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    Jonathan Lin

    TitleAssociate Professor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0612
    CA La Jolla 92093
    Phone858-534-2743
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      Collapse Research 
      Collapse Research Activities and Funding
      Molecular Pathology of Achromatopsia
      NIH/NEI R01EY027335Sep 30, 2017 - Jun 30, 2020
      Role: Principal Investigator
      Endoplasmic Reticulum Stress in Neurodegeneration
      VA I01RX002340Feb 1, 2017 - Jan 31, 2021
      Role: Principal Investigator
      Protein Homeostasis and Proteotoxicity Mechanisms
      NIH/NINDS R01NS088485Feb 1, 2015 - Jan 31, 2020
      Role: Principal Investigator
      Cellular and Molecular Mechanisms of Age-Related Retinal Degeneration
      VA I01BX002284Apr 1, 2014 - Mar 31, 2018
      Role: Principal Investigator
      Endoplasmic Reticulum Stress in Retinal Degeneration
      NIH/NEI R01EY020846Sep 1, 2010 - May 31, 2015
      Role: Principal Investigator
      Endoplasmic Reticulum Stress in Retinal Degeneration
      NIH/NEI K08EY018313Aug 1, 2007 - Jul 31, 2012
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Skorczyk-Werner A, Chiang WC, Wawrocka A, Wicher K, Jarmuz-Szymczak M, Kostrzewska-Poczekaj M, Jamsheer A, Ploski R, Rydzanicz M, Pojda-Wilczek D, Weisschuh N, Wissinger B, Kohl S, Lin J, Krawczynski MR. Autosomal recessive cone-rod dystrophy can be caused by mutations in the ATF6 gene. Eur J Hum Genet. 2017 Aug 16. PMID: 28812650.
        View in: PubMed
      2. Rodvold JJ, Chiu KT, Hiramatsu N, Nussbacher JK, Galimberti V, Mahadevan NR, Willert K, Lin J, Zanetti M. Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci Signal. 2017 Jun 06; 10(482). PMID: 28588081.
        View in: PubMed
      3. Whipple KM, Godfrey KJ, Solomon JP, Lin J, Korn BS, Kikkawa DO. Glomuvenous Malformation: A Rare Periorbital Lesion of the Thermoregulatory Apparatus. Ophthal Plast Reconstr Surg. 2017 Mar/Apr; 33(2):e36-e37. PMID: 27065433.
        View in: PubMed
      4. Biswas P, Duncan JL, Maranhao B, Kozak I, Branham K, Gabriel L, Lin J, Barteselli G, Navani M, Suk J, Parke M, Schlechter C, Weleber RG, Heckenlively JR, Dagnelie G, Lee P, Riazuddin SA, Ayyagari R. Genetic analysis of 10 pedigrees with inherited retinal degeneration by exome sequencing and phenotype-genotype association. Physiol Genomics. 2017 Apr 01; 49(4):216-229. PMID: 28130426.
        View in: PubMed
      5. Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczynski MR, Kaufman RJ, Tsang SH, Héon E, Kohl S, Lin J. Achromatopsia mutations target sequential steps of ATF6 activation. Proc Natl Acad Sci U S A. 2017 Jan 10; 114(2):400-405. PMID: 28028229.
        View in: PubMed
      6. Kinori M, Ko AC, Alameddine RM, Snyder V, Lin J, Korn BS, Granet DB. Extraocular Muscle Fibrosis in Idiopathic Orbital Inflammation. J Pediatr Ophthalmol Strabismus. 2016 Jul 01; 53(4):256. PMID: 27428626.
        View in: PubMed
      7. Kim JS, Scawn RL, Lee BW, Lin J, Korn BS, Kikkawa DO. Masquerading Orbital Sarcoidosis with Isolated Extraocular Muscle Involvement. Open Ophthalmol J. 2016; 10:140-145. PMID: 28484581.
        View in: PubMed
      8. Chan P, Stolz J, Kohl S, Chiang WC, Lin J. Endoplasmic reticulum stress in human photoreceptor diseases. Brain Res. 2016 Oct 01; 1648(Pt B):538-541. PMID: 27117871.
        View in: PubMed
      9. Westenskow PD, Bucher F, Bravo S, Kurihara T, Feitelberg D, Paris LP, Aguilar E, Lin J, Friedlander M. iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study. Stem Cells Int. 2016; 2016:8470263. PMID: 26880994; PMCID: PMC4736415.
      10. Chiang WC, Joseph V, Yasumura D, Matthes MT, Lewin AS, Gorbatyuk MS, Ahern K, LaVail MM, Lin J. Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin. Adv Exp Med Biol. 2016; 854:185-91. PMID: 26427410; PMCID: PMC4731204.
      11. Alavi MV, Chiang WC, Kroeger H, Yasumura D, Matthes MT, Iwawaki T, LaVail MM, Gould DB, Lin J. In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse. Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6961-70. PMID: 26513501; PMCID: PMC4627472.
      12. Kobalka PJ, Abboud JP, Liao X, Jones K, Lee BW, Korn BS, Kikkawa DO, Lin J. p16INK4A expression is frequently increased in periorbital and ocular squamous lesions. Diagn Pathol. 2015 Sep 24; 10:175. PMID: 26400483; PMCID: PMC4581440.
      13. Lee BW, Kumar UR, Lin J, Amaro DE, Kikkawa DO, Alameddine RM, Lowe MC, Hilger PA, Vinetz JM, Korn BS. Cysticercosis with an Orbital Tropism in Twins. Am J Trop Med Hyg. 2015 Oct; 93(4):828-30. PMID: 26217041; PMCID: PMC4596607 [Available on 10/07/16].
      14. Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin J. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet. 2015 Jul; 47(7):757-65. PMID: 26029869; PMCID: PMC4610820.
      15. Hiramatsu N, Chiang WC, Kurt TD, Sigurdson CJ, Lin J. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8. PMID: 25956028; PMCID: PMC4484218.
      16. Zou AE, Ku J, Honda TK, Yu V, Kuo SZ, Zheng H, Xuan Y, Saad MA, Hinton A, Brumund KT, Lin J, Wang-Rodriguez J, Ongkeko WM. Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA. 2015 Jun; 21(6):1122-34. PMID: 25904139; PMCID: PMC4436665.
      17. Karam R, Lou CH, Kroeger H, Huang L, Lin J, Wilkinson MF. The unfolded protein response is shaped by the NMD pathway. EMBO Rep. 2015 May; 16(5):599-609. PMID: 25807986; PMCID: PMC4428047.
      18. Salganik M, Sergeyev VG, Shinde V, Meyers CA, Gorbatyuk MS, Lin J, Zolotukhin S, Gorbatyuk OS. The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (a-syn) toxicity to rat nigral neurons. Neurobiol Aging. 2015 Jun; 36(6):2213-23. PMID: 25863526; PMCID: PMC4433578.
      19. Lin J, German M, Wong B. Use of copolymer polylactic and polyglycolic acid resorbable plates in repair of orbital floor fractures. Facial Plast Surg. 2014 Oct; 30(5):581-6. PMID: 25397715.
        View in: PubMed
      20. Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin J. Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol. 2015 Aug; 52(1):679-95. PMID: 25270370; PMCID: PMC4383737.
      21. Muller K, Lin J. Orbital granulomatosis with polyangiitis (Wegener granulomatosis): clinical and pathologic findings. Arch Pathol Lab Med. 2014 Aug; 138(8):1110-4. PMID: 25076302; PMCID: PMC4140401.
      22. Lin J, Jain S, Sun X, Liu V, Sato YZ, Jimenez-Fernandez S, Newfield RS, Pourfarzib R, Tremoulet AH, Gordon JB, Daniels LB, Burns JC. Lipoprotein particle concentrations in children and adults following Kawasaki disease. J Pediatr. 2014 Oct; 165(4):727-31. PMID: 25039043; PMCID: PMC4207833.
      23. Ouyang H, Xue Y, Lin Y, Zhang X, Xi L, Patel S, Cai H, Luo J, Zhang M, Zhang M, Yang Y, Li G, Li H, Jiang W, Yeh E, Lin J, Pei M, Zhu J, Cao G, Zhang L, Yu B, Chen S, Fu XD, Liu Y, Zhang K. WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature. 2014 Jul 17; 511(7509):358-61. PMID: 25030175; PMCID: PMC4610745.
      24. Wert KJ, Lin J, Tsang SH. General pathophysiology in retinal degeneration. Dev Ophthalmol. 2014; 53:33-43. PMID: 24732759; PMCID: PMC4405532.
      25. Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin J. Translational and posttranslational regulation of XIAP by eIF2a and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Mol Biol Cell. 2014 May; 25(9):1411-20. PMID: 24623724; PMCID: PMC4004591.
      26. Kroeger H, LaVail MM, Lin J. Endoplasmic reticulum stress in vertebrate mutant rhodopsin models of retinal degeneration. Adv Exp Med Biol. 2014; 801:585-92. PMID: 24664747; PMCID: PMC4103620.
      27. Jerry Chiang WC, Lin J. The effects of IRE1, ATF6, and PERK signaling on adRP-linked rhodopsins. Adv Exp Med Biol. 2014; 801:661-7. PMID: 24664756.
        View in: PubMed
      28. Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin J, Masliah E, Sigurdson CJ. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82. PMID: 24307586; PMCID: PMC3911572.
      29. Hodgson N, Whipple K, Lin J, Brumund KT, Kikkawa DO, Korn BS. Bilateral squamous cell carcinoma of the lacrimal sac. Ophthal Plast Reconstr Surg. 2013 Nov-Dec; 29(6):e149-51. PMID: 24217491; PMCID: PMC4081470.
      30. Mahajan VB, Lin J. Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy. Clin Ophthalmol. 2013; 7:1339-45. PMID: 23861576; PMCID: PMC3704602.
      31. Kroeger H, Messah C, Ahern K, Gee J, Joseph V, Matthes MT, Yasumura D, Gorbatyuk MS, Chiang WC, LaVail MM, Lin J. Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration. Invest Ophthalmol Vis Sci. 2012 Nov 09; 53(12):7590-9. PMID: 23074209; PMCID: PMC3495601.
      32. Chiang WC, Hiramatsu N, Messah C, Kroeger H, Lin J. Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation. Invest Ophthalmol Vis Sci. 2012 Oct 01; 53(11):7159-66. PMID: 22956602; PMCID: PMC3474590.
      33. Gorbatyuk MS, Shabashvili A, Chen W, Meyers C, Sullivan LF, Salganik M, Lin J, Lewin AS, Muzyczka N, Gorbatyuk OS. Glucose regulated protein 78 diminishes a-synuclein neurotoxicity in a rat model of Parkinson disease. Mol Ther. 2012 Jul; 20(7):1327-37. PMID: 22434142; PMCID: PMC3392977.
      34. Shinde VM, Sizova OS, Lin J, LaVail MM, Gorbatyuk MS. ER stress in retinal degeneration in S334ter Rho rats. PLoS One. 2012; 7(3):e33266. PMID: 22432009; PMCID: PMC3303830.
      35. Chiang WC, Messah C, Lin J. IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin. Mol Biol Cell. 2012 Mar; 23(5):758-70. PMID: 22219383; PMCID: PMC3290636.
      36. Kroeger H, Chiang WC, Lin J. Endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins and mutant P23H rhodopsin in photoreceptor cells. Adv Exp Med Biol. 2012; 723:559-65. PMID: 22183378; PMCID: PMC3651033.
      37. Gorbatyuk MS, Gorbatyuk OS, LaVail MM, Lin J, Hauswirth WW, Lewin AS. Functional rescue of P23H rhodopsin photoreceptors by gene delivery. Adv Exp Med Biol. 2012; 723:191-7. PMID: 22183333; PMCID: PMC3365920.
      38. Mantuano E, Henry K, Yamauchi T, Hiramatsu N, Yamauchi K, Orita S, Takahashi K, Lin J, Gonias SL, Campana WM. The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci. 2011 Sep 21; 31(38):13376-85. PMID: 21940431; PMCID: PMC3188465.
      39. Vasireddy V, Chavali VR, Joseph VT, Kadam R, Lin J, Jamison JA, Kompella UB, Reddy GB, Ayyagari R. Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PLoS One. 2011; 6(6):e21193. PMID: 21738619; PMCID: PMC3126808.
      40. Hiramatsu N, Joseph VT, Lin J. Monitoring and manipulating mammalian unfolded protein response. Methods Enzymol. 2011; 491:183-98. PMID: 21329801; PMCID: PMC3658618.
      41. Mahajan VB, Vallone JG, Lin J, Mullins RF, Ko AC, Folk JC, Stone EM. T-cell infiltration in autosomal dominant neovascular inflammatory vitreoretinopathy. Mol Vis. 2010 Jun 08; 16:1034-40. PMID: 20596252; PMCID: PMC2893052.
      42. Gorbatyuk MS, Knox T, LaVail MM, Gorbatyuk OS, Noorwez SM, Hauswirth WW, Lin J, Muzyczka N, Lewin AS. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5961-6. PMID: 20231467; PMCID: PMC2851865.
      43. Lin J, Lavail MM. Misfolded proteins and retinal dystrophies. Adv Exp Med Biol. 2010; 664:115-21. PMID: 20238009; PMCID: PMC2955894.
      44. Hollien J, Lin J, Li H, Stevens N, Walter P, Weissman JS. Regulated Ire1-dependent decay of messenger RNAs in mammalian cells. J Cell Biol. 2009 Aug 10; 186(3):323-31. PMID: 19651891; PMCID: PMC2728407.
      45. Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin J, Walter P, Reed JC, Glimcher LH, Hetz C. BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell. 2009 Mar 27; 33(6):679-91. PMID: 19328063; PMCID: PMC2818874.
      46. Lin J, Li H, Zhang Y, Ron D, Walter P. Divergent effects of PERK and IRE1 signaling on cell viability. PLoS One. 2009; 4(1):e4170. PMID: 19137072; PMCID: PMC2614882.
      47. Lin J, Walter P, Yen TS. Endoplasmic reticulum stress in disease pathogenesis. Annu Rev Pathol. 2008; 3:399-425. PMID: 18039139; PMCID: PMC3653419.
      48. Lin J, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P. IRE1 signaling affects cell fate during the unfolded protein response. Science. 2007 Nov 09; 318(5852):944-9. PMID: 17991856; PMCID: PMC3670588.