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    Janelle Ayres

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentCell and Developmental Biology
    Address9500 Gilman Drive #0932
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Tolerance defenses in host-microbiota interactions
      NIH/NIAID R01AI114929May 10, 2015 - Apr 30, 2020
      Role: Principal Investigator
      Control of intestinal microflora and inflammation by immune sensing of flagellin
      NIH/NIAID F32AI091068Jul 1, 2010 - Jun 30, 2013
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Rao S, Ayres J. Resistance and tolerance defenses in cancer: Lessons from infectious diseases. Semin Immunol. 2017 Aug 30. PMID: 28865876.
        View in: PubMed
      2. Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres J, Brodsky IE, Gronert K, Vance RE. NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8. Immunity. 2017 Apr 18; 46(4):649-659. PMID: 28410991.
        View in: PubMed
      3. Rao S, Schieber AM, O'Connor CP, Leblanc M, Michel D, Ayres J. Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission. Cell. 2017 Jan 26; 168(3):503-516.e12. PMID: 28129542.
        View in: PubMed
      4. Ayres J. Microbes Dress for Success: Tolerance or Resistance? Trends Microbiol. 2017 Jan; 25(1):1-3. PMID: 27894645.
        View in: PubMed
      5. Schieber AM, Ayres J. Thermoregulation as a disease tolerance defense strategy. Pathog Dis. 2016 Dec; 74(9). PMID: 27815313.
        View in: PubMed
      6. Ayres J. Disease Tolerance Trick or Treat: Give Your Brain Something Good to Eat. Cell. 2016 Sep 08; 166(6):1368-70. PMID: 27610563.
        View in: PubMed
      7. Ayres J. Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism. Cell. 2016 Jun 02; 165(6):1323-1331. PMID: 27259146; PMCID: PMC4903080 [Available on 06/02/17].
      8. Schieber AM, Lee YM, Chang MW, Leblanc M, Collins B, Downes M, Evans RM, Ayres J. Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. Science. 2015 Oct 30; 350(6260):558-63. PMID: 26516283; PMCID: PMC4732872 [Available on 10/30/16].
      9. Ayres J. Inflammasome-microbiota interplay in host physiologies. Cell Host Microbe. 2013 Nov 13; 14(5):491-7. PMID: 24237695.
        View in: PubMed
      10. Manzanillo PS, Ayres J, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature. 2013 Sep 26; 501(7468):512-6. PMID: 24005326; PMCID: PMC3886920.
      11. von Moltke J, Ayres J, Kofoed EM, Chavarría-Smith J, Vance RE. Recognition of bacteria by inflammasomes. Annu Rev Immunol. 2013; 31:73-106. PMID: 23215645.
        View in: PubMed
      12. Ayres J, Trinidad NJ, Vance RE. Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota. Nat Med. 2012 May; 18(5):799-806. PMID: 22522562; PMCID: PMC3472005.
      13. Ayres J, Vance RE. Cellular teamwork in antibacterial innate immunity. Nat Immunol. 2012 Jan 19; 13(2):115-7. PMID: 22261960.
        View in: PubMed
      14. Stone EF, Fulton BO, Ayres J, Pham LN, Ziauddin J, Shirasu-Hiza MM. The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathog. 2012 Jan; 8(1):e1002445. PMID: 22253593; PMCID: PMC3257305.
      15. Ayres J, Schneider DS. Tolerance of infections. Annu Rev Immunol. 2012; 30:271-94. PMID: 22224770.
        View in: PubMed
      16. Ayres J, Schneider DS. The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol. 2009 Jul; 7(7):e1000150. PMID: 19597539; PMCID: PMC2701602.
      17. Ayres J, Schneider DS. A signaling protease required for melanization in Drosophila affects resistance and tolerance of infections. PLoS Biol. 2008 Dec 09; 6(12):2764-73. PMID: 19071960.
        View in: PubMed
      18. Schneider DS, Ayres J. Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases. Nat Rev Immunol. 2008 11; 8(11):889-95. PMID: 18927577; PMCID: PMC4368196.
      19. Gordon MD, Ayres J, Schneider DS, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008 Jul 25; 4(7):e1000111. PMID: 18654628; PMCID: PMC2453329.
      20. Ayres J, Freitag N, Schneider DS. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics. 2008 Mar; 178(3):1807-15. PMID: 18245331; PMCID: PMC2278058.
      21. Shirasu-Hiza MM, Dionne MS, Pham LN, Ayres J, Schneider DS. Interactions between circadian rhythm and immunity in Drosophila melanogaster. Curr Biol. 2007 May 15; 17(10):R353-5. PMID: 17502084.
        View in: PubMed
      22. Schneider DS, Ayres J, Brandt SM, Costa A, Dionne MS, Gordon MD, Mabery EM, Moule MG, Pham LN, Shirasu-Hiza MM. Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathog. 2007 Mar; 3(3):e41. PMID: 17381241; PMCID: PMC1829408.
      23. Ayres J, Schneider DS. Genomic dissection of microbial pathogenesis in cultured Drosophila cells. Trends Microbiol. 2006 Mar; 14(3):101-4. PMID: 16473012.
        View in: PubMed