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    Inge Holtman

    TitlePostdoctoral Scholar
    SchoolUniversity of California, San Diego
    DepartmentCellular and Molecular Medicine
    Address9500 Gilman Drive #0651
    CA La Jolla 92093
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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Holtman I, Bsibsi M, Gerritsen WH, Boddeke HW, Eggen BJ, van der Valk P, Kipp M, van Noort JM, Amor S. Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin. Glia. 2017 Mar; 65(3):460-473. PMID: 28063173.
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      2. Janssen L, Dubbelaar ML, Holtman I, de Boer-Bergsma J, Eggen BJ, Boddeke HW, De Deyn PP, Van Dam D. Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease. Biochim Biophys Acta. 2017 Feb; 1863(2):395-405. PMID: 27838490.
        View in: PubMed
      3. Oosterhof N, Holtman I, Kuil LE, van der Linde HC, Boddeke EW, Eggen BJ, van Ham TJ. Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 2017 Jan; 65(1):138-149. PMID: 27757989.
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      4. Scheffold A, Holtman I, Dieni S, Brouwer N, Katz SF, Jebaraj BM, Kahle PJ, Hengerer B, Lechel A, Stilgenbauer S, Boddeke EW, Eggen BJ, Rudolph KL, Biber K. Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model. Acta Neuropathol Commun. 2016; 4(1):87. PMID: 27550225; PMCID: PMC4994259.
      5. Janova H, Böttcher C, Holtman I, Regen T, van Rossum D, Götz A, Ernst AS, Fritsche C, Gertig U, Saiepour N, Gronke K, Wrzos C, Ribes S, Rolfes S, Weinstein J, Ehrenreich H, Pukrop T, Kopatz J, Stadelmann C, Salinas-Riester G, Weber MS, Prinz M, Brück W, Eggen BJ, Boddeke HW, Priller J, Hanisch UK. CD14 is a key organizer of microglial responses to CNS infection and injury. Glia. 2016 Apr; 64(4):635-49. PMID: 26683584.
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      6. Raj DD, Moser J, van der Pol SM, van Os RP, Holtman I, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW. Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening. Aging Cell. 2015 Dec; 14(6):1003-13. PMID: 26238505; PMCID: PMC4693462.
      7. Wes PD, Holtman I, Boddeke EW, Möller T, Eggen BJ. Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease. Glia. 2016 Feb; 64(2):197-213. PMID: 26040959.
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      8. Holtman I, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ. Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathol Commun. 2015; 3:31. PMID: 26001565; PMCID: PMC4489356.
      9. Holtman I, Noback M, Bijlsma M, Duong KN, van der Geest MA, Ketelaars PT, Brouwer N, Vainchtein ID, Eggen BJ, Boddeke HW. Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease. Glia. 2015 Sep; 63(9):1495-506. PMID: 25808223.
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      10. Szulzewsky F, Pelz A, Feng X, Synowitz M, Markovic D, Langmann T, Holtman I, Wang X, Eggen BJ, Boddeke HW, Hambardzumyan D, Wolf SA, Kettenmann H. Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1. PLoS One. 2015; 10(2):e0116644. PMID: 25658639; PMCID: PMC4320099.
      11. Bsibsi M, Peferoen LA, Holtman I, Nacken PJ, Gerritsen WH, Witte ME, van Horssen J, Eggen BJ, van der Valk P, Amor S, van Noort JM. Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-? and alpha B-crystallin. Acta Neuropathol. 2014 Aug; 128(2):215-29. PMID: 24997049.
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      12. Raj DD, Jaarsma D, Holtman I, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW. Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiol Aging. 2014 Sep; 35(9):2147-60. PMID: 24799273.
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      13. Bsibsi M, Holtman I, Gerritsen WH, Eggen BJ, Boddeke E, van der Valk P, van Noort JM, Amor S. Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions. J Neuropathol Exp Neurol. 2013 Oct; 72(10):970-9. PMID: 24042199.
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      14. van Noort JM, Bsibsi M, Nacken PJ, Gerritsen WH, Amor S, Holtman I, Boddeke E, van Ark I, Leusink-Muis T, Folkerts G, Hennink WE, Amidi M. Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles. Biomaterials. 2013 Jan; 34(3):831-40. PMID: 23117214.
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