH. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011 Apr 28; 30(17):2003-16. PMID: 21217780.
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      128. Patel S, Bhirde AA, Rusling JF, Chen X, Gutkind J, Patel V. Nano delivers big: designing molecular missiles for cancer therapeutics. Pharmaceutics. 2011; 3(1):34-52. PMID: 21949900.
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      129. Patel V, Iglesias-Bartolome R, Siegele B, Marsh CA, Leelahavanichkul K, Molinolo AA, Gutkind J. Cellular systems for studying human oral squamous cell carcinomas. Adv Exp Med Biol. 2011; 720:27-38. PMID: 21901616.
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      130. Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind J, Parsons RE, Kazanietz MG. Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell. 2010 Dec 22; 40(6):877-92. PMID: 21172654; NIHMSID: NIHMS259422.
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      131. Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind J, Chen W. Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol. 2011 Jan; 12(1):86-95. PMID: 21131965.
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      132. Bhirde AA, Patel S, Sousa AA, Patel V, Molinolo AA, Ji Y, Leapman RD, Gutkind J, Rusling JF. Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice. Nanomedicine (Lond). 2010 Dec; 5(10):1535-46. PMID: 21143032.
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      133. Cervenka I, Wolf J, Mašek J, Krejci P, Wilcox WR, Kozubík A, Schulte G, Gutkind J, Bryja V. Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6. Mol Cell Biol. 2011 Jan; 31(1):179-89. PMID: 20974802; PMCID: PMC3019858.
      134. Abrahao AC, Castilho RM, Squarize CH, Molinolo AA, dos Santos-Pinto D, Gutkind J. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol. 2010 Dec; 46(12):880-7. PMID: 20951077.
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      135. Giulianelli S, Herschkowitz JI, Patel V, Lamb CA, Gutkind J, Molinolo A, Perou CM, Lanari C. MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements. Breast Cancer Res Treat. 2011 Aug; 129(1):49-67. PMID: 20890655.
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      136. Knox SM, Lombaert IM, Reed X, Vitale-Cross L, Gutkind J, Hoffman MP. Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science. 2010 Sep 24; 329(5999):1645-7. PMID: 20929848.
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      137. Dwyer J, Le Guelte A, Galan Moya EM, Sumbal M, Carlotti A, Douguet L, Gutkind J, Grange PA, Dupin N, Gavard J. Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor. Oncogene. 2011 Jan 13; 30(2):190-200. PMID: 20818438.
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      138. Iglesias-Bartolome R, Gutkind J. Keeping the epidermal stem cell niche in shape. Cell Stem Cell. 2010 Aug 6; 7(2):143-5. PMID: 20682441.
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      139. Rusling JF, Kumar CV, Gutkind J, Patel V. Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer. Analyst. 2010 Oct; 135(10):2496-511. PMID: 20614087; NIHMSID: NIHMS254363.
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      140. Facchinetti MM, Gandini NA, Fermento ME, Sterin-Speziale NB, Ji Y, Patel V, Gutkind J, Rivadulla MG, Curino AC. The expression of sphingosine kinase-1 in head and neck carcinoma. Cells Tissues Organs. 2010; 192(5):314-24. PMID: 20606403.
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      141. Hou X, Kumar A, Lee C, Wang B, Arjunan P, Dong L, Maminishkis A, Tang Z, Li Y, Zhang F, Zhang SZ, Wardega P, Chakrabarty S, Liu B, Wu Z, Colosi P, Fariss RN, Lennartsson J, Nussenblatt R, Gutkind J, Cao Y, Li X. PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl Acad Sci U S A. 2010 Jul 6; 107(27):12216-21. PMID: 20566880.
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      142. Bottino MC, Cerliani JP, Rojas P, Giulianelli S, Soldati R, Mondillo C, Gorostiaga MA, Pignataro OP, Calvo JC, Gutkind J. Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects. Breast Cancer Res Treat. 2011 Apr; 126(3):621-36. PMID: 20535544.
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      143. Squarize CH, Castilho RM, Bugge TH, Gutkind J. Accelerated wound healing by mTOR activation in genetically defined mouse models. PLoS One. 2010; 5(5):e10643. PMID: 20498714.
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      144. Weller ML, Amornphimoltham P, Schmidt M, Wilson PA, Gutkind J, Chiorini JA. Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6. Nat Med. 2010 Jun; 16(6):662-4. PMID: 20473307.
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      145. Castilho RM, Squarize CH, Leelahavanichkul K, Zheng Y, Bugge T, Gutkind J. Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice. PLoS One. 2010; 5(5):e10503. PMID: 20463891.
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      146. Malhotra R, Patel V, Vaqué JP, Gutkind J, Rusling JF. Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Anal Chem. 2010 Apr 15; 82(8):3118-23. PMID: 20192182.
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      147. Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind J. Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras. Mol Cell Biol. 2010 Jun; 30(12):3086-98. PMID: 20385769.
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      148. Wang H, Teh MT, Ji Y, Patel V, Firouzabadian S, Patel AA, Gutkind J, Yeudall WA. EPS8 upregulates FOXM1 expression, enhancing cell growth and motility. Carcinogenesis. 2010 Jun; 31(6):1132-41. PMID: 20351091.
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      149. Chiariello M, Vaqué JP, Crespo P, Gutkind J. Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors. Methods Mol Biol. 2010; 661:137-50. PMID: 20811981.
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      150. El-Naggar AK, Kaye FJ, Shirazi Y, Gutkind J, Forastiere AA. Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008. Head Neck. 2009 Dec; 31(12):1542-3. PMID: 19890918.
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      151. Gonzalez-Pardo V, Martin D, Gutkind J, Verstuyf A, Bouillon R, de Boland AR, Boland RL. 1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo. Endocrinology. 2010 Jan; 151(1):23-31. PMID: 19915163.
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      152. Chikkaveeraiah BV, Bhirde A, Malhotra R, Patel V, Gutkind J, Rusling JF. Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer. Anal Chem. 2009 Nov 1; 81(21):9129-34. PMID: 19775154; NIHMSID: NIHMS148152.
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      153. Bhirde AA, Sousa AA, Patel V, Azari AA, Gutkind J, Leapman RD, Rusling JF. Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes. Nanomedicine (Lond). 2009 Oct; 4(7):763-72. PMID: 19839812.
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      154. Castilho RM, Squarize CH, Chodosh LA, Williams BO, Gutkind J. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. Cell Stem Cell. 2009 Sep 4; 5(3):279-89. PMID: 19733540.
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      155. Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind J, Wakefield LM, Kulkarni AB. Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res. 2009 Jul 15; 69(14):5918-26. PMID: 19584284.
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      156. Raimondi AR, Molinolo A, Gutkind J. Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model. Cancer Res. 2009 May 15; 69(10):4159-66. PMID: 19435901.
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      157. Turjanski AG, Hummer G, Gutkind J. How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study. J Am Chem Soc. 2009 May 6; 131(17):6141-8. PMID: 19361221.
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      158. Guzmán-Hernández ML, Vázquez-Macías A, Carretero-Ortega J, Hernández-García R, García-Regalado A, Hernández-Negrete I, Reyes-Cruz G, Gutkind J, Vázquez-Prado J. Differential inhibitor of Gbetagamma signaling to AKT and ERK derived from phosducin-like protein: effect on sphingosine 1-phosphate-induced endothelial cell migration and in vitro angiogenesis. J Biol Chem. 2009 Jul 3; 284(27):18334-46. PMID: 19403526; PMCID: PMC2709366.
      159. Vitale-Cross L, Czerninski R, Amornphimoltham P, Patel V, Molinolo AA, Gutkind J. Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer. Cancer Prev Res (Phila). 2009 May; 2(5):419-22. PMID: 19401522.
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      160. Mani V, Chikkaveeraiah BV, Patel V, Gutkind J, Rusling JF. Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification. ACS Nano. 2009 Mar 24; 3(3):585-94. PMID: 19216571; NIHMSID: NIHMS95831.
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      161. Gavard J, Hou X, Qu Y, Masedunskas A, Martin D, Weigert R, Li X, Gutkind J. A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability. Mol Cell Biol. 2009 May; 29(9):2469-80. PMID: 19255141.
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      162. Bhirde AA, Patel V, Gavard J, Zhang G, Sousa AA, Masedunskas A, Leapman RD, Weigert R, Gutkind J, Rusling JF. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano. 2009 Feb 24; 3(2):307-16. PMID: 19236065.
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      163. Castellone MD, De Falco V, Rao DM, Bellelli R, Muthu M, Basolo F, Fusco A, Gutkind J, Santoro M. The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation. Cancer Res. 2009 Mar 1; 69(5):1867-76. PMID: 19223551; NIHMSID: NIHMS105085.
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      164. Gutkind J, Offermanns S. A new G(q)-initiated MAPK signaling pathway in the heart. Dev Cell. 2009 Feb; 16(2):163-4. PMID: 19217418.
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      165. Cheong SC, Chandramouli GV, Saleh A, Zain RB, Lau SH, Sivakumaren S, Pathmanathan R, Prime SS, Teo SH, Patel V, Gutkind J. Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. Oral Oncol. 2009 Aug; 45(8):712-9. PMID: 19147396.
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      166. Munge BS, Krause CE, Malhotra R, Patel V, Gutkind J, Rusling JF. Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms. Electrochem commun. 2009; 11(5):1009-1012. PMID: 20046945.
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      167. Czerninski R, Amornphimoltham P, Patel V, Molinolo AA, Gutkind J. Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. Cancer Prev Res (Phila). 2009 Jan; 2(1):27-36. PMID: 19139015.
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      168. Martin D, Gutkind J. Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation. Methods Enzymol. 2009; 460:125-50. PMID: 19446723.
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      169. Martin D, Galisteo R, Gutkind J. CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem. 2009 Mar 6; 284(10):6038-42. PMID: 19112107.
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      170. Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind J, Koh GY, Mochizuki N. Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2. J Biol Chem. 2009 Feb 27; 284(9):5592-601. PMID: 19106103.
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      171. Amornphimoltham P, Leelahavanichkul K, Molinolo A, Patel V, Gutkind J. Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions. Clin Cancer Res. 2008 Dec 15; 14(24):8094-101. PMID: 19073969.
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      172. Martin D, Gutkind J. Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene. 2008 Dec; 27 Suppl 2:S31-42. PMID: 19956178.
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      173. Wang H, Patel V, Miyazaki H, Gutkind J, Yeudall WA. Role for EPS8 in squamous carcinogenesis. Carcinogenesis. 2009 Jan; 30(1):165-74. PMID: 19008210.
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      174. Schneider A, Younis RH, Gutkind J. Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma. Neoplasia. 2008 Nov; 10(11):1295-302. PMID: 18953439.
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      175. Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, Gutkind J. Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol. 2009 Apr-May; 45(4-5):324-34. PMID: 18805044.
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      176. Paccione RJ, Miyazaki H, Patel V, Waseem A, Gutkind J, Zehner ZE, Yeudall WA. Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility. Mol Cancer Ther. 2008 Sep; 7(9):2894-903. PMID: 18790770.
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      177. Squarize CH, Castilho RM, Gutkind J. Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin. Cancer Res. 2008 Sep 1; 68(17):7066-72. PMID: 18757421.
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      178. Gavard J, Gutkind J. Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q. J Biol Chem. 2008 Oct 31; 283(44):29888-96. PMID: 18713748.
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      179. Gavard J, Gutkind J. VE-cadherin and claudin-5: it takes two to tango. Nat Cell Biol. 2008 Aug; 10(8):883-5. PMID: 18670447; PMCID: PMC2666287.
      180. Sausville J, Molinolo AA, Cheng X, Frampton J, Takebe N, Gutkind J, Feldman RA. RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development. Clin Cancer Res. 2008 Jun 15; 14(12):3948-55. PMID: 18559617.
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      181. Lyons JG, Patel V, Roue NC, Fok SY, Soon LL, Halliday GM, Gutkind J. Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes. Cancer Res. 2008 Jun 15; 68(12):4525-30. PMID: 18559496.
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      182. Sun C, Dobi A, Mohamed A, Li H, Thangapazham RL, Furusato B, Shaheduzzaman S, Tan SH, Vaidyanathan G, Whitman E, Hawksworth DJ, Chen Y, Nau M, Patel V, Vahey M, Gutkind J, Sreenath T, Petrovics G, Sesterhenn IA, McLeod DG, Srivastava S. TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene. 2008 Sep 11; 27(40):5348-53. PMID: 18542058.
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      183. Turjanski AG, Gutkind J, Best RB, Hummer G. Binding-induced folding of a natively unstructured transcription factor. PLoS Comput Biol. 2008 Apr; 4(4):e1000060. PMID: 18404207.
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      184. Amornphimoltham P, Patel V, Leelahavanichkul K, Abraham RT, Gutkind J. A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer. Cancer Res. 2008 Feb 15; 68(4):1144-53. PMID: 18281490.
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      185. Patel V, Hood BL, Molinolo AA, Lee NH, Conrads TP, Braisted JC, Krizman DB, Veenstra TD, Gutkind J. Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res. 2008 Feb 15; 14(4):1002-14. PMID: 18281532.
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      186. Tan W, Palmby TR, Gavard J, Amornphimoltham P, Zheng Y, Gutkind J. An essential role for Rac1 in endothelial cell function and vascular development. FASEB J. 2008 Jun; 22(6):1829-38. PMID: 18245172.
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      187. Zhou G, Xie TX, Zhao M, Jasser SA, Younes MN, Sano D, Lin J, Kupferman ME, Santillan AA, Patel V, Gutkind J, Ei-Naggar AK, Emberley ED, Watson PH, Matsuzawa SI, Reed JC, Myers JN. Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity. Oncogene. 2008 Jun 5; 27(25):3527-38. PMID: 18223693.
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      188. Gavard J, Patel V, Gutkind J. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell. 2008 Jan; 14(1):25-36. PMID: 18194650.
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      189. Wolf J, Palmby TR, Gavard J, Williams BO, Gutkind J. Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6. FEBS Lett. 2008 Jan 23; 582(2):255-61. PMID: 18083125.
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      190. Wirth A, Benyó Z, Lukasova M, Leutgeb B, Wettschureck N, Gorbey S, Orsy P, Horváth B, Maser-Gluth C, Greiner E, Lemmer B, Schütz G, Gutkind J, Offermanns S. G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan; 14(1):64-8. PMID: 18084302.
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      191. Liu S, Wang H, Currie BM, Molinolo A, Leung HJ, Moayeri M, Basile JR, Alfano RW, Gutkind J, Frankel AE, Bugge TH, Leppla SH. Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature. J Biol Chem. 2008 Jan 4; 283(1):529-40. PMID: 17974567.
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      192. Martin D, Galisteo R, Ji Y, Montaner S, Gutkind J. An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia. Oncogene. 2008 Mar 20; 27(13):1844-52. PMID: 17934524.
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      193. Martín MJ, Tanos T, García AB, Martin D, Gutkind J, Coso OA, Marinissen MJ. The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis. J Biol Chem. 2007 Nov 23; 282(47):34510-24. PMID: 17881360.
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      194. Basile JR, Gavard J, Gutkind J. Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. J Biol Chem. 2007 Nov 30; 282(48):34888-95. PMID: 17855350.
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      195. Molinolo AA, Hewitt SM, Amornphimoltham P, Keelawat S, Rangdaeng S, Meneses García A, Raimondi AR, Jufe R, Itoiz M, Gao Y, Saranath D, Kaleebi GS, Yoo GH, Leak L, Myers EM, Shintani S, Wong D, Massey HD, Yeudall WA, Lonardo F, Ensley J, Gutkind J. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res. 2007 Sep 1; 13(17):4964-73. PMID: 17785546.
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      196. Liu H, Fergusson MM, Castilho RM, Liu J, Cao L, Chen J, Malide D, Rovira II, Schimel D, Kuo CJ, Gutkind J, Hwang PM, Finkel T. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 2007 Aug 10; 317(5839):803-6. PMID: 17690294.
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      197. Kesavapany S, Patel V, Zheng YL, Pareek TK, Bjelogrlic M, Albers W, Amin N, Jaffe H, Gutkind J, Strong MJ, Grant P, Pant HC. Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol Biol Cell. 2007 Sep; 18(9):3645-55. PMID: 17626162.
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      198. Wagenaar-Miller RA, Engelholm LH, Gavard J, Yamada SS, Gutkind J, Behrendt N, Bugge TH, Holmbeck K. Complementary roles of intracellular and pericellular collagen degradation pathways in vivo. Mol Cell Biol. 2007 Sep; 27(18):6309-22. PMID: 17620416.
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      199. Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, Gutkind J, Vázquez-Prado J. P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem. 2007 Aug 10; 282(32):23708-15. PMID: 17565979.
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      200. Honjo Y, Bian Y, Kawakami K, Molinolo A, Longenecker G, Boppana R, Larsson J, Karlsson S, Gutkind J, Puri RK, Kulkarni AB. TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma. Cell Cycle. 2007 Jun 1; 6(11):1360-6. PMID: 17534148.
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      201. Turjanski AG, Vaqué JP, Gutkind J. MAP kinases and the control of nuclear events. Oncogene. 2007 May 14; 26(22):3240-53. PMID: 17496919.
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      202. Castilho RM, Squarize CH, Patel V, Millar SE, Zheng Y, Molinolo A, Gutkind J. Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells. Oncogene. 2007 Aug 2; 26(35):5078-85. PMID: 17334398.
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      203. Touge H, Chikumi H, Igishi T, Kurai J, Makino H, Tamura Y, Takata M, Yoneda K, Nakamoto M, Suyama H, Gutkind J, Shimizu E. Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors. Int J Oncol. 2007 Mar; 30(3):709-15. PMID: 17273773.
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      204. Gavard J, Gutkind J. [VE-cadherin takes a walk on the wild side]. Med Sci (Paris). 2007 Feb; 23(2):119-21. PMID: 17291415.
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      205. Dorsam RT, Gutkind J. G-protein-coupled receptors and cancer. Nat Rev Cancer. 2007 Feb; 7(2):79-94. PMID: 17251915.
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      206. Patel V, Rosenfeldt HM, Lyons R, Servitja JM, Bustelo XR, Siroff M, Gutkind J. Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. Carcinogenesis. 2007 Jun; 28(6):1145-52. PMID: 17234718.
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      207. Basile JR, Holmbeck K, Bugge TH, Gutkind J. MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D. J Biol Chem. 2007 Mar 2; 282(9):6899-905. PMID: 17204469.
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      208. Rosenfeldt H, Castellone MD, Randazzo PA, Gutkind J. Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk. J Mol Signal. 2006; 1:8. PMID: 17224083.
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      209. Castellone MD, Teramoto H, Gutkind J. Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. Cancer Res. 2006 Dec 1; 66(23):11085-8. PMID: 17145847.
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      210. Gavard J, Gutkind J. VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin. Nat Cell Biol. 2006 Nov; 8(11):1223-34. PMID: 17060906.
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      211. Tan W, Martin D, Gutkind J. The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4. J Biol Chem. 2006 Dec 22; 281(51):39542-9. PMID: 17056591.
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      212. Squarize CH, Castilho RM, Sriuranpong V, Pinto DS, Gutkind J. Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia. 2006 Sep; 8(9):733-46. PMID: 16984731.
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      213. Yu X, Munge B, Patel V, Jensen G, Bhirde A, Gong JD, Kim SN, Gillespie J, Gutkind J, Papadimitrakopoulos F, Rusling JF. Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J Am Chem Soc. 2006 Aug 30; 128(34):11199-205. PMID: 16925438; NIHMSID: NIHMS47728.
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      214. Kesavapany S, Pareek TK, Zheng YL, Amin N, Gutkind J, Ma W, Kulkarni AB, Grant P, Pant HC. Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1. Neurosignals. 2006-2007; 15(4):157-73. PMID: 16921254.
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      215. Sodhi A, Chaisuparat R, Hu J, Ramsdell AK, Manning BD, Sausville EA, Sawai ET, Molinolo A, Gutkind J, Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell. 2006 Aug; 10(2):133-43. PMID: 16904612.
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      216. Teramoto H, Miwa H, Patel V, Letwin N, Castellone MD, Imai N, Shikami M, Imamura A, Gutkind J, Nitta M, Lee NH. Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray. Clin Lab Haematol. 2006 Aug; 28(4):262-6. PMID: 16898967.
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      217. Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind J, Berman DM. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer. 2006 Jun 15; 106(12):2716-24. PMID: 16691626.
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      218. Basile JR, Castilho RM, Williams VP, Gutkind J. Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9017-22. PMID: 16754882.
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      219. Raimondi AR, Vitale-Cross L, Amornphimoltham P, Gutkind J, Molinolo A. Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter. Am J Pathol. 2006 May; 168(5):1654-65. PMID: 16651631.
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      220. Miyazaki H, Patel V, Wang H, Edmunds RK, Gutkind J, Yeudall WA. Down-regulation of CXCL5 inhibits squamous carcinogenesis. Cancer Res. 2006 Apr 15; 66(8):4279-84. PMID: 16618752.
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      221. Gelbard A, Garnett CT, Abrams SI, Patel V, Gutkind J, Palena C, Tsang KY, Schlom J, Hodge JW. Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis. Clin Cancer Res. 2006 Mar 15; 12(6):1897-905. PMID: 16551875.
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      222. Kehat I, Heinrich R, Ben-Izhak O, Miyazaki H, Gutkind J, Aronheim A. Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation. Cardiovasc Res. 2006 Jun 01; 70(3):543-54. PMID: 16631626.
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      223. Kaur S, Castellone MD, Bedell VM, Konar M, Gutkind J, Ramchandran R. Robo4 signaling in endothelial cells implies attraction guidance mechanisms. J Biol Chem. 2006 Apr 21; 281(16):11347-56. PMID: 16481322.
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      224. Montaner S, Sodhi A, Ramsdell AK, Martin D, Hu J, Sawai ET, Gutkind J. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma. Cancer Res. 2006 Jan 1; 66(1):168-74. PMID: 16397229.
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      225. Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind J. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science. 2005 Dec 2; 310(5753):1504-10. PMID: 16293724.
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      226. Miyazaki H, Patel V, Wang H, Ensley JF, Gutkind J, Yeudall WA. Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis. Oral Oncol. 2006 Mar; 42(3):240-56. PMID: 16266819.
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      227. Amornphimoltham P, Patel V, Sodhi A, Nikitakis NG, Sauk JJ, Sausville EA, Molinolo AA, Gutkind J. Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res. 2005 Nov 1; 65(21):9953-61. PMID: 16267020.
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      228. Monje P, Hernández-Losa J, Lyons RJ, Castellone MD, Gutkind J. Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. J Biol Chem. 2005 Oct 21; 280(42):35081-4. PMID: 16123044.
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      229. List K, Szabo R, Molinolo A, Sriuranpong V, Redeye V, Murdock T, Burke B, Nielsen BS, Gutkind J, Bugge TH. Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev. 2005 Aug 15; 19(16):1934-50. PMID: 16103220.
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      230. Basile JR, Afkhami T, Gutkind J. Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway. Mol Cell Biol. 2005 Aug; 25(16):6889-98. PMID: 16055703.
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      231. Yeudall WA, Miyazaki H, Ensley JF, Cardinali M, Gutkind J, Patel V. Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression. Oral Oncol. 2005 Aug; 41(7):698-708. PMID: 15935723.
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      232. Marinissen MJ, Gutkind J. Scaffold proteins dictate Rho GTPase-signaling specificity. Trends Biochem Sci. 2005 Aug; 30(8):423-6. PMID: 15996870.
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      233. Patel V, Ramesh A, Traicoff JL, Baibakov G, Emmert-Buck MR, Gutkind J, Knezevic V. Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology. Oral Oncol. 2005 May; 41(5):503-8. PMID: 15878755.
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      234. Dennis PA, Van Waes C, Gutkind J, Kellar KJ, Vinson C, Mukhin AG, Spitz MR, Bailey-Wilson JE, Yeh GC, Anderson LM, Wiest JS. The biology of tobacco and nicotine: bench to bedside. Cancer Epidemiol Biomarkers Prev. 2005 Apr; 14(4):764-7. PMID: 15824140.
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      235. Tanos T, Marinissen MJ, Leskow FC, Hochbaum D, Martinetto H, Gutkind J, Coso OA. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem. 2005 May 13; 280(19):18842-52. PMID: 15708845.
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      236. Brantley E, Patel V, Stinson SF, Trapani V, Hose CD, Ciolino HP, Yeh GC, Gutkind J, Sausville EA, Loaiza-Pérez AI. The antitumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces NF-kappaB activity in drug-sensitive MCF-7 cells. Anticancer Drugs. 2005 Feb; 16(2):137-43. PMID: 15655410.
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      237. Baker H, Patel V, Molinolo AA, Shillitoe EJ, Ensley JF, Yoo GH, Meneses-García A, Myers JN, El-Naggar AK, Gutkind J, Hancock WS. Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry. Oral Oncol. 2005 Feb; 41(2):183-99. PMID: 15695121.
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      238. Teramoto H, Castellone MD, Malek RL, Letwin N, Frank B, Gutkind J, Lee NH. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12. Oncogene. 2005 Jan 13; 24(3):489-501. PMID: 15516973.
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      239. Vitale-Cross L, Amornphimoltham P, Fisher G, Molinolo AA, Gutkind J. Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res. 2004 Dec 15; 64(24):8804-7. PMID: 15604235.
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      240. Sodhi A, Montaner S, Gutkind J. Viral hijacking of G-protein-coupled-receptor signalling networks. Nat Rev Mol Cell Biol. 2004 Dec; 5(12):998-1012. PMID: 15573137.
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      241. Curino A, Patel V, Nielsen BS, Iskander AJ, Ensley JF, Yoo GH, Holsinger FC, Myers JN, El-Nagaar A, Kellman RM, Shillitoe EJ, Molinolo AA, Gutkind J, Bugge TH. Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography. Oral Oncol. 2004 Nov; 40(10):1026-32. PMID: 15509494.
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      242. Jeon GA, Lee JS, Patel V, Gutkind J, Thorgeirsson SS, Kim EC, Chu IS, Amornphimoltham P, Park MH. Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer. 2004 Nov 1; 112(2):249-58. PMID: 15352037.
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      243. Vázquez-Prado J, Miyazaki H, Castellone MD, Teramoto H, Gutkind J. Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13. J Biol Chem. 2004 Dec 24; 279(52):54283-90. PMID: 15485891.
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      244. Rosenfeldt H, Vázquez-Prado J, Gutkind J. P-REX2, a novel PI-3-kinase sensitive Rac exchange factor. FEBS Lett. 2004 Aug 13; 572(1-3):167-71. PMID: 15304342.
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      245. Sriuranpong V, Mutirangura A, Gillespie JW, Patel V, Amornphimoltham P, Molinolo AA, Kerekhanjanarong V, Supanakorn S, Supiyaphun P, Rangdaeng S, Voravud N, Gutkind J. Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays. Clin Cancer Res. 2004 Aug 1; 10(15):4944-58. PMID: 15297395.
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      246. Basile JR, Barac A, Zhu T, Guan KL, Gutkind J. Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B. Cancer Res. 2004 Aug 1; 64(15):5212-24. PMID: 15289326.
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      247. Montaner S, Sodhi A, Servitja JM, Ramsdell AK, Barac A, Sawai ET, Gutkind J. The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia. Blood. 2004 Nov 1; 104(9):2903-11. PMID: 15231571.
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      248. Amornphimoltham P, Sriuranpong V, Patel V, Benavides F, Conti CJ, Sauk J, Sausville EA, Molinolo AA, Gutkind J. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 1):4029-37. PMID: 15217935.
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      249. Oliva JL, Zarich N, Martínez N, Jorge R, Castrillo A, Azañedo M, García-Vargas S, Gutiérrez-Eisman S, Juarranz A, Boscá L, Gutkind J, Rojas JM. The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras. J Biol Chem. 2004 Aug 6; 279(32):33480-91. PMID: 15181015.
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      250. Kesavapany S, Amin N, Zheng YL, Nijhara R, Jaffe H, Sihag R, Gutkind J, Takahashi S, Kulkarni A, Grant P, Pant HC. p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. J Neurosci. 2004 May 5; 24(18):4421-31. PMID: 15128856.
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      251. Marinissen MJ, Chiariello M, Tanos T, Bernard O, Narumiya S, Gutkind J. The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis. Mol Cell. 2004 Apr 9; 14(1):29-41. PMID: 15068801.
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      252. Sodhi A, Montaner S, Patel V, Gómez-Román JJ, Li Y, Sausville EA, Sawai ET, Gutkind J. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci U S A. 2004 Apr 6; 101(14):4821-6. PMID: 15047889.
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      253. Sodhi A, Montaner S, Gutkind J. Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis? FASEB J. 2004 Mar; 18(3):422-7. PMID: 15003988.
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      254. Chikumi H, Barac A, Behbahani B, Gao Y, Teramoto H, Zheng Y, Gutkind J. Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. Oncogene. 2004 Jan 8; 23(1):233-40. PMID: 14712228.
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      255. Crespo P, Gutkind J. Activation of MAPKs by G protein-coupled receptors. Methods Mol Biol. 2004; 250:203-10. PMID: 14755090.
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      256. Vázquez-Prado J, Basile J, Gutkind J. Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors. Methods Enzymol. 2004; 390:259-85. PMID: 15488183.
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      257. Barac A, Basile J, Vázquez-Prado J, Gao Y, Zheng Y, Gutkind J. Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J Biol Chem. 2004 Feb 13; 279(7):6182-9. PMID: 14625312.
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      258. Monje P, Marinissen MJ, Gutkind J. Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol. 2003 Oct; 23(19):7030-43. PMID: 12972619.
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      259. Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind J, Hitsuda Y, Shimizu E. Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells. Int J Oncol. 2003 Oct; 23(4):1079-85. PMID: 12963988.
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      260. Iavarone C, Catania A, Marinissen MJ, Visconti R, Acunzo M, Tarantino C, Carlomagno MS, Bruni CB, Gutkind J, Chiariello M. The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway. J Biol Chem. 2003 Dec 12; 278(50):50024-30. PMID: 14523011.
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      261. Marinissen MJ, Servitja JM, Offermanns S, Simon MI, Gutkind J. Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation. J Biol Chem. 2003 Nov 21; 278(47):46814-25. PMID: 12954641.
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      262. Pedersen TX, Leethanakul C, Patel V, Mitola D, Lund LR, Danø K, Johnsen M, Gutkind J, Bugge TH. Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma. Oncogene. 2003 Jun 19; 22(25):3964-76. PMID: 12813470.
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      263. Servitja JM, Marinissen MJ, Sodhi A, Bustelo XR, Gutkind J. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem. 2003 Sep 5; 278(36):34339-46. PMID: 12810717.
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      264. Sriuranpong V, Park JI, Amornphimoltham P, Patel V, Nelkin BD, Gutkind J. Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 2003 Jun 1; 63(11):2948-56. PMID: 12782602.
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      265. Teramoto H, Malek RL, Behbahani B, Castellone MD, Lee NH, Gutkind J. Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes. Oncogene. 2003 May 1; 22(17):2689-97. PMID: 12730683.
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      266. Leethanakul C, Knezevic V, Patel V, Amornphimoltham P, Gillespie J, Shillitoe EJ, Emko P, Park MH, Emmert-Buck MR, Strausberg RL, Krizman DB, Gutkind J. Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis. Oral Oncol. 2003 Apr; 39(3):248-58. PMID: 12618197.
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      267. Nishigaki K, Thompson D, Yugawa T, Rulli K, Hanson C, Cmarik J, Gutkind J, Teramoto H, Ruscetti S. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. J Biol Chem. 2003 Apr 11; 278(15):13520-30. PMID: 12574163.
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      268. Servitja JM, Masgrau R, Pardo R, Sarri E, von Eichel-Streiber C, Gutkind J, Picatoste F. Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Neuropharmacology. 2003 Feb; 44(2):171-80. PMID: 12623215.
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      269. Montaner S, Sodhi A, Molinolo A, Bugge TH, Sawai ET, He Y, Li Y, Ray PE, Gutkind J. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell. 2003 Jan; 3(1):23-36. PMID: 12559173.
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      270. Patel V, Lahusen T, Leethanakul C, Igishi T, Kremer M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind J, Senderowicz AM. Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1). Clin Cancer Res. 2002 Nov; 8(11):3549-60. PMID: 12429646.
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      271. Katz BZ, Miyamoto S, Teramoto H, Zohar M, Krylov D, Vinson C, Gutkind J, Yamada KM. Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim Biophys Acta. 2002 Oct 21; 1592(2):141-52. PMID: 12379477.
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      272. Guo YS, Cheng JZ, Jin GF, Gutkind J, Hellmich MR, Townsend CM. Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 13; 277(50):48755-63. PMID: 12239223.
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      273. Aurandt J, Vikis HG, Gutkind J, Ahn N, Guan KL. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12085-90. PMID: 12196628.
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      274. Perrot V, Vazquez-Prado J, Gutkind J. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. J Biol Chem. 2002 Nov 8; 277(45):43115-20. PMID: 12183458.
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      275. Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind J, Li W. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene. 2002 Aug 8; 21(34):5289-300. PMID: 12149650.
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      276. Patel V, Aldridge K, Ensley JF, Odell E, Boyd A, Jones J, Gutkind J, Yeudall WA. Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma. Int J Cancer. 2002 Jun 1; 99(4):583-8. PMID: 11992550.
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      277. Chikumi H, Vázquez-Prado J, Servitja JM, Miyazaki H, Gutkind J. Potent activation of RhoA by Galpha q and Gq-coupled receptors. J Biol Chem. 2002 Jul 26; 277(30):27130-4. PMID: 12016230.
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      278. Pece S, Gutkind J. E-cadherin and Hakai: signalling, remodeling or destruction? Nat Cell Biol. 2002 Apr; 4(4):E72-4. PMID: 11944035.
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      279. Chen HW, Marinissen MJ, Oh SW, Chen X, Melnick M, Perrimon N, Gutkind J, Hou SX. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002 Mar; 22(6):1792-803. PMID: 11865058.
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      280. Chen HW, Chen X, Oh SW, Marinissen MJ, Gutkind J, Hou SX. mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family. Genes Dev. 2002 Feb 1; 16(3):388-98. PMID: 11825879.
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      281. Orsulic S, Li Y, Soslow RA, Vitale-Cross LA, Gutkind J, Varmus HE. Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell. 2002 Feb; 1(1):53-62. PMID: 12086888; NIHMSID: NIHMS41746.
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      282. Sanchez-Prieto R, Sanchez-Arevalo VJ, Servitja JM, Gutkind J. Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene. 2002 Jan 31; 21(6):974-9. PMID: 11840343.
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      283. Sakabe K, Teramoto H, Zohar M, Behbahani B, Miyazaki H, Chikumi H, Gutkind J. Potent transforming activity of the small GTP-binding protein Rit in NIH 3T3 cells: evidence for a role of a p38gamma-dependent signaling pathway. FEBS Lett. 2002 Jan 30; 511(1-3):15-20. PMID: 11821041.
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      284. Chikumi H, Fukuhara S, Gutkind J. Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. J Biol Chem. 2002 Apr 5; 277(14):12463-73. PMID: 11799111.
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      285. Murga C, Zohar M, Teramoto H, Gutkind J. Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB. Oncogene. 2002 Jan 10; 21(2):207-16. PMID: 11803464.
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      286. Segrelles C, Ruiz S, Perez P, Murga C, Santos M, Budunova IV, Martínez J, Larcher F, Slaga TJ, Gutkind J, Jorcano JL, Paramio JM. Functional roles of Akt signaling in mouse skin tumorigenesis. Oncogene. 2002 Jan 3; 21(1):53-64. PMID: 11791176.
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      287. Chiariello M, Gutkind J. Regulation of mitogen-activated protein kinases by G-protein-coupled receptors. Methods Enzymol. 2002; 345:437-47. PMID: 11665627.
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      288. Knezevic V, Leethanakul C, Bichsel VE, Worth JM, Prabhu VV, Gutkind J, Liotta LA, Munson PJ, Petricoin EF, Krizman DB. Proteomic profiling of the cancer microenvironment by antibody arrays. Proteomics. 2001 Oct; 1(10):1271-8. PMID: 11721638.
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      289. Sodhi A, Montaner S, Miyazaki H, Gutkind J. MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF. Biochem Biophys Res Commun. 2001 Sep 14; 287(1):292-300. PMID: 11549290.
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      290. Longenecker KL, Lewis ME, Chikumi H, Gutkind J, Derewenda ZS. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. Structure. 2001 Jul 3; 9(7):559-69. PMID: 11470431.
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      291. Marinissen MJ, Gutkind J. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci. 2001 Jul; 22(7):368-76. PMID: 11431032.
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      292. Chiariello M, Marinissen MJ, Gutkind J. Regulation of c-myc expression by PDGF through Rho GTPases. Nat Cell Biol. 2001 Jun; 3(6):580-6. PMID: 11389443.
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      293. Fukuhara S, Chikumi H, Gutkind J. RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? Oncogene. 2001 Mar 26; 20(13):1661-8. PMID: 11313914.
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      294. Montaner S, Sodhi A, Pece S, Mesri EA, Gutkind J. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res. 2001 Mar 15; 61(6):2641-8. PMID: 11289142.
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      295. Marinissen MJ, Chiariello M, Gutkind J. Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. Genes Dev. 2001 Mar 1; 15(5):535-53. PMID: 11238375.
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      296. Dong F, Gutkind J, Larner AC. Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. J Biol Chem. 2001 Apr 6; 276(14):10811-6. PMID: 11278431.
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      297. Patel V, Leethanakul C, Gutkind J. New approaches to the understanding of the molecular basis of oral cancer. Crit Rev Oral Biol Med. 2001; 12(1):55-63. PMID: 11349962.
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      298. Pece S, Gutkind J. Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation. J Biol Chem. 2000 Dec 29; 275(52):41227-33. PMID: 10969083.
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      299. Patel V, Ensley JF, Gutkind J, Yeudall WA. Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent. Int J Cancer. 2000 Dec 1; 88(5):737-43. PMID: 11072242.
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      300. Fukuhara S, Chikumi H, Gutkind J. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. FEBS Lett. 2000 Nov 24; 485(2-3):183-8. PMID: 11094164.
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      301. Hyun T, Yam A, Pece S, Xie X, Zhang J, Miki T, Gutkind J, Li W. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood. 2000 Nov 15; 96(10):3560-8. PMID: 11071655.
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      302. Du Villard JA, Wicker R, Crespo P, Russo D, Filetti S, Gutkind J, Sarasin A, Suárez HG. Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation. Oncogene. 2000 Oct 5; 19(42):4896-905. PMID: 11039907.
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      303. Visconti R, Gadina M, Chiariello M, Chen EH, Stancato LF, Gutkind J, O'Shea JJ. Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood. 2000 Sep 1; 96(5):1844-52. PMID: 10961885.
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      304. Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind J. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res. 2000 Sep 1; 60(17):4873-80. PMID: 10987301.
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      305. Leethanakul C, Patel V, Gillespie J, Shillitoe E, Kellman RM, Ensley JF, Limwongse V, Emmert-Buck MR, Krizman DB, Gutkind J. Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries. Oral Oncol. 2000 Sep; 36(5):474-83. PMID: 10964057.
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      306. Chiariello M, Gomez E, Gutkind J. Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase. Biochem J. 2000 Aug 1; 349 Pt 3:869-76. PMID: 10903150.
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      307. Izevbigie EB, Gutkind J, Ray PE. Isoproterenol inhibits fibroblast growth factor-2-induced growth of renal epithelial cells. Pediatr Nephrol. 2000 Aug; 14(8-9):726-34. PMID: 10955916.
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      308. Pirone DM, Fukuhara S, Gutkind J, Burbelo PD. SPECs, small binding proteins for Cdc42. J Biol Chem. 2000 Jul 28; 275(30):22650-6. PMID: 10816584.
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      309. Fukuhara S, Marinissen MJ, Chiariello M, Gutkind J. Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway. J Biol Chem. 2000 Jul 14; 275(28):21730-6. PMID: 10781600.
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      310. Gutkind J. Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. Sci STKE. 2000 Jul 11; 2000(40):re1. PMID: 11752597.
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      311. Leethanakul C, Patel V, Gillespie J, Pallente M, Ensley JF, Koontongkaew S, Liotta LA, Emmert-Buck M, Gutkind J. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene. 2000 Jun 29; 19(28):3220-4. PMID: 10918578.
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      312. Katz BZ, Zohar M, Teramoto H, Matsumoto K, Gutkind J, Lin DC, Lin S, Yamada KM. Tensin can induce JNK and p38 activation. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):717-20. PMID: 10860821.
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      313. Sanchez-Prieto R, Rojas JM, Taya Y, Gutkind J. A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents. Cancer Res. 2000 May 1; 60(9):2464-72. PMID: 10811125.
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      314. Fukuhara S, Gutkind J. A new twist for the tumour suppressor hamartin. Nat Cell Biol. 2000 May; 2(5):E76-8. PMID: 10806489.
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      315. Izevbigie EB, Gutkind J, Ray PE. Angiotensin II and basic fibroblast growth factor mitogenic pathways in human fetal mesangial cells. Pediatr Res. 2000 May; 47(5):614-21. PMID: 10813586.
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      316. Murga C, Fukuhara S, Gutkind J. A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J Biol Chem. 2000 Apr 21; 275(16):12069-73. PMID: 10766839.
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      317. Majidi M, Gutkind J, Lichy JH. Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. J Biol Chem. 2000 Mar 3; 275(9):6560-5. PMID: 10692462.
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      318. Chiariello M, Marinissen MJ, Gutkind J. Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation. Mol Cell Biol. 2000 Mar; 20(5):1747-58. PMID: 10669751.
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      319. Chiang YJ, Kole HK, Brown K, Naramura M, Fukuhara S, Hu RJ, Jang IK, Gutkind J, Shevach E, Gu H. Cbl-b regulates the CD28 dependence of T-cell activation. Nature. 2000 Jan 13; 403(6766):216-20. PMID: 10646609.
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      320. Shillitoe EJ, May M, Patel V, Lethanakul C, Ensley JF, Strausberg RL, Gutkind J. Genome-wide analysis of oral cancer--early results from the Cancer Genome Anatomy Project. Oral Oncol. 2000 Jan; 36(1):8-16. PMID: 10889913.
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      321. Tassi E, Biesova Z, Di Fiore PP, Gutkind J, Wong WT. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. J Biol Chem. 1999 Nov 19; 274(47):33287-95. PMID: 10559204.
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      322. Igishi T, Fukuhara S, Patel V, Katz BZ, Yamada KM, Gutkind J. Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation. J Biol Chem. 1999 Oct 22; 274(43):30738-46. PMID: 10521463.
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      323. Pece S, Chiariello M, Murga C, Gutkind J. Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex. J Biol Chem. 1999 Jul 2; 274(27):19347-51. PMID: 10383446.
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      324. Marinissen MJ, Chiariello M, Pallante M, Gutkind J. A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5. Mol Cell Biol. 1999 Jun; 19(6):4289-301. PMID: 10330170.
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      325. Soon L, Flechner L, Gutkind J, Wang LH, Baserga R, Pierce JH, Li W. Insulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression. Mol Cell Biol. 1999 May; 19(5):3816-28. PMID: 10207105.
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      326. Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind J. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. J Biol Chem. 1999 Feb 26; 274(9):5868-79. PMID: 10026210.
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      327. Janulis M, Silberman S, Ambegaokar A, Gutkind J, Schultz RM. Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts. J Biol Chem. 1999 Jan 8; 274(2):801-13. PMID: 9873019.
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      328. Patel V, Senderowicz AM, Pinto D, Igishi T, Raffeld M, Quintanilla-Martinez L, Ensley JF, Sausville EA, Gutkind J. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis. J Clin Invest. 1998 Nov 1; 102(9):1674-81. PMID: 9802881.
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      329. Burstein ES, Hesterberg DJ, Gutkind J, Brann MR, Currier EA, Messier TL. The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors. Oncogene. 1998 Sep 24; 17(12):1617-23. PMID: 9794239.
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      330. Gutkind J. Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene. 1998 Sep 17; 17(11 Reviews):1331-42. PMID: 9779981.
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      331. Zohar M, Teramoto H, Katz BZ, Yamada KM, Gutkind J. Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation. Oncogene. 1998 Aug 27; 17(8):991-8. PMID: 9747878.
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      332. Murga C, Laguinge L, Wetzker R, Cuadrado A, Gutkind J. Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma. J Biol Chem. 1998 Jul 24; 273(30):19080-5. PMID: 9668091.
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      333. Deb TB, Wong L, Salomon DS, Zhou G, Dixon JE, Gutkind J, Thompson SA, Johnson GR. A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation. J Biol Chem. 1998 Jul 3; 273(27):16643-6. PMID: 9642214.
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      334. Chiariello M, Visconti R, Carlomagno F, Melillo RM, Bucci C, de Franciscis V, Fox GM, Jing S, Coso OA, Gutkind J, Fusco A, Santoro M. Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene. 1998 May 14; 16(19):2435-45. PMID: 9627110.
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      335. Crespo P, Font de Mora J, Aaronson DS, Santos E, Gutkind J. Transforming G protein-coupled receptors block insulin and ras-induced adipocytic differentiation in 3T3-L1 cells: evidence for a PKC and MAP kinase independent pathway. Biochem Biophys Res Commun. 1998 Apr 17; 245(2):554-61. PMID: 9571194.
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      336. Igishi T, Gutkind J. Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. Biochem Biophys Res Commun. 1998 Mar 6; 244(1):5-10. PMID: 9514877.
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      337. Jones TL, Gutkind J. Galpha12 requires acylation for its transforming activity. Biochemistry. 1998 Mar 3; 37(9):3196-202. PMID: 9485474.
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      338. Lopez-Ilasaca M, Gutkind J, Wetzker R. Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation. J Biol Chem. 1998 Jan 30; 273(5):2505-8. PMID: 9446550.
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      339. Gutkind J. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem. 1998 Jan 23; 273(4):1839-42. PMID: 9442012.
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      340. Bais C, Santomasso B, Coso O, Arvanitakis L, Raaka EG, Gutkind J, Asch AS, Cesarman E, Gershengorn MC, Mesri EA, Gerhengorn MC. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 1998 Jan 1; 391(6662):86-9. PMID: 9422510.
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      341. Liu JL, Blakesley VA, Gutkind J, LeRoith D. The constitutively active mutant Galpha13 transforms mouse fibroblast cells deficient in insulin-like growth factor-I receptor. J Biol Chem. 1997 Nov 21; 272(47):29438-41. PMID: 9368001.
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      342. Bustelo XR, Crespo P, López-Barahona M, Gutkind J, Barbacid M. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene. 1997 Nov 20; 15(21):2511-20. PMID: 9399639.
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      343. Jin DY, Teramoto H, Giam CZ, Chun RF, Gutkind J, Jeang KT. A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha. J Biol Chem. 1997 Oct 10; 272(41):25816-23. PMID: 9325311.
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      344. Fromm C, Coso OA, Montaner S, Xu N, Gutkind J. The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10098-103. PMID: 9294169.
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      345. Coso OA, Montaner S, Fromm C, Lacal JC, Prywes R, Teramoto H, Gutkind J. Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway. J Biol Chem. 1997 Aug 15; 272(33):20691-7. PMID: 9252389.
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      346. Alimandi M, Heidaran MA, Gutkind J, Zhang J, Ellmore N, Valius M, Kazlauskas A, Pierce JH, Li W. PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene. 1997 Jul 31; 15(5):585-93. PMID: 9247312.
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      347. Teramoto H, Salem P, Robbins KC, Bustelo XR, Gutkind J. Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway. J Biol Chem. 1997 Apr 18; 272(16):10751-5. PMID: 9099726.
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      348. Lopez-Ilasaca M, Li W, Uren A, Yu JC, Kazlauskas A, Gutkind J, Heidaran MA. Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Biochem Biophys Res Commun. 1997 Mar 17; 232(2):273-7. PMID: 9125162.
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      349. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind J, Wetzker R. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science. 1997 Jan 17; 275(5298):394-7. PMID: 8994038.
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      350. Crespo P, Schuebel KE, Ostrom AA, Gutkind J, Bustelo XR. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature. 1997 Jan 9; 385(6612):169-72. PMID: 8990121.
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      351. Gutkind J, Crespo P, Xu N, Teramoto H, Coso OA. The pathway connecting m2 receptors to the nucleus involves small GTP-binding proteins acting on divergent MAP kinase cascades. Life Sci. 1997; 60(13-14):999-1006. PMID: 9121367.
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      352. Zhang S, Coso OA, Lee C, Gutkind J, Simonds WF. Selective activation of effector pathways by brain-specific G protein beta5. J Biol Chem. 1996 Dec 27; 271(52):33575-9. PMID: 8969224.
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      353. Miyamoto S, Teramoto H, Gutkind J, Yamada KM. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol. 1996 Dec; 135(6 Pt 1):1633-42. PMID: 8978828.
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      354. Teramoto H, Coso OA, Miyata H, Igishi T, Miki T, Gutkind J. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J Biol Chem. 1996 Nov 1; 271(44):27225-8. PMID: 8910292.
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      355. Teramoto H, Crespo P, Coso OA, Igishi T, Xu N, Gutkind J. The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway. J Biol Chem. 1996 Oct 18; 271(42):25731-4. PMID: 8824197.
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      356. Sundaresan M, Yu ZX, Ferrans VJ, Sulciner DJ, Gutkind J, Irani K, Goldschmidt-Clermont PJ, Finkel T. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J. 1996 Sep 1; 318 ( Pt 2):379-82. PMID: 8809022; PMCID: PMC1217632.
      357. Zhang S, Coso OA, Collins R, Gutkind J, Simonds WF. A C-terminal mutant of the G protein beta subunit deficient in the activation of phospholipase C-beta. J Biol Chem. 1996 Aug 16; 271(33):20208-12. PMID: 8702747.
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      358. Crespo P, Bustelo XR, Aaronson DS, Coso OA, Lopez-Barahona M, Barbacid M, Gutkind J. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene. 1996 Aug 1; 13(3):455-60. PMID: 8760286.
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      359. Kieser A, Seitz T, Adler HS, Coffer P, Kremmer E, Crespo P, Gutkind J, Henderson DW, Mushinski JF, Kolch W, Mischak H. Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells. Genes Dev. 1996 Jun 15; 10(12):1455-66. PMID: 8666230.
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      360. Coso OA, Teramoto H, Simonds WF, Gutkind J. Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J Biol Chem. 1996 Feb 23; 271(8):3963-6. PMID: 8626724.
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      361. Xu N, Coso O, Mahadevan D, De Blasi A, Goldsmith PK, Simonds WF, Gutkind J. The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins. Cell Mol Neurobiol. 1996 Feb; 16(1):51-9. PMID: 8714559.
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      362. Miyamoto S, Teramoto H, Coso OA, Gutkind J, Burbelo PD, Akiyama SK, Yamada KM. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol. 1995 Nov; 131(3):791-805. PMID: 7593197.
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      363. Crespo P, Cachero TG, Xu N, Gutkind J. Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition. J Biol Chem. 1995 Oct 20; 270(42):25259-65. PMID: 7559665.
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      364. Crespo P, Mischak H, Gutkind J. Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells. Biochem Biophys Res Commun. 1995 Aug 4; 213(1):266-72. PMID: 7639744.
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      365. Coso OA, Chiariello M, Yu JC, Teramoto H, Crespo P, Xu N, Miki T, Gutkind J. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell. 1995 Jun 30; 81(7):1137-46. PMID: 7600581.
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      366. Coso OA, Chiariello M, Kalinec G, Kyriakis JM, Woodgett J, Gutkind J. Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. J Biol Chem. 1995 Mar 10; 270(10):5620-4. PMID: 7890682.
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      367. Yu JC, Gutkind J, Mahadevan D, Li W, Meyers KA, Pierce JH, Heidaran MA. Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling. J Cell Biol. 1994 Oct; 127(2):479-87. PMID: 7929590; PMCID: PMC2120211.
      368. Crespo P, Xu N, Daniotti JL, Troppmair J, Rapp UR, Gutkind J. Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J Biol Chem. 1994 Aug 19; 269(33):21103-9. PMID: 8063729.
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      369. Calderon SN, Izenwasser S, Heller B, Gutkind J, Mattson MV, Su TP, Newman AH. Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands. J Med Chem. 1994 Jul 22; 37(15):2285-91. PMID: 8057277.
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      370. Xu N, Voyno-Yasenetskaya T, Gutkind J. Potent transforming activity of the G13 alpha subunit defines a novel family of oncogenes. Biochem Biophys Res Commun. 1994 Jun 15; 201(2):603-9. PMID: 8002992.
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      371. Crespo P, Xu N, Simonds WF, Gutkind J. Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature. 1994 Jun 2; 369(6479):418-20. PMID: 8196770.
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      372. Xu N, McCormick F, Gutkind J. The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors. Oncogene. 1994 Feb; 9(2):597-601. PMID: 8290270.
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      373. Xu N, Bradley L, Ambdukar I, Gutkind J. A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6741-5. PMID: 8393576.
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      374. Wang LM, Keegan AD, Li W, Lienhard GE, Pacini S, Gutkind J, Myers MG, Sun XJ, White MF, Aaronson SA. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):4032-6. PMID: 7683417.
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      375. Stephens EV, Kalinec G, Brann MR, Gutkind J. Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C. Oncogene. 1993 Jan; 8(1):19-26. PMID: 8380916.
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      376. Wang LM, Keegan AD, Paul WE, Heidaran MA, Gutkind J, Pierce JH. IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J. 1992 Dec; 11(13):4899-908. PMID: 1334461; PMCID: PMC556967.
      377. Gutkind J, Robbins KC. Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate. Biochem Biophys Res Commun. 1992 Oct 15; 188(1):155-61. PMID: 1329743.
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      378. Kalinec G, Nazarali AJ, Hermouet S, Xu N, Gutkind J. Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol Cell Biol. 1992 Oct; 12(10):4687-93. PMID: 1328859.
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      379. Thompson PA, Gutkind J, Robbins KC, Ledbetter JA, Bolen JB. Identification of distinct populations of PI-3 kinase activity following T-cell activation. Oncogene. 1992 Apr; 7(4):719-25. PMID: 1373484.
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      380. Stephan V, Benhamou M, Gutkind J, Robbins KC, Siraganian RP. Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis. J Biol Chem. 1992 Mar 15; 267(8):5434-41. PMID: 1372002.
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      381. Sartor O, Moriuchi R, Sameshima JH, Severino M, Gutkind J, Robbins KC. Diverse biologic properties imparted by the c-fgr proto-oncogene. J Biol Chem. 1992 Feb 15; 267(5):3460-5. PMID: 1737799.
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      382. Hermouet S, Merendino JJ, Gutkind J, Spiegel AM. Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells. Proc Natl Acad Sci U S A. 1991 Dec 1; 88(23):10455-9. PMID: 1660138.
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      383. Yu JC, Heidaran MA, Pierce JH, Gutkind J, Lombardi D, Ruggiero M, Aaronson SA. Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol Cell Biol. 1991 Jul; 11(7):3780-5. PMID: 1646396; PMCID: PMC361148.
      384. Gutkind J, Novotny EA, Brann MR, Robbins KC. Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci U S A. 1991 Jun 1; 88(11):4703-7. PMID: 1905013.
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      385. Gutkind J, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC. A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes. Mol Cell Biol. 1991 Mar; 11(3):1500-7. PMID: 1847500.
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      386. Gusovsky F, Gutkind J. Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation. Mol Pharmacol. 1991 Feb; 39(2):124-9. PMID: 1847491.
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      387. Heidaran MA, Pierce JH, Lombardi D, Ruggiero M, Gutkind J, Matsui T, Aaronson SA. Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol Cell Biol. 1991 Jan; 11(1):134-42. PMID: 1702511; PMCID: PMC359603.
      388. Kazanietz MG, Gutkind J, Enero MA. Effects of clenbuterol treatment on the responses to vasodilators in urethane-anaesthetized rats. J Pharm Pharmacol. 1990 Oct; 42(10):735-7. PMID: 1982150.
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      389. Gutkind J, Lacal PM, Robbins KC. Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets. Mol Cell Biol. 1990 Jul; 10(7):3806-9. PMID: 2162481.
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      390. Vukicevic S, Paralkar VM, Cunningham NS, Gutkind J, Reddi AH. Autoradiographic localization of osteogenin binding sites in cartilage and bone during rat embryonic development. Dev Biol. 1990 Jul; 140(1):209-14. PMID: 2358119.
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      391. Benhamou M, Gutkind J, Robbins KC, Siraganian RP. Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5327-30. PMID: 1695377.
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      392. Nazarali AJ, Gutkind J, Correa FM, Saavedra JM. Decreased angiotensin II receptors in subfornical organ of spontaneously hypertensive rats after chronic antihypertensive treatment with enalapril. Am J Hypertens. 1990 Jan; 3(1):59-61. PMID: 2405884.
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      393. Kazanietz MG, Gutkind J, Puyo A, Armando I, Enero MA. Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats. J Cardiovasc Pharmacol. 1989 Dec; 14(6):874-80. PMID: 2481776.
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      394. Nazarali AJ, Gutkind J, Saavedra JM. Calibration of 125I-polymer standards with 125I-brain paste standards for use in quantitative receptor autoradiography. J Neurosci Methods. 1989 Dec; 30(3):247-53. PMID: 2607785.
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      395. Notario V, Gutkind J, Imaizumi M, Katamine S, Robbins KC. Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation. J Cell Biol. 1989 Dec; 109(6 Pt 1):3129-36. PMID: 2687293.
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      396. Gutkind J, Robbins KC. Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8783-7. PMID: 2682659.
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      397. Nazarali AJ, Gutkind J, Correa FM, Saavedra JM. Enalapril decreases angiotensin II receptors in subfornical organ of SHR. Am J Physiol. 1989 Jun; 256(6 Pt 2):H1609-14. PMID: 2544109.
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      398. Gutkind J, Kazanietz MG, Armando I, Puyó A, Enero MA. Pressor response induced by clenbuterol treatment in immobilized normotensive rats. J Cardiovasc Pharmacol. 1989 May; 13(5):793-8. PMID: 2472529.
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      399. Sugita K, Gutkind J, Katamine S, Kawakami T, Robbins KC. The actin domain of Gardner-Rasheed feline sarcoma virus inhibits kinase and transforming activities. J Virol. 1989 Apr; 63(4):1715-20. PMID: 2538651.
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      400. Saavedra JM, Castrén E, Gutkind J, Nazarali AJ. Regulation of brain atrial natriuretic peptide and angiotensin receptors: quantitative autoradiographic studies. Int Rev Neurobiol. 1989; 31:257-96. PMID: 2557296.
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      401. Nazarali AJ, Gutkind J, Correa FM, Saavedra JM. Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats. Brain Res. 1988 Dec 13; 475(1):134-40. PMID: 2850834.
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      402. Gutkind J, Kurihara M, Saavedra JM. Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats. Am J Physiol. 1988 Sep; 255(3 Pt 2):H646-50. PMID: 3414825.
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      403. Gutkind J, Kurihara M, Castrén E, Saavedra JM. Autoradiographic quantification of vasoactive intestinal peptide binding sites in sections from human blood mononuclear cell pellets. Neuropsychopharmacology. 1988 Sep; 1(3):251-5. PMID: 2855201.
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      404. Kurihara M, Gutkind J, Saavedra JM. Alteration of atrial natriuretic peptide binding sites in spontaneously hypertensive rats. Am J Hypertens. 1988 Jul; 1(3 Pt 3):12S-14S. PMID: 2970851.
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      405. Kurihara M, Castrén E, Gutkind J, Saito K, Saavedra JM. Characterization of beta-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography. Biol Psychiatry. 1988 Apr 1; 23(7):749-54. PMID: 2835997.
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      406. Gutkind J, Castrén E, Saavedra JM. Decreased angiotensin II binding affinity and binding capacity in the anterior pituitary gland of adult spontaneously hypertensive rats. Life Sci. 1988; 43(5):445-51. PMID: 3398707.
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      407. Gutkind J, Kurihara M, Castren E, Saavedra JM. Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. J Hypertens. 1988 Jan; 6(1):79-84. PMID: 3351297.
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      408. Kurihara M, Castrén E, Gutkind J, Saavedra JM. Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):1132-40. PMID: 2827653.
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      409. Nazarali AJ, Gutkind J, Saavedra JM. Regulation of angiotensin II binding sites in the subfornical organ and other rat brain nuclei after water deprivation. Cell Mol Neurobiol. 1987 Dec; 7(4):447-55. PMID: 3451799.
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      410. Saito K, Gutkind J, Saavedra JM. Angiotensin II binding sites in the conduction system of rat hearts. Am J Physiol. 1987 Dec; 253(6 Pt 2):H1618-22. PMID: 3425757.
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      411. Gutkind J, Kurihara M, Castrén E, Saavedra JM. Atrial natriuretic peptide receptors in sympathetic ganglia: biochemical response and alterations in genetically hypertensive rats. Biochem Biophys Res Commun. 1987 Nov 30; 149(1):65-72. PMID: 2825702.
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      412. Castrén E, Kurihara M, Gutkind J, Saavedra JM. Specific angiotensin II binding sites in the rat stellate and superior cervical ganglia. Brain Res. 1987 Oct 6; 422(2):347-51. PMID: 3676793.
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      413. Gutkind J, Enero MA. Different pharmacological interaction of clonidine and guanabenz with antidepressive drugs. Clin Exp Hypertens A. 1987; 9(10):1531-47. PMID: 2824097.
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