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    Jean Wang

    TitleRecall Faculty
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0820
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Protein Tyrosine Kinases in Leiomyomata Uteri
      NIH/NICHD R01HD046225Sep 26, 2003 - Jul 31, 2009
      Role: Principal Investigator
      Integrin Signaling in Hemostasis and Blood Diseases
      NIH/NHLBI P01HL057900Apr 1, 1997 - Jan 31, 2014
      Role: Co-Investigator
      Predoctoral and Postdoctoral Training in Cancer Cell Biology
      NIH/NCI T32CA067754Sep 25, 1995 - Jun 30, 2022
      Role: Co-Principal Investigator
      Biological Function of the Retinoblastoma Gene Product
      NIH/NCI R01CA058320May 1, 1992 - Feb 28, 2014
      Role: Principal Investigator
      FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS
      NIH/NCI P01CA050528Sep 8, 1989 - Jan 31, 1998
      Role: Co-Investigator
      Nuclear Function of Abl in DNA Damage Response
      NIH/NCI R01CA043054Aug 1, 1986 - Nov 30, 2018
      Role: Principal Investigator
      Nuclear Function of the c-Abl Protooncoprotien
      NIH/NCI R37CA043054Aug 1, 1986 - Feb 25, 2008
      Role: Principal Investigator
      BASIC BIOCHEMICAL AND BIOLOGICAL MECHANISMS IN CANCER
      NIH/NCI T32CA009345Aug 1, 1984 - Nov 30, 2000
      Role: Principal Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hu WH, Miyai K, Sporn JC, Luo L, Wang J, Cosman B, Ramamoorthy S. Loss of histone variant macroH2A2 expression associates with progression of anal neoplasm. J Clin Pathol. 2016 Jul; 69(7):627-31. PMID: 26658220; PMCID: PMC4941135.
      2. Tu CC, Wang J. EnABLing microprocessor for apoptosis. Mol Cell Oncol. 2016; 3(2). PMID: 27182551.
        View in: PubMed
      3. Suknuntha K, Ishii Y, Tao L, Hu K, McIntosh BE, Yang D, Swanson S, Stewart R, Wang J, Thomson J, Slukvin I. Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells. Stem Cell Res. 2015 Nov; 15(3):678-693. PMID: 26561938; PMCID: PMC5003778.
      4. Pineda G, Shen Z, de Albuquerque CP, Reynoso E, Chen J, Tu CC, Tang W, Briggs S, Zhou H, Wang J. Proteomics studies of the interactome of RNA polymerase II C-terminal repeated domain. BMC Res Notes. 2015 Oct 29; 8:616. PMID: 26515650; PMCID: PMC4627417.
      5. Ishii Y, Nhiayi MK, Tse E, Cheng J, Massimino M, Durden DL, Vigneri P, Wang J. Knockout Serum Replacement Promotes Cell Survival by Preventing BIM from Inducing Mitochondrial Cytochrome C Release. PLoS One. 2015; 10(10):e0140585. PMID: 26473951; PMCID: PMC4608728.
      6. Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, Wang J. The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage. Sci Signal. 2015 Jun 30; 8(383):ra64. PMID: 26126715; PMCID: PMC4499470.
      7. Tonino SH, Mulkens CE, van Laar J, Derks IA, Suo G, Croon-de Boer F, van Oers MH, Eldering E, Wang J, Kater AP. Induction of TAp73 by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia. Leuk Lymphoma. 2015; 56(8):2439-47. PMID: 25511680; PMCID: PMC4592483.
      8. Manthey CF, Calabio CB, Wosinski A, Hanson EM, Vallance BA, Groisman A, Martín MG, Wang J, Eckmann L. Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions. Am J Physiol Cell Physiol. 2014 Jul 15; 307(2):C180-9. PMID: 24848114; PMCID: PMC4101622.
      9. Suo G, Sadarangani A, Tang W, Cowan BD, Wang J. Telomerase expression abrogates rapamycin-induced irreversible growth arrest of uterine fibroid smooth muscle cells. Reprod Sci. 2014 Sep; 21(9):1161-70. PMID: 24784716; PMCID: PMC4212341.
      10. de Souza JE, Fonseca AF, Valieris R, Carraro DM, Wang J, Kolodner RD, de Souza SJ. S-score: a scoring system for the identification and prioritization of predicted cancer genes. PLoS One. 2014; 9(4):e94147. PMID: 24710071; PMCID: PMC3978018.
      11. Wang J. The capable ABL: what is its biological function? Mol Cell Biol. 2014 Apr; 34(7):1188-97. PMID: 24421390; PMCID: PMC3993570.
      12. Sridevi P, Nhiayi MK, Setten RL, Wang J. Persistent inhibition of ABL tyrosine kinase causes enhanced apoptotic response to TRAIL and disrupts the pro-apoptotic effect of chloroquine. PLoS One. 2013; 8(10):e77495. PMID: 24147007; PMCID: PMC3795698.
      13. Spehlmann ME, Manthey CF, Dann SM, Hanson E, Sandhu SS, Liu LY, Abdelmalak FK, Diamanti MA, Retzlaff K, Scheller J, Rose-John S, Greten FR, Wang J, Eckmann L. Trp53 deficiency protects against acute intestinal inflammation. J Immunol. 2013 Jul 15; 191(2):837-47. PMID: 23772033; PMCID: PMC3710108.
      14. Ludwig K, Tse ES, Wang J. Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors. BMC Cancer. 2013 May 02; 13:221. PMID: 23638973; PMCID: PMC3667045.
      15. Han J, Soletti RC, Sadarangani A, Sridevi P, Ramirez ME, Eckmann L, Borges HL, Wang J. Nuclear expression of ß-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013 Mar; 11(3):207-18. PMID: 23339186; PMCID: PMC4191841.
      16. Han J, Sridevi P, Ramirez M, Ludwig KJ, Wang J. ß-Catenin-dependent lysosomal targeting of internalized tumor necrosis factor-a suppresses caspase-8 activation in apoptosis-resistant colon cancer cells. Mol Biol Cell. 2013 Feb; 24(4):465-73. PMID: 23264463; PMCID: PMC3571869.
      17. Tang J, Wang J, Parker LL. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. Chembiochem. 2012 Mar 19; 13(5):665-73. PMID: 22334513; PMCID: PMC3429332.
      18. Wang J. Checking before changing: cell cycle checkpoints inhibit muscle differentiation. Cell Cycle. 2011 Oct 01; 10(19):3234-5. PMID: 21946520.
        View in: PubMed
      19. Bourgo RJ, Thangavel C, Ertel A, Bergseid J, McClendon AK, Wilkens L, Witkiewicz AK, Wang J, Knudsen ES. RB restricts DNA damage-initiated tumorigenesis through an LXCXE-dependent mechanism of transcriptional control. Mol Cell. 2011 Aug 19; 43(4):663-72. PMID: 21855804; PMCID: PMC4271833.
      20. Zeitlin SG, Chapados BR, Baker NM, Tai C, Slupphaug G, Wang J. Uracil DNA N-glycosylase promotes assembly of human centromere protein A. PLoS One. 2011 Mar 02; 6(3):e17151. PMID: 21399697; PMCID: PMC3047565.
      21. Preyer M, Vigneri P, Wang J. Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL. PLoS One. 2011 Feb 11; 6(2):e17020. PMID: 21347248; PMCID: PMC3037956.
      22. Innocenzi A, Latella L, Messina G, Simonatto M, Marullo F, Berghella L, Poizat C, Shu CW, Wang J, Puri PL, Cossu G. An evolutionarily acquired genotoxic response discriminates MyoD from Myf5, and differentially regulates hypaxial and epaxial myogenesis. EMBO Rep. 2011 Feb; 12(2):164-71. PMID: 21212806; PMCID: PMC3049428.
      23. Jiang Y, Suo G, Sadarangani A, Cowan B, Wang J. Expression profiling of protein tyrosine kinases and their ligand activators in leiomyoma uteri. Syst Biol Reprod Med. 2010 Aug; 56(4):318-26. PMID: 20462350.
        View in: PubMed
      24. Knudsen ES, Wang J. Targeting the RB-pathway in cancer therapy. Clin Cancer Res. 2010 Feb 15; 16(4):1094-9. PMID: 20145169; PMCID: PMC2822892.
      25. Zeitlin SG, Baker NM, Chapados BR, Soutoglou E, Wang J, Berns MW, Cleveland DW. Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15762-7. PMID: 19717431; PMCID: PMC2747192.
      26. Huang V, Lu X, Jiang Y, Wang J. Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73. BMC Biol. 2009 Jun 26; 7:35. PMID: 19558638; PMCID: PMC2711048.
      27. Suo G, Jiang Y, Cowan B, Wang J. Platelet-derived growth factor C is upregulated in human uterine fibroids and regulates uterine smooth muscle cell growth. Biol Reprod. 2009 Oct; 81(4):749-58. PMID: 19553600; PMCID: PMC2754888.
      28. Suo G, Sadarangani A, Lamarca B, Cowan B, Wang J. Murine xenograft model for human uterine fibroids: an in vivo imaging approach. Reprod Sci. 2009 Sep; 16(9):827-42. PMID: 19516078.
        View in: PubMed
      29. Francis SM, Bergsied J, Isaac CE, Coschi CH, Martens AL, Hojilla CV, Chakrabarti S, Dimattia GE, Khoka R, Wang J, Dick FA. A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development. Mol Cell Biol. 2009 Aug; 29(16):4455-66. PMID: 19506017; PMCID: PMC2725731.
      30. Stuart SA, Minami Y, Wang J. The CML stem cell: evolution of the progenitor. Cell Cycle. 2009 May 01; 8(9):1338-43. PMID: 19342894; PMCID: PMC2792634.
      31. Lee SJ, Wang J. Exploiting the promiscuity of imatinib. J Biol. 2009; 8(3):30. PMID: 19435483; PMCID: PMC2689438.
      32. Stuart SA, Wang J. Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells. J Biol Chem. 2009 May 29; 284(22):15061-70. PMID: 19332548; PMCID: PMC2685688.
      33. Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang J, Naoe T. Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. Int J Hematol. 2008 Dec; 88(5):471-5. PMID: 19039626; PMCID: PMC2626150.
      34. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang J. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17967-72. PMID: 19004799.
        View in: PubMed
      35. Huang X, Wu D, Jin H, Stupack D, Wang J. Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol. 2008 Nov 17; 183(4):711-23. PMID: 19001122; PMCID: PMC2582888.
      36. Marinovic-Terzic I, Yoshioka-Yamashita A, Shimodaira H, Avdievich E, Hunton IC, Kolodner RD, Edelmann W, Wang J. Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13993-8. PMID: 18768816; PMCID: PMC2528866.
      37. Liu X, Shi Y, Woods KW, Hessler P, Kroeger P, Wilsbacher J, Wang J, Wang J, Li C, Li Q, Rosenberg SH, Giranda VL, Luo Y. Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression. Neoplasia. 2008 Aug; 10(8):828-37. PMID: 18670641; PMCID: PMC2481570.
      38. Huang X, Wang J, Lu X. Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion. BMC Syst Biol. 2008 Jun 13; 2:49. PMID: 18549508; PMCID: PMC2441606.
      39. Borges HL, Linden R, Wang J. DNA damage-induced cell death: lessons from the central nervous system. Cell Res. 2008 Jan; 18(1):17-26. PMID: 18087290; PMCID: PMC2626635.
      40. Huang X, Masselli A, Frisch SM, Hunton IC, Jiang Y, Wang J. Blockade of tumor necrosis factor-induced Bid cleavage by caspase-resistant Rb. J Biol Chem. 2007 Oct 05; 282(40):29401-13. PMID: 17686781.
        View in: PubMed
      41. Jin H, Wang J. Abl tyrosine kinase promotes dorsal ruffles but restrains lamellipodia extension during cell spreading on fibronectin. Mol Biol Cell. 2007 Oct; 18(10):4143-54. PMID: 17686996; PMCID: PMC1995715.
      42. Cui H, Levesque MP, Vernoux T, Jung JW, Paquette AJ, Gallagher KL, Wang J, Blilou I, Scheres B, Benfey PN. An evolutionarily conserved mechanism delimiting SHR movement defines a single layer of endodermis in plants. Science. 2007 Apr 20; 316(5823):421-5. PMID: 17446396.
        View in: PubMed
      43. Chau BN, Pan CW, Wang J. Separation of anti-proliferation and anti-apoptotic functions of retinoblastoma protein through targeted mutations of its A/B domain. PLoS One. 2006 Dec 20; 1:e82. PMID: 17183714; PMCID: PMC1762320.
      44. Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang J, Sowin TJ, Rosenberg SH, Zhang H. Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics. Int J Cancer. 2006 Dec 15; 119(12):2784-94. PMID: 17019715.
        View in: PubMed
      45. Chao C, Wu Z, Mazur SJ, Borges H, Rossi M, Lin T, Wang J, Anderson CW, Appella E, Xu Y. Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage. Mol Cell Biol. 2006 Sep; 26(18):6859-69. PMID: 16943427; PMCID: PMC1592865.
      46. Wang J. Eph tumour suppression: the dark side of Gleevec. Nat Cell Biol. 2006 Aug; 8(8):785-6. PMID: 16880809.
        View in: PubMed
      47. Dicker F, Kater AP, Prada CE, Fukuda T, Castro JE, Sun G, Wang J, Kipps TJ. CD154 induces p73 to overcome the resistance to apoptosis of chronic lymphocytic leukemia cells lacking functional p53. Blood. 2006 Nov 15; 108(10):3450-7. PMID: 16741250; PMCID: PMC1895435.
      48. Wang J, Edelmann W. Mismatch repair proteins as sensors of alkylation DNA damage. Cancer Cell. 2006 Jun; 9(6):417-8. PMID: 16766259.
        View in: PubMed
      49. Borges HL, Bird J, Wasson K, Cardiff RD, Varki N, Eckmann L, Wang J. Tumor promotion by caspase-resistant retinoblastoma protein. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15587-92. PMID: 16227443; PMCID: PMC1255734.
      50. Naderi S, Wang J, Chen TT, Gutzkow KB, Blomhoff HK. cAMP-mediated inhibition of DNA replication and S phase progression: involvement of Rb, p21Cip1, and PCNA. Mol Biol Cell. 2005 Mar; 16(3):1527-42. PMID: 15647383; PMCID: PMC551513.
      51. Woodring PJ, Hunter T, Wang J. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. J Biol Chem. 2005 Mar 18; 280(11):10318-25. PMID: 15632178.
        View in: PubMed
      52. Wang J. Nucleo-cytoplasmic communication in apoptotic response to genotoxic and inflammatory stress. Cell Res. 2005 Jan; 15(1):43-8. PMID: 15686626.
        View in: PubMed
      53. Li CY, Zhu J, Wang J. Ectopic expression of p73alpha, but not p73beta, suppresses myogenic differentiation. J Biol Chem. 2005 Jan 21; 280(3):2159-64. PMID: 15545283.
        View in: PubMed
      54. Woodring PJ, Meisenhelder J, Johnson SA, Zhou GL, Field J, Shah K, Bladt F, Pawson T, Niki M, Pandolfi PP, Wang J, Hunter T. c-Abl phosphorylates Dok1 to promote filopodia during cell spreading. J Cell Biol. 2004 May 24; 165(4):493-503. PMID: 15148308; PMCID: PMC2172353.
      55. Chau BN, Chen TT, Wan YY, DeGregori J, Wang J. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Mol Cell Biol. 2004 May; 24(10):4438-47. PMID: 15121862; PMCID: PMC400462.
      56. Wang J, Cho SK. Coordination of repair, checkpoint, and cell death responses to DNA damage. Adv Protein Chem. 2004; 69:101-35. PMID: 15588841.
        View in: PubMed
      57. Zhu J, Wang J. Death by Abl: a matter of location. Curr Top Dev Biol. 2004; 59:165-92. PMID: 14975251.
        View in: PubMed
      58. Wang J. Controlling Abl: auto-inhibition and co-inhibition? Nat Cell Biol. 2004 Jan; 6(1):3-7. PMID: 14704671.
        View in: PubMed
      59. Truong T, Sun G, Doorly M, Wang J, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10281-6. PMID: 12928501; PMCID: PMC193552.
      60. Guerra B, Issinger OG, Wang J. Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2. Oncogene. 2003 Aug 07; 22(32):4933-42. PMID: 12902976.
        View in: PubMed
      61. Woodring PJ, Hunter T, Wang J. Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases. J Cell Sci. 2003 Jul 01; 116(Pt 13):2613-26. PMID: 12775773.
        View in: PubMed
      62. Vella V, Zhu J, Frasca F, Li CY, Vigneri P, Vigneri R, Wang J. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003 Jul 04; 278(27):25151-7. PMID: 12716888.
        View in: PubMed
      63. Shimodaira H, Yoshioka-Yamashita A, Kolodner RD, Wang J. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2420-5. PMID: 12601175; PMCID: PMC151356.
      64. Chau BN, Wang J. Coordinated regulation of life and death by RB. Nat Rev Cancer. 2003 Feb; 3(2):130-8. PMID: 12563312.
        View in: PubMed
      65. Zhang P, Bhakta KS, Puri PL, Newbury RO, Feramisco JR, Wang J. Association of ataxia telangiectasia mutated (ATM) gene mutation/deletion with rhabdomyosarcoma. Cancer Biol Ther. 2003 Jan-Feb; 2(1):87-91. PMID: 12673126.
        View in: PubMed
      66. Puri PL, Bhakta K, Wood LD, Costanzo A, Zhu J, Wang J. A myogenic differentiation checkpoint activated by genotoxic stress. Nat Genet. 2002 Dec; 32(4):585-93. PMID: 12415271.
        View in: PubMed
      67. Chau BN, Borges HL, Chen TT, Masselli A, Hunton IC, Wang J. Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb. Nat Cell Biol. 2002 Oct; 4(10):757-65. PMID: 12360286.
        View in: PubMed
      68. Cheng K, Kurzrock R, Qiu X, Estrov Z, Ku S, Dulski KM, Wang J, Talpaz M. Reduced focal adhesion kinase and paxillin phosphorylation in BCR-ABL-transfected cells. Cancer. 2002 Jul 15; 95(2):440-50. PMID: 12124845.
        View in: PubMed
      69. Catani MV, Costanzo A, Savini I, Levrero M, de Laurenzi V, Wang J, Melino G, Avigliano L. Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage. Biochem J. 2002 Jun 01; 364(Pt 2):441-7. PMID: 12023887; PMCID: PMC1222589.
      70. Naderi S, Hunton IC, Wang J. Radiation dose-dependent maintenance of G(2) arrest requires retinoblastoma protein. Cell Cycle. 2002 May-Jun; 1(3):193-200. PMID: 12429933.
        View in: PubMed
      71. Woodring PJ, Litwack ED, O'Leary DD, Lucero GR, Wang J, Hunter T. Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension. J Cell Biol. 2002 Mar 04; 156(5):879-92. PMID: 11864995; PMCID: PMC2173320.
      72. Wang J, Ki SW. Choosing between growth arrest and apoptosis through the retinoblastoma tumour suppressor protein, Abl and p73. Biochem Soc Trans. 2001 Nov; 29(Pt 6):666-73. PMID: 11709051.
        View in: PubMed
      73. Wang J, Naderi S, Chen TT. Role of retinoblastoma tumor suppressor protein in DNA damage response. Acta Oncol. 2001; 40(6):689-95. PMID: 11765062.
        View in: PubMed
      74. Wang J, Kolodner RD. Keystone Symposia on Molecular and Cellular Biology: 'The molecular basis of cancer'. Organizers: Carol L. Prives and George F. Vande Woude, Taos, NM, 15-21 March 1999. Biochim Biophys Acta. 2000 Feb 14; 1470(1):R21-8. PMID: 10656992.
        View in: PubMed
      75. Wang J. Cellular responses to DNA damage. Curr Opin Cell Biol. 1998 Apr; 10(2):240-7. PMID: 9561848.
        View in: PubMed
      76. Wang J. Retinoblastoma protein in growth suppression and death protection. Curr Opin Genet Dev. 1997 Feb; 7(1):39-45. PMID: 9024632.
        View in: PubMed
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