Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    George Feher

    TitleEmeritus Professor
    SchoolUniversity of California, San Diego
    DepartmentPhysics
    Address9500 Gilman Drive #0319
    CA La Jolla 92093
    Phone858-534-4389
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      STRUCTURE &FUNCTION OF PHOTOSYNTHETIC REACTION CENTERS
      NIH/NIGMS R01GM013191May 10, 1976 - Jun 30, 2005
      Role: Principal Investigator
      SPECTROSCOPIC INVESTIGATIONS OF BIOLOGICAL SYSTEMS
      NIH/NIGMS R37GM013191May 10, 1976 - Jun 30, 1996
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Flores M, Isaacson R, Abresch E, Calvo R, Lubitz W, Feher G. Protein-cofactor interactions in bacterial reaction centers from Rhodobacter sphaeroides R-26: II. Geometry of the hydrogen bonds to the primary quinone formula by 1H and 2H ENDOR spectroscopy. Biophys J. 2007 Jan 15; 92(2):671-82. PMID: 17071655; PMCID: PMC1751397.
      2. Flores M, Isaacson R, Abresch E, Calvo R, Lubitz W, Feher G. Protein-cofactor interactions in bacterial reaction centers from Rhodobacter sphaeroides R-26: I. Identification of the ENDOR lines associated with the hydrogen bonds to the primary quinone QA*-. Biophys J. 2006 May 01; 90(9):3356-62. PMID: 16473904; PMCID: PMC1432105.
      3. Paddock ML, Chang C, Xu Q, Abresch EC, Axelrod HL, Feher G, Okamura MY. Quinone (QB) reduction by B-branch electron transfer in mutant bacterial reaction centers from Rhodobacter sphaeroides: quantum efficiency and X-ray structure. Biochemistry. 2005 May 10; 44(18):6920-8. PMID: 15865437.
        View in: PubMed
      4. Xu Q, Axelrod HL, Abresch EC, Paddock ML, Okamura MY, Feher G. X-Ray structure determination of three mutants of the bacterial photosynthetic reaction centers from Rb. sphaeroides; altered proton transfer pathways. Structure. 2004 Apr; 12(4):703-15. PMID: 15062092.
        View in: PubMed
      5. Paddock ML, Feher G, Okamura MY. Proton transfer pathways and mechanism in bacterial reaction centers. FEBS Lett. 2003 Nov 27; 555(1):45-50. PMID: 14630317.
        View in: PubMed
      6. Paddock ML, Sagle L, Tehrani A, Beatty JT, Feher G, Okamura MY. Mechanism of proton transfer inhibition by Cd(2+) binding to bacterial reaction centers: determination of the pK(A) of functionally important histidine residues. Biochemistry. 2003 Aug 19; 42(32):9626-32. PMID: 12911304.
        View in: PubMed
      7. Paddock ML, Adelroth P, Feher G, Okamura MY, Beatty JT. Determination of proton transfer rates by chemical rescue: application to bacterial reaction centers. Biochemistry. 2002 Dec 17; 41(50):14716-25. PMID: 12475220.
        View in: PubMed
      8. Calvo R, Isaacson RA, Abresch EC, Okamura MY, Feher G. Spin-lattice relaxation of coupled metal-radical spin-dimers in proteins: application to Fe(2+)-cofactor (Q(A)(-.), Q(B)(-.), phi(-.)) dimers in reaction centers from photosynthetic bacteria. Biophys J. 2002 Nov; 83(5):2440-56. PMID: 12414679; PMCID: PMC1302331.
      9. Axelrod HL, Abresch EC, Okamura MY, Yeh AP, Rees DC, Feher G. X-ray structure determination of the cytochrome c2: reaction center electron transfer complex from Rhodobacter sphaeroides. J Mol Biol. 2002 May 31; 319(2):501-15. PMID: 12051924.
        View in: PubMed
      10. Adelroth P, Paddock ML, Tehrani A, Beatty JT, Feher G, Okamura MY. Identification of the proton pathway in bacterial reaction centers: decrease of proton transfer rate by mutation of surface histidines at H126 and H128 and chemical rescue by imidazole identifies the initial proton donors. Biochemistry. 2001 Dec 04; 40(48):14538-46. PMID: 11724567.
        View in: PubMed
      11. Feher G. My road to biophysics: picking flowers on the way to photosynthesis. Annu Rev Biophys Biomol Struct. 2002; 31:1-44. PMID: 11988461.
        View in: PubMed
      12. Tetreault M, Rongey SH, Feher G, Okamura MY. Interaction between cytochrome c2 and the photosynthetic reaction center from Rhodobacter sphaeroides: effects of charge-modifying mutations on binding and electron transfer. Biochemistry. 2001 Jul 24; 40(29):8452-62. PMID: 11456482.
        View in: PubMed
      13. Paddock ML, Adelroth P, Chang C, Abresch EC, Feher G, Okamura MY. Identification of the proton pathway in bacterial reaction centers: cooperation between Asp-M17 and Asp-L210 facilitates proton transfer to the secondary quinone (QB). Biochemistry. 2001 Jun 12; 40(23):6893-902. PMID: 11389604.
        View in: PubMed
      14. Adelroth P, Paddock ML, Sagle LB, Feher G, Okamura MY. Identification of the proton pathway in bacterial reaction centers: both protons associated with reduction of QB to QBH2 share a common entry point. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13086-91. PMID: 11078513; PMCID: PMC27182.
      15. Okamura MY, Paddock ML, Graige MS, Feher G. Proton and electron transfer in bacterial reaction centers. Biochim Biophys Acta. 2000 May 12; 1458(1):148-63. PMID: 10812030.
        View in: PubMed
      16. Axelrod HL, Abresch EC, Paddock ML, Okamura MY, Feher G. Determination of the binding sites of the proton transfer inhibitors Cd2+ and Zn2+ in bacterial reaction centers. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1542-7. PMID: 10677497; PMCID: PMC26471.
      17. Paddock ML, Feher G, Okamura MY. Identification of the proton pathway in bacterial reaction centers: replacement of Asp-M17 and Asp-L210 with asn reduces the proton transfer rate in the presence of Cd2+. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1548-53. PMID: 10677498; PMCID: PMC26472.
      18. Graige MS, Paddock ML, Feher G, Okamura MY. Observation of the protonated semiquinone intermediate in isolated reaction centers from Rhodobacter sphaeroides: implications for the mechanism of electron and proton transfer in proteins. Biochemistry. 1999 Aug 31; 38(35):11465-73. PMID: 10471298.
        View in: PubMed
      19. Paddock ML, Graige MS, Feher G, Okamura MY. Identification of the proton pathway in bacterial reaction centers: inhibition of proton transfer by binding of Zn2+ or Cd2+. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6183-8. PMID: 10339562; PMCID: PMC26856.
      20. Graige MS, Feher G, Okamura MY. Conformational gating of the electron transfer reaction QA-.QB --> QAQB-. in bacterial reaction centers of Rhodobacter sphaeroides determined by a driving force assay. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11679-84. PMID: 9751725; PMCID: PMC21700.
      21. Paddock ML, Feher G, Okamura MY. Proton and electron transfer to the secondary quinone (QB) in bacterial reaction centers: the effect of changing the electrostatics in the vicinity of QB by interchanging asp and glu at the L212 and L213 sites. Biochemistry. 1997 Nov 18; 36(46):14238-49. PMID: 9369497.
        View in: PubMed
      22. Adir N, Axelrod HL, Beroza P, Isaacson RA, Rongey SH, Okamura MY, Feher G. Co-crystallization and characterization of the photosynthetic reaction center-cytochrome c2 complex from Rhodobacter sphaeroides. Biochemistry. 1996 Feb 27; 35(8):2535-47. PMID: 8611557.
        View in: PubMed
      23. Paddock ML, Feher G, Okamura MY. Pathway of proton transfer in bacterial reaction centers: further investigations on the role of Ser-L223 studied by site-directed mutagenesis. Biochemistry. 1995 Dec 05; 34(48):15742-50. PMID: 7495805.
        View in: PubMed
      24. Isaacson RA, Lendzian F, Abresch EC, Lubitz W, Feher G. Electronic structure of Q-A in reaction centers from Rhodobacter sphaeroides. I. Electron paramagnetic resonance in single crystals. Biophys J. 1995 Aug; 69(2):311-22. PMID: 8527644; PMCID: PMC1236255.
      25. Beroza P, Fredkin DR, Okamura MY, Feher G. Electrostatic calculations of amino acid titration and electron transfer, Q-AQB-->QAQ-B, in the reaction center. Biophys J. 1995 Jun; 68(6):2233-50. PMID: 7647231; PMCID: PMC1282134.
      26. Axelrod HL, Feher G, Allen JP, Chirino AJ, Day MW, Hsu BT, Rees DC. Crystallization and X-ray structure determination of cytochrome c2 from Rhodobacter sphaeroides in three crystal forms. Acta Crystallogr D Biol Crystallogr. 1994 Jul 01; 50(Pt 4):596-602. PMID: 15299423.
        View in: PubMed
      27. McPherson PH, Schönfeld M, Paddock ML, Okamura MY, Feher G. Protonation and free energy changes associated with formation of QBH2 in native and Glu-L212-->Gln mutant reaction centers from Rhodobacter sphaeroides. Biochemistry. 1994 Feb 08; 33(5):1181-93. PMID: 8110749.
        View in: PubMed
      28. Paddock ML, Rongey SH, McPherson PH, Juth A, Feher G, Okamura MY. Pathway of proton transfer in bacterial reaction centers: role of aspartate-L213 in proton transfers associated with reduction of quinoneto dihydroquinone. Biochemistry. 1994 Jan 25; 33(3):734-45. PMID: 8292601.
        View in: PubMed
      29. McPherson PH, Okamura MY, Feher G. Light-induced proton uptake by photosynthetic reaction centers from Rhodobacter sphaeroides R-26.1. II. Protonation of the state DQAQB2-. Biochim Biophys Acta. 1993 Oct 04; 1144(3):309-24. PMID: 8399281.
        View in: PubMed
      30. Rongey SH, Paddock ML, Feher G, Okamura MY. Pathway of proton transfer in bacterial reaction centers: second-site mutation Asn-M44-->Asp restores electron and proton transfer in reaction centers from the photosynthetically deficient Asp-L213-->Asn mutant of Rhodobacter sphaeroides. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1325-9. PMID: 8381964; PMCID: PMC45865.
      31. Okamura MY, Feher G. Proton transfer in reaction centers from photosynthetic bacteria. Annu Rev Biochem. 1992; 61:861-96. PMID: 1323240.
        View in: PubMed
      32. Beroza P, Fredkin DR, Okamura MY, Feher G. Protonation of interacting residues in a protein by a Monte Carlo method: application to lysozyme and the photosynthetic reaction center of Rhodobacter sphaeroides. Proc Natl Acad Sci U S A. 1991 Jul 01; 88(13):5804-8. PMID: 2062860; PMCID: PMC51966.
      33. Paddock ML, Feher G, Okamura MY. Reaction centers from three herbicide resistant mutants of Rhodobacter sphaeroides 2.4.1: Kinetics of electron transfer reactions. Photosynth Res. 1991 Feb; 27(2):109-19. PMID: 24414574.
        View in: PubMed
      34. Paddock ML, McPherson PH, Feher G, Okamura MY. Pathway of proton transfer in bacterial reaction centers: replacement of serine-L223 by alanine inhibits electron and proton transfers associated with reduction of quinone to dihydroquinone. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6803-7. PMID: 2168561; PMCID: PMC54626.
      35. Durbin SD, Feher G. Studies of crystal growth mechanisms of proteins by electron microscopy. J Mol Biol. 1990 Apr 20; 212(4):763-74. PMID: 2329581.
        View in: PubMed
      36. Paddock ML, Rongey SH, Feher G, Okamura MY. Pathway of proton transfer in bacterial reaction centers: replacement of glutamic acid 212 in the L subunit by glutamine inhibits quinone (secondary acceptor) turnover. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6602-6. PMID: 2570421; PMCID: PMC297892.
      37. Allen JP, Feher G, Yeates TO, Komiya H, Rees DC. Structure of the reaction center from Rhodobacter sphaeroides R-26: protein-cofactor (quinones and Fe2+) interactions. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8487-91. PMID: 3054889; PMCID: PMC282483.
      38. Paddock ML, Rongey SH, Abresch EC, Feher G, Okamura MY. Reaction centers from three herbicide-resistant mutants of Rhodobacter sphaeroides 2.4.1: sequence analysis and preliminary characterization. Photosynth Res. 1988 Jul; 17(1-2):75-96. PMID: 24429662.
        View in: PubMed
      39. Lösche M, Feher G, Okamura MY. The Stark effect in reaction centers from Rhodobacter sphaeroides R-26 and Rhodopseudomonas viridis. Proc Natl Acad Sci U S A. 1987 Nov; 84(21):7537-41. PMID: 3313396; PMCID: PMC299334.
      40. Williams JC, Steiner LA, Feher G. Primary structure of the reaction center from Rhodopseudomonas sphaeroides. Proteins. 1986 Dec; 1(4):312-25. PMID: 3329732.
        View in: PubMed
      41. Okamura MY, Feher G. Isotope effect on electron transfer in reaction centers from Rhodopseudomonas sphaeroides. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8152-6. PMID: 16593776.
        View in: PubMed
      42. Williams JC, Steiner LA, Ogden RC, Simon MI, Feher G. Primary structure of the M subunit of the reaction center from Rhodopseudomonas sphaeroides. Proc Natl Acad Sci U S A. 1983 Nov; 80(21):6505-9. PMID: 16593385.
        View in: PubMed
      43. Schönfeld M, Montal M, Feher G. Functional reconstitution of photosynthetic reaction centers in planar lipid bilayers. Proc Natl Acad Sci U S A. 1979 Dec; 76(12):6351-5. PMID: 16592737.
        View in: PubMed
      44. McElroy JD, Mauzerall DC, Feher G. Characterization of primary reactants in bacterial photosynthesis. II. Kinetic studies of the light-induced EPR signal (g = 2.0026) and the optical absorbance changes at cryogenic temperatures. Biochim Biophys Acta. 1974 Feb 22; 333(2):261-78. PMID: 19400038.
        View in: PubMed
      45. Feher G, Weissman M. Fluctuation spectroscopy: determination of chemical reaction kinetics from the frequency spectrum of fluctuations. Proc Natl Acad Sci U S A. 1973 Mar; 70(3):870-5. PMID: 16592071.
        View in: PubMed
      George's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department