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    Fred Levine

    TitleSenate Emeritus
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0816
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      High-Throughput Screen for Beta-Cell Replication
      NIH/NINDS R21NS057001Sep 5, 2006 - Aug 31, 2008
      Role: Principal Investigator
      Small Molecular Regulation of Beta-Cell Differentiation
      NIH/NIDDK R01DK068754Jul 1, 2004 - Jun 30, 2006
      Role: Principal Investigator
      Growth Versus Differentiation in Human Beta Cells
      NIH/NIDDK R01DK055283Sep 30, 1998 - Mar 31, 2010
      Role: Principal Investigator
      INHIBITION OF APOPTOSIS IN PANCREATIC BETA CELLS
      NIH/NIDDK R01DK055065Sep 30, 1998 - Sep 29, 2002
      Role: Principal Investigator
      PANCREATIC CELL LINES--DEVELOPMENT AND CHARACTERIZATION
      NIH/NIDDK R55DK050171Sep 1, 1995 - Aug 31, 1997
      Role: Principal Investigator
      GENE EXPRESSION FROM RETROVIRAL VECTORS AND GENE THERAPY
      NIH/NIGMS F32GM013538Jan 19, 1990
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Lee SH, Cunha D, Piermarocchi C, Paternostro G, Pinkerton A, Ladriere L, Marchetti P, Eizirik DL, Cnop M, Levine F. High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced ß-cell apoptosis. Biochem Pharmacol. 2017 Aug 15; 138:140-149. PMID: 28522407.
        View in: PubMed
      2. Piran R, Lee SH, Kuss P, Hao E, Newlin R, Millán JL, Levine F. PAR2 regulates regeneration, transdifferentiation, and death. Cell Death Dis. 2016 Nov 03; 7(11):e2452. PMID: 27809303.
        View in: PubMed
      3. Chung CH, Miller A, Panopoulos A, Hao E, Margolis R, Terskikh A, Levine F. Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not ß-cell, regeneration. Physiol Rep. 2014 Sep 01; 2(9). PMID: 25194022; PMCID: PMC4270240.
      4. Hao E, Lee SH, Levine F. Efficient ß-cell regeneration by a combination of neogenesis and replication following ß-cell ablation and reversal of pancreatic duct ligation. Stem Cells. 2013 Nov; 31(11):2388-95. PMID: 23922239.
        View in: PubMed
      5. Lee SH, Piran R, Keinan E, Pinkerton A, Levine F. Induction of ß-cell replication by a synthetic HNF4a antagonist. Stem Cells. 2013 Nov; 31(11):2396-407. PMID: 23922283.
        View in: PubMed
      6. Lee SH, Athavankar S, Cohen T, Piran R, Kiselyuk A, Levine F. Identification of alverine and benfluorex as HNF4a activators. ACS Chem Biol. 2013 Aug 16; 8(8):1730-6. PMID: 23675775; PMCID: PMC3922238.
      7. Kiselyuk A, Lee SH, Farber-Katz S, Zhang M, Athavankar S, Cohen T, Pinkerton AB, Ye M, Bushway P, Richardson AD, Hostetler HA, Rodriguez-Lee M, Huang L, Spangler B, Smith L, Higginbotham J, Cashman J, Freeze H, Itkin-Ansari P, Dawson MI, Schroeder F, Cang Y, Mercola M, Levine F. HNF4a antagonists discovered by a high-throughput screen for modulators of the human insulin promoter. Chem Biol. 2012 Jul 27; 19(7):806-18. PMID: 22840769; PMCID: PMC3447631.
      8. Tyrberg B, Miles P, Azizian KT, Denzel MS, Nieves ML, Monosov EZ, Levine F, Ranscht B. T-cadherin (Cdh13) in association with pancreatic ß-cell granules contributes to second phase insulin secretion. Islets. 2011 Nov-Dec; 3(6):327-37. PMID: 21975561; PMCID: PMC3329514.
      9. Lee SH, Hao E, Levine F, Itkin-Ansari P. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic ß-cells. Islets. 2011 Nov-Dec; 3(6):358-66. PMID: 21964314; PMCID: PMC3329516.
      10. Lee SH, Hao E, Levine F. ß-Cell replication and islet neogenesis following partial pancreatectomy. Islets. 2011 Jul-Aug; 3(4):188-95. PMID: 21623169.
        View in: PubMed
      11. Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P. The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res. 2011 Jun; 9(6):782-90. PMID: 21498546; PMCID: PMC3954712.
      12. Lee SH, Itkin-Ansari P, Levine F. CENP-A, a protein required for chromosome segregation in mitosis, declines with age in islet but not exocrine cells. Aging (Albany NY). 2010 Nov; 2(11):785-90. PMID: 21068465; PMCID: PMC3006021.
      13. Chung CH, Hao E, Piran R, Keinan E, Levine F. Pancreatic ß-cell neogenesis by direct conversion from mature a-cells. Stem Cells. 2010 Sep; 28(9):1630-8. PMID: 20653050.
        View in: PubMed
      14. Chung CH, Levine F. Adult pancreatic alpha-cells: a new source of cells for beta-cell regeneration. Rev Diabet Stud. 2010; 7(2):124-31. PMID: 21060971; PMCID: PMC2989785.
      15. Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F. Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen. J Biomol Screen. 2010 Jul; 15(6):663-70. PMID: 20547533; PMCID: PMC3374493.
      16. Demeterco C, Hao E, Lee SH, Itkin-Ansari P, Levine F. Adult human beta-cell neogenesis? Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:46-53. PMID: 19817788.
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      17. Dawson MI, Ye M, Cao X, Farhana L, Hu QY, Zhao Y, Xu LP, Kiselyuk A, Correa RG, Yang L, Hou T, Reed JC, Itkin-Ansari P, Levine F, Sanner MF, Fontana JA, Zhang XK. Derivation of a retinoid X receptor scaffold from peroxisome proliferator-activated receptor gamma ligand 1-Di(1H-indol-3-yl)methyl-4-trifluoromethylbenzene. ChemMedChem. 2009 Jul; 4(7):1106-19. PMID: 19378296; PMCID: PMC3031428.
      18. Zhang SS, Hao E, Yu J, Liu W, Wang J, Levine F, Feng GS. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7531-6. PMID: 19380737; PMCID: PMC2678606.
      19. Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P. Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res. 2008; 2008:728763. PMID: 19165345; PMCID: PMC2628766.
      20. Levine F, Itkin-Ansari P. beta-cell Regeneration: neogenesis, replication or both? J Mol Med (Berl). 2008 Mar; 86(3):247-58. PMID: 17922102.
        View in: PubMed
      21. Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F. HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion. Biochem Biophys Res Commun. 2007 Apr 06; 355(2):331-7. PMID: 17300753; PMCID: PMC1852427.
      22. Katkov II, Kim MS, Bajpai R, Altman YS, Mercola M, Loring JF, Terskikh AV, Snyder EY, Levine F. Cryopreservation by slow cooling with DMSO diminished production of Oct-4 pluripotency marker in human embryonic stem cells. Cryobiology. 2006 Oct; 53(2):194-205. PMID: 16839540.
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      23. Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F. Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med. 2006 Mar; 12(3):310-6. PMID: 16491084.
        View in: PubMed
      24. Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F. NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor. Dev Dyn. 2005 Jul; 233(3):946-53. PMID: 15906379.
        View in: PubMed
      25. Ball AJ, Levine F. Telomere-independent cellular senescence in human fetal cardiomyocytes. Aging Cell. 2005 Feb; 4(1):21-30. PMID: 15659210.
        View in: PubMed
      26. Levine F, Mercola M. No pancreatic endocrine stem cells? N Engl J Med. 2004 Sep 02; 351(10):1024-6. PMID: 15342812.
        View in: PubMed
      27. Barshop BA, Naviaux RK, McGowan KA, Levine F, Nyhan WL, Loupis-Geller A, Haas RH. Chronic treatment of mitochondrial disease patients with dichloroacetate. Mol Genet Metab. 2004 Sep-Oct; 83(1-2):138-49. PMID: 15464428.
        View in: PubMed
      28. Katkov II, Levine F. Prediction of the glass transition temperature of water solutions: comparison of different models. Cryobiology. 2004 Aug; 49(1):62-82. PMID: 15265717.
        View in: PubMed
      29. Itkin-Ansari P, Levine F. Sources of beta-cells for human cell-based therapies for diabetes. Cell Biochem Biophys. 2004; 40(3 Suppl):103-12. PMID: 15289647.
        View in: PubMed
      30. Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F. Cell-based therapies for diabetes: progress towards a transplantable human beta cell line. Ann N Y Acad Sci. 2003 Nov; 1005:138-47. PMID: 14679048.
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      31. Demeterco C, Itkin-Ansari P, Tyrberg B, Ford LP, Jarvis RA, Levine F. c-Myc controls proliferation versus differentiation in human pancreatic endocrine cells. J Clin Endocrinol Metab. 2002 Jul; 87(7):3475-85. PMID: 12107268.
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      32. Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. BMC Endocr Disord. 2002 Apr 25; 2(1):2. PMID: 12003641.
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      33. Tyrberg B, Levine F. Current and future treatment strategies for type 2 diabetes: the beta-cell as a therapeutic target. Curr Opin Investig Drugs. 2001 Nov; 2(11):1568-74. PMID: 11763159.
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      34. Puhlev I, Guo N, Brown DR, Levine F. Desiccation tolerance in human cells. Cryobiology. 2001 May; 42(3):207-17. PMID: 11578120.
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      35. Halvorsen T, Levine F. Diabetes mellitus-cell transplantation and gene therapy approaches. Curr Mol Med. 2001 May; 1(2):273-86. PMID: 11899076.
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      36. de la Tour D, Halvorsen T, Demeterco C, Tyrberg B, Itkin-Ansari P, Loy M, Yoo SJ, Hao E, Bossie S, Levine F. Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo. Mol Endocrinol. 2001 Mar; 15(3):476-83. PMID: 11222748.
        View in: PubMed
      37. Demeterco C, Levine F. Gene therapy for diabetes. Front Biosci. 2001 Feb 01; 6:D175-91. PMID: 11171547.
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      38. Wood LD, Halvorsen TL, Dhar S, Baur JA, Pandita RK, Wright WE, Hande MP, Calaf G, Hei TK, Levine F, Shay JW, Wang JJ, Pandita TK. Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene. 2001 Jan 18; 20(3):278-88. PMID: 11313956.
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      39. Halvorsen TL, Beattie GM, Lopez AD, Hayek A, Levine F. Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. J Endocrinol. 2000 Jul; 166(1):103-9. PMID: 10856888.
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      40. Itkin-Ansari P, Demeterco C, Bossie S, de la Tour DD, Beattie GM, Movassat J, Mally MI, Hayek A, Levine F. PDX-1 and cell-cell contact act in synergy to promote delta-cell development in a human pancreatic endocrine precursor cell line. Mol Endocrinol. 2000 Jun; 14(6):814-22. PMID: 10847584.
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      41. Beattie GM, Leibowitz G, Lopez AD, Levine F, Hayek A. Protection from cell death in cultured human fetal pancreatic cells. Cell Transplant. 2000 May-Jun; 9(3):431-8. PMID: 10972342.
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      42. Guo N, Puhlev I, Brown DR, Mansbridge J, Levine F. Trehalose expression confers desiccation tolerance on human cells. Nat Biotechnol. 2000 Feb; 18(2):168-71. PMID: 10657122.
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      43. Beattie GM, Hayek A, Levine F. Growth and genetic modification of human beta-cells and beta-cell precursors. Genet Eng (N Y). 2000; 22:99-120. PMID: 11501383.
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      44. Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. J Neurosci. 1999 Jun 01; 19(11):4229-37. PMID: 10341227.
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      45. Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F, Hayek A. Sustained proliferation of PDX-1+ cells derived from human islets. Diabetes. 1999 May; 48(5):1013-9. PMID: 10331405.
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      46. Leibowitz G, Beattie GM, Kafri T, Cirulli V, Lopez AD, Hayek A, Levine F. Gene transfer to human pancreatic endocrine cells using viral vectors. Diabetes. 1999 Apr; 48(4):745-53. PMID: 10102690.
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      47. Levine F, Leibowitz G. Towards gene therapy of diabetes mellitus. Mol Med Today. 1999 Apr; 5(4):165-71. PMID: 10203749.
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      48. Halvorsen TL, Leibowitz G, Levine F. Telomerase activity is sufficient to allow transformed cells to escape from crisis. Mol Cell Biol. 1999 Mar; 19(3):1864-70. PMID: 10022873; PMCID: PMC83979.
      49. Levine F. Gene therapy for diabetes: strategies for beta-cell modification and replacement. Diabetes Metab Rev. 1997 Dec; 13(4):209-46. PMID: 9509277.
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      50. Wang S, Beattie GM, Mally MI, Lopez AD, Hayek A, Levine F. Analysis of a human fetal pancreatic islet cell line. Transplant Proc. 1997 Jun; 29(4):2219. PMID: 9193600.
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      51. Wang S, Beattie GM, Mally MI, Cirulli V, Itkin-Ansari P, Lopez AD, Hayek A, Levine F. Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplant. 1997 Jan-Feb; 6(1):59-67. PMID: 9040956.
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      52. Wang S, Beattie GM, Hayek A, Levine F. Development of a VSV-G protein pseudotyped retroviral vector system expressing dominant oncogenes from a lacO-modified inducible LTR promoter. Gene. 1996 Dec 05; 182(1-2):145-50. PMID: 8982080.
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      53. Itkin-Ansari P, Bain G, Beattie GM, Murre C, Hayek A, Levine F. E2A gene products are not required for insulin gene expression. Endocrinology. 1996 Aug; 137(8):3540-3. PMID: 8754784.
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      54. Agrawal YP, Agrawal RS, Sinclair AM, Young D, Maruyama M, Levine F, Ho AD. Cell-cycle kinetics and VSV-G pseudotyped retrovirus-mediated gene transfer in blood-derived CD34+ cells. Exp Hematol. 1996 May; 24(6):738-47. PMID: 8635530.
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      55. Levine F, Wang S, Beattie GM, Mally MI, Cirulli V, Lopez AD, Hayek A. Development of a cell line from the human fetal pancreas. Transplant Proc. 1995 Dec; 27(6):3410. PMID: 8540023.
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      56. Levine F, Beattie GM, Hayek A. Differential integrin expression facilitates isolation of human fetal pancreatic epithelial cells. Cell Transplant. 1994 Jul-Aug; 3(4):307-13. PMID: 7921635.
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      57. Lu M, Maruyama M, Zhang N, Levine F, Friedmann T, Ho AD. High efficiency retroviral-mediated gene transduction into CD34+ cells purified from peripheral blood of breast cancer patients primed with chemotherapy and granulocyte-macrophage colony-stimulating factor. Hum Gene Ther. 1994 Feb; 5(2):203-8. PMID: 7514449.
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      58. Levine F, Friedmann T. Gene therapy. Am J Dis Child. 1993 Nov; 147(11):1167-74. PMID: 8237910.
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      59. Kurdi-Haidar B, Levine F, Roemer K, LaPorte P, Friedmann T. Provirus-anchored long-range (PAL) mapping of mammalian genomes. Genomics. 1993 Feb; 15(2):305-10. PMID: 8449495.
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      60. Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1. J Virol. 1992 May; 66(5):2952-65. PMID: 1373198; PMCID: PMC241054.
      61. Levine F, Yee JK, Friedmann T. Efficient gene expression in mammalian cells from a dicistronic transcriptional unit in an improved retroviral vector. Gene. 1991 Dec 15; 108(2):167-74. PMID: 1660834.
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      62. Levine F, Friedmann T. Gene therapy techniques. Curr Opin Biotechnol. 1991 Dec; 2(6):840-4. PMID: 1367958.
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      63. Lowenstein E, Hallowell P, Levine F, Daggett WM, Austen WG, Laver MB. Antiduresis during morphine anesthesia. N Engl J Med. 1970 Jul 30; 283(5):266-7. PMID: 5424747.
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      64. Lowenstein E, Hallowell P, Levine F, Daggett WM, Austen WG, Laver MB. Hypotension after morphine. N Engl J Med. 1970 Mar 05; 282(10):570-1. PMID: 5413116.
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      65. Lowenstein E, Hallowell P, Levine F, Daggett WM, Austen WG, Laver MB. Cardiovascular response to large doses of intravenous morphine in man. N Engl J Med. 1969 Dec 18; 281(25):1389-93. PMID: 5355454.
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