Gregg Silverman

Title(s)Senate Emeritus, Medicine
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Collapse Research 
    Collapse Research Activities and Funding
    Gut dysbiosis and tryptophan metabolism in lupus
    NIH R01AI143313Jan 11, 2019 - Dec 31, 2023
    Role: Co-Principal Investigator
    Lupus and the inhibitory dual receptor hypothesis
    NIH R01AI090118Jun 7, 2010 - May 31, 2016
    Role: Principal Investigator
    alpha4beta1 Intergrin Signaling In Immunity And Arthritis
    NIH R01AR052367Jul 1, 2007 - May 31, 2012
    Role: Co-Principal Investigator
    Arthritis Research Conference 2007
    NIH R13AR055046Mar 1, 2007 - Aug 31, 2007
    Role: Principal Investigator
    Cell Death and Antibody-Mediated Protection from Autoimmunity
    NIH R01AI068063Jul 15, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Arthritis Research Conference 2005
    NIH R13AR052639Jun 1, 2005 - Aug 31, 2005
    Role: Principal Investigator
    BCR Mediated Apoptotic Death of Leukemia B Cells
    NIH R21CA104815Mar 9, 2004 - Feb 28, 2007
    Role: Principal Investigator
    Mechanisms to Induce Protective Natural Autoimmunity
    NIH R21AR050659Sep 26, 2003 - Jun 30, 2006
    Role: Principal Investigator
    RHEUMATIC DISEASES CORE CENTER
    NIH P30AR047360Sep 28, 2001 - Mar 31, 2008
    Role: Principal Investigator
    ENGINEERED B-CELL SUPERANTIGENS AND IMMUNE TOLERANCE
    NIH R03AI046637Sep 30, 1999 - Aug 31, 2003
    Role: Principal Investigator
    B Cell Superantigens and Immune Regulation
    NIH R01AI040305May 1, 1998 - Jan 31, 2010
    Role: Principal Investigator
    BACTERIAL B-CELL SUPERANTIGENS
    NIH K02AI001378Jul 1, 1996 - Jun 30, 2001
    Role: Principal Investigator
    B CELL SUPERANTIGENS AND HUMAN IMMUNE REGULATION
    NIH R29AI034001May 1, 1993 - Apr 30, 1998
    Role: Principal Investigator
    VARIABLE REGION GENE EXPRESSION IN HUMAN AUTOANTIBODIES
    NIH K11AI000866May 1, 1988 - Apr 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The gut microbiome in systemic lupus erythematosus: lessons from rheumatic fever. Nat Rev Rheumatol. 2024 Mar; 20(3):143-157. Silverman GJ, Azzouz DF, Gisch N, Amarnani A. PMID: 38321297.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Understanding the roles of the microbiome in autoimmune rheumatic diseases. Rheumatol Immunol Res. 2023 Dec; 4(4):177-187. Amarnani A, Silverman GJ. PMID: 38125641; PMCID: PMC10729600.
      View in: PubMed   Mentions: 1  
    3. Longitudinal gut microbiome analyses and blooms of pathogenic strains during lupus disease flares. Ann Rheum Dis. 2023 10; 82(10):1315-1327. Azzouz DF, Chen Z, Izmirly PM, Chen LA, Li Z, Zhang C, Mieles D, Trujillo K, Heguy A, Pironti A, Putzel GG, Schwudke D, Fenyo D, Buyon JP, Alekseyenko AV, Gisch N, Silverman GJ. PMID: 37365013; PMCID: PMC10511964.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    4. Pharmacologic inhibition of glycolysis prevents the development of lupus by altering the gut microbiome in mice. iScience. 2023 Jul 21; 26(7):107122. Elshikha AS, Ge Y, Brown J, Kanda N, Zadeh M, Abboud G, Choi SC, Silverman G, Garrett TJ, Clapp WL, Mohamadzadeh M, Morel L. PMID: 37416482; PMCID: PMC10320500.
      View in: PubMed   Mentions: 2  
    5. Hybrid and vaccine-induced immunity against SAR-CoV-2 in MS patients on different disease-modifying therapies. Ann Clin Transl Neurol. 2022 10; 9(10):1643-1659. Kister I, Curtin R, Pei J, Perdomo K, Bacon TE, Voloshyna I, Kim J, Tardio E, Velmurugu Y, Nyovanie S, Valeria Calderon A, Dibba F, Stanzin I, Samanovic MI, Raut P, Raposo C, Priest J, Cabatingan M, Winger RC, Mulligan MJ, Patskovsky Y, Silverman GJ, Krogsgaard M. PMID: 36165097; PMCID: PMC9538694.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    6. Sex-dependent Lupus Blautia (Ruminococcus) gnavus strain induction of zonulin-mediated intestinal permeability and autoimmunity. Front Immunol. 2022; 13:897971. Silverman GJ, Deng J, Azzouz DF. PMID: 36032126; PMCID: PMC9405438.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    7. Predictors of Postacute Sequelae of COVID-19 Development and Rehabilitation: A Retrospective Study. Arch Phys Med Rehabil. 2022 10; 103(10):2001-2008. Abdelwahab N, Ingraham NE, Nguyen N, Siegel L, Silverman G, Sahoo HS, Pakhomov S, Morse LR, Billings J, Usher MG, Melnik TE, Tignanelli CJ, Ikramuddin F. PMID: 35569640; PMCID: PMC9098397.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Faster B-cell repletion after anti-CD20 infusion in Black patients compared to white patients with neurologic diseases. Mult Scler Relat Disord. 2022 Jul; 63:103830. Saidenberg L, Arbini AA, Silverman GJ, Lotan I, Cutter G, Kister I. PMID: 35490448.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Cellular and Humoral Immunity to SARS-CoV-2 Infection in Multiple Sclerosis Patients on Ocrelizumab and Other Disease-Modifying Therapies: A Multi-Ethnic Observational Study. Ann Neurol. 2022 06; 91(6):782-795. Kister I, Patskovsky Y, Curtin R, Pei J, Perdomo K, Rimler Z, Voloshyna I, Samanovic MI, Cornelius AR, Velmurugu Y, Nyovanie S, Kim JJ, Tardio E, Bacon TE, Zhovtis Ryerson L, Raut P, Pedotti R, Hawker K, Raposo C, Priest J, Cabatingan M, Winger RC, Mulligan MJ, Krogsgaard M, Silverman GJ. PMID: 35289960; PMCID: PMC9082484.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    10. Lupus gut microbiota transplants cause autoimmunity and inflammation. Clin Immunol. 2021 12; 233:108892. Ma Y, Guo R, Sun Y, Li X, He L, Li Z, Silverman GJ, Chen G, Gao F, Yuan J, Wei Q, Li M, Lu L, Niu H. PMID: 34813937.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    11. Editorial: Pathogens, Pathobionts, and Autoimmunity. Front Immunol. 2021; 12:752980. Spatz LA, Silverman GJ, James JA. PMID: 34567014; PMCID: PMC8456017.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome. Elife. 2021 08 11; 10. Marié IJ, Brambilla L, Azzouz D, Chen Z, Baracho GV, Arnett A, Li HS, Liu W, Cimmino L, Chattopadhyay P, Silverman G, Watowich SS, Khor B, Levy DE. PMID: 34378531; PMCID: PMC8376249.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    13. Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus. J Exp Med. 2021 05 03; 218(5). Hartl J, Serpas L, Wang Y, Rashidfarrokhi A, Perez OA, Sally B, Sisirak V, Soni C, Khodadadi-Jamayran A, Tsirigos A, Caiello I, Bracaglia C, Volpi S, Ghiggeri GM, Chida AS, Sanz I, Kim MY, Belmont HM, Silverman GJ, Clancy RM, Izmirly PM, Buyon JP, Reizis B. PMID: 33783474; PMCID: PMC8020718.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    14. Diversity of Functionally Distinct Clonal Sets of Human Conventional Memory B Cells That Bind Staphylococcal Protein A. Front Immunol. 2021; 12:662782. Radke EE, Li Z, Hernandez DN, El Bannoudi H, Kosakovsky Pond SL, Shopsin B, Lopez P, Fenyö D, Silverman GJ. PMID: 33995388; PMCID: PMC8113617.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    15. Could Compensatory Autoantibody Production Affect Rheumatoid Arthritis Etiopathogenesis? Arthritis Rheumatol. 2021 05; 73(5):728-730. Silverman GJ. PMID: 33538128.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Blood clots and TAM receptor signalling in COVID-19 pathogenesis. Nat Rev Immunol. 2020 07; 20(7):395-396. Lemke G, Silverman GJ. PMID: 32488201; PMCID: PMC7264968.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    17. Convergent Evolution of Neutralizing Antibodies to Staphylococcus aureus γ-Hemolysin C That Recognize an Immunodominant Primary Sequence-Dependent B-Cell Epitope. mBio. 2020 06 16; 11(3). Hernandez DN, Tam K, Shopsin B, Radke EE, Law K, Cardozo T, Torres VJ, Silverman GJ. PMID: 32546616; PMCID: PMC7298706.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Unbiased Identification of Immunogenic Staphylococcus aureus Leukotoxin B-Cell Epitopes. Infect Immun. 2020 03 23; 88(4). Hernandez DN, Tam K, Shopsin B, Radke EE, Kolahi P, Copin R, Stubbe FX, Cardozo T, Torres VJ, Silverman GJ. PMID: 32014894; PMCID: PMC7093132.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Response to: 'The level of peripheral regulatory T cells is linked to changes in gut commensal microflora in patients with systemic lupus erythematosus' by Zhang et al and the phylogeny of a candidate pathobiont in lupus nephritis. Ann Rheum Dis. 2021 11; 80(11):e178. Silverman GJ, Azzouz DF. PMID: 31732516.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Systemic Lupus Erythematosus and dysbiosis in the microbiome: cause or effect or both? Curr Opin Immunol. 2019 12; 61:80-85. Silverman GJ, Azzouz DF, Alekseyenko AV. PMID: 31590039; PMCID: PMC6901743.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    21. Protective effect of hydroxychloroquine on rheumatoid arthritis-associated atherosclerosis. Animal Model Exp Med. 2019 Jun; 2(2):98-106. Shi N, Zhang S, Silverman G, Li M, Cai J, Niu H. PMID: 31392302; PMCID: PMC6600633.
      View in: PubMed   Mentions: 18     Fields:    
    22. B1 B cell progenitors. Science. 2019 04 19; 364(6437):248. Ghosn E, Dorshkind K, Herzenberg LA, Holodick N, Kantor A, Montecino-Rodriguez E, Rothstein TL, Silverman GJ, Yang Y, Yoder MC, Yoshimoto M. PMID: 31000655; PMCID: PMC7257805.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    23. Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels. Nat Commun. 2019 03 12; 10(1):1183. Vaeth M, Wang YH, Eckstein M, Yang J, Silverman GJ, Lacruz RS, Kannan K, Feske S. PMID: 30862784; PMCID: PMC6414608.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    24. Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal. Ann Rheum Dis. 2019 07; 78(7):947-956. Azzouz D, Omarbekova A, Heguy A, Schwudke D, Gisch N, Rovin BH, Caricchio R, Buyon JP, Alekseyenko AV, Silverman GJ. PMID: 30782585; PMCID: PMC6585303.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    25. The microbiome in SLE pathogenesis. Nat Rev Rheumatol. 2019 02; 15(2):72-74. Silverman GJ. PMID: 30607012.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    26. Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A: Resolving the B-Cell Superantigen Paradox. Front Immunol. 2018; 9:2011. Ulloa-Morales AJ, Goodyear CS, Silverman GJ. PMID: 30283436; PMCID: PMC6156153.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    27. Hierarchy of human IgG recognition within the Staphylococcus aureus immunome. Sci Rep. 2018 09 05; 8(1):13296. Radke EE, Brown SM, Pelzek AJ, Fulmer Y, Hernandez DN, Torres VJ, Thomsen IP, Chiang WK, Miller AO, Shopsin B, Silverman GJ. PMID: 30185867; PMCID: PMC6125462.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    28. The Microbiome and Systemic Lupus Erythematosus. N Engl J Med. 2018 06 07; 378(23):2236-2237. Rosenbaum JT, Silverman GJ. PMID: 29874543.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    29. Immune checkpoint inhibitors and the union of bugs against cancer. Kidney Int. 2018 05; 93(5):1030-1032. Silverman GJ, Azzouz DF, Mor A. PMID: 29680016; PMCID: PMC6488224.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    30. Human Memory B Cells Targeting Staphylococcus aureus Exotoxins Are Prevalent with Skin and Soft Tissue Infection. mBio. 2018 03 13; 9(2). Pelzek AJ, Shopsin B, Radke EE, Tam K, Ueberheide BM, Fenyö D, Brown SM, Li Q, Rubin A, Fulmer Y, Chiang WK, Hernandez DN, El Bannoudi H, Sause WE, Sommerfield A, Thomsen IP, Miller AO, Torres VJ, Silverman GJ. PMID: 29535203; PMCID: PMC5850327.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    31. Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis. Arthritis Res Ther. 2018 02 26; 20(1):36. Hardt U, Larsson A, Gunnarsson I, Clancy RM, Petri M, Buyon JP, Silverman GJ, Svenungsson E, Grönwall C. PMID: 29482604; PMCID: PMC5827973.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    32. Is Gut Microbial LPS a Potential Trigger of Juvenile Idiopathic Arthritis? J Rheumatol. 2017 11; 44(11):1569-1571. Azzouz DF, Silverman GJ. PMID: 29093074.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    33. Depressed serum IgM levels in SLE are restricted to defined subgroups. Clin Immunol. 2017 10; 183:304-315. Grönwall C, Hardt U, Gustafsson JT, Elvin K, Jensen-Urstad K, Kvarnström M, Grosso G, Rönnelid J, Padykov L, Gunnarsson I, Silverman GJ, Svenungsson E. PMID: 28919518.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    34. Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis. J Autoimmun. 2017 Nov; 84:29-45. Grönwall C, Amara K, Hardt U, Krishnamurthy A, Steen J, Engström M, Sun M, Ytterberg AJ, Zubarev RA, Scheel-Toellner D, Greenberg JD, Klareskog L, Catrina AI, Malmström V, Silverman GJ. PMID: 28647488.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    35. Targeting the programmed cell death-1 pathway in rheumatoid arthritis. Autoimmun Rev. 2017 Aug; 16(8):767-773. Sandigursky S, Silverman GJ, Mor A. PMID: 28572054; PMCID: PMC5596871.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. Persistence of Disease-Associated Anti-Citrullinated Protein Antibody-Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission. Arthritis Rheumatol. 2017 06; 69(6):1176-1186. Pelzek AJ, Grönwall C, Rosenthal P, Greenberg JD, McGeachy M, Moreland L, Rigby WFC, Silverman GJ. PMID: 28118534; PMCID: PMC5569882.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    37. Unbiased RACE-Based Massive Parallel Surveys of Human IgA Antibody Repertoires. Methods Mol Biol. 2017; 1643:45-73. El Bannoudi H, Anquetil C, Braunstein MJ, Pond SLK, Silverman GJ. PMID: 28667529.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    38. miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation. Cell Rep. 2016 11 22; 17(9):2271-2285. Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, Koralov SB. PMID: 27880903; PMCID: PMC5679080.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    39. Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity. J Autoimmun. 2016 09; 73:30-41. Grönwall C, Clancy RM, Getu L, Lloyd KA, Siegel DL, Reed JH, Buyon JP, Silverman GJ. PMID: 27289167; PMCID: PMC5003717.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Role of Natural Autoantibodies in Ugandans With Rheumatic Heart Disease and HIV. EBioMedicine. 2016 Mar; 5:161-6. Huck DM, Okello E, Mirembe G, Ssinabulya I, Zidar DA, Silverman GJ, Getu L, Nowacki AS, Calabrese LH, Salata RA, Longenecker CT. PMID: 27077123; PMCID: PMC4816839.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. Anti-carbamylated Protein Antibody Levels Correlate with Anti-Sa (Citrullinated Vimentin) Antibody Levels in Rheumatoid Arthritis. J Rheumatol. 2016 Feb; 43(2):273-281. Challener GJ, Jones JD, Pelzek AJ, Hamilton BJ, Boire G, de Brum-Fernandes AJ, Masetto A, Carrier N, Ménard HA, Silverman GJ, Rigby WFC. PMID: 26669911; PMCID: PMC4737983.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    42. Assigning and visualizing germline genes in antibody repertoires. Philos Trans R Soc Lond B Biol Sci. 2015 Sep 05; 370(1676). Frost SD, Murrell B, Hossain AS, Silverman GJ, Pond SL. PMID: 26194754; PMCID: PMC4528417.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    43. Erratum to: Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis. Inflammation. 2015 Aug; 38(4):1580. Peled M, Strazza M, Azoulay-Alfaguter I, Silverman GJ, Scher JU, Mor A. PMID: 25847627.
      View in: PubMed   Mentions: 1     Fields:    
    44. Analysis of Programmed Death-1 in Patients with Psoriatic Arthritis. Inflammation. 2015 Aug; 38(4):1573-9. Peled M, Strazza M, Azoulay-Alfaguter I, Silverman GJ, Scher JU, Mor A. PMID: 25663558.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    45. Efficacy and Safety of Tabalumab, an Anti-B-Cell-Activating Factor Monoclonal Antibody, in a Heterogeneous Rheumatoid Arthritis Population: Results From a Randomized, Placebo-Controlled, Phase 3 Trial (FLEX-O). J Clin Rheumatol. 2015 Aug; 21(5):231-8. Genovese MC, Silverman GJ, Emery P, Gupta RC, Gill A, Veenhuizen M, Xie L, Komocsar WJ, Berclaz PY, Lee C. PMID: 26203826.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    46. Protective natural autoantibodies to apoptotic cells: evidence of convergent selection of recurrent innate-like clones. Ann N Y Acad Sci. 2015 Dec; 1362:164-75. Silverman GJ. PMID: 25990717; PMCID: PMC4651665.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    47. T cell chemokine receptor patterns as pathogenic signatures in autoimmunity. Discov Med. 2015 Feb; 19(103):117-25. Strazza M, Azoulay-Alfaguter I, Silverman GJ, Mor A. PMID: 25725226.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. Programmed death-1 pathway in cancer and autoimmunity. Clin Immunol. 2014 Jul; 153(1):145-52. Pedoeem A, Azoulay-Alfaguter I, Strazza M, Silverman GJ, Mor A. PMID: 24780173.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
    49. Selection of apoptotic cell specific human antibodies from adult bone marrow. PLoS One. 2014; 9(4):e95999. Grönwall C, Charles ED, Dustin LB, Rader C, Silverman GJ. PMID: 24760047; PMCID: PMC3997490.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    50. Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus. Clin Immunol. 2014 Jul; 153(1):1-7. Grönwall C, Reynolds H, Kim JK, Buyon J, Goldberg JD, Clancy RM, Silverman GJ. PMID: 24704464; PMCID: PMC4068957.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    51. Natural IgM: beneficial autoantibodies for the control of inflammatory and autoimmune disease. J Clin Immunol. 2014 Jul; 34 Suppl 1:S12-21. Grönwall C, Silverman GJ. PMID: 24691998; PMCID: PMC4354681.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansAnimals
    52. Rheumatoid arthritis clinical benefits from abatacept, cytokine blockers, and rituximab are all linked to modulation of memory B cell responses. J Rheumatol. 2014 May; 41(5):825-8. Silverman GJ, Pelzek A. PMID: 24692519; PMCID: PMC4386843.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    53. Protective autoantibodies in the rheumatic diseases: lessons for therapy. Nat Rev Rheumatol. 2013 May; 9(5):291-300. Silverman GJ, Vas J, Grönwall C. PMID: 23507902.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    54. Fundamental roles of the innate-like repertoire of natural antibodies in immune homeostasis. Front Immunol. 2013; 4:4. Vas J, Grönwall C, Silverman GJ. PMID: 23386848; PMCID: PMC3564042.
      View in: PubMed   Mentions: 27     Fields:    
    55. MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19745-50. Grönwall C, Chen Y, Vas J, Khanna S, Thiel S, Corr M, Kono DH, Silverman GJ. PMID: 23139409; PMCID: PMC3511709.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    56. Natural antibody to apoptotic cell membranes inhibits the proinflammatory properties of lupus autoantibody immune complexes. Arthritis Rheum. 2012 Oct; 64(10):3388-98. Vas J, Grönwall C, Marshak-Rothstein A, Silverman GJ. PMID: 22577035; PMCID: PMC3462267.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    57. In vivo VL-targeted microbial superantigen induced global shifts in the B cell repertoire. J Immunol. 2012 Jul 15; 189(2):850-9. Grönwall C, Kosakovsky Pond SL, Young JA, Silverman GJ. PMID: 22696444; PMCID: PMC3598568.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    58. Protective Roles of Natural IgM Antibodies. Front Immunol. 2012; 3:66. Grönwall C, Vas J, Silverman GJ. PMID: 22566947; PMCID: PMC3341951.
      View in: PubMed   Mentions: 170     Fields:    
    59. Natural IgM in immune equilibrium and harnessing their therapeutic potential. J Immunol. 2012 Feb 01; 188(3):939-45. Kaveri SV, Silverman GJ, Bayry J. PMID: 22262757; PMCID: PMC3266110.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    60. IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE. Clin Immunol. 2012 Mar; 142(3):390-8. Grönwall C, Akhter E, Oh C, Burlingame RW, Petri M, Silverman GJ. PMID: 22297166; PMCID: PMC3632049.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    61. Naturally occurring autoantibodies to apoptotic cells. Adv Exp Med Biol. 2012; 750:14-26. Elkon KB, Silverman GJ. PMID: 22903663.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    62. Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment. Arthritis Rheum. 2011 Dec; 63(12):3681-91. Lal P, Su Z, Holweg CT, Silverman GJ, Schwartzman S, Kelman A, Read S, Spaniolo G, Monroe JG, Behrens TW, Townsend MJ. PMID: 22127691.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    63. Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice. Arthritis Rheum. 2011 Dec; 63(12):3897-907. MacLellan LM, Montgomery J, Sugiyama F, Kitson SM, Thümmler K, Silverman GJ, Beers SA, Nibbs RJ, McInnes IB, Goodyear CS. PMID: 22127707; PMCID: PMC3598489.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    64. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. J Exp Med. 2011 Sep 26; 208(10):2033-42. Becker-Herman S, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE, Rawlings DJ. PMID: 21875954; PMCID: PMC3182055.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    65. Development of anti-CD20 therapy for multiple sclerosis. Exp Cell Res. 2011 May 15; 317(9):1312-8. Bartok B, Silverman GJ. PMID: 21510932; PMCID: PMC3266104.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    66. Regulatory natural autoantibodies to apoptotic cells: pallbearers and protectors. Arthritis Rheum. 2011 Mar; 63(3):597-602. Silverman GJ. PMID: 21360488; PMCID: PMC3056121.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    67. Rethinking the red wolf disease: does Protein S suppress systemic lupus erythematosus clinical activity? Arthritis Res Ther. 2010; 12(5):144. Silverman GJ. PMID: 21067626; PMCID: PMC2991027.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    68. Natural autoantibodies to apoptotic cell membranes regulate fundamental innate immune functions and suppress inflammation. Discov Med. 2009 Oct; 8(42):151-6. Silverman GJ, Grönwall C, Vas J, Chen Y. PMID: 19833064.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    69. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12061-6. Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh YT, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler BA, Theofilopoulos AN. PMID: 19574451; PMCID: PMC2715524.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    70. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol. 2009 Jul 15; 183(2):1346-59. Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ. PMID: 19564341; PMCID: PMC2713016.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    71. IgM antibodies to apoptosis-associated determinants recruit C1q and enhance dendritic cell phagocytosis of apoptotic cells. J Immunol. 2009 May 15; 182(10):6031-43. Chen Y, Park YB, Patel E, Silverman GJ. PMID: 19414754; PMCID: PMC4428684.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    72. Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury. J Immunol. 2009 May 01; 182(9):5363-73. Kulik L, Fleming SD, Moratz C, Reuter JW, Novikov A, Chen K, Andrews KA, Markaryan A, Quigg RJ, Silverman GJ, Tsokos GC, Holers VM. PMID: 19380783; PMCID: PMC2820395.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    73. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med. 2008 Nov-Dec; 14(11-12):665-74. Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, Hervé M, Meffre E, Oscier DG, Vlassara H, Scofield RH, Chen Y, Allen SL, Kolitz J, Rai KR, Chu CC, Chiorazzi N. PMID: 19009014; PMCID: PMC2582860.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    74. Phage-display methodology for the study of protein-protein interactions: stage 2, panning. CSH Protoc. 2008 Aug 01; 2008:pdb.prot5021. Goodyear CS, Silverman GJ. PMID: 21356887.
      View in: PubMed   Mentions:
    75. Phage-display methodology for the study of protein-protein interactions: stage 1, generating libraries. CSH Protoc. 2008 Aug 01; 2008:pdb.prot5020. Goodyear CS, Silverman GJ. PMID: 21356886.
      View in: PubMed   Mentions:
    76. Phage-display methodology for the study of protein-protein interactions: overview. CSH Protoc. 2008 Aug 01; 2008:pdb.top48. Goodyear CS, Silverman GJ. PMID: 21356898.
      View in: PubMed   Mentions:
    77. Phage-display methodology for the study of protein-protein interactions: stage 3, binding analysis. CSH Protoc. 2008 Aug 01; 2008:pdb.prot5022. Goodyear CS, Silverman GJ. PMID: 21356888.
      View in: PubMed   Mentions:
    78. Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis. Immunol Rev. 2008 Jun; 223:175-85. Silverman GJ, Boyle DL. PMID: 18613836.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    79. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosus patients. Clin Exp Immunol. 2008 Jul; 153(1):102-16. Silverman GJ, Srikrishnan R, Germar K, Goodyear CS, Andrews KA, Ginzler EM, Tsao BP. PMID: 18510544; PMCID: PMC2432104.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    80. Therapeutic potential (2). Lupus. 2008 Mar; 17(3):262-5. Silverman GJ, Linnik MD. PMID: 18372374.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    81. Quantitation of DNA and RNA. CSH Protoc. 2007 Nov 01; 2007:pdb.ip47. Barbas CF, Burton DR, Scott JK, Silverman GJ. PMID: 21356961.
      View in: PubMed   Mentions: 18  
    82. B cell modulation in rheumatology. Curr Opin Pharmacol. 2007 Aug; 7(4):426-33. Silverman GJ, Khanna S. PMID: 17625968; PMCID: PMC2693398.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    83. Cutting Edge: Bim is required for superantigen-mediated B cell death. J Immunol. 2007 Mar 01; 178(5):2636-40. Goodyear CS, Corr M, Sugiyama F, Boyle DL, Silverman GJ. PMID: 17312102.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    84. Anti-CD20 therapy and autoimmune disease: therapeutic opportunities and evolving insights. Front Biosci. 2007 Jan 01; 12:2194-206. Silverman GJ. PMID: 17127456.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    85. Staphylococcus aureus protein A binding to von Willebrand factor A1 domain is mediated by conserved IgG binding regions. FEBS J. 2006 Nov; 273(21):4831-41. O'Seaghdha M, van Schooten CJ, Kerrigan SW, Emsley J, Silverman GJ, Cox D, Lenting PJ, Foster TJ. PMID: 16999823.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    86. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 2006 Sep; 25(3):403-15. Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. PMID: 16973390.
      View in: PubMed   Mentions: 78     Fields:    Translation:AnimalsCells
    87. Therapeutic B cell depletion and regeneration in rheumatoid arthritis: emerging patterns and paradigms. Arthritis Rheum. 2006 Aug; 54(8):2356-67. Silverman GJ. PMID: 16868991.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    88. Confounding B-cell defences: lessons from a staphylococcal superantigen. Nat Rev Immunol. 2006 Jun; 6(6):465-75. Silverman GJ, Goodyear CS. PMID: 16724100.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    89. Temporal and dose-dependent relationships between in vivo B cell receptor-targeted proliferation and deletion-induced by a microbial B cell toxin. J Immunol. 2006 Feb 15; 176(4):2262-71. Goodyear CS, Sugiyama F, Silverman GJ. PMID: 16455982.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    90. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest. 2006 Mar; 116(3):715-23. Féral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH. PMID: 16470243; PMCID: PMC1361348.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    91. Prevention and reversal of nephritis in MRL/lpr mice with a single injection of C-reactive protein. Arthritis Rheum. 2006 Jan; 54(1):325-35. Rodriguez W, Mold C, Marnell LL, Hutt J, Silverman GJ, Tran D, Du Clos TW. PMID: 16385552.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    92. Targeting of B cells in SLE: rationale and therapeutic opportunities. Bull NYU Hosp Jt Dis. 2006; 64(1-2):51-6. Silverman GJ. PMID: 17121490.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    93. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J Clin Invest. 2005 Nov; 115(11):3205-16. Cappione A, Anolik JH, Pugh-Bernard A, Barnard J, Dutcher P, Silverman G, Sanz I. PMID: 16211091; PMCID: PMC1242189.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansCells
    94. Bacterial cell wall-expressed protein A triggers supraclonal B-cell responses upon in vivo infection with Staphylococcus aureus. Microbes Infect. 2005 Dec; 7(15):1501-11. Palmqvist N, Silverman GJ, Josefsson E, Tarkowski A. PMID: 16039897.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    95. B cell superantigens: a microbe's answer to innate-like B cells and natural antibodies. Springer Semin Immunopathol. 2005 Mar; 26(4):463-84. Goodyear CS, Silverman GJ. PMID: 15633015.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    96. Natural antibodies and the autoimmunity of atherosclerosis. Springer Semin Immunopathol. 2005 Mar; 26(4):385-404. Binder CJ, Silverman GJ. PMID: 15609021.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    97. Anti-CD20 therapy in systemic lupus erythematosus: a step closer to the clinic. Arthritis Rheum. 2005 Feb; 52(2):371-7. Silverman GJ. PMID: 15692969.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    98. On the mechanism of staphylococcal protein A immunomodulation. Transfusion. 2005 Feb; 45(2):274-80. Silverman GJ, Goodyear CS, Siegel DL. PMID: 15660839.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    99. Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med. 2004 Dec 06; 200(11):1359-70. Chang MK, Binder CJ, Miller YI, Subbanagounder G, Silverman GJ, Berliner JA, Witztum JL. PMID: 15583011; PMCID: PMC2211955.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    100. Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11392-7. Goodyear CS, Silverman GJ. PMID: 15273292; PMCID: PMC509211.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    101. A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation. FASEB J. 2004 Aug; 18(11):1312-4. Meyer M, Belke DD, Trost SU, Swanson E, Dieterle T, Scott B, Cary SP, Ho P, Bluhm WF, McDonough PM, Silverman GJ, Dillmann WH. PMID: 15180962.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    102. In vivo VL-targeted activation-induced apoptotic supraclonal deletion by a microbial B cell toxin. J Immunol. 2004 Mar 01; 172(5):2870-7. Goodyear CS, Narita M, Silverman GJ. PMID: 14978088.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    103. Roles of B cells in rheumatoid arthritis. Arthritis Res Ther. 2003; 5 Suppl 4:S1-6. Silverman GJ, Carson DA. PMID: 15180890; PMCID: PMC2833442.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    104. The autoreactivity of anti-phosphorylcholine antibodies for atherosclerosis-associated neo-antigens and apoptotic cells. J Immunol. 2003 Jun 15; 170(12):6151-7. Shaw PX, Goodyear CS, Chang MK, Witztum JL, Silverman GJ. PMID: 12794145.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    105. Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy. Arthritis Rheum. 2003 Jun; 48(6):1484-92. Silverman GJ, Weisman S. PMID: 12794814.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    106. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003 Jun; 9(6):736-43. Binder CJ, Hörkkö S, Dewan A, Chang MK, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ. PMID: 12740573.
      View in: PubMed   Mentions: 279     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    107. Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal Toxin. J Exp Med. 2003 May 05; 197(9):1125-39. Goodyear CS, Silverman GJ. PMID: 12719481; PMCID: PMC2193973.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    108. Development of functional human monoclonal single-chain variable fragment antibody against HIV-1 from human cervical B cells. Hybrid Hybridomics. 2003 Apr; 22(2):97-108. Berry JD, Rutherford J, Silverman GJ, Kaul R, Elia M, Gobuty S, Fuller R, Plummer FA, Barbas CF. PMID: 12831535.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    109. Adoptive transfer of a superantigen-induced hole in the repertoire of natural IgM-secreting cells. Cell Immunol. 2001 Apr 10; 209(1):76-80. Silverman GJ. PMID: 11414738.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    110. A B cell superantigen-induced persistent "Hole" in the B-1 repertoire. J Exp Med. 2000 Jul 03; 192(1):87-98. Silverman GJ, Cary SP, Dwyer DC, Luo L, Wagenknecht R, Curtiss VE. PMID: 10880529; PMCID: PMC1887708.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    111. The dual phases of the response to neonatal exposure to a VH family-restricted staphylococcal B cell superantigen. J Immunol. 1998 Nov 15; 161(10):5720-32. Silverman GJ, Nayak JV, Warnatz K, Hajjar FF, Cary S, Tighe H, Curtiss VE. PMID: 9820554.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    112. B-cell superantigens. Immunol Today. 1997 Aug; 18(8):379-86. Silverman GJ. PMID: 9267080.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    113. B-cell superantigens: molecular and cellular implications. Int Rev Immunol. 1997; 14(4):259-90. Silverman GJ, Nayak JV, La Cava A. PMID: 9186781.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
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