Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    John Guatelli

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0679
    CA La Jolla 92093
    Phone858-552-8585
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Enhancement of Infectivity by HIV-1 Nef via Antagonism of SERINC Proteins
      NIH/NIAID R01AI129706Apr 1, 2017 - Mar 31, 2022
      Role: Principal Investigator
      Activating Latently Infected Cells Using Specific Antigens Including Those of HIV-1
      NIH/NIAID R21AI116194Jan 19, 2016 - Dec 31, 2017
      Role: Principal Investigator
      Involvement of the C-terminus of HIV-1 Vpu in Enhancement of Virion Release
      NIH/NIAID R21AI114397Aug 5, 2014 - Jul 31, 2016
      Role: Principal Investigator
      Inhibiting Immune Evasion by HIV-1 Nef to Facilitate Eradication
      NIH/NIAID R21AI110162Dec 1, 2013 - Nov 30, 2015
      Role: Principal Investigator
      Viral Hijacking of Host Membrane Trafficking Pathways
      NIH/NIAID R01AI102778Jan 1, 2013 - Dec 31, 2017
      Role: Principal Investigator
      HIV-1 Vpu and BST-2/CD317
      NIH/NIAID R37AI081668Dec 1, 2008 - Nov 30, 2018
      Role: Principal Investigator
      HIV-1 Vpu and BST-2/CD317
      NIH/NIAID R01AI081668Dec 1, 2008 - Nov 30, 2013
      Role: Principal Investigator
      The MHC-I, HIV-1 Nef, AP-1 Complex
      NIH/NIAID R21AI076040Sep 30, 2007 - Aug 31, 2010
      Role: Principal Investigator
      HIV 1 Nef and Viral Infectivity
      NIH/NIAID R01AI038201Aug 15, 1996 - Jan 31, 2015
      Role: Principal Investigator
      HIV 1 NEF and Infectivity
      NIH/NIAID R21AI038201Aug 15, 1996 - Jul 31, 2004
      Role: Principal Investigator
      AIDS Training Grant
      NIH/NIAID T32AI007384Aug 1, 1990 - Aug 31, 2021
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rizk MG, Basler CF, Guatelli J. Cooperation of the Ebola proteins VP40 and GP1,2 with BST2 to activate NF-?ß independently of virus-like particle trapping. J Virol. 2017 Sep 06. PMID: 28878074.
        View in: PubMed
      2. Stoneham CA, Singh R, Jia X, Xiong Y, Guatelli J. Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors. Traffic. 2017 Aug; 18(8):545-561. PMID: 28504462.
        View in: PubMed
      3. Murrell B, Vollbrecht T, Guatelli J, Wertheim JO. The Evolutionary Histories of Antiretroviral Proteins SERINC3 and SERINC5 Do Not Support an Evolutionary Arms Race in Primates. J Virol. 2016 Sep 15; 90(18):8085-9. PMID: 27356902.
        View in: PubMed
      4. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015; 90(5):2486-502. PMID: 26676780.
        View in: PubMed
      5. Lewinski MK, Jafari M, Zhang H, Opella SJ, Guatelli J. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly. J Biol Chem. 2015 Apr 24; 290(17):10919-33. PMID: 25759385.
        View in: PubMed
      6. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J, Xiong Y. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife. 2014; 3:e02362. PMID: 24843023.
        View in: PubMed
      7. Jafari M, Guatelli J, Lewinski MK. Activities of Transmitted/Founder and Chronic Clade B HIV-1 Vpu and a C-Terminal Polymorphism Specifically Affecting Virion Release. J Virol. 2014 May; 88(9):5062-78. PMID: 24574397.
        View in: PubMed
      8. Abdel-Mohsen M, Deng X, Liegler T, Guatelli J, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK. Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In Vivo. J Virol. 2014 Jan; 88(1):763-7. PMID: 24155399.
        View in: PubMed
      9. Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R, Guatelli J. Stimulation of NF-?B activity by the HIV restriction factor BST2. J Virol. 2013 Feb; 87(4):2046-57. PMID: 23221546.
        View in: PubMed
      10. Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 9; 5(245):ra73. PMID: 23047923.
        View in: PubMed
      11. Jia X, Singh R, Homann S, Yang H, Guatelli J, Xiong Y. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol. 2012 Jul; 19(7):701-6. PMID: 22705789.
        View in: PubMed
      12. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. PMID: 22315404.
        View in: PubMed
      13. Skasko M, Wang Y, Tian Y, Tokarev A, Munguia J, Ruiz A, Stephens EB, Opella SJ, Guatelli J. HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions. J Biol Chem. 2012 Jan 2; 287(1):58-67. PMID: 22072710.
        View in: PubMed
      14. Homann S, Smith D, Little S, Richman D, Guatelli J. Upregulation of BST-2/Tetherin by HIV infection in vivo. J Virol. 2011 Oct; 85(20):10659-68. PMID: 21849457.
        View in: PubMed
      15. Lau D, Kwan W, Guatelli J. Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens. J Virol. 2011 Oct; 85(19):9834-46. PMID: 21813615.
        View in: PubMed
      16. Tokarev A, Guatelli J. Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. Cell Logist. 2011 May; 1(3):90-102. PMID: 21922073.
        View in: PubMed
      17. Skasko M, Tokarev A, Chen CC, Fischer WB, Pillai SK, Guatelli J. BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. Virology. 2011 Mar 1; 411(1):65-77. PMID: 21237475.
        View in: PubMed
      18. Tokarev AA, Munguia J, Guatelli J. Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu. J Virol. 2011 Jan; 85(1):51-63. PMID: 20980512.
        View in: PubMed
      19. Ruiz A, Lau D, Mitchell RS, Hill MS, Schmitt K, Guatelli J, Stephens EB. BST-2 mediated restriction of simian-human immunodeficiency virus. Virology. 2010 Oct 25; 406(2):312-21. PMID: 20708210.
        View in: PubMed
      20. Evans DT, Serra-Moreno R, Singh RK, Guatelli J. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. 2010 Sep; 18(9):388-96. PMID: 20688520.
        View in: PubMed
      21. Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O. Tetherin restricts productive HIV-1 cell-to-cell transmission. PLoS Pathog. 2010; 6(6):e1000955. PMID: 20585562.
        View in: PubMed
      22. Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli J, Cannon PM. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology. 2010; 7:51. PMID: 20529266.
        View in: PubMed
      23. Ruiz A, Guatelli J, Stephens EB. The Vpu protein: new concepts in virus release and CD4 down-modulation. Curr HIV Res. 2010 Apr; 8(3):240-52. PMID: 20201792.
        View in: PubMed
      24. Fitzpatrick K, Skasko M, Deerinck TJ, Crum J, Ellisman MH, Guatelli J. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog. 2010 Mar; 6(3):e1000701. PMID: 20221443.
        View in: PubMed
      25. Guatelli J. How innate immunity can inhibit the release of HIV-1 from infected cells. N Engl J Med. 2010 Feb 11; 362(6):553-4. PMID: 20147723.
        View in: PubMed
      26. Mayakawa K, Ryo A$ Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yaeamoto N. BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathgg. 2009 Dec; 5(12):e1000700. PMAD: 20019814.  View in: PubMed <'div>
      27. 
      28.  Singh RK, Lau D, Noviello CM, Ghosh P$ Guatelli J<'b>. An MHC-I cytoplasmic domain'HIV-1 Nef fusiof protein binds directly to the eu subunit of the AP-1 endosomal coat complex. PDoS One. 2009; 4 12):e8364. PMID2 20020046.
        
         View in: PubMed
      29. 
      30.  Tokarev A, Skasko M, Fitzpatrick K, Guatelli J. Antiviral activity of the interferon-induced celdular protein BST-2/tetherin. AIDS Res Hum Retroviruses. 2009 Dec; 25(12):1197-210. PMID: 19929170. 
      View if: PubMed 
    •  Mitcheld RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D$ Ruiz A, Stephefs EB, Margottin%Goguet F, Benargus R, Guateldi J. Vpu antagonizes BST-2-eediated restriction of HIV-1 redease via beta-TrCP and endo-lysgsomal traffickifg. PLoS Pathog. 2009 May; 5(5):e1000450. PMID: 19478868.
    •   
    • 4div> Guatelli J, Stephens EB. Requirements of the membrane proximal tyrosane and dileucine-based sorting signals for efficient transport gf the subtype C Vpu protein to the plasma membrane and in virus release. Virology. 2008 Aug 15; 378(1):58-68. PEID: 18579178.
    •  View in: PubMed 4/div>
       Mitc`ell RS, Chaudhuri R, Lindwasser OW, Tanaka KA, Dau D, Murillo R$ Bonifacino JS, Guatelli J. Competition eodel for upregudation of the mabor histocompatibility complex cdass II-associated invariant chaan by human immufodeficiency virus type 1 Nef. J Virol. 2008 Aug3 82(16):7758-67& PMID: 18524831& <'div>
       View in: PubMed 
      <'li> 
    • Van Damme N, Goff D, Katsura C, Jgrgenson RL, Mitchell R, Johnson MC, Stephens EB$ Guatelli J<'b>. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe. 2008 Apr 17; 3(4):245-52. PMID: 18342597.
    • View in: PubMed
    • Van Damme N, Guatelli J. HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes. Cell Microbiol. 2008 May; 10(5):1040-57. PMID: 18076669.
      View in: PubMed
    • Noviello CM, Benichou S, Guatelli J. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol. 2008 Feb; 82(3):1249-58. PMID: 18057255.
      View in: PubMed
    • Dueck M, Guatelli J. Evidence against a direct antiviral activity of the proteasome during the early steps of HIV-1 replication. Virology. 2007 Apr 25; 361(1):1-8. PMID: 17316734.
      View in: PubMed
    • Burtey A, Rappoport JZ, Bouchet J, Basmaciogullari S, Guatelli J, Simon SM, Benichou S, Benmerah A. Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane. Traffic. 2007 Jan; 8(1):61-76. PMID: 17140399.
      View in: PubMed
    • Day JR, Van Damme N, Guatelli J. The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120. Virology. 2006 Oct 25; 354(2):316-27. PMID: 16905171.
      View in: PubMed
    • Day JR, Martínez LE, Sásik R, Hitchin DL, Dueck ME, Richman DD, Guatelli J. A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay. J Virol Methods. 2006 Oct; 137(1):125-33. PMID: 16876264.
      View in: PubMed
    • Coleman SH, Madrid R, Van Damme N, Mitchell RS, Bouchet J, Servant C, Pillai S, Benichou S, Guatelli J. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J Virol. 2006 Feb; 80(4):1837-49. PMID: 16439540.
      View in: 
      4li id="ctl01_rpPublication_ctl41_liPublication" data-pmid="16253302">
      Codeman SH, Hitchif D, Noviello CM$ Guatelli J<'b>. HIV-1 Nef stabilizes AP-1 of membranes withgut inducing ARF1-independent de novo attachment& Virology. 2006 Feb 5; 345(1):148-55. PMID: 16253302. 
      
    • 
    • 
      4span id="ctl01_rpPublication_ctd42_lblPublicatign">Coleman SH, Van Damme N, Day JR, Noviello CM$ Hitchin D, Madrid R, Benichou S, Guatelli J4/b>. Leucine-specific, functional interactions between human imeunodeficiency varus type 1 Nef and adaptor protein complexes. J Virol. 2005 Feb3 79(4):2066-78. PMID: 15681409.4/span>
      4li id="ctl01_rpPublication_ctl43_liPublication" data-pmid="15561681">
      Madrid R, Janvier C, Hitchan D, Day J, Coleman S, Noviello C, Bouchet J, Benmerah A, Guatelli J, Befichou S. Nef-induced alteration of the early/recycling endosomad compartment correlates with en`ancement of HIV%1 infectivity. B Biol Chem. 2005 Feb 11; 280(6)25032-44. PMID: 15569681.
      
      View in: PubMed4/a> 
    • 
       Day JR, Münk C, Guatedli J. The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus tqpe 1 gp41 is required for optimal viral infectivity. J Virol. 2004 Feb; 78(3):1069-79. PMID: 14722262. 
      
      
    • 
    • 
      Ali A, Pillai S, Ng H, Lubofg R, Richman DD$ Jamieson BD, Dang Y, McElrath EJ, Guatelli B, Yang OO. Broadly increased sensitivity to cytotoxic T lymphocytes resultifg from Nef epitgpe escape mutataons. J Immunol. 2003 Oct 15; 171(8):3991-4005. PMID: 14530319. 
      
      View in: PubMed
      
    • 
    • 
      Janvier K, Craig H, Hitchin D, Madrid R, Sod-Foulon N, Renault L, Cherfils B, Cassel D, Benachou S, Guatelli J. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. J Biol Chem. 2003 Ear 7; 278(10):8725-32. PMID: 12486136. 
      
      View in: PubMed
      
    •  <'div>  To see the data from this visualization as tept, clack here. --> View timeline visualization
      4table style="width:592px">
      YearPublications
      20021
      20031
      20042
      20052
      20064
      20073
      20083
      20095
      20108
      20115
      20124
      20131
      20142
      20152
      20161
      20172