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    Jack Dixon

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0721
    CA La Jolla 92093
    Phone858-822-0491
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Nguyen KB, Sreelatha A, Durrant ES, Lopez-Garrido J, Muszewska A, Dudkiewicz M, Grynberg M, Yee S, Pogliano K, Tomchick DR, Pawlowski K, Dixon JE, Tagliabracci VS. Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc Natl Acad Sci U S A. 2016 Jun 21; 113(25):E3482-91. PMID: 27185916.
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      2. Guo X, Wang X, Wang Z, Banerjee S, Yang J, Huang L, Dixon JE. Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol. 2016 Feb; 18(2):202-12. PMID: 26655835.
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      3. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE. A Single Kinase Generates the Majority of the Secreted Phosphoproteome. Cell. 2015 Jun 18; 161(7):1619-32. PMID: 26091039.
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      4. Worby CA, Dixon JE. Unpacking the unfolded protein response. Cell. 2014 Sep 11; 158(6):1221-4. PMID: 25215479.
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      5. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-44. PMID: 25171405.
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      6. Worby CA, Dixon JE. Pten. Annu Rev Biochem. 2014 Jun 2; 83:641-69. PMID: 24905788.
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      7. Tagliabracci VS, Engel JL, Wiley SE, Xiao J, Gonzalez DJ, Nidumanda Appaiah H, Koller A, Nizet V, White KE, Dixon JE. Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5520-5. PMID: 24706917.
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      8. Bahmanyar S, Biggs R, Schuh AL, Desai A, Müller-Reichert T, Audhya A, Dixon JE, Oegema K. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Genes Dev. 2014 Jan 15; 28(2):121-6. PMID: 24449268.
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      9. Wang Z, Hou Y, Guo X, van der Voet M, Boxem M, Dixon JE, Chisholm AD, Jin Y. The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron. 2013 Sep 4; 79(5):903-16. PMID: 24012004.
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      10. Tagliabracci VS, Xiao J, Dixon JE. Phosphorylation of substrates destined for secretion by the Fam20 kinases. Biochem Soc Trans. 2013 Aug; 41(4):1061-5. PMID: 23863179.
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      11. Xiao J, Tagliabracci VS, Wen J, Kim SA, Dixon JE. Crystal structure of the Golgi casein kinase. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10574-9. PMID: 23754375.
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      12. Wiley SE, Andreyev AY, Divakaruni AS, Karisch R, Perkins G, Wall EA, van der Geer P, Chen YF, Tsai TF, Simon MI, Neel BG, Dixon JE, Murphy AN. Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med. 2013 Jun; 5(6):904-18. PMID: 23703906.
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      13. Teh PG, Chen MJ, Engel JL, Worby CA, Manning G, Dixon JE, Zhang J. Identification of a mammalian-type phosphatidylglycerophosphate phosphatase in the Eubacterium Rhodopirellula baltica. J Biol Chem. 2013 Feb 15; 288(7):5176-85. PMID: 23293031.
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      14. Tagliabracci VS, Pinna LA, Dixon JE. Secreted protein kinases. Trends Biochem Sci. 2013 Mar; 38(3):121-30. PMID: 23276407.
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      15. Tagliabracci VS, Engel JL, Wen J, Wiley SE, Worby CA, Kinch LN, Xiao J, Grishin NV, Dixon JE. Secreted kinase phosphorylates extracellular proteins that regulate biomineralization. Science. 2012 Jun 1; 336(6085):1150-3. PMID: 22582013.
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      16. Gonzalez DJ, Okumura CY, Hollands A, Kersten R, Akong-Moore K, Pence MA, Malone CL, Derieux J, Moore BS, Horswill AR, Dixon JE, Dorrestein PC, Nizet V. Novel phenol-soluble modulin derivatives in community-associated methicillin-resistant Staphylococcus aureus identified through imaging mass spectrometry. J Biol Chem. 2012 Apr 20; 287(17):13889-98. PMID: 22371493.
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      17. Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon JE. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18649-54. PMID: 21949367.
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      18. Mattoo S, Durrant E, Chen MJ, Xiao J, Lazar CS, Manning G, Dixon JE, Worby CA. Comparative analysis of Histophilus somni immunoglobulin-binding protein A (IbpA) with other fic domain-containing enzymes reveals differences in substrate and nucleotide specificities. J Biol Chem. 2011 Sep 16; 286(37):32834-42. PMID: 21795713.
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      19. Xiao J, Engel JL, Zhang J, Chen MJ, Manning G, Dixon JE. Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11860-5. PMID: 21730175.
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      20. Zhang J, Guan Z, Murphy AN, Wiley SE, Perkins GA, Worby CA, Engel JL, Heacock P, Nguyen OK, Wang JH, Raetz CR, Dowhan W, Dixon JE. Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab. 2011 Jun 8; 13(6):690-700. PMID: 21641550.
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      21. Worby CA, Dixon JE. Glycogen synthase: an old enzyme with a new trick. Cell Metab. 2011 Mar 2; 13(3):233-4. PMID: 21356510.
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      22. Xiao J, Worby CA, Mattoo S, Sankaran B, Dixon JE. Structural basis of Fic-mediated adenylylation. Nat Struct Mol Biol. 2010 Aug; 17(8):1004-10. PMID: 20622875.
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      23. Gonzalez DJ, Lee SW, Hensler ME, Markley AL, Dahesh S, Mitchell DA, Bandeira N, Nizet V, Dixon JE, Dorrestein PC. Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem. 2010 Sep 3; 285(36):28220-8. PMID: 20581111.
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      24. Gentry MS, Dixon JE, Worby CA. Lafora disease: insights into neurodegeneration from plant metabolism. Trends Biochem Sci. 2009 Dec; 34(12):628-39. PMID: 19818631.
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      25. Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE. The fic domain: regulation of cell signaling by adenylylation. Mol Cell. 2009 Apr 10; 34(1):93-103. PMID: 19362538.
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      26. Dowen RH, Engel JL, Shao F, Ecker JR, Dixon JE. A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes. J Biol Chem. 2009 Jun 5; 284(23):15867-79. PMID: 19346252.
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      27. Rardin MJ, Wiley SE, Naviaux RK, Murphy AN, Dixon JE. Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem. 2009 Jun 15; 389(2):157-64. PMID: 19341700.
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      28. Mitchell DA, Lee SW, Pence MA, Markley AL, Limm JD, Nizet V, Dixon JE. Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S. J Biol Chem. 2009 May 8; 284(19):13004-12. PMID: 19286651.
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      29. Rardin MJ, Taylor GS, Dixon JE. Distinguishing mitochondrial inner membrane orientation of dual specific phosphatase 18 and 21. Methods Enzymol. 2009; 457:275-87. PMID: 19426873.
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      30. Wiley SE, Rardin MJ, Dixon JE. Chapter 13 Localization and function of the 2Fe-2S outer mitochondrial membrane protein mitoNEET. Methods Enzymol. 2009; 456:233-46. PMID: 19348892.
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      31. Iwasaki H, Murata Y, Kim Y, Hossain MI, Worby CA, Dixon JE, McCormack T, Sasaki T, Okamura Y. A voltage-sensing phosphatase, Ci-VSP, which shares sequence identity with PTEN, dephosphorylates phosphatidylinositol 4,5-bisphosphate. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):7970-5. PMID: 18524949.
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      32. Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008 May 30; 283(22):15440-50. PMID: 18385140.
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      33. Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A. 2008 Apr 15; 105(15):5879-84. PMID: 18375757.
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      34. Robinson FL, Niesman IR, Beiswenger KK, Dixon JE. Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4916-21. PMID: 18349142.
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      35. Mattoo S, Alto NM, Dixon JE. Subversion of myosin function by E. coli. Dev Cell. 2008 Jan; 14(1):8-10. PMID: 18194648.
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      36. Worby CA, Gentry MS, Dixon JE. Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). J Biol Chem. 2008 Feb 15; 283(7):4069-76. PMID: 18070875.
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      37. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 1; 21(19):2399-409. PMID: 17908927.
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      38. Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. J Cell Biol. 2007 Sep 24; 178(7):1265-78. PMID: 17893247.
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      39. Paddock ML, Wiley SE, Axelrod HL, Cohen AE, Roy M, Abresch EC, Capraro D, Murphy AN, Nechushtai R, Dixon JE, Jennings PA. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A. 2007 Sep 4; 104(36):14342-7. PMID: 17766440.
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      40. Mattoo S, Lee YM, Dixon JE. Interactions of bacterial effector proteins with host proteins. Curr Opin Immunol. 2007 Aug; 19(4):392-401. PMID: 17662586.
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      41. Gentry MS, Dowen RH, Worby CA, Mattoo S, Ecker JR, Dixon JE. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol. 2007 Jul 30; 178(3):477-88. PMID: 17646401.
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      42. Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem. 2007 Aug 17; 282(33):23745-9. PMID: 17584744.
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      43. Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE. Identification of a molecular target for the Yersinia protein kinase A. Mol Cell. 2007 May 25; 26(4):465-77. PMID: 17531806.
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      44. Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC, Dixon JE. A conserved phosphatase cascade that regulates nuclear membrane biogenesis. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6596-601. PMID: 17420445.
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      45. Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5318-23. PMID: 17376863.
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      46. Worby CA, Gentry MS, Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem. 2006 Oct 13; 281(41):30412-8. PMID: 16901901.
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      47. Robinson FL, Dixon JE. Myotubularin phosphatases: policing 3-phosphoinositides. Trends Cell Biol. 2006 Aug; 16(8):403-12. PMID: 16828287.
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      48. Worby CA, Dixon JE. Microbiology. Bacteria seize control by acetylating host proteins. Science. 2006 May 26; 312(5777):1150-1. PMID: 16731519.
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      49. Alto NM, Shao F, Lazar CS, Brost RL, Chua G, Mattoo S, McMahon SA, Ghosh P, Hughes TR, Boone C, Dixon JE. Identification of a bacterial type III effector family with G protein mimicry functions. Cell. 2006 Jan 13; 124(1):133-45. PMID: 16413487.
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      50. Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE. Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):927-32. PMID: 16410353.
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      51. Pagliarini DJ, Dixon JE. Mitochondrial modulation: reversible phosphorylation takes center stage? Trends Biochem Sci. 2006 Jan; 31(1):26-34. PMID: 16337125.
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      52. Begley MJ, Dixon JE. The structure and regulation of myotubularin phosphatases. Curr Opin Struct Biol. 2005 Dec; 15(6):614-20. PMID: 16289848.
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      53. Worby CA, Dixon JE. Phosphoinositide phosphatases: emerging roles as voltage sensors? Mol Interv. 2005 Oct; 5(5):274-7. PMID: 16249522.
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      54. Pagliarini DJ, Wiley SE, Kimple ME, Dixon JR, Kelly P, Worby CA, Casey PJ, Dixon JE. Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells. Mol Cell. 2005 Jul 22; 19(2):197-207. PMID: 16039589.
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      55. Robinson FL, Dixon JE. The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease. J Biol Chem. 2005 Sep 9; 280(36):31699-707. PMID: 15998640.
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      56. Gentry MS, Worby CA, Dixon JE. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005 Jun 14; 102(24):8501-6. PMID: 15930137.
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      57. Navarro L, Alto NM, Dixon JE. Functions of the Yersinia effector proteins in inhibiting host immune responses. Curr Opin Microbiol. 2005 Feb; 8(1):21-7. PMID: 15694853.
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      58. Pagliarini DJ, Worby CA, Dixon JE. A PTEN-like phosphatase with a novel substrate specificity. J Biol Chem. 2004 Sep 10; 279(37):38590-6. PMID: 15247229.
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      59. Worby CA, Dixon JE. RNA interference in cultured Drosophila cells. Curr Protoc Mol Biol. 2004 Feb; Chapter 26:Unit 26.5. PMID: 18265350.
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      60. Taylor GS, Dixon JE. Assaying phosphoinositide phosphatases. Methods Mol Biol. 2004; 284:217-27. PMID: 15173619.
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      61. Merlot S, Meili R, Pagliarini DJ, Maehama T, Dixon JE, Firtel RA. A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi. J Biol Chem. 2003 Oct 10; 278(41):39866-73. PMID: 12878591.
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      62. Das S, Dixon JE, Cho W. Membrane-binding and activation mechanism of PTEN. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7491-6. PMID: 12808147.
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      63. Taylor GS, Dixon JE. PTEN and myotubularins: families of phosphoinositide phosphatases. Methods Enzymol. 2003; 366:43-56. PMID: 14674238.
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      64. Worby CA, Dixon JE. Sorting out the cellular functions of sorting nexins. Nat Rev Mol Cell Biol. 2002 Dec; 3(12):919-31. PMID: 12461558.
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      65. Muda M, Worby CA, Simonson-Leff N, Clemens JC, Dixon JE. Use of double-stranded RNA-mediated interference to determine the substrates of protein tyrosine kinases and phosphatases. Biochem J. 2002 Aug 15; 366(Pt 1):73-7. PMID: 12014990.
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      66. Worby CA, Simonson-Leff N, Clemens JC, Huddler D, Muda M, Dixon JE. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002 Mar 15; 277(11):9422-8. PMID: 11773052.
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      67. Mayo LD, Dixon JE, Durden DL, Tonks NK, Donner DB. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem. 2002 Feb 15; 277(7):5484-9. PMID: 11729185.
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