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    Gregory Heldt

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address200 W. Arbor Drive #8774
    CA San Diego 92103
    Phone619-543-3759
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gibu CK, Cheng PY, Ward RJ, Castro B, Heldt G. Feasibility and physiological effects of noninvasive neurally adjusted ventilatory assist in preterm infants. Pediatr Res. 2017 Jul 12. PMID: 28399118.
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      2. Heldt G, Ward Iii RJ. Evaluation of Ultrasound-Based Sensor to Monitor Respiratory and Nonrespiratory Movement and Timing in Infants. IEEE Trans Biomed Eng. 2016 Mar; 63(3):619-29. PMID: 26276983.
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      3. Ryu J, Heldt G, Nguyen M, Gavrialov O, Haddad GG. Chronic hypercapnia alters lung matrix composition in mouse pups. J Appl Physiol (1985). 2010 Jul; 109(1):203-10. PMID: 20360436.
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      4. Larsen GL, Morgan W, Heldt G, Mauger DT, Boehmer SJ, Chinchilli VM, Lemanske RF, Martinez F, Strunk RC, Szefler SJ, Zeiger RS, Taussig LM, Bacharier LB, Guilbert TW, Radford S, Sorkness CA. Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma. J Allergy Clin Immunol. 2009 Apr; 123(4):861-7.e1. PMID: 19070356.
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      5. Garey DM, Ward R, Rich W, Heldt G, Leone T, Finer NN. Tidal volume threshold for colorimetric carbon dioxide detectors available for use in neonates. Pediatrics. 2008 Jun; 121(6):e1524-7. PMID: 18458036.
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      6. Walsh M, Laptook A, Kazzi SN, Engle WA, Yao Q, Rasmussen M, Buchter S, Heldt G, Rhine W, Higgins R, Poole K. A cluster-randomized trial of benchmarking and multimodal quality improvement to improve rates of survival free of bronchopulmonary dysplasia for infants with birth weights of less than 1250 grams. Pediatrics. 2007 May; 119(5):876-90. PMID: 17473087.
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      7. Sorkness CA, Lemanske RF, Mauger DT, Boehmer SJ, Chinchilli VM, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Bloomberg GR, Covar RA, Guilbert TW, Heldt G, Larsen G, Mellon MH, Morgan WJ, Moss MH, Spahn JD, Taussig LM. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 2007 Jan; 119(1):64-72. PMID: 17140647.
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      8. Guilbert TW, Morgan WJ, Zeiger RS, Mauger DT, Boehmer SJ, Szefler SJ, Bacharier LB, Lemanske RF, Strunk RC, Allen DB, Bloomberg GR, Heldt G, Krawiec M, Larsen G, Liu AH, Chinchilli VM, Sorkness CA, Taussig LM, Martinez FD. Long-term inhaled corticosteroids in preschool children at high risk for asthma. N Engl J Med. 2006 May 11; 354(19):1985-97. PMID: 16687711.
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      9. Zeiger RS, Szefler SJ, Phillips BR, Schatz M, Martinez FD, Chinchilli VM, Lemanske RF, Strunk RC, Larsen G, Spahn JD, Bacharier LB, Bloomberg GR, Guilbert TW, Heldt G, Morgan WJ, Moss MH, Sorkness CA, Taussig LM. Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma. J Allergy Clin Immunol. 2006 Jan; 117(1):45-52. PMID: 16387583.
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      10. Hensler ME, Liu GY, Sobczak S, Benirschke K, Nizet V, Heldt G. Virulence role of group B Streptococcus beta-hemolysin/cytolysin in a neonatal rabbit model of early-onset pulmonary infection. J Infect Dis. 2005 Apr 15; 191(8):1287-91. PMID: 15776375.
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      11. Szefler SJ, Phillips BR, Martinez FD, Chinchilli VM, Lemanske RF, Strunk RC, Zeiger RS, Larsen G, Spahn JD, Bacharier LB, Bloomberg GR, Guilbert TW, Heldt G, Morgan WJ, Moss MH, Sorkness CA, Taussig LM. Characterization of within-subject responses to fluticasone and montelukast in childhood asthma. J Allergy Clin Immunol. 2005 Feb; 115(2):233-42. PMID: 15696076.
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      12. Guilbert TW, Morgan WJ, Krawiec M, Lemanske RF, Sorkness C, Szefler SJ, Larsen G, Spahn JD, Zeiger RS, Heldt G, Strunk RC, Bacharier LB, Bloomberg GR, Chinchilli VM, Boehmer SJ, Mauger EA, Mauger DT, Taussig LM, Martinez FD. The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network. Control Clin Trials. 2004 Jun; 25(3):286-310. PMID: 15157730.
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      13. Fu Z, Heldt G, West JB. Thickness of the blood-gas barrier in premature and 1-day-old newborn rabbit lungs. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L130-6. PMID: 12639844.
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      14. Fu Z, Heldt G, West JB. Increased fragility of pulmonary capillaries in newborn rabbit. Am J Physiol Lung Cell Mol Physiol. 2003 May; 284(5):L703-9. PMID: 12676761.
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      15. Schulze A, Rich W, Schellenberg L, Schaller P, Heldt G. Effects of different gain settings during assisted mechanical ventilation using respiratory unloading in rabbits. Pediatr Res. 1998 Jul; 44(1):132-8. PMID: 9667383.
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      16. Kiciman NM, Andréasson B, Bernstein G, Mannino FL, Rich W, Henderson C, Heldt G. Thoracoabdominal motion in newborns during ventilation delivered by endotracheal tube or nasal prongs. Pediatr Pulmonol. 1998 Mar; 25(3):175-81. PMID: 9556009.
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      17. Bernstein G, Heldt G, Mannino FL. Body surface and airway triggered ventilation in extremely premature infants. Acta Paediatr. 1997 Nov; 86(11):1275-6. PMID: 9401529.
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      18. Merritt TA, Heldt G. Partial liquid ventilation--the future is now. N Engl J Med. 1996 Sep 12; 335(11):814-5. PMID: 8703188.
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      19. Liu EA, Heldt G. A trial of the safety of inhaled beclomethasone in ventilator-treated neonates. J Pediatr. 1996 Jul; 129(1):154-6. PMID: 8757577.
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      20. Revak SD, Merritt TA, Cochrane CG, Heldt G, Alberts MS, Anderson DW, Kheiter A. Efficacy of synthetic peptide-containing surfactant in the treatment of respiratory distress syndrome in preterm infant rhesus monkeys. Pediatr Res. 1996 Apr; 39(4 Pt 1):715-24. PMID: 8848350.
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      21. Pappert D, Gilliard N, Heldt G, Merritt TA, Wagner PD, Spragg RG. Effect of N-nitroso-N-methylurethane on gas exchange, lung compliance, and surfactant function of rabbits. Intensive Care Med. 1996 Apr; 22(4):345-52. PMID: 8708173.
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      22. Bernstein G, Mannino FL, Heldt G, Callahan JD, Bull DH, Sola A, Ariagno RL, Hoffman GL, Frantz ID, Troche BI, Roberts JL, Dela Cruz TV, Costa E. Randomized multicenter trial comparing synchronized and conventional intermittent mandatory ventilation in neonates. J Pediatr. 1996 Apr; 128(4):453-63. PMID: 8618177.
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      23. Cochrane CG, Revak SD, Merritt TA, Heldt G, Hallman M, Cunningham MD, Easa D, Pramanik A, Edwards DK, Alberts MS. The efficacy and safety of KL4-surfactant in preterm infants with respiratory distress syndrome. Am J Respir Crit Care Med. 1996 Jan; 153(1):404-10. PMID: 8542150.
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      24. Bernstein G, Knodel E, Heldt G. Airway leak size in neonates and autocycling of three flow-triggered ventilators. Crit Care Med. 1995 Oct; 23(10):1739-44. PMID: 7587241.
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      25. Cleary JP, Bernstein G, Mannino FL, Heldt G. Improved oxygenation during synchronized intermittent mandatory ventilation in neonates with respiratory distress syndrome: a randomized, crossover study. J Pediatr. 1995 Mar; 126(3):407-11. PMID: 7869203.
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      26. Bernstein G, Heldt G, Mannino FL. Increased and more consistent tidal volumes during synchronized intermittent mandatory ventilation in newborn infants. Am J Respir Crit Care Med. 1994 Nov; 150(5 Pt 1):1444-8. PMID: 7952573.
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      27. Gilliard N, Heldt G, Loredo J, Gasser H, Redl H, Merritt TA, Spragg RG. Exposure of the hydrophobic components of porcine lung surfactant to oxidant stress alters surface tension properties. J Clin Invest. 1994 Jun; 93(6):2608-15. PMID: 8200999.
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      28. Bernstein G, Heldt G, Mannino FL. Synchronous mechanical ventilation of neonates. Crit Care Med. 1993 Dec; 21(12):1984-5. PMID: 8252909.
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      29. Bernstein G, Cleary JP, Heldt G, Rosas JF, Schellenberg LD, Mannino FL. Response time and reliability of three neonatal patient-triggered ventilators. Am Rev Respir Dis. 1993 Aug; 148(2):358-64. PMID: 8342899.
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      30. Pesonen E, Heldt G, Merritt TA, Sahn DJ, Elias W, Tikkanen I, Fyhrquist F, Andersson S. Atrial natriuretic factor and pulmonary status in premature infants with respiratory distress syndrome: preliminary investigation. Pediatr Pulmonol. 1993 Jun; 15(6):362-4. PMID: 8337015.
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      31. Vaucher YE, Harker L, Merritt TA, Hallman M, Gist K, Bejar R, Heldt G, Edwards D, Pohjavuori M. Outcome at twelve months of adjusted age in very low birth weight infants with lung immaturity: a randomized, placebo-controlled trial of human surfactant. J Pediatr. 1993 Jan; 122(1):126-32. PMID: 8419599.
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      32. Heldt G, Merritt TA, Golembeski D, Gilliard N, Bloor C, Spragg R. Distribution of surfactant, lung compliance, and aeration of preterm rabbit lungs after surfactant therapy and conventional and high-frequency oscillatory ventilation. Pediatr Res. 1992 Mar; 31(3):270-5. PMID: 1561014.
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      33. Liu A, Hahn JS, Heldt G, Coen RW. Detection of neonatal seizures through computerized EEG analysis. Electroencephalogr Clin Neurophysiol. 1992 Jan; 82(1):30-7. PMID: 1370141.
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      34. Revak SD, Merritt TA, Hallman M, Heldt G, La Polla RJ, Hoey K, Houghten RA, Cochrane CG. The use of synthetic peptides in the formation of biophysically and biologically active pulmonary surfactants. Pediatr Res. 1991 May; 29(5):460-5. PMID: 1896249.
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      35. Merritt TA, Hallman M, Berry C, Pohjavuori M, Edwards DK, Jaaskelainen J, Grafe MR, Vaucher Y, Wozniak P, Heldt G. Randomized, placebo-controlled trial of human surfactant given at birth versus rescue administration in very low birth weight infants with lung immaturity. J Pediatr. 1991 Apr; 118(4 Pt 1):581-94. PMID: 2007937.
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      36. Gilliard N, Pappert D, Merritt TA, Heldt G, Spragg RG. Radiolabeling of the hydrophobic components of lung surfactant with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. Anal Biochem. 1991 Mar 2; 193(2):310-5. PMID: 1872476.
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      37. Nielson DW, Heldt G, Tooley WH. Stridor and gastroesophageal reflux in infants. Pediatrics. 1990 Jun; 85(6):1034-9. PMID: 2339026.
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      38. Pesonen E, Merritt AT, Heldt G, Sahn DJ, Elias W, Tikkanen I, Fyhrquist F, Andersson S. Correlation of patent ductus arteriosus shunting with plasma atrial natriuretic factor concentration in preterm infants with respiratory distress syndrome. Pediatr Res. 1990 Feb; 27(2):137-9. PMID: 2138278.
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      39. Bernstein G, Mannino F, Heldt G, Kopotic R. Some infant ventilators do not limit peak inspiratory pressure reliably during active expiration. Crit Care Med. 1989 Sep; 17(9):969-70. PMID: 2766776.
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      40. Heldt G, Pesonen E, Merritt TA, Elias W, Sahn DJ. Closure of the ductus arteriosus and mechanics of breathing in preterm infants after surfactant replacement therapy. Pediatr Res. 1989 Mar; 25(3):305-10. PMID: 2649864.
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      41. Heldt G. The effect of gavage feeding on the mechanics of the lung, chest wall, and diaphragm of preterm infants. Pediatr Res. 1988 Jul; 24(1):55-8. PMID: 3137518.
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      42. Heldt G. Simultaneous quantification of chest wall distortion by multiple methods in preterm infants. Am Rev Respir Dis. 1988 Jul; 138(1):20-5. PMID: 3202395.
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      43. Heldt G. Development of stability of the respiratory system in preterm infants. J Appl Physiol (1985). 1988 Jul; 65(1):441-4. PMID: 3403487.
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      44. Teague WG, Pian MS, Heldt G, Tooley WH. An acute reduction in the fraction of inspired oxygen increases airway constriction in infants with chronic lung disease. Am Rev Respir Dis. 1988 Apr; 137(4):861-5. PMID: 3354992.
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      45. Heldt G, McIlroy MB. Distortion of chest wall and work of diaphragm in preterm infants. J Appl Physiol (1985). 1987 Jan; 62(1):164-9. PMID: 3558176.
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      46. Heldt G, McIlroy MB. Dynamics of chest wall in preterm infants. J Appl Physiol (1985). 1987 Jan; 62(1):170-4. PMID: 3558177.
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      47. Guilleminault C, Nino-Murcia G, Heldt G, Baldwin R, Hutchinson D. Alternative treatment to tracheostomy in obstructive sleep apnea syndrome: nasal continuous positive airway pressure in young children. Pediatrics. 1986 Nov; 78(5):797-802. PMID: 3532018.
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      48. Pérez Fontán JJ, Turner BS, Heldt G, Gregory GA. Pulmonary mechanics during rapid mechanical ventilation in rabbits with saline-lavaged lungs. J Appl Physiol (1985). 1986 Oct; 61(4):1431-7. PMID: 3096938.
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      49. Pérez Fontán JJ, Heldt G, Gregory GA. Dynamics of respiration during rapid rate mechanical ventilation in anesthetized and paralyzed rabbits. Pediatr Res. 1986 Aug; 20(8):750-5. PMID: 3737287.
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      50. Pérez Fontán JJ, Heldt G, Gregory GA. Mean airway pressure and mean alveolar pressure during high-frequency jet ventilation in rabbits. J Appl Physiol (1985). 1986 Aug; 61(2):456-63. PMID: 3745038.
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      51. Pérez Fontán JJ, Heldt G, Targett RC, Willis MM, Gregory GA. Dynamics of expiration and gas trapping in rabbits during mechanical ventilation at rapid rates. Crit Care Med. 1986 Jan; 14(1):39-47. PMID: 3940753.
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      52. Pérez Fontán JJ, Heldt G, Gregory GA. Resistance and inertia of endotracheal tubes used in infants during periodic flow. Crit Care Med. 1985 Dec; 13(12):1052-5. PMID: 4064716.
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      53. Pérez Fontán JJ, Heldt G, Gregory GA. The effect of a gas leak around the endotracheal tube on the mean tracheal pressure during mechanical ventilation. Am Rev Respir Dis. 1985 Aug; 132(2):339-42. PMID: 4026056.
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      54. Johnston K, Newth CJ, Sheu KF, Patel MS, Heldt G, Schmidt KA, Packman S. Central hypoventilation syndrome in pyruvate dehydrogenase complex deficiency. Pediatrics. 1984 Dec; 74(6):1034-40. PMID: 6438601.
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      55. Fontán JP, Heldt G, Heyman MB, Marin MS, Tooley WH. Esophageal spasm associated with apnea and bradycardia in an infant. Pediatrics. 1984 Jan; 73(1):52-5. PMID: 6691040.
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      56. Brasch RC, Heldt G, Hecht ST. Endotracheal tube orifice abutting the tracheal wall: a cause of infant airway obstruction. Radiology. 1981 Nov; 141(2):387-91. PMID: 7291561.
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      57. Perman JA, Waters LA, Harrison MR, Yee ES, Heldt G. Breath hydrogen reflects canine intestinal ischemia. Pediatr Res. 1981 Sep; 15(9):1229-33. PMID: 7290774.
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      58. Heldt G, McIlroy MB, Hansen TN, Tooley WH. Exercise performance of the survivors of hyaline membrane disease. J Pediatr. 1980 Jun; 96(6):995-9. PMID: 6768870.
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      59. Heldt G, Peters RM. A simplified method to determine functional residual capacity during mechanical ventilation. Chest. 1978 Nov; 74(5):492-6. PMID: 738086.
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