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    Gerald Newton

    TitleRecall Non-faculty Academic
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0377
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chaikeeratisak V, Nguyen K, Khanna K, Brilot AF, Erb ML, Coker JK, Vavilina A, Newton G, Buschauer R, Pogliano K, Villa E, Agard DA, Pogliano J. Assembly of a nucleus-like structure during viral replication in bacteria. Science. 2017 01 13; 355(6321):194-197. PMID: 28082593.
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      2. Nonejuie P, Trial RM, Newton G, Lamsa A, Ranmali Perera V, Aguilar J, Liu WT, Dorrestein PC, Pogliano J, Pogliano K. Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis. J Antibiot (Tokyo). 2016 05; 69(5):353-61. PMID: 26648120.
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      3. Perera VR, Newton G, Pogliano K. Bacillithiol: a key protective thiol in Staphylococcus aureus. Expert Rev Anti Infect Ther. 2015; 13(9):1089-107. PMID: 26184907; PMCID: PMC4914364.
      4. Perera VR, Newton G, Parnell JM, Komives EA, Pogliano K. Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA. Biochim Biophys Acta. 2014 Sep; 1840(9):2851-61. PMID: 24821014; PMCID: PMC4802972.
      5. Dedrick RM, Marinelli LJ, Newton G, Pogliano K, Pogliano J, Hatfull GF. Functional requirements for bacteriophage growth: gene essentiality and expression in mycobacteriophage Giles. Mol Microbiol. 2013 May; 88(3):577-89. PMID: 23560716; PMCID: PMC3641587.
      6. Upton H, Newton G, Gushiken M, Lo K, Holden D, Fahey RC, Rawat M. Characterization of BshA, bacillithiol glycosyltransferase from Staphylococcus aureus and Bacillus subtilis. FEBS Lett. 2012 Apr 05; 586(7):1004-8. PMID: 22569254; PMCID: PMC3668096.
      7. Newton G, Fahey RC, Rawat M. Detoxification of toxins by bacillithiol in Staphylococcus aureus. Microbiology. 2012 Apr; 158(Pt 4):1117-26. PMID: 22262099; PMCID: PMC3949421.
      8. Newton G, Leung SS, Wakabayashi JI, Rawat M, Fahey RC. The DinB superfamily includes novel mycothiol, bacillithiol, and glutathione S-transferases. Biochemistry. 2011 Dec 13; 50(49):10751-60. PMID: 22059487; PMCID: PMC3232311.
      9. Sharma SV, Jothivasan VK, Newton G, Upton H, Wakabayashi JI, Kane MG, Roberts AA, Rawat M, La Clair JJ, Hamilton CJ. Chemical and Chemoenzymatic syntheses of bacillithiol: a unique low-molecular-weight thiol amongst low G + C Gram-positive bacteria. Angew Chem Int Ed Engl. 2011 Jul 25; 50(31):7101-4. PMID: 21751306.
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      10. Hatzios SK, Schelle MW, Newton G, Sogi KM, Holsclaw CM, Fahey RC, Bertozzi CR. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4956-9. PMID: 21795043; PMCID: PMC3184767.
      11. Newton G, Buchmeier N, La Clair JJ, Fahey RC. Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis. Bioorg Med Chem. 2011 Jul 01; 19(13):3956-64. PMID: 21665483; PMCID: PMC3123436.
      12. Ta P, Buchmeier N, Newton G, Rawat M, Fahey RC. Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. J Bacteriol. 2011 Apr; 193(8):1981-90. PMID: 21335456; PMCID: PMC3133051.
      13. Parsonage D, Newton G, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-a-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry. 2010 Sep 28; 49(38):8398-414. PMID: 20799687; PMCID: PMC2943542.
      14. Gaballa A, Newton G, Antelmann H, Parsonage D, Upton H, Rawat M, Claiborne A, Fahey RC, Helmann JD. Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli. Proc Natl Acad Sci U S A. 2010 Apr 06; 107(14):6482-6. PMID: 20308541; PMCID: PMC2851989.
      15. Newton G, Rawat M, La Clair JJ, Jothivasan VK, Budiarto T, Hamilton CJ, Claiborne A, Helmann JD, Fahey RC. Bacillithiol is an antioxidant thiol produced in Bacilli. Nat Chem Biol. 2009 Sep; 5(9):625-7. PMID: 19578333; PMCID: PMC3510479.
      16. Dosanjh M, Newton G, Davies J. Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1. Res Microbiol. 2008 Nov-Dec; 159(9-10):643-50. PMID: 18832026.
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      17. Newton G, Buchmeier N, Fahey RC. Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria. Microbiol Mol Biol Rev. 2008 Sep; 72(3):471-94. PMID: 18772286; PMCID: PMC2546866.
      18. Johnson T, Newton G, Fahey RC, Rawat M. Unusual production of glutathione in Actinobacteria. Arch Microbiol. 2009 Jan; 191(1):89-93. PMID: 18719892; PMCID: PMC2605195.
      19. Newton G, Jensen PR, Macmillan JB, Fenical W, Fahey RC. An N-acyl homolog of mycothiol is produced in marine actinomycetes. Arch Microbiol. 2008 Nov; 190(5):547-57. PMID: 18629474; PMCID: PMC2574923.
      20. Newton G, Fahey RC. Regulation of mycothiol metabolism by sigma(R) and the thiol redox sensor anti-sigma factor RsrA. Mol Microbiol. 2008 May; 68(4):805-9. PMID: 18430078.
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      21. Bzymek KP, Newton G, Ta P, Fahey RC. Mycothiol import by Mycobacterium smegmatis and function as a resource for metabolic precursors and energy production. J Bacteriol. 2007 Oct; 189(19):6796-805. PMID: 17644601; PMCID: PMC2045207.
      22. Nicely NI, Parsonage D, Paige C, Newton G, Fahey RC, Leonardi R, Jackowski S, Mallett TC, Claiborne A. Structure of the type III pantothenate kinase from Bacillus anthracis at 2.0 A resolution: implications for coenzyme A-dependent redox biology. Biochemistry. 2007 Mar 20; 46(11):3234-45. PMID: 17323930; PMCID: PMC2613803.
      23. Buchmeier NA, Newton G, Fahey RC. A mycothiol synthase mutant of Mycobacterium tuberculosis has an altered thiol-disulfide content and limited tolerance to stress. J Bacteriol. 2006 Sep; 188(17):6245-52. PMID: 16923891; PMCID: PMC1595396.
      24. Newton G, Ta P, Bzymek KP, Fahey RC. Biochemistry of the initial steps of mycothiol biosynthesis. J Biol Chem. 2006 Nov 10; 281(45):33910-20. PMID: 16940050.
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      25. Gutierrez-Lugo MT, Newton G, Fahey RC, Bewley CA. Cloning, expression and rapid purification of active recombinant mycothiol ligase as B1 immunoglobulin binding domain of streptococcal protein G, glutathione-S-transferase and maltose binding protein fusion proteins in Mycobacterium smegmatis. Protein Expr Purif. 2006 Nov; 50(1):128-36. PMID: 16908186.
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      26. Newton G, Ta P, Sareen D, Fahey RC. A coupled spectrophotometric assay for l-cysteine:1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase and its application for inhibitor screening. Anal Biochem. 2006 Jun 15; 353(2):167-73. PMID: 16674910.
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      27. Newton G, Ko M, Ta P, Av-Gay Y, Fahey RC. Purification and characterization of Mycobacterium tuberculosis 1D-myo-inosityl-2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase, MshB, a mycothiol biosynthetic enzyme. Protein Expr Purif. 2006 Jun; 47(2):542-50. PMID: 16630724.
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      28. Newton G, Ta P, Fahey RC. A mycothiol synthase mutant of Mycobacterium smegmatis produces novel thiols and has an altered thiol redox status. J Bacteriol. 2005 Nov; 187(21):7309-16. PMID: 16237013; PMCID: PMC1272995.
      29. Seligman J, Newton G, Fahey RC, Shalgi R, Kosower NS. Nonprotein thiols and disulfides in rat epididymal spermatozoa and epididymal fluid: role of gamma-glutamyl-transpeptidase in sperm maturation. J Androl. 2005 Sep-Oct; 26(5):629-37; discussion 638-40. PMID: 16088041.
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      30. Newton G, Ly A, Tran NQ, Ward JF, Milligan JR. Radioprotection of plasmid DNA by oligolysines. Int J Radiat Biol. 2004 Sep; 80(9):643-51. PMID: 15586884.
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      31. Rawat M, Uppal M, Newton G, Steffek M, Fahey RC, Av-Gay Y. Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein. J Bacteriol. 2004 Sep; 186(18):6050-8. PMID: 15342574; PMCID: PMC515152.
      32. Sareen D, Newton G, Fahey RC, Buchmeier NA. Mycothiol is essential for growth of Mycobacterium tuberculosis Erdman. J Bacteriol. 2003 Nov; 185(22):6736-40. PMID: 14594852; PMCID: PMC262099.
      33. Steffek M, Newton G, Av-Gay Y, Fahey RC. Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase. Biochemistry. 2003 Oct 21; 42(41):12067-76. PMID: 14556638.
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      34. Maynes JT, Garen C, Cherney MM, Newton G, Arad D, Av-Gay Y, Fahey RC, James MN. The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold. J Biol Chem. 2003 Nov 21; 278(47):47166-70. PMID: 12958317.
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      35. Newton G, Koledin T, Gorovitz B, Rawat M, Fahey RC, Av-Gay Y. The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA). J Bacteriol. 2003 Jun; 185(11):3476-9. PMID: 12754249; PMCID: PMC155378.
      36. Buchmeier NA, Newton G, Koledin T, Fahey RC. Association of mycothiol with protection of Mycobacterium tuberculosis from toxic oxidants and antibiotics. Mol Microbiol. 2003 Mar; 47(6):1723-32. PMID: 12622824.
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      37. Nicholas GM, Eckman LL, Newton G, Fahey RC, Ray S, Bewley CA. Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem. 2003 Feb 20; 11(4):601-8. PMID: 12538025.
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      38. Rawat M, Newton G, Ko M, Martinez GJ, Fahey RC, Av-Gay Y. Mycothiol-deficient Mycobacterium smegmatis mutants are hypersensitive to alkylating agents, free radicals, and antibiotics. Antimicrob Agents Chemother. 2002 Nov; 46(11):3348-55. PMID: 12384335; PMCID: PMC128700.
      39. Newton G, Fahey RC. Mycothiol biochemistry. Arch Microbiol. 2002 Dec; 178(6):388-94. PMID: 12420157.
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      40. Koledin T, Newton G, Fahey RC. Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Arch Microbiol. 2002 Nov; 178(5):331-7. PMID: 12375100.
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      41. Sareen D, Steffek M, Newton G, Fahey RC. ATP-dependent L-cysteine:1D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase, mycothiol biosynthesis enzyme MshC, is related to class I cysteinyl-tRNA synthetases. Biochemistry. 2002 Jun 04; 41(22):6885-90. PMID: 12033919.
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      42. Newton G, Av-Gay Y, Fahey RC. N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis. J Bacteriol. 2000 Dec; 182(24):6958-63. PMID: 11092856; PMCID: PMC94821.
      43. Newton G, Av-Gay Y, Fahey RC. A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase. Biochemistry. 2000 Sep 05; 39(35):10739-46. PMID: 10978158.
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      44. Unson MD, Newton G, Arnold KF, Davis CE, Fahey RC. Improved methods for immunoassay of mycothiol. J Clin Microbiol. 1999 Jul; 37(7):2153-7. PMID: 10364578; PMCID: PMC85106.
      45. Newton G, Unson MD, Anderberg SJ, Aguilera JA, Oh NN, delCardayre SB, Av-Gay Y, Fahey RC. Characterization of Mycobacterium smegmatis mutants defective in 1-d-myo-inosityl-2-amino-2-deoxy-alpha-d-glucopyranoside and mycothiol biosynthesis. Biochem Biophys Res Commun. 1999 Feb 16; 255(2):239-44. PMID: 10049692.
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      46. Anderberg SJ, Newton G, Fahey RC. Mycothiol biosynthesis and metabolism. Cellular levels of potential intermediates in the biosynthesis and degradation of mycothiol in mycobacterium smegmatis. J Biol Chem. 1998 Nov 13; 273(46):30391-7. PMID: 9804803.
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      47. Unson MD, Newton G, Davis C, Fahey RC. An immunoassay for the detection and quantitative determination of mycothiol. J Immunol Methods. 1998 May 01; 214(1-2):29-39. PMID: 9692856.
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      48. Newton G, Aguilera JA, Ward JF, Fahey RC. Effect of polyamine-induced compaction and aggregation of DNA on the formation of radiation-induced strand breaks: quantitative models for cellular radiation damage. Radiat Res. 1997 Sep; 148(3):272-84. PMID: 9291359.
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      49. Newton G, Aguilera JA, Ward JF, Fahey RC. Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei. Radiat Res. 1996 Sep; 146(3):298-305. PMID: 8752308.
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      50. Newton G, Aguilera JA, Kim T, Ward JF, Fahey RC. Transport of aminothiol radioprotectors into mammalian cells: passive diffusion versus mediated uptake. Radiat Res. 1996 Aug; 146(2):206-15. PMID: 8693070.
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      51. Bartsch RG, Newton G, Sherrill C, Fahey RC. Glutathione amide and its perthiol in anaerobic sulfur bacteria. J Bacteriol. 1996 Aug; 178(15):4742-6. PMID: 8755912; PMCID: PMC178251.
      52. Newton G, Aguilera JA, Ward JF, Fahey RC. Polyamine-induced compaction and aggregation of DNA--a major factor in radioprotection of chromatin under physiological conditions. Radiat Res. 1996 Jun; 145(6):776-80. PMID: 8643839.
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      53. Newton G, Arnold K, Price MS, Sherrill C, Delcardayre SB, Aharonowitz Y, Cohen G, Davies J, Fahey RC, Davis C. Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J Bacteriol. 1996 Apr; 178(7):1990-5. PMID: 8606174; PMCID: PMC177895.
      54. Newton G, Bewley CA, Dwyer TJ, Horn R, Aharonowitz Y, Cohen G, Davies J, Faulkner DJ, Fahey RC. The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol. Eur J Biochem. 1995 Jun 01; 230(2):821-5. PMID: 7607257.
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      55. Keefe AD, Newton G, Miller SL. A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A. Nature. 1995 Feb 23; 373(6516):683-5. PMID: 7854449.
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      56. Newton G, Fahey RC. Determination of biothiols by bromobimane labeling and high-performance liquid chromatography. Methods Enzymol. 1995; 251:148-66. PMID: 7651194.
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      57. Newton G, Fahey RC, Cohen G, Aharonowitz Y. Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants. J Bacteriol. 1993 May; 175(9):2734-42. PMID: 8478335; PMCID: PMC204577.
      58. Newton G, Dwyer TJ, Kim T, Ward JF, Fahey RC. Determination of the acid dissociation constants for WR-1065 by proton NMR spectroscopy. Radiat Res. 1992 Aug; 131(2):143-51. PMID: 1641468.
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      59. Aguilera JA, Newton G, Fahey RC, Ward JF. Thiol uptake by Chinese hamster V79 cells and aerobic radioprotection as a function of the net charge on the thiol. Radiat Res. 1992 May; 130(2):194-204. PMID: 1574575.
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      60. Zheng S, Newton G, Ward JF, Fahey RC. Aerobic radioprotection of pBR322 by thiols: effect of thiol net charge upon scavenging of hydroxyl radicals and repair of DNA radicals. Radiat Res. 1992 May; 130(2):183-93. PMID: 1574574.
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      61. Newton G, Aguilera JA, Fahey RC, Ward JF, Radkowsky AE, Kosower EM. para-sulfobenzoyloxybromobimane: a new membrane-impermeable reagent useful for the analysis of thiols and their export from cells. Anal Biochem. 1992 Feb 14; 201(1):30-42. PMID: 1621960.
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      62. Zheng S, Newton G, Gonick G, Fahey RC, Ward JF. Radioprotection of DNA by thiols: relationship between the net charge on a thiol and its ability to protect DNA. Radiat Res. 1988 Apr; 114(1):11-27. PMID: 3127858.
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      63. Fahey RC, Buschbacher RM, Newton G. The evolution of glutathione metabolism in phototrophic microorganisms. J Mol Evol. 1987; 25:81-8. PMID: 11542078.
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