James Golden

Title(s)	Professor, Molecular Biology
School	Vc-academic Affairs
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Development of an efficient cyanobacterial platform for heterologous expression and biosynthetic interrogations of natural products.
NIH R01GM118815Jan 12, 2017 - Dec 31, 2020
Role: Principal Investigator

Regulation of Cyanobacterial Multicellular Development
NIH R01GM036890Aug 1, 1986 - Nov 30, 2008
Role: Principal Investigator

TRANSCRIPTIONAL PROGRAM OF HETEROCYST DEVELOPMENT
NIH F32GM009733Oct 1, 1985
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Synechococcus elongatus Argonaute reduces natural transformation efficiency and provides immunity against exogenous plasmids. mBio. 2023 Oct 31; 14(5):e0184323. Taton A, Gilderman TS, Ernst DC, Omaga CA, Cohen LA, Rey-Bedon C, Golden JW, Golden SS. PMID: 37791787; PMCID: PMC10653904.

View in: PubMed Mentions: 1 Fields:
Mic Microbiology
Translation:Cells
Phenotypically complex living materials containing engineered cyanobacteria. Nat Commun. 2023 08 07; 14(1):4742. Datta D, Weiss EL, Wangpraseurt D, Hild E, Chen S, Golden JW, Golden SS, Pokorski JK. PMID: 37550278; PMCID: PMC10406891.

View in: PubMed Mentions: 1 Fields:
Bio Biology Sci Science
Translation:Cells
Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit. Life Sci Space Res (Amst). 2023 Feb; 36:18-26. Bishé B, Golden SS, Golden JW. PMID: 36682825; PMCID: PMC9989776.

View in: PubMed Mentions: 1 Fields:
Aer Aerospace Medicine Sci Science
Translation:Humans
Heterologous Expression in Anabaena of the Columbamide Pathway from the Cyanobacterium Moorena bouillonii and Production of New Analogs. ACS Chem Biol. 2022 07 15; 17(7):1910-1923. Taton A, Rohrer S, Diaz B, Reher R, Caraballo Rodriguez AM, Pierce ML, Dorrestein PC, Gerwick L, Gerwick WH, Golden JW. PMID: 35761435.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry Bio Biology
Translation:Cells
Altered Carbon Partitioning Enhances CO2 to Terpene Conversion in Cyanobacteria. Biodes Res. 2022; 2022:9897425. Li M, Long B, Dai SY, Golden JW, Wang X, Yuan JS. PMID: 37850123; PMCID: PMC10521692.

View in: PubMed Mentions:
Heterologous Expression of Cryptomaldamide in a Cyanobacterial Host. ACS Synth Biol. 2020 12 18; 9(12):3364-3376. Taton A, Ecker A, Diaz B, Moss NA, Anderson B, Reher R, Leão TF, Simkovsky R, Dorrestein PC, Gerwick L, Gerwick WH, Golden JW. PMID: 33180461; PMCID: PMC8514081.

View in: PubMed Mentions: 16 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Cells
The circadian clock and darkness control natural competence in cyanobacteria. Nat Commun. 2020 04 03; 11(1):1688. Taton A, Erikson C, Yang Y, Rubin BE, Rifkin SA, Golden JW, Golden SS. PMID: 32245943; PMCID: PMC7125226.

View in: PubMed Mentions: 36 Fields:
Bio Biology Sci Science
Translation:Cells
Expression of Heterologous OsDHAR Gene Improves Glutathione (GSH)-Dependent Antioxidant System and Maintenance of Cellular Redox Status in Synechococcus elongatus PCC 7942. Front Plant Sci. 2020; 11:231. Kim YS, Park SI, Kim JJ, Boyd JS, Beld J, Taton A, Lee KI, Kim IS, Golden JW, Yoon HS. PMID: 32194605; PMCID: PMC7063034.

View in: PubMed Mentions: 2
Modification of RSF1010-Based Broad-Host-Range Plasmids for Improved Conjugation and Cyanobacterial Bioprospecting. iScience. 2019 Oct 25; 20:216-228. Bishé B, Taton A, Golden JW. PMID: 31585408; PMCID: PMC6817606.

View in: PubMed Mentions: 17
Expression of OsTPX Gene Improves Cellular Redox Homeostasis and Photosynthesis Efficiency in Synechococcus elongatus PCC 7942. Front Plant Sci. 2018; 9:1848. Kim YS, Kim JJ, Park SI, Diamond S, Boyd JS, Taton A, Kim IS, Golden JW, Yoon HS. PMID: 30619416; PMCID: PMC6297720.

View in: PubMed Mentions: 5
Development of a cyanobacterial heterologous polyketide production platform. Metab Eng. 2018 09; 49:94-104. Roulet J, Taton A, Golden JW, Arabolaza A, Burkart MD, Gramajo H. PMID: 30036678; PMCID: PMC6279439.

View in: PubMed Mentions: 11 Fields:
Bio Biomedical Engineering Met Metabolism
NOT Gate Genetic Circuits to Control Gene Expression in Cyanobacteria. ACS Synth Biol. 2017 12 15; 6(12):2175-2182. Taton A, Ma AT, Ota M, Golden SS, Golden JW. PMID: 28803467; PMCID: PMC5732051.

View in: PubMed Mentions: 13 Fields:
Bio Biotechnology Mol Molecular Biology
Translation:Cells
Enhanced biomass and oxidative stress tolerance of Synechococcus elongatus PCC 7942 overexpressing the DHAR gene from Brassica juncea. Biotechnol Lett. 2017 Oct; 39(10):1499-1507. Kim YS, Kim IS, Boyd JS, Taton A, Golden JW, Yoon HS. PMID: 28667417.

View in: PubMed Mentions: 3 Fields:
Bio Biotechnology
Translation:Animals Cells
Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges. Nat Chem Biol. 2017 05; 13(5):537-543. Agarwal V, Blanton JM, Podell S, Taton A, Schorn MA, Busch J, Lin Z, Schmidt EW, Jensen PR, Paul VJ, Biggs JS, Golden JW, Allen EE, Moore BS. PMID: 28319100; PMCID: PMC5391271.

View in: PubMed Mentions: 54 Fields:
Bio Biology Che Chemistry
Translation:Animals Cells
Self-replicating shuttle vectors based on pANS, a small endogenous plasmid of the unicellular cyanobacterium Synechococcus elongatus PCC 7942. Microbiology (Reading). 2016 12; 162(12):2029-2041. Chen Y, Taton A, Go M, London RE, Pieper LM, Golden SS, Golden JW. PMID: 27902432.

View in: PubMed Mentions: 18 Fields:
Mic Microbiology
Translation:Cells
Deep sequencing of HetR-bound DNA reveals novel HetR targets in Anabaena sp. strain PCC7120. BMC Microbiol. 2014 Oct 03; 14:255. Flaherty BL, Johnson DB, Golden JW. PMID: 25278209; PMCID: PMC4192349.

View in: PubMed Mentions: 9 Fields:
Mic Microbiology
Translation:Cells
Regulation of gene expression in diverse cyanobacterial species by using theophylline-responsive riboswitches. Appl Environ Microbiol. 2014 Nov; 80(21):6704-13. Ma AT, Schmidt CM, Golden JW. PMID: 25149516; PMCID: PMC4249034.

View in: PubMed Mentions: 42 Fields:
Mic Microbiology
Translation:Cells
Broad-host-range vector system for synthetic biology and biotechnology in cyanobacteria. Nucleic Acids Res. 2014; 42(17):e136. Taton A, Unglaub F, Wright NE, Zeng WY, Paz-Yepes J, Brahamsha B, Palenik B, Peterson TC, Haerizadeh F, Golden SS, Golden JW. PMID: 25074377; PMCID: PMC4176158.

View in: PubMed Mentions: 74 Fields:
Bio Biochemistry
Translation:Cells
Gene transfer in Leptolyngbya sp. strain BL0902, a cyanobacterium suitable for production of biomass and bioproducts. PLoS One. 2012; 7(1):e30901. Taton A, Lis E, Adin DM, Dong G, Cookson S, Kay SA, Golden SS, Golden JW. PMID: 22292073; PMCID: PMC3265524.

View in: PubMed Mentions: 22 Fields:
Med Medicine (General)Sci Science
Translation:Cells
Directional RNA deep sequencing sheds new light on the transcriptional response of Anabaena sp. strain PCC 7120 to combined-nitrogen deprivation. BMC Genomics. 2011 Jun 28; 12:332. Flaherty BL, Van Nieuwerburgh F, Head SR, Golden JW. PMID: 21711558; PMCID: PMC3141674.

View in: PubMed Mentions: 75 Fields:
Gen Genetics
Translation:Cells
Overexpression of pknE blocks heterocyst development in Anabaena sp. strain PCC 7120. J Bacteriol. 2011 May; 193(10):2619-29. Saha SK, Golden JW. PMID: 21421755; PMCID: PMC3133150.

View in: PubMed Mentions: 8 Fields:
Bac Bacteriology
Translation:Cells
The sigE gene is required for normal expression of heterocyst-specific genes in Anabaena sp. strain PCC 7120. J Bacteriol. 2011 Apr; 193(8):1823-32. Mella-Herrera RA, Neunuebel MR, Kumar K, Saha SK, Golden JW. PMID: 21317330; PMCID: PMC3133031.

View in: PubMed Mentions: 9 Fields:
Bac Bacteriology
Translation:Cells
Anabaena sp. strain PCC 7120 conR contains a LytR-CpsA-Psr domain, is developmentally regulated, and is essential for diazotrophic growth and heterocyst morphogenesis. Microbiology (Reading). 2011 Mar; 157(Pt 3):617-626. Mella-Herrera RA, Neunuebel MR, Golden JW. PMID: 21088107.

View in: PubMed Mentions: 10 Fields:
Mic Microbiology
Translation:Cells
Cyanobacterial heterocysts. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a000315. Kumar K, Mella-Herrera RA, Golden JW. PMID: 20452939; PMCID: PMC2845205.

View in: PubMed Mentions: 153 Fields:
Bio Biology
Translation:Cells
The Anabaena sp. strain PCC 7120 gene all2874 encodes a diguanylate cyclase and is required for normal heterocyst development under high-light growth conditions. J Bacteriol. 2008 Oct; 190(20):6829-36. Neunuebel MR, Golden JW. PMID: 18723619; PMCID: PMC2566204.

View in: PubMed Mentions: 24 Fields:
Bac Bacteriology
Translation:Cells
Sigma factor genes sigC, sigE, and sigG are upregulated in heterocysts of the cyanobacterium Anabaena sp. strain PCC 7120. J Bacteriol. 2007 Nov; 189(22):8392-6. Aldea MR, Mella-Herrera RA, Golden JW. PMID: 17873052; PMCID: PMC2168693.

View in: PubMed Mentions: 17 Fields:
Bac Bacteriology
Translation:Cells
The Anabaena sp. strain PCC 7120 asr1734 gene encodes a negative regulator of heterocyst development. Mol Microbiol. 2007 May; 64(3):782-94. Wu X, Lee DW, Mella RA, Golden JW. PMID: 17462023.

View in: PubMed Mentions: 7 Fields:
Mic Microbiology Mol Molecular Biology
Translation:Cells
Heterocyst-specific excision of the Anabaena sp. strain PCC 7120 hupL element requires xisC. J Bacteriol. 2005 Sep; 187(17):6031-8. Carrasco CD, Holliday SD, Hansel A, Lindblad P, Golden JW. PMID: 16109944; PMCID: PMC1196164.

View in: PubMed Mentions: 19 Fields:
Bac Bacteriology
Translation:Cells
A zinc(II)/lead(II)/cadmium(II)-inducible operon from the Cyanobacterium anabaena is regulated by AztR, an alpha3N ArsR/SmtB metalloregulator. Biochemistry. 2005 Jun 21; 44(24):8673-83. Liu T, Golden JW, Giedroc DP. PMID: 15952774.

View in: PubMed Mentions: 29 Fields:
Bio Biochemistry
Translation:Cells
Different functions of HetR, a master regulator of heterocyst differentiation in Anabaena sp. PCC 7120, can be separated by mutation. Proc Natl Acad Sci U S A. 2004 Nov 09; 101(45):16040-5. Khudyakov IY, Golden JW. PMID: 15520378; PMCID: PMC528747.

View in: PubMed Mentions: 35 Fields:
Sci Science
Translation:Cells
patS minigenes inhibit heterocyst development of Anabaena sp. strain PCC 7120. J Bacteriol. 2004 Oct; 186(19):6422-9. Wu X, Liu D, Lee MH, Golden JW. PMID: 15375122; PMCID: PMC516582.

View in: PubMed Mentions: 24 Fields:
Bac Bacteriology
Translation:Cells
Anabaena sp. strain PCC 7120 hetY gene influences heterocyst development. J Bacteriol. 2003 Dec; 185(23):6995-7000. Yoon HS, Lee MH, Xiong J, Golden JW. PMID: 14617665; PMCID: PMC262716.

View in: PubMed Mentions: 4 Fields:
Bac Bacteriology
Translation:Cells
Heterocyst development in Anabaena. Curr Opin Microbiol. 2003 Dec; 6(6):557-63. Golden JW, Yoon HS. PMID: 14662350.

View in: PubMed Mentions: 70 Fields:
Mic Microbiology
Translation:Cells
PlmA, a new member of the GntR family, has plasmid maintenance functions in Anabaena sp. strain PCC 7120. J Bacteriol. 2003 Aug; 185(15):4315-25. Lee MH, Scherer M, Rigali S, Golden JW. PMID: 12867439; PMCID: PMC165748.

View in: PubMed Mentions: 36 Fields:
Bac Bacteriology
Translation:Cells