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    Iftach Shaked

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0319
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Shaked I, Hanna RN, Shaked H, Chodaczek G, Nowyhed HN, Tweet G, Tacke R, Basat AB, Mikulski Z, Togher S, Miller J, Blatchley A, Salek-Ardakani S, Darvas M, Kaikkonen MU, Thomas GD, Lai-Wing-Sun S, Rezk A, Bar-Or A, Glass CK, Bandukwala H, Hedrick CC. Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation. Nat Immunol. 2015 Dec; 16(12):1228-34. PMID: 26523867; PMCID: PMC4833087.
      2. Hanna RN, Cekic C, Sag D, Tacke R, Thomas GD, Nowyhed H, Herrley E, Rasquinha N, McArdle S, Wu R, Peluso E, Metzger D, Ichinose H, Shaked I, Chodaczek G, Biswas SK, Hedrick CC. Patrolling monocytes control tumor metastasis to the lung. Science. 2015 Nov 20; 350(6263):985-90. PMID: 26494174; PMCID: PMC4869713.
      3. Mikulski Z, Johnson R, Shaked I, Kim G, Nowyhed H, Goodman W, Chodaczek G, Pizarro TT, Cominelli F, Ley K. SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration. Gastroenterology. 2015 Apr; 148(4):783-793.e5. PMID: 25620669; PMCID: PMC4375031.
      4. Shaked I, Hanna DB, Gleißner C, Marsh B, Plants J, Tracy D, Anastos K, Cohen M, Golub ET, Karim R, Lazar J, Prasad V, Tien PC, Young MA, Landay AL, Kaplan RC, Ley K. Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1085-92. PMID: 24651679; PMCID: PMC4067091.
      5. Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity. 2013 Jul 25; 39(1):111-22. PMID: 23871208; PMCID: PMC3830738.
      6. Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28; 151(1):138-52. PMID: 23021221; PMCID: PMC3464914.
      7. Shaked I, Ley K. Protective role for myeloid specific KLF2 in atherosclerosis. Circ Res. 2012 May 11; 110(10):1266. PMID: 22581916.
        View in: PubMed
      8. Hanna RN, Shaked I, Hubbeling HG, Punt JA, Wu R, Herrley E, Zaugg C, Pei H, Geissmann F, Ley K, Hedrick CC. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res. 2012 Feb 03; 110(3):416-27. PMID: 22194622; PMCID: PMC3309661.
      9. Gleissner CA, Shaked I, Little KM, Ley K. CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages. J Immunol. 2010 May 01; 184(9):4810-8. PMID: 20335529; PMCID: PMC3418140.
      10. Shaked I, Meerson A, Wolf Y, Avni R, Greenberg D, Gilboa-Geffen A, Soreq H. MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity. 2009 Dec 18; 31(6):965-73. PMID: 20005135.
        View in: PubMed
      11. Gleissner CA, Shaked I, Erbel C, Böckler D, Katus HA, Ley K. CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages. Circ Res. 2010 Jan 08; 106(1):203-11. PMID: 19910578; PMCID: PMC2876722.
      12. Shaked I, Zimmerman G, Soreq H. Stress-induced alternative splicing modulations in brain and periphery: acetylcholinesterase as a case study. Ann N Y Acad Sci. 2008 Dec; 1148:269-81. PMID: 19120119.
        View in: PubMed
      13. Gilboa-Geffen A, Lacoste PP, Soreq L, Cizeron-Clairac G, Le Panse R, Truffault F, Shaked I, Soreq H, Berrih-Aknin S. The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood. 2007 May 15; 109(10):4383-91. PMID: 17272501.
        View in: PubMed
      14. Guimaraes-Sternberg C, Meerson A, Shaked I, Soreq H. MicroRNA modulation of megakaryoblast fate involves cholinergic signaling. Leuk Res. 2006 May; 30(5):583-95. PMID: 16249029.
        View in: PubMed
      15. Bakalash S, Ben-Shlomo G, Shlomo GB, Aloni E, Shaked I, Wheeler L, Ofri R, Schwartz M. T-cell-based vaccination for morphological and functional neuroprotection in a rat model of chronically elevated intraocular pressure. J Mol Med (Berl). 2005 Nov; 83(11):904-16. PMID: 16096740.
        View in: PubMed
      16. Shaked I, Tchoresh D, Gersner R, Meiri G, Mordechai S, Xiao X, Hart RP, Schwartz M. Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators. J Neurochem. 2005 Mar; 92(5):997-1009. PMID: 15715651.
        View in: PubMed
      17. Shaked I, Porat Z, Gersner R, Kipnis J, Schwartz M. Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system. J Neuroimmunol. 2004 Jan; 146(1-2):84-93. PMID: 14698850.
        View in: PubMed
      18. Schwartz M, Shaked I, Fisher J, Mizrahi T, Schori H. Protective autoimmunity against the enemy within: fighting glutamate toxicity. Trends Neurosci. 2003 Jun; 26(6):297-302. PMID: 12798598.
        View in: PubMed
      19. Nevo U, Kipnis J, Golding I, Shaked I, Neumann A, Akselrod S, Schwartz M. Autoimmunity as a special case of immunity: removing threats from within. Trends Mol Med. 2003 Mar; 9(3):88-93. PMID: 12657429.
        View in: PubMed
      20. Kipnis J, Mizrahi T, Hauben E, Shaked I, Shevach E, Schwartz M. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15620-5. PMID: 12429857; PMCID: PMC137766.
      21. Shaked I, Ben-Dror I, Vardimon L. Glutamine synthetase enhances the clearance of extracellular glutamate by the neural retina. J Neurochem. 2002 Nov; 83(3):574-80. PMID: 12390519.
        View in: PubMed
      22. Kipnis J, Yoles E, Schori H, Hauben E, Shaked I, Schwartz M. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. J Neurosci. 2001 Jul 01; 21(13):4564-71. PMID: 11425884.
        View in: PubMed
      23. Komlosh A, Momburg F, Weinschenk T, Emmerich N, Schild H, Nadav E, Shaked I, Reiss Y. A role for a novel luminal endoplasmic reticulum aminopeptidase in final trimming of 26 S proteasome-generated major histocompatability complex class I antigenic peptides. J Biol Chem. 2001 Aug 10; 276(32):30050-6. PMID: 11373290.
        View in: PubMed
      24. Ben-Shahar S, Komlosh A, Nadav E, Shaked I, Ziv T, Admon A, DeMartino GN, Reiss Y. 26 S proteasome-mediated production of an authentic major histocompatibility class I-restricted epitope from an intact protein substrate. J Biol Chem. 1999 Jul 30; 274(31):21963-72. PMID: 10419519.
        View in: PubMed
      25. Gorovits R, Avidan N, Avisar N, Shaked I, Vardimon L. Glutamine synthetase protects against neuronal degeneration in injured retinal tissue. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):7024-9. PMID: 9192685; PMCID: PMC21278.
      26. Azem A, Shaked I, Rosenbusch JP, Daniel E. Cross-linking of porin with glutardialdehyde: a test for the adequacy of premises of cross-linking theory. Biochim Biophys Acta. 1995 Feb 23; 1243(2):151-6. PMID: 7873557.
        View in: PubMed
      27. Rubinstein E, Findler G, Amit P, Shaked I. Perioperative prophylactic cephazolin in spinal surgery. A double-blind placebo-controlled trial. J Bone Joint Surg Br. 1994 Jan; 76(1):99-102. PMID: 8300691.
        View in: PubMed
      28. Tsfadia Y, Shaked I, Daniel E. Molecular symmetry and arrangement of subunits in extracellular hemoglobin from Caenestheria inopinata. Eur J Biochem. 1990 Oct 05; 193(1):25-9. PMID: 2121477.
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