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    Immo Scheffler

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0322
    CA La Jolla 92093
    Phone858-534-2741
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      Collapse Research 
      Collapse Research Activities and Funding
      MOLEC GENETICS OF COMPLEX I IN MAMMALIAN MITOCHONDRIA
      NIH/NIGMS R01GM059909Jul 1, 2001 - Dec 31, 2005
      Role: Principal Investigator
      MOLECULAR GENETICS OF RESPIRATION-DEFICIENT CELLS
      NIH/NIGMS R01GM033752Aug 1, 1984 - Mar 31, 1996
      Role: Principal Investigator
      MOLECULAR CHARACTERIZATION OF A HUMAN CENTROMERE
      NIH/NIGMS R01GM018835Sep 1, 1977 - Aug 31, 1993
      Role: Principal Investigator
      Cell and Molecular Genetics Training Program
      NIH/NIGMS T32GM007240Jul 1, 1975 - Jun 30, 2020
      Role: Co-Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Fogal V, Richardson AD, Karmali PP, Scheffler I, Smith JW, Ruoslahti E. Correction for Fogal et al., "Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation". Mol Cell Biol. 2017 Jul 15; 37(14). PMID: 28663271.
        View in: PubMed
      2. Potluri P, Procaccio V, Scheffler I, Wallace DC. High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (?(-)) mutant. Biochim Biophys Acta. 2016 Aug; 1857(8):1336-1343. PMID: 26946086; PMCID: PMC4893908 [Available on 08/01/17].
      3. Scheffler I. Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. J Inherit Metab Dis. 2015 May; 38(3):405-15. PMID: 25224827.
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      4. Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, Ronai ZA. PKCe promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell. 2012 Feb 03; 148(3):543-55. PMID: 22304920; PMCID: PMC3615433.
      5. Compton S, Kim C, Griner NB, Potluri P, Scheffler I, Sen S, Jerry DJ, Schneider S, Yadava N. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J Biol Chem. 2011 Jun 10; 286(23):20297-312. PMID: 21502317; PMCID: PMC3121470.
      6. Scheffler I. Assembling complex I with ACAD9. Cell Metab. 2010 Sep 08; 12(3):211-2. PMID: 20816087.
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      7. Fogal V, Richardson AD, Karmali PP, Scheffler I, Smith JW, Ruoslahti E. Mitochondrial p32 protein is a critical regulator of tumor metabolism via maintenance of oxidative phosphorylation. Mol Cell Biol. 2010 Mar; 30(6):1303-18. PMID: 20100866; PMCID: PMC2832503.
      8. Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler I, Ralph SJ, Neuzil J. Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res. 2009 Mar 01; 15(5):1593-600. PMID: 19223492.
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      9. Potluri P, Davila A, Ruiz-Pesini E, Mishmar D, O'Hearn S, Hancock S, Simon M, Scheffler I, Wallace DC, Procaccio V. A novel NDUFA1 mutation leads to a progressive mitochondrial complex I-specific neurodegenerative disease. Mol Genet Metab. 2009 Apr; 96(4):189-95. PMID: 19185523; PMCID: PMC2693342.
      10. Dong LF, Low P, Dyason JC, Wang XF, Prochazka L, Witting PK, Freeman R, Swettenham E, Valis K, Liu J, Zobalova R, Turanek J, Spitz DR, Domann FE, Scheffler I, Ralph SJ, Neuzil J. Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. Oncogene. 2008 Jul 17; 27(31):4324-35. PMID: 18372923; PMCID: PMC2668987.
      11. Yadava N, Potluri P, Scheffler I. Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. Int J Biochem Cell Biol. 2008; 40(3):447-60. PMID: 17931954.
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      12. Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X, Scheffler I, Mock DC, Bataille AR, Robert F, Lee CH, Giguère V, Evans RM. Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev. 2007 Aug 01; 21(15):1909-20. PMID: 17671090; PMCID: PMC1935029.
      13. Neuzil J, Dyason JC, Freeman R, Dong LF, Prochazka L, Wang XF, Scheffler I, Ralph SJ. Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. J Bioenerg Biomembr. 2007 Feb; 39(1):65-72. PMID: 17294131.
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      14. Broderick KE, Potluri P, Zhuang S, Scheffler I, Sharma VS, Pilz RB, Boss GR. Cyanide detoxification by the cobalamin precursor cobinamide. Exp Biol Med (Maywood). 2006 May; 231(5):641-9. PMID: 16636313.
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      15. Scheffler I, Yadava N, Potluri P. Molecular genetics of complex I-deficient Chinese hamster cell lines. Biochim Biophys Acta. 2004 Dec 06; 1659(2-3):160-71. PMID: 15576048.
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      16. Potluri P, Yadava N, Scheffler I. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur J Biochem. 2004 Aug; 271(15):3265-73. PMID: 15265046.
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      17. Ricci JE, Muñoz-Pinedo C, Fitzgerald P, Bailly-Maitre B, Perkins GA, Yadava N, Scheffler I, Ellisman MH, Green DR. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Cell. 2004 Jun 11; 117(6):773-86. PMID: 15186778.
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      18. Yadava N, Scheffler I. Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion. 2004 Jun; 4(1):1-12. PMID: 16120368.
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      19. Yadava N, Houchens T, Potluri P, Scheffler I. Development and characterization of a conditional mitochondrial complex I assembly system. J Biol Chem. 2004 Mar 26; 279(13):12406-13. PMID: 14722084.
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      20. Albayrak T, Scherhammer V, Schoenfeld N, Braziulis E, Mund T, Bauer MK, Scheffler I, Grimm S. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. Mol Biol Cell. 2003 Aug; 14(8):3082-96. PMID: 12925748; PMCID: PMC181552.
      21. de la Cruz BJ, Prieto S, Scheffler I. The role of the 5' untranslated region (UTR) in glucose-dependent mRNA decay. Yeast. 2002 Jul; 19(10):887-902. PMID: 12112242.
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      22. Yadava N, Potluri P, Smith EN, Bisevac A, Scheffler I. Species-specific and mutant MWFE proteins. Their effect on the assembly of a functional mammalian mitochondrial complex I. J Biol Chem. 2002 Jun 14; 277(24):21221-30. PMID: 11937507.
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      23. Scheffler I. Mitochondria make a come back. Adv Drug Deliv Rev. 2001 Jul 02; 49(1-2):3-26. PMID: 11377800.
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      24. Scheffler I. A century of mitochondrial research: achievements and perspectives. Mitochondrion. 2001 Jun; 1(1):3-31. PMID: 16120266.
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      25. Scheffler I, Yadava N. Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase. J Bioenerg Biomembr. 2001 Jun; 33(3):243-50. PMID: 11695834.
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      26. Lin KM, Lin B, Lian IY, Mestril R, Scheffler I, Dillmann WH. Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation. Circulation. 2001 Apr 03; 103(13):1787-92. PMID: 11282911.
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      27. Prieto S, de la Cruz BJ, Scheffler I. Glucose-regulated turnover of mRNA and the influence of poly(A) tail length on half-life. J Biol Chem. 2000 May 12; 275(19):14155-66. PMID: 10799492.
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      28. Au HC, Seo BB, Matsuno-Yagi A, Yagi T, Scheffler I. The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4354-9. PMID: 10200266; PMCID: PMC16336.
      29. Au HC, Mascarello JT, Scheffler I. Targeted integration of a dominant neo(R) marker into a 2- to 3-Mb human minichromosome and transfer between cells. Cytogenet Cell Genet. 1999; 86(3-4):194-203. PMID: 10575205.
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      30. Scheffler I, de la Cruz BJ, Prieto S. Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. Int J Biochem Cell Biol. 1998 Nov; 30(11):1175-93. PMID: 9839444.
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      31. Seo BB, Kitajima-Ihara T, Chan EK, Scheffler I, Matsuno-Yagi A, Yagi T. Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc Natl Acad Sci U S A. 1998 Aug 04; 95(16):9167-71. PMID: 9689052; PMCID: PMC21310.
      32. Elbehti-Green A, Au HC, Mascarello JT, Ream-Robinson D, Scheffler I. Characterization of the human SDHC gene encoding of the integral membrane proteins of succinate-quinone oxidoreductase in mitochondria. Gene. 1998 Jun 15; 213(1-2):133-40. PMID: 9714607.
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      33. Au HC, Scheffler I. Promoter analysis of the human succinate dehydrogenase iron-protein gene--both nuclear respiratory factors NRF-1 and NRF-2 are required. Eur J Biochem. 1998 Jan 15; 251(1-2):164-74. PMID: 9492280.
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      34. Scheffler I. Molecular genetics of succinate:quinone oxidoreductase in eukaryotes. Prog Nucleic Acid Res Mol Biol. 1998; 60:267-315. PMID: 9594577.
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      35. Lorenzini EC, Scheffler I. Co-operation of the 5' and 3' untranslated regions of ornithine decarboxylase mRNA and inhibitory role of its 3' untranslated region in regulating the translational efficiency of hybrid RNA species via cellular factor. Biochem J. 1997 Sep 01; 326 ( Pt 2):361-7. PMID: 9291106; PMCID: PMC1218679.
      36. Au HC, Scheffler I. A respiration-deficient Chinese hamster cell line with a defect in mitochondrial protein synthesis: rapid turnover of some mitochondrial transcripts. Somat Cell Mol Genet. 1997 Jan; 23(1):27-35. PMID: 9217999.
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      37. Cereghino GP, Scheffler I. Genetic analysis of glucose regulation in saccharomyces cerevisiae: control of transcription versus mRNA turnover. EMBO J. 1996 Jan 15; 15(2):363-74. PMID: 8617211; PMCID: PMC449951.
      38. Oostveen FG, Au HC, Meijer PJ, Scheffler I. A Chinese hamster mutant cell line with a defect in the integral membrane protein CII-3 of complex II of the mitochondrial electron transport chain. J Biol Chem. 1995 Nov 03; 270(44):26104-8. PMID: 7592812.
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      39. Cereghino GP, Atencio DP, Saghbini M, Beiner J, Scheffler I. Glucose-dependent turnover of the mRNAs encoding succinate dehydrogenase peptides in Saccharomyces cerevisiae: sequence elements in the 5' untranslated region of the Ip mRNA play a dominant role. Mol Biol Cell. 1995 Sep; 6(9):1125-43. PMID: 8534911; PMCID: PMC301272.
      40. Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler I. Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. Gene. 1995 Jul 04; 159(2):249-53. PMID: 7622059.
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      41. Lövkvist-Wallström E, Stjernborg-Ulvsbäck L, Scheffler I, Persson L. Regulation of mammalian ornithine decarboxylase. Studies on the induction of the enzyme by hypotonic stress. Eur J Biochem. 1995 Jul 01; 231(1):40-4. PMID: 7628482.
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      42. Pilz RB, Berjis M, Idriss SD, Scheele JS, Suhasini M, Gao L, Scheffler I, Boss GR. Isolation and characterization of HL-60 cells resistant to nitroprusside-induced differentiation. J Biol Chem. 1994 Dec 23; 269(51):32155-61. PMID: 7798212.
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      43. Au HC, Scheffler I. Characterization of the gene encoding the iron-sulfur protein subunit of succinate dehydrogenase from Drosophila melanogaster. Gene. 1994 Nov 18; 149(2):261-5. PMID: 7958999.
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      44. Saghbini M, Broomfield PL, Scheffler I. Studies on the assembly of complex II in yeast mitochondria using chimeric human/yeast genes for the iron-sulfur protein subunit. Biochemistry. 1994 Jan 11; 33(1):159-65. PMID: 8286334.
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      45. Leckschat S, Ream-Robinson D, Scheffler I. The gene for the iron sulfur protein of succinate dehydrogenase (SDH-IP) maps to human chromosome 1p35-36.1. Somat Cell Mol Genet. 1993 Sep; 19(5):505-11. PMID: 8291026.
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      46. Schmidt DM, Saghbini M, Scheffler I. The C-terminus of the succinate dehydrogenase IP peptide of Saccharomyces cerevisiae is significant for assembly of complex II. Biochemistry. 1992 Sep 15; 31(36):8442-8. PMID: 1390628.
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      47. Lombardo A, Cereghino GP, Scheffler I. Control of mRNA turnover as a mechanism of glucose repression in Saccharomyces cerevisiae. Mol Cell Biol. 1992 Jul; 12(7):2941-8. PMID: 1620107; PMCID: PMC364507.
      48. Grens A, Scheffler I. The 5'- and 3'-untranslated regions of ornithine decarboxylase mRNA affect the translational efficiency. J Biol Chem. 1990 Jul 15; 265(20):11810-6. PMID: 2365700.
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      49. Lombardo A, Carine K, Scheffler I. Cloning and characterization of the iron-sulfur subunit gene of succinate dehydrogenase from Saccharomyces cerevisiae. J Biol Chem. 1990 Jun 25; 265(18):10419-23. PMID: 2191948.
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      50. Pilz RB, Steglich C, Scheffler I. Molecular and genetic characterization of an ornithine decarboxylase-deficient Chinese hamster cell line. J Biol Chem. 1990 May 25; 265(15):8880-6. PMID: 1692838.
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      51. Grens A, Steglich C, Pilz R, Scheffler I. Nucleotide sequence of the Chinese hamster ornithine decarboxylase gene. Nucleic Acids Res. 1989 Dec 25; 17(24):10497. PMID: 2602162; PMCID: PMC335322.
      52. Lombardo A, Scheffler I. Isolation and characterization of a Saccharomyces cerevisiae mutant with a disrupted gene for the IP subunit of succinate dehydrogenase. J Biol Chem. 1989 Nov 15; 264(32):18874-7. PMID: 2681203.
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      53. Carine K, Jacquemin-Sablon A, Waltzer E, Mascarello J, Scheffler I. Molecular characterization of human minichromosomes with centromere from chromosome 1 in human-hamster hybrid cells. Somat Cell Mol Genet. 1989 Sep; 15(5):445-60. PMID: 2781415.
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      54. Gould SJ, Subramani S, Scheffler I. Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species. Proc Natl Acad Sci U S A. 1989 Mar; 86(6):1934-8. PMID: 2494655; PMCID: PMC286819.
      55. Scheffler I, Carine K. Molecular characterization of human minichromosomes in Chinese hamster/human somatic cell hybrids. Prog Clin Biol Res. 1989; 318:19-31. PMID: 2576309.
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      56. Slezynger TC, Scheffler I. Steady-state and nuclear run-on analyses of transcription in a temperature-sensitive Chinese hamster cell mutant with a defect in RNA metabolism. Somat Cell Mol Genet. 1988 Sep; 14(5):439-59. PMID: 2459782.
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      57. Feige JJ, Keller GA, Scheffler I. Temperature-sensitive Chinese hamster cell mutant with a defect in glycoprotein synthesis: accumulation of the EGF receptor in the endoplasmic reticulum and the role of the glucose-regulated protein GRP78. J Cell Physiol. 1988 Jul; 136(1):33-42. PMID: 3294237.
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      58. Solus J, Jacquemin-Sablon A, Carine K, Waltzer E, Scheffler I. Characterization of single-copy probe from vicinity of centromere of human chromosome 1. Somat Cell Mol Genet. 1988 Jul; 14(4):381-91. PMID: 2840744.
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      59. Feige JJ, Scheffler I. Analysis of the protein glycosylation defect of a temperature-sensitive cell cycle mutant by the use of mutant cells overexpressing the human epidermal growth factor receptor after transfection of the gene. J Cell Physiol. 1987 Dec; 133(3):461-70. PMID: 3121640.
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      60. Lee AS, Wells S, Kim KS, Scheffler I. Enhanced synthesis of the glucose/calcium-regulated proteins in a hamster cell mutant deficient in transfer of oligosaccharide core to polypeptides. J Cell Physiol. 1986 Dec; 129(3):277-82. PMID: 3782307.
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      61. Carine K, Solus J, Waltzer E, Manch-Citron J, Hamkalo BA, Scheffler I. Chinese hamster cells with a minichromosome containing the centromere region of human chromosome 1. Somat Cell Mol Genet. 1986 Sep; 12(5):479-91. PMID: 3020713.
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      62. Dircks L, Grens A, Slezynger TC, Scheffler I. Posttranscriptional regulation of ornithine decarboxylase activity. J Cell Physiol. 1986 Mar; 126(3):371-8. PMID: 3081524.
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      63. Steglich C, Grens A, Scheffler I. Chinese hamster cells deficient in ornithine decarboxylase activity: reversion by gene amplification and by azacytidine treatment. Somat Cell Mol Genet. 1985 Jan; 11(1):11-23. PMID: 2579446.
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      64. Anehus S, Emanuelsson H, Persson L, Sundler F, Scheffler I, Heby O. Localization of ornithine decarboxylase in mutant CHO cells that overproduce the enzyme. Differences between the intracellular distribution of monospecific ornithine decarboxylase antibodies and radiolabeled alpha-difluoromethylornithine. Eur J Cell Biol. 1984 Nov; 35(2):264-72. PMID: 6440787.
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      65. Choi JH, Scheffler I. Chinese hamster ovary cells resistant to alpha-difluoromethylornithine are overproducers of ornithine decarboxylase. J Biol Chem. 1983 Oct 25; 258(20):12601-8. PMID: 6415054.
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      66. Steglich C, Scheffler I. Selection of ornithine decarboxylase-deficient mutants of Chinese hamster ovary cells. Methods Enzymol. 1983; 94:108-11. PMID: 6684725.
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      67. Wong EA, Scheffler I. Temperature-sensitive Chinese hamster fibroblast mutant with a defect in RNA metabolism. Mol Cell Biol. 1982 Dec; 2(12):1558-73. PMID: 14582197; PMCID: PMC369964.
      68. Day CE, Scheffler I. Mapping of the genes of some components of the electron transport chain (complex I) on the X chromosome of mammals. Somatic Cell Genet. 1982 Nov; 8(6):691-707. PMID: 6819642.
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      69. Steglich C, Scheffler I. An ornithine decarboxylase-deficient mutant of Chinese hamster ovary cells. J Biol Chem. 1982 Apr 25; 257(8):4603-9. PMID: 7068654.
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      70. Burnett KG, Scheffler I. Integrity of mitochondria in a mammalian cell mutant defective in mitochondrial protein synthesis. J Cell Biol. 1981 Jul; 90(1):108-15. PMID: 6265473; PMCID: PMC2111829.
      71. Choi J, Scheffler I. A mutant of Chinese hamster ovary cells resistant to alpha-methyl- and alpha-difluoromethylornithine. Somatic Cell Genet. 1981 Mar; 7(2):219-33. PMID: 6794163.
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      72. Schlosser CA, Steglich C, deWet JR, Scheffler I. Cell cycle-dependent regulation of thymidine kinase activity introduced into mouse LMTK- cells by DNA and chromatin-mediated gene transfer. Proc Natl Acad Sci U S A. 1981 Feb; 78(2):1119-23. PMID: 6940130; PMCID: PMC319958.
      73. Landy-Otsuka F, Scheffler I. Enzyme induction in a temperature-sensitive cell cycle mutant of Chinese hamster fibroblasts. J Cell Physiol. 1980 Nov; 105(2):209-20. PMID: 7462327.
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      74. Breen GA, Scheffler I. Cytoplasmic inheritance of oligomycin resistance in Chinese hamster ovary cells. J Cell Biol. 1980 Sep; 86(3):723-9. PMID: 6447704; PMCID: PMC2110697.
      75. Soderberg K, Nissinen E, Bakay B, Scheffler I. The energy charge in wild-type and respiration-deficient Chinese hamster cell mutants. J Cell Physiol. 1980 Apr; 103(1):169-72. PMID: 7191856.
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      76. Mascarello JT, Soderberg K, Scheffler I. Assignment of a gene for succinate dehydrogenase to human chromosome 1 by somatic cell hybridization. Cytogenet Cell Genet. 1980; 28(1-2):121-35. PMID: 6934864.
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      77. Draper RK, Chin D, Eurey-Owens D, Scheffler I, Simon MI. Biochemical and genetic characterization of three hamster cell mutants resistant to diphtheria toxin. J Cell Biol. 1979 Oct; 83(1):116-25. PMID: 117016; PMCID: PMC2110445.
      78. Breen GA, Scheffler I. Respiration-deficient Chinese hamster cell mutants: biochemical characterization. Somatic Cell Genet. 1979 Jul; 5(4):441-51. PMID: 494059.
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      79. Soderberg K, Mascarello JT, Breen GA, Scheffler I. Respiration-deficient Chinese hamster cell mutants: genetic characterization. Somatic Cell Genet. 1979 Mar; 5(2):225-40. PMID: 483122.
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      80. Tenner AJ, Scheffler I. Lipid-saccharide intermediates and glycoprotein biosynthesis in a temperature-sensitive Chinese hamster cell mutant. J Cell Physiol. 1979 Feb; 98(2):251-66. PMID: 217883.
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      81. Landy-Otsuka F, Scheffler I. Induction of ornithine decarboxylase activity in a temperature-sensitive cell cycle mutant of Chinese hamster cells. Proc Natl Acad Sci U S A. 1978 Oct; 75(10):5001-5. PMID: 283409; PMCID: PMC336250.
      82. Ditta G, Soderberg K, Scheffler I. Chinese hamster cell mutant with defective mitochondrial protein synthesis. Nature. 1977 Jul 07; 268(5615):64-7. PMID: 196202.
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      83. Soderberg KL, Ditta GS, Scheffler I. Mammalian cells with defective mitochondrial functions: a Chinese hamster mutant cell line lacking succinate dehydrogenase activity. Cell. 1977 Apr; 10(4):697-702. PMID: 558831.
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      84. Tenner A, Zieg J, Scheffler I. Glycoprotein synthesis in a temperature-sensitive Chinese hamster cell cycle mutant. J Cell Physiol. 1977 Feb; 90(2):145-60. PMID: 557044.
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      85. Donnelly M, Scheffler I. Energy metabolism in respiration-deficient and wild type Chinese hamster fibroblasts in culture. J Cell Physiol. 1976 Sep; 89(1):39-51. PMID: 8468.
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      86. DeFrancesco L, Scheffler I, Bissell MJ. A respiration-deficient Chinese hamster cell line with a defect in NADH-coenzyme Q reductase. J Biol Chem. 1976 Aug 10; 251(15):4588-95. PMID: 947896.
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      87. Ditta G, Soderberg K, Landy F, Scheffler I. The selection of Chinese hamster cells deficient in oxidative energy metabolism. Somatic Cell Genet. 1976 Jul; 2(4):331-44. PMID: 1027147.
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      88. DeFrancesco L, Werntz D, Scheffler I. Conditionally lethal mutations in chinese hamster cells. Characterization of a cell line with a possible defect in the Krebs cycle. J Cell Physiol. 1975 Apr; 85(2 Pt 1):293-305. PMID: 1123408.
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      89. Chan RT, Scheffler I. Isopycnic centrifugation of chromatin in renografin solutions. J Cell Biol. 1974 Jun; 61(3):780-8. PMID: 4836392; PMCID: PMC2109313.
      90. Scheffler I. Conditional lethal mutants of Chinese hamster cells: mutants requiring exogenous carbondioxide for growth. J Cell Physiol. 1974 Apr; 83(2):219-30. PMID: 4822527.
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      91. Scheffler I, Buttin G. Conditionally lethal mutations in Chinese hamster cells. I. Isolation of a temperature-sensitive line and its investigation by cell cycle studies. J Cell Physiol. 1973 Apr; 81(2):199-216. PMID: 4348554.
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      92. Hirota Y, Mordoh J, Scheffler I, Jacob F. Genetic approach to DNA replication and its control in Escherichia coli. Fed Proc. 1972 Sep-Oct; 31(5):1422-7. PMID: 4561641.
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