|School||University of California, San Diego|
|Address||9500 Gilman Drive #0636|
CA La Jolla 92093
|University of California, San Diego||M.B.A.||Rady School of Management||2015|
|University of California, San Diego||Ph.D.||School of Medicine||1992|
|University of California, Davis||B.S.||Toxicology/Biochemistry||1986|
|2015||American Society for Biochemistry and Molecular Biology Ruth Kirchstein Diversity in Science Award|
|2014||UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring|
|2012||Women Who Mean Business Award, San Diego Business Journal|
|2006||American Heart Association Established Investigator Award |
|1995||American Heart Association Scientist Career Development Grant Award|
|1993||University of California President’s Postdoctoral Fellowship Award |
Our research is focused on cell signaling and how it regulates vascular barrier leakage and breast cancer progression. We are examining how activation of GPCRs, specifically PARs, by distinct proteases differentially regulates endothelial barrier breakdown (pro-inflammatory signaling) versus cytoprotection (anti-inflammatory signaling) through selective activation of specific signaling pathways. We discovered that aberrant PAR1 trafficking results in dysregulated signaling in invasive breast cancer and consequently promotes tumor progression. We are examining how the endocytic machinery and the tumor suppressor ARRDC3 contribute to the dysregulation of GPCR trafficking and signaling to the Hippo pathway and the impact on breast carcinoma growth, invasion and metastasis.
endothelial cells, sepsis, breast cancer, proteases, GPCRs, cell signaling, membrane trafficking, endocytosis, caveolae, lysosomes, G proteins, thrombin, cytoprotection, arrestins, ubiquitin
Derived automatically from this person's publications.
People in Profiles who have published with this person.
People who share similar concepts with this person.
People whose addresses are nearby this person.