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    Eugene Tkachenko

    TitleAssistant Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0726
    CA La Jolla 92093
    Phone858-822-6492
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      Collapse Research 
      Collapse Research Activities and Funding
      Endothelial Mechanotaxis During Development
      NIH/NHLBI R56HL124195Sep 1, 2016 - Aug 31, 2017
      Role: Principal Investigator
      Visualization of shear stress-induced endothelial cell signaling.
      NIH/NHLBI F32HL094012Aug 1, 2008 - Jul 31, 2010
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Weijts B, Tkachenko E, Traver D, Groisman A. A Four-Well Dish for High-Resolution Longitudinal Imaging of the Tail and Posterior Trunk of Larval Zebrafish. Zebrafish. 2017 Jan 24. PMID: 28118101.
        View in: PubMed
      2. Vertelov G, Gutierrez E, Lee SA, Ronan E, Groisman A, Tkachenko E. Rigidity of silicone substrates controls cell spreading and stem cell differentiation. Sci Rep. 2016 Sep 21; 6:33411. PMID: 27651230; PMCID: PMC5030667.
      3. Tkachenko E, Rawson R, La E, Doherty TA, Baum R, Cavagnero K, Miyanohara A, Dohil R, Kurten RC, Aceves SS. Rigid substrate induces esophageal smooth muscle hypertrophy and eosinophilic esophagitis fibrotic gene expression. J Allergy Clin Immunol. 2016 Apr; 137(4):1270-1272.e1. PMID: 26542032; PMCID: PMC4826849 [Available on 04/01/17].
      4. Tkachenko E, Gutierrez E, Saikin SK, Fogelstrand P, Kim C, Groisman A, Ginsberg MH. The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open. 2013; 2(10):1007-12. PMID: 24167710; PMCID: PMC3798183.
      5. Gutierrez E, Tkachenko E, Besser A, Sundd P, Ley K, Danuser G, Ginsberg MH, Groisman A. High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One. 2011; 6(9):e23807. PMID: 21961031; PMCID: PMC3178539.
      6. Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH. Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol. 2011 Jun; 13(6):660-7. PMID: 21572420; PMCID: PMC3746034.
      7. Ablooglu AJ, Tkachenko E, Kang J, Shattil SJ. Integrin alphaV is necessary for gastrulation movements that regulate vertebrate body asymmetry. Development. 2010 Oct; 137(20):3449-58. PMID: 20843856; PMCID: PMC2947757.
      8. Tkachenko E, Gutierrez E, Ginsberg MH, Groisman A. An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip. 2009 Apr 21; 9(8):1085-95. PMID: 19350090; PMCID: PMC2742503.
      9. Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell. 2008 Nov; 19(11):4930-41. PMID: 18784251; PMCID: PMC2575143.
      10. Goldfinger LE, Tzima E, Stockton R, Kiosses WB, Kinbara K, Tkachenko E, Gutierrez E, Groisman A, Nguyen P, Chien S, Ginsberg MH. Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res. 2008 Jul 18; 103(2):177-85. PMID: 18583710; PMCID: PMC2669779.
      11. FĂ©ral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH. CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol. 2007 Aug 13; 178(4):701-11. PMID: 17682053; PMCID: PMC2064475.
      12. Geddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle. 2007 Feb 15; 6(4):455-60. PMID: 17312391.
        View in: PubMed