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    Hilde Cheroutre

    TitleAdjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address200 W. Arbor Drive #8897
    CA San Diego 92103
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      Collapse Research 
      Collapse Research Activities and Funding
      Control of the Functional Fate of CD4 T Cells by LncRNA-Switch
      NIH/NIAID U01AI125957Jul 1, 2016 - Jun 30, 2021
      Role: Principal Investigator
      DIFFERENTIATION AND ANTI-VIRAL PROTECTIVE AND PATHOGENIC ROLES OF CD4 CTL
      NIH/NIAID R01AI106298Apr 7, 2014 - Mar 31, 2019
      Role: Principal Investigator
      Uncovering the Missing Link that Determines Susceptibility to Autoimmunity
      NIH/NIGMS DP1GM105384Sep 30, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Uncovering the Missing Link that Determines Susceptibility to Autoimmunity
      NIH DP1OD006433Sep 30, 2009 - Jul 31, 2014
      Role: Principal Investigator
      Selective Instructions for Memory T Cells
      NIH/NIAID R01AI064584Mar 15, 2005 - Jan 31, 2016
      Role: Principal Investigator
      A Comprehensive Study of a Novel Type of Mucosal CD4 Effector T cells
      NIH/NIAID R01AI050265Jul 1, 2001 - Jul 31, 2016
      Role: Principal Investigator
      Inhibition of Immune Responses Mediated by CD8aa-TL
      NIH/NIAID R56AI050265Jul 1, 2001 - Jan 31, 2006
      Role: Principal Investigator
      Regulation and mechanism of agonist selection
      NIH/NIDDK R01DK054451Aug 5, 1998 - Jul 31, 2009
      Role: Principal Investigator
      SELECTION OF INTESTINAL INTRAEPITHELIAL T CELLS
      NIH/NIDDK R29DK054451Aug 5, 1998 - Jul 31, 2003
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Verstichel G, Vermijlen D, Martens L, Goetgeluk G, Brouwer M, Thiault N, Van Caeneghem Y, De Munter S, Weening K, Bonte S, Leclercq G, Taghon T, Kerre T, Saeys Y, Van Dorpe J, Cheroutre H, Vandekerckhove B. The checkpoint for agonist selection precedes conventional selection in human thymus. Sci Immunol. 2017 Feb 24; 2(8). PMID: 28783686.
        View in: PubMed
      2. Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M. Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes. Arthritis Rheumatol. 2016 Jul; 68(7):1614-26. PMID: 26815411; PMCID: PMC4963240.
      3. Larange A, Cheroutre H. Retinoic Acid and Retinoic Acid Receptors as Pleiotropic Modulators of the Immune System. Annu Rev Immunol. 2016 May 20; 34:369-94. PMID: 27168242.
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      4. Krause P, Morris V, Greenbaum JA, Park Y, Bjoerheden U, Mikulski Z, Muffley T, Shui JW, Kim G, Cheroutre H, Liu YC, Peters B, Kronenberg M, Murai M. IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis. Nat Commun. 2015 May 11; 6:7055. PMID: 25959063; PMCID: PMC4428691.
      5. Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K. T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunol Res. 2015 Jul; 3(7):806-14. PMID: 25855122; PMCID: PMC4749132.
      6. Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, Park Y, Obata Y, Gold R, Wang-Zhu Y, Lena C, Zajonc DM, Schoenberger SP, Kronenberg M, Cheroutre H. Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol. 2015 Jan; 8(1):141-51. PMID: 24938743; PMCID: PMC4268120.
      7. Davani D, Pancer Z, Cheroutre H, Ratcliffe MJ. Negative selection of self-reactive chicken B cells requires B cell receptor signaling and is independent of the bursal microenvironment. J Immunol. 2014 Apr 01; 192(7):3207-17. PMID: 24516196; PMCID: PMC4266589.
      8. Cheroutre H, Husain MM. CD4 CTL: living up to the challenge. Semin Immunol. 2013 Nov 15; 25(4):273-81. PMID: 24246226; PMCID: PMC3886800.
      9. Fu G, Casas J, Rigaud S, Rybakin V, Lambolez F, Brzostek J, Hoerter JA, Paster W, Acuto O, Cheroutre H, Sauer K, Gascoigne NR. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature. 2013 Dec 19; 504(7480):441-5. PMID: 24226767; PMCID: PMC3977001.
      10. Steinberg MW, Huang Y, Wang-Zhu Y, Ware CF, Cheroutre H, Kronenberg M. BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection. PLoS One. 2013; 8(10):e77992. PMID: 24205057; PMCID: PMC3813523.
      11. Walker LJ, Marrinan E, Muenchhoff M, Ferguson J, Kloverpris H, Cheroutre H, Barnes E, Goulder P, Klenerman P. CD8aa Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection. Front Immunol. 2013; 4:223. PMID: 23964274; PMCID: PMC3734367.
      12. Carrera Silva EA, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV. T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity. 2013 Jul 25; 39(1):160-70. PMID: 23850380; PMCID: PMC4017237.
      13. Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I, Cheroutre H. Transcriptional reprogramming of mature CD4? helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol. 2013 Mar; 14(3):281-9. PMID: 23334788; PMCID: PMC3581083.
      14. Kim G, Shinnakasu R, Saris CJ, Cheroutre H, Kronenberg M. A novel role for IL-27 in mediating the survival of activated mouse CD4 T lymphocytes. J Immunol. 2013 Feb 15; 190(4):1510-8. PMID: 23335749; PMCID: PMC4060896.
      15. Cheroutre H, Huang Y. Crosstalk between adaptive and innate immune cells leads to high quality immune protection at the mucosal borders. Adv Exp Med Biol. 2013; 785:43-7. PMID: 23456836; PMCID: PMC3913074.
      16. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012 Nov 08; 491(7423):254-8. PMID: 23034650; PMCID: PMC3601659.
      17. Lee SW, Park Y, Eun SY, Madireddi S, Cheroutre H, Croft M. Cutting edge: 4-1BB controls regulatory activity in dendritic cells through promoting optimal expression of retinal dehydrogenase. J Immunol. 2012 Sep 15; 189(6):2697-701. PMID: 22896640; PMCID: PMC3436963.
      18. Shui JW, Larange A, Kim G, Vela JL, Zahner S, Cheroutre H, Kronenberg M. HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria. Nature. 2012 Aug 09; 488(7410):222-5. PMID: 22801499; PMCID: PMC3477500.
      19. Fousteri G, Jasinski J, Dave A, Nakayama M, Pagni P, Lambolez F, Juntti T, Sarikonda G, Cheng Y, Croft M, Cheroutre H, Eisenbarth G, von Herrath M. Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice. Diabetes. 2012 May; 61(5):1169-79. PMID: 22403296; PMCID: PMC3331775.
      20. Fu G, Hu J, Niederberger-Magnenat N, Rybakin V, Casas J, Yachi PP, Feldstein S, Ma B, Hoerter JA, Ampudia J, Rigaud S, Lambolez F, Gavin AL, Sauer K, Cheroutre H, Gascoigne NR. Protein kinase C ? is required for T cell activation and homeostatic proliferation. Sci Signal. 2011 Dec 06; 4(202):ra84. PMID: 22155788; PMCID: PMC3242502.
      21. Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H. Mucosal memory CD8? T cells are selected in the periphery by an MHC class I molecule. Nat Immunol. 2011 Oct 02; 12(11):1086-95. PMID: 21964609; PMCID: PMC3197978.
      22. Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. Constitutive intestinal NF-?B does not trigger destructive inflammation unless accompanied by MAPK activation. J Exp Med. 2011 Aug 29; 208(9):1889-900. PMID: 21825016; PMCID: PMC3171091.
      23. Cheroutre H, Lambolez F, Mucida D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2011 Jun 17; 11(7):445-56. PMID: 21681197; PMCID: PMC3140792.
      24. Ichikawa S, Mucida D, Tyznik AJ, Kronenberg M, Cheroutre H. Hepatic stellate cells function as regulatory bystanders. J Immunol. 2011 May 15; 186(10):5549-55. PMID: 21460203; PMCID: PMC3132534.
      25. van Wijk F, Cheroutre H. Mucosal T cells in gut homeostasis and inflammation. Expert Rev Clin Immunol. 2010 Jul; 6(4):559-66. PMID: 20594129; PMCID: PMC2976609.
      26. Murai M, Krause P, Cheroutre H, Kronenberg M. Regulatory T-cell stability and plasticity in mucosal and systemic immune systems. Mucosal Immunol. 2010 Sep; 3(5):443-9. PMID: 20505662; PMCID: PMC2924438.
      27. Schoenberger SP, Cheroutre H, Uittenbogaart C, Marshak-Rothstein A. The 2010 Midwinter Conference of Immunologists at Asilomar. Nat Immunol. 2010 May; 11(5):359-61. PMID: 20404845.
        View in: PubMed
      28. Mucida D, Cheroutre H. The many face-lifts of CD4 T helper cells. Adv Immunol. 2010; 107:139-52. PMID: 21034973.
        View in: PubMed
      29. Cheroutre H. HIV vaccination: turning the spotlight on effector memory T cells as mucosal gatekeepers. F1000 Biol Rep. 2009 Nov 26; 1:89. PMID: 20046812.
        View in: PubMed
      30. Cheroutre H, Mucida D, Lambolez F. The importance of being earnestly selfish. Nat Immunol. 2009 Oct; 10(10):1047-9. PMID: 19767722; PMCID: PMC3061549.
      31. Murai M, Turovskaya O, Kim G, Madan R, Karp CL, Cheroutre H, Kronenberg M. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol. 2009 Nov; 10(11):1178-84. PMID: 19783988; PMCID: PMC2898179.
      32. van Wijk F, Cheroutre H. Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity. Semin Immunol. 2009 Jun; 21(3):130-8. PMID: 19386513; PMCID: PMC2794834.
      33. Mucida D, Pino-Lagos K, Kim G, Nowak E, Benson MJ, Kronenberg M, Noelle RJ, Cheroutre H. Retinoic acid can directly promote TGF-beta-mediated Foxp3(+) Treg cell conversion of naive T cells. Immunity. 2009 Apr 17; 30(4):471-2; author reply 472-3. PMID: 19371709; PMCID: PMC2864308.
      34. Basso AS, Cheroutre H, Mucida D. More stories on Th17 cells. Cell Res. 2009 Apr; 19(4):399-411. PMID: 19255592; PMCID: PMC2838708.
      35. Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 2009 Feb 03; 15(2):103-13. PMID: 19185845; PMCID: PMC2667107.
      36. Olivares-Villagómez D, Mendez-Fernandez YV, Parekh VV, Lalani S, Vincent TL, Cheroutre H, Van Kaer L. Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17931-6. PMID: 19004778; PMCID: PMC2584730.
      37. Mucida D, Park Y, Cheroutre H. From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine. Semin Immunol. 2009 Feb; 21(1):14-21. PMID: 18809338; PMCID: PMC2643336.
      38. Kotturi MF, Scott I, Wolfe T, Peters B, Sidney J, Cheroutre H, von Herrath MG, Buchmeier MJ, Grey H, Sette A. Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J Immunol. 2008 Aug 01; 181(3):2124-33. PMID: 18641351; PMCID: PMC3319690.
      39. Lee SW, Park Y, So T, Kwon BS, Cheroutre H, Mittler RS, Croft M. Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells. Nat Immunol. 2008 Aug; 9(8):917-26. PMID: 18604213; PMCID: PMC2561255.
      40. Wang R, Song A, Levin J, Dennis D, Zhang NJ, Yoshida H, Koriazova L, Madura L, Shapiro L, Matsumoto A, Yoshida H, Mikayama T, Kubo RT, Sarawar S, Cheroutre H, Kato S. Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein. Antiviral Res. 2008 Nov; 80(2):168-77. PMID: 18598723.
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      41. Cheroutre H, Lambolez F. The thymus chapter in the life of gut-specific intra epithelial lymphocytes. Curr Opin Immunol. 2008 Apr; 20(2):185-91. PMID: 18456487; PMCID: PMC2527581.
      42. Cheroutre H. Ultimately, it matters where, when, and what they'll meet. Gastroenterology. 2008 Apr; 134(4):1249-51. PMID: 18395103.
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      43. Cheroutre H, Lambolez F. Doubting the TCR coreceptor function of CD8alphaalpha. Immunity. 2008 Feb; 28(2):149-59. PMID: 18275828.
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      44. Mucida D, Cheroutre H. TGFbeta and retinoic acid intersect in immune-regulation. Cell Adh Migr. 2007 Jul-Sep; 1(3):142-4. PMID: 19262136; PMCID: PMC2634017.
      45. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, Cheroutre H. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science. 2007 Jul 13; 317(5835):256-60. PMID: 17569825.
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      46. Denning TL, Granger SW, Granger S, Mucida D, Graddy R, Leclercq G, Zhang W, Honey K, Rasmussen JP, Cheroutre H, Rudensky AY, Kronenberg M. Mouse TCRalphabeta+CD8alphaalpha intraepithelial lymphocytes express genes that down-regulate their antigen reactivity and suppress immune responses. J Immunol. 2007 Apr 01; 178(7):4230-9. PMID: 17371979.
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      47. Lambolez F, Kronenberg M, Cheroutre H. Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs. Immunol Rev. 2007 Feb; 215:178-88. PMID: 17291288.
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      48. Gangadharan D, Lambolez F, Attinger A, Wang-Zhu Y, Sullivan BA, Cheroutre H. Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus. Immunity. 2006 Oct; 25(4):631-41. PMID: 17045820.
        View in: PubMed
      49. Lee SW, Park Y, Song A, Cheroutre H, Kwon BS, Croft M. Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses. J Immunol. 2006 Oct 01; 177(7):4464-72. PMID: 16982882.
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      50. Cheroutre H. In IBD eight can come before four. Gastroenterology. 2006 Aug; 131(2):667-70. PMID: 16890619.
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      51. Iltanen S, Tervo L, Halttunen T, Wei B, Braun J, Rantala I, Honkanen T, Kronenberg M, Cheroutre H, Turovskaya O, Autio V, Ashorn M. Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD. Inflamm Bowel Dis. 2006 May; 12(5):389-94. PMID: 16670528.
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      52. Cheroutre H, Madakamutil L. Mucosal effector memory T cells: the other side of the coin. Cell Mol Life Sci. 2005 Dec; 62(23):2853-66. PMID: 16314932.
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      53. Cheroutre H. IELs: enforcing law and order in the court of the intestinal epithelium. Immunol Rev. 2005 Aug; 206:114-31. PMID: 16048545.
        View in: PubMed
      54. Cheroutre H, Kronenberg M. Mucosal T lymphocytes--peacekeepers and warriors. Springer Semin Immunopathol. 2005 Sep; 27(2):147-65. PMID: 15931528.
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      55. Attinger A, Devine L, Wang-Zhu Y, Martin D, Wang JH, Reinherz EL, Kronenberg M, Cheroutre H, Kavathas P. Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. J Immunol. 2005 Mar 15; 174(6):3501-7. PMID: 15749886.
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      56. Gangadharan D, Cheroutre H. The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR co-receptor CD8alphabeta. Curr Opin Immunol. 2004 Jun; 16(3):264-70. PMID: 15134773.
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      57. Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H. CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science. 2004 Apr 23; 304(5670):590-3. PMID: 15105501.
        View in: PubMed
      58. Cheroutre H, Madakamutil L. Acquired and natural memory T cells join forces at the mucosal front line. Nat Rev Immunol. 2004 Apr; 4(4):290-300. PMID: 15057787.
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      59. Cheroutre H. Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu Rev Immunol. 2004; 22:217-46. PMID: 15032579.
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      60. Elewaut D, Shaikh RB, Hammond KJ, De Winter H, Leishman AJ, Sidobre S, Turovskaya O, Prigozy TI, Ma L, Banks TA, Lo D, Ware CF, Cheroutre H, Kronenberg M. NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells. J Exp Med. 2003 Jun 16; 197(12):1623-33. PMID: 12810685; PMCID: PMC2193960.
      61. Liu Y, Xiong Y, Naidenko OV, Liu JH, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang JH. The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. Immunity. 2003 Feb; 18(2):205-15. PMID: 12594948.
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      62. Weber DA, Attinger A, Kemball CC, Wigal JL, Pohl J, Xiong Y, Reinherz EL, Cheroutre H, Kronenberg M, Jensen PE. Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen. J Immunol. 2002 Nov 15; 169(10):5708-14. PMID: 12421950.
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      63. Hoyer KK, French SW, Turner DE, Nguyen MT, Renard M, Malone CS, Knoetig S, Qi CF, Su TT, Cheroutre H, Wall R, Rawlings DJ, Morse HC, Teitell MA. Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14392-7. PMID: 12381789; PMCID: PMC137894.
      64. De Winter H, Elewaut D, Turovskaya O, Huflejt M, Shimeld C, Hagenbaugh A, Binder S, Takahashi I, Kronenberg M, Cheroutre H. Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice. Gastroenterology. 2002 Jun; 122(7):1829-41. PMID: 12055591.
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      65. Pinderski LJ, Fischbein MP, Subbanagounder G, Fishbein MC, Kubo N, Cheroutre H, Curtiss LK, Berliner JA, Boisvert WA. Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypes. Circ Res. 2002 May 31; 90(10):1064-71. PMID: 12039795.
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      66. Devine L, Rogozinski L, Naidenko OV, Cheroutre H, Kavathas PB. The complementarity-determining region-like loops of CD8 alpha interact differently with beta 2-microglobulin of the class I molecules H-2Kb and thymic leukemia antigen, while similarly with their alpha 3 domains. J Immunol. 2002 Apr 15; 168(8):3881-6. PMID: 11937542.
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      67. Leishman AJ, Gapin L, Capone M, Palmer E, MacDonald HR, Kronenberg M, Cheroutre H. Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides. Immunity. 2002 Mar; 16(3):355-64. PMID: 11911821.
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      68. Shaikh RB, Santee S, Granger SW, Butrovich K, Cheung T, Kronenberg M, Cheroutre H, Ware CF. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction. J Immunol. 2001 Dec 01; 167(11):6330-7. PMID: 11714797.
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      69. Leishman AJ, Naidenko OV, Attinger A, Koning F, Lena CJ, Xiong Y, Chang HC, Reinherz E, Kronenberg M, Cheroutre H. T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science. 2001 Nov 30; 294(5548):1936-9. PMID: 11729321.
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      70. Elewaut D, Brossay L, Santee SM, Naidenko OV, Burdin N, De Winter H, Matsuda J, Ware CF, Cheroutre H, Kronenberg M. Membrane lymphotoxin is required for the development of different subpopulations of NK T cells. J Immunol. 2000 Jul 15; 165(2):671-9. PMID: 10878339.
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      71. Shih DM, Xia YR, Wang XP, Miller E, Castellani LW, Subbanagounder G, Cheroutre H, Faull KF, Berliner JA, Witztum JL, Lusis AJ. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem. 2000 Jun 09; 275(23):17527-35. PMID: 10748217.
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      72. Kronenberg M, Cheroutre H. Do mucosal T cells prevent intestinal inflammation? Gastroenterology. 2000 May; 118(5):974-7. PMID: 10784599.
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      73. Gapin L, Cheroutre H, Kronenberg M. Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules. J Immunol. 1999 Oct 15; 163(8):4100-4. PMID: 10510343.
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      74. Pauza ME, Neal H, Hagenbaugh A, Cheroutre H, Lo D. T-cell production of an inducible interleukin-10 transgene provides limited protection from autoimmune diabetes. Diabetes. 1999 Oct; 48(10):1948-53. PMID: 10512358.
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      75. De Winter H, Cheroutre H, Kronenberg M. Mucosal immunity and inflammation. II. The yin and yang of T cells in intestinal inflammation: pathogenic and protective roles in a mouse colitis model. Am J Physiol. 1999 Jun; 276(6 Pt 1):G1317-21. PMID: 10362634.
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      76. Cruz D, Sydora BC, Hetzel K, Yakoub G, Kronenberg M, Cheroutre H. An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes. J Exp Med. 1998 Jul 20; 188(2):255-65. PMID: 9670038; PMCID: PMC2212444.
      77. Crew MD, Effros RB, Walford RL, Zeller E, Cheroutre H, Brahn E. Transgenic mice expressing a truncated Peromyscus leucopus TNF-alpha gene manifest an arthritis resembling ankylosing spondylitis. J Interferon Cytokine Res. 1998 Apr; 18(4):219-25. PMID: 9568723.
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      78. Satterthwaite AB, Cheroutre H, Khan WN, Sideras P, Witte ON. Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13152-7. PMID: 9371815; PMCID: PMC24278.
      79. Hagenbaugh A, Sharma S, Dubinett SM, Wei SH, Aranda R, Cheroutre H, Fowell DJ, Binder S, Tsao B, Locksley RM, Moore KW, Kronenberg M. Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 1997 Jun 16; 185(12):2101-10. PMID: 9182682; PMCID: PMC2196349.
      80. Sydora BC, Brossay L, Hagenbaugh A, Kronenberg M, Cheroutre H. TAP-independent selection of CD8+ intestinal intraepithelial lymphocytes. J Immunol. 1996 Jun 01; 156(11):4209-16. PMID: 8666789.
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      81. Cheroutre H, Holcombe HR, Tangri S, Castaño AR, Teitell M, Miller JE, Cardell S, Benoist C, Mathis D, Huse WD. Antigen-presenting function of the TL antigen and mouse CD1 molecules. Immunol Rev. 1995 Oct; 147:31-52. PMID: 8847078.
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      82. Holcombe HR, Castaño AR, Cheroutre H, Teitell M, Maher JK, Peterson PA, Kronenberg M. Nonclassical behavior of the thymus leukemia antigen: peptide transporter-independent expression of a nonclassical class I molecule. J Exp Med. 1995 Apr 01; 181(4):1433-43. PMID: 7699328; PMCID: PMC2191972.
      83. Teitell M, Cheroutre H, Panwala C, Holcombe H, Eghtesady P, Kronenberg M. Structure and function of H-2 T (Tla) region class I MHC molecules. Crit Rev Immunol. 1994; 14(1):1-27. PMID: 7741975.
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      84. Teitell M, Holcombe H, Cheroutre H, Aldrich CJ, Stroynowski I, Forman J, Kronenberg M. The alpha 3 domain of the Qa-2 molecule is defective for CD8 binding and cytotoxic T lymphocyte activation. J Exp Med. 1993 Dec 01; 178(6):2139-45. PMID: 8245786; PMCID: PMC2191298.
      85. Tsao BP, Chow A, Cheroutre H, Song YW, McGrath ME, Kronenberg M. B cells are anergic in transgenic mice that express IgM anti-DNA antibodies. Eur J Immunol. 1993 Sep; 23(9):2332-9. PMID: 8370409.
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      86. Tsao BP, Ohnishi K, Cheroutre H, Mitchell B, Teitell M, Mixter P, Kronenberg M, Hahn BH. Failed self-tolerance and autoimmunity in IgG anti-DNA transgenic mice. J Immunol. 1992 Jul 01; 149(1):350-8. PMID: 1607661.
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      87. Eghtesady P, Brorson KA, Cheroutre H, Tigelaar RE, Hood L, Kronenberg M. Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells. Immunogenetics. 1992; 36(6):377-88. PMID: 1388139.
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      88. Cheroutre H, Kronenberg M, Brorson K, Hunt SW, Eghtesady P, Hood L, Nickerson DA. Analysis of MHC class I gene expression in adult bone marrow and fetal liver of the BALB/c mouse. J Immunol. 1991 May 15; 146(10):3263-72. PMID: 2026867.
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      89. Hershberg R, Eghtesady P, Sydora B, Brorson K, Cheroutre H, Modlin R, Kronenberg M. Expression of the thymus leukemia antigen in mouse intestinal epithelium. Proc Natl Acad Sci U S A. 1990 Dec; 87(24):9727-31. PMID: 2263622; PMCID: PMC55246.
      90. Brorson KA, Hunt SW, Hunkapiller T, Sun YH, Cheroutre H, Nickerson DA, Hood L. Comparison of exon 5 sequences from 35 class I genes of the BALB/c mouse. J Exp Med. 1989 Dec 01; 170(6):1837-58. PMID: 2584927; PMCID: PMC2189523.
      91. Brorson KA, Richards S, Hunt SW, Cheroutre H, Lindahl KF, Hood L. Analysis of a new class I gene mapping to the Hmt region of the mouse. Immunogenetics. 1989; 30(4):273-83. PMID: 2793207.
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      92. Devos R, Plaetinck G, Cheroutre H, Simons G, Degrave W, Tavernier J, Remaut E, Fiers W. Molecular cloning of human interleukin 2 cDNA and its expression in E. coli. Nucleic Acids Res. 1983 Jul 11; 11(13):4307-23. PMID: 6306584; PMCID: PMC326048.
      93. Contreras R, Cheroutre H, Degrave W, Fiers W. Simple, efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes. Nucleic Acids Res. 1982 Oct 25; 10(20):6353-62. PMID: 6294601; PMCID: PMC326924.
      94. Fiers W, Remaut E, Devos R, Cheroutre H, Contreras R, Gheysen D, Degrave W, Stanssens P, Tavernier J, Taya Y, Content J. The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells. Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24; 299(1094):29-38. PMID: 6183692.
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      95. Devos R, Cheroutre H, Taya Y, Degrave W, Van Heuverswyn H, Fiers W. Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells. Nucleic Acids Res. 1982 Apr 24; 10(8):2487-501. PMID: 6176945; PMCID: PMC320629.
      96. Taya Y, Devos R, Tavernier J, Cheroutre H, Engler G, Fiers W. Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1982; 1(8):953-8. PMID: 6329718; PMCID: PMC553141.
      97. Devos R, Cheroutre H, Taya Y, Fiers W. Isolation and characterization of IFN-gamma mRNA derived from mitogen-induced human splenocytes. J Interferon Res. 1982; 2(3):409-20. PMID: 6182256.
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      98. Contreras R, Cheroutre H, Fiers W. A simple apparatus for injection of nanoliter quantities into Xenopus laevis oocytes. Anal Biochem. 1981 May 01; 113(1):185-7. PMID: 7270884.
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