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    John Guatelli

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0679
    CA La Jolla 92093
    Phone858-552-8585
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      Collapse Research 
      Collapse Research Activities and Funding
      Enhancement of Infectivity by HIV-1 Nef via Antagonism of SERINC Proteins
      NIH/NIAID R01AI129706Apr 1, 2017 - Mar 31, 2022
      Role: Principal Investigator
      Activating Latently Infected Cells Using Specific Antigens Including Those of HIV-1
      NIH/NIAID R21AI116194Jan 19, 2016 - Dec 31, 2017
      Role: Principal Investigator
      Involvement of the C-terminus of HIV-1 Vpu in Enhancement of Virion Release
      NIH/NIAID R21AI114397Aug 5, 2014 - Jul 31, 2016
      Role: Principal Investigator
      Inhibiting Immune Evasion by HIV-1 Nef to Facilitate Eradication
      NIH/NIAID R21AI110162Dec 1, 2013 - Nov 30, 2015
      Role: Principal Investigator
      Viral Hijacking of Host Membrane Trafficking Pathways
      NIH/NIAID R01AI102778Jan 1, 2013 - Dec 31, 2017
      Role: Principal Investigator
      HIV-1 Vpu and BST-2/CD317
      NIH/NIAID R37AI081668Dec 1, 2008 - Nov 30, 2018
      Role: Principal Investigator
      HIV-1 Vpu and BST-2/CD317
      NIH/NIAID R01AI081668Dec 1, 2008 - Nov 30, 2013
      Role: Principal Investigator
      The MHC-I, HIV-1 Nef, AP-1 Complex
      NIH/NIAID R21AI076040Sep 30, 2007 - Aug 31, 2010
      Role: Principal Investigator
      HIV 1 Nef and Viral Infectivity
      NIH/NIAID R01AI038201Aug 15, 1996 - Jan 31, 2015
      Role: Principal Investigator
      HIV 1 NEF and Infectivity
      NIH/NIAID R21AI038201Aug 15, 1996 - Jul 31, 2004
      Role: Principal Investigator
      AIDS Training Grant
      NIH/NIAID T32AI007384Aug 1, 1990 - Aug 31, 2021
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator
      General Clinical Research Center
      NIH/NCRR M01RR000827Mar 1, 1974 - Nov 30, 2010
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rizk MG, Basler CF, Guatelli J. Cooperation of the Ebola proteins VP40 and GP1,2 with BST2 to activate NF-?ß independently of virus-like particle trapping. J Virol. 2017 Sep 06. PMID: 28878074.
        View in: PubMed
      2. Stoneham CA, Singh R, Jia X, Xiong Y, Guatelli J. Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors. Traffic. 2017 Aug; 18(8):545-561. PMID: 28504462.
        View in: PubMed
      3. Murrell B, Vollbrecht T, Guatelli J, Wertheim JO. The Evolutionary Histories of Antiretroviral Proteins SERINC3 and SERINC5 Do Not Support an Evolutionary Arms Race in Primates. J Virol. 2016 Sep 15; 90(18):8085-9. PMID: 27356902; PMCID: PMC5008085 [Available on 02/26/17].
      4. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina CA, Guatelli J. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015 Dec 16; 90(5):2486-502. PMID: 26676780; PMCID: PMC4810708.
      5. Lewinski MK, Jafari M, Zhang H, Opella SJ, Guatelli J. Membrane Anchoring by a C-terminal Tryptophan Enables HIV-1 Vpu to Displace Bone Marrow Stromal Antigen 2 (BST2) from Sites of Viral Assembly. J Biol Chem. 2015 Apr 24; 290(17):10919-33. PMID: 25759385; PMCID: PMC4409254.
      6. Jia X, Weber E, Tokarev A, Lewinski M, Rizk M, Suarez M, Guatelli J, Xiong Y. Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1. Elife. 2014 Apr 29; 3:e02362. PMID: 24843023; PMCID: PMC4018625.
      7. Jafari M, Guatelli J, Lewinski MK. Activities of transmitted/founder and chronic clade B HIV-1 Vpu and a C-terminal polymorphism specifically affecting virion release. J Virol. 2014 May; 88(9):5062-78. PMID: 24574397; PMCID: PMC3993827.
      8. Abdel-Mohsen M, Deng X, Liegler T, Guatelli J, Salama MS, Ghanem Hel-D, Rauch A, Ledergerber B, Deeks SG, Günthard HF, Wong JK, Pillai SK. Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo. J Virol. 2014 Jan; 88(1):763-7. PMID: 24155399; PMCID: PMC3911728.
      9. Tokarev A, Suarez M, Kwan W, Fitzpatrick K, Singh R, Guatelli J. Stimulation of NF-?B activity by the HIV restriction factor BST2. J Virol. 2013 Feb; 87(4):2046-57. PMID: 23221546; PMCID: PMC3571454.
      10. Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A. Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 09; 5(245):ra73. PMID: 23047923.
        View in: PubMed
      11. Jia X, Singh R, Homann S, Yang H, Guatelli J, Xiong Y. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol. 2012 Jun 17; 19(7):701-6. PMID: 22705789; PMCID: PMC3407041.
      12. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK. Role of retroviral restriction factors in the interferon-a-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3035-40. PMID: 22315404; PMCID: PMC3286922.
      13. Skasko M, Wang Y, Tian Y, Tokarev A, Munguia J, Ruiz A, Stephens EB, Opella SJ, Guatelli J. HIV-1 Vpu protein antagonizes innate restriction factor BST-2 via lipid-embedded helix-helix interactions. J Biol Chem. 2012 Jan 02; 287(1):58-67. PMID: 22072710; PMCID: PMC3249111.
      14. Homann S, Smith D, Little S, Richman D, Guatelli J. Upregulation of BST-2/Tetherin by HIV infection in vivo. J Virol. 2011 Oct; 85(20):10659-68. PMID: 21849457; PMCID: PMC3187519.
      15. Lau D, Kwan W, Guatelli J. Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens. J Virol. 2011 Oct; 85(19):9834-46. PMID: 21813615; PMCID: PMC3196438.
      16. Tokarev A, Guatelli J. Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. Cell Logist. 2011 May; 1(3):90-102. PMID: 21922073.
        View in: PubMed
      17. Skasko M, Tokarev A, Chen CC, Fischer WB, Pillai SK, Guatelli J. BST-2 is rapidly down-regulated from the cell surface by the HIV-1 protein Vpu: evidence for a post-ER mechanism of Vpu-action. Virology. 2011 Mar 01; 411(1):65-77. PMID: 21237475; PMCID: PMC3086044.
      18. Tokarev AA, Munguia J, Guatelli J. Serine-threonine ubiquitination mediates downregulation of BST-2/tetherin and relief of restricted virion release by HIV-1 Vpu. J Virol. 2011 Jan; 85(1):51-63. PMID: 20980512; PMCID: PMC3014196.
      19. Ruiz A, Lau D, Mitchell RS, Hill MS, Schmitt K, Guatelli J, Stephens EB. BST-2 mediated restriction of simian-human immunodeficiency virus. Virology. 2010 Oct 25; 406(2):312-21. PMID: 20708210; PMCID: PMC4104713.
      20. Evans DT, Serra-Moreno R, Singh RK, Guatelli J. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. 2010 Sep; 18(9):388-96. PMID: 20688520; PMCID: PMC2956607.
      21. Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O. Tetherin restricts productive HIV-1 cell-to-cell transmission. PLoS Pathog. 2010 Jun 17; 6(6):e1000955. PMID: 20585562; PMCID: PMC2887479.
      22. Hauser H, Lopez LA, Yang SJ, Oldenburg JE, Exline CM, Guatelli J, Cannon PM. HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment. Retrovirology. 2010 Jun 07; 7:51. PMID: 20529266; PMCID: PMC2890665.
      23. Ruiz A, Guatelli J, Stephens EB. The Vpu protein: new concepts in virus release and CD4 down-modulation. Curr HIV Res. 2010 Apr; 8(3):240-52. PMID: 20201792; PMCID: PMC4290667.
      24. Fitzpatrick K, Skasko M, Deerinck TJ, Crum J, Ellisman MH, Guatelli J. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. PLoS Pathog. 2010 Mar 05; 6(3):e1000701. PMID: 20221443; PMCID: PMC2832767.
      25. Guatelli J. How innate immunity can inhibit the release of HIV-1 from infected cells. N Engl J Med. 2010 Feb 11; 362(6):553-4. PMID: 20147723.
        View in: PubMed
      26. Miyakawa K, Ryo A, Murakami T, Ohba K, Yamaoka S, Fukuda M, Guatelli J, Yamamoto N. BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction. PLoS Pathog. 2009 Dec; 5(12):e1000700. PMID: 20019814; PMCID: PMC2788703.
      27. Singh RK, Lau D, Noviello CM, Ghosh P, Guatelli J. An MHC-I cytoplasmic domain/HIV-1 Nef fusion protein binds directly to the mu subunit of the AP-1 endosomal coat complex. PLoS One. 2009 Dec 18; 4(12):e8364. PMID: 20020046; PMCID: PMC2791223.
      28. Tokarev A, Skasko M, Fitzpatrick K, Guatelli J. Antiviral activity of the interferon-induced cellular protein BST-2/tetherin. AIDS Res Hum Retroviruses. 2009 Dec; 25(12):1197-210. PMID: 19929170; PMCID: PMC2858902.
      29. Mitchell RS, Katsura C, Skasko MA, Fitzpatrick K, Lau D, Ruiz A, Stephens EB, Margottin-Goguet F, Benarous R, Guatelli J. Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking. PLoS Pathog. 2009 May; 5(5):e1000450. PMID: 19478868; PMCID: PMC2679223.
      30. Guatelli J. Interactions of viral protein U (Vpu) with cellular factors. Curr Top Microbiol Immunol. 2009; 339:27-45. PMID: 20012522.
        View in: PubMed
      31. Ruiz A, Hill MS, Schmitt K, Guatelli J, Stephens EB. Requirements of the membrane proximal tyrosine and dileucine-based sorting signals for efficient transport of the subtype C Vpu protein to the plasma membrane and in virus release. Virology. 2008 Aug 15; 378(1):58-68. PMID: 18579178; PMCID: PMC4104992.
      32. Mitchell RS, Chaudhuri R, Lindwasser OW, Tanaka KA, Lau D, Murillo R, Bonifacino JS, Guatelli J. Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 Nef. J Virol. 2008 Aug; 82(16):7758-67. PMID: 18524831; PMCID: PMC2519569.
      33. Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, Stephens EB, Guatelli J. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe. 2008 Apr 17; 3(4):245-52. PMID: 18342597; PMCID: PMC2474773.
      34. Van Damme N, Guatelli J. HIV-1 Vpu inhibits accumulation of the envelope glycoprotein within clathrin-coated, Gag-containing endosomes. Cell Microbiol. 2008 May; 10(5):1040-57. PMID: 18076669.
        View in: PubMed
      35. Noviello CM, Benichou S, Guatelli J. Cooperative binding of the class I major histocompatibility complex cytoplasmic domain and human immunodeficiency virus type 1 Nef to the endosomal AP-1 complex via its mu subunit. J Virol. 2008 Feb; 82(3):1249-58. PMID: 18057255; PMCID: PMC2224416.
      36. Dueck M, Guatelli J. Evidence against a direct antiviral activity of the proteasome during the early steps of HIV-1 replication. Virology. 2007 Apr 25; 361(1):1-8. PMID: 17316734; PMCID: PMC2753395.
      37. Burtey A, Rappoport JZ, Bouchet J, Basmaciogullari S, Guatelli J, Simon SM, Benichou S, Benmerah A. Dynamic interaction of HIV-1 Nef with the clathrin-mediated endocytic pathway at the plasma membrane. Traffic. 2007 Jan; 8(1):61-76. PMID: 17140399.
        View in: PubMed
      38. Day JR, Van Damme N, Guatelli J. The effect of the membrane-proximal tyrosine-based sorting signal of HIV-1 gp41 on viral infectivity depends on sequences within gp120. Virology. 2006 Oct 25; 354(2):316-27. PMID: 16905171.
        View in: PubMed
      39. Day JR, Martínez LE, Sásik R, Hitchin DL, Dueck ME, Richman DD, Guatelli J. A computer-based, image-analysis method to quantify HIV-1 infection in a single-cycle infectious center assay. J Virol Methods. 2006 Oct; 137(1):125-33. PMID: 16876264.
        View in: PubMed
      40. Coleman SH, Madrid R, Van Damme N, Mitchell RS, Bouchet J, Servant C, Pillai S, Benichou S, Guatelli J. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J Virol. 2006 Feb; 80(4):1837-49. PMID: 16439540; PMCID: PMC1367136.
      41. Coleman SH, Hitchin D, Noviello CM, Guatelli J. HIV-1 Nef stabilizes AP-1 on membranes without inducing ARF1-independent de novo attachment. Virology. 2006 Feb 05; 345(1):148-55. PMID: 16253302.
        View in: PubMed
      42. Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli J. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. J Virol. 2005 Feb; 79(4):2066-78. PMID: 15681409; PMCID: PMC546596.
      43. Madrid R, Janvier K, Hitchin D, Day J, Coleman S, Noviello C, Bouchet J, Benmerah A, Guatelli J, Benichou S. Nef-induced alteration of the early/recycling endosomal compartment correlates with enhancement of HIV-1 infectivity. J Biol Chem. 2005 Feb 11; 280(6):5032-44. PMID: 15569681.
        View in: PubMed
      44. Day JR, Münk C, Guatelli J. The membrane-proximal tyrosine-based sorting signal of human immunodeficiency virus type 1 gp41 is required for optimal viral infectivity. J Virol. 2004 Feb; 78(3):1069-79. PMID: 14722262; PMCID: PMC321364.
      45. Ali A, Pillai S, Ng H, Lubong R, Richman DD, Jamieson BD, Ding Y, McElrath MJ, Guatelli J, Yang OO. Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. J Immunol. 2003 Oct 15; 171(8):3999-4005. PMID: 14530319.
        View in: PubMed
      46. Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J. HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. J Biol Chem. 2003 Mar 07; 278(10):8725-32. PMID: 12486136.
        View in: PubMed