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    Eric Courchesne

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentNeurosciences
    Address9500 Gilman Drive #0217
    CA La Jolla 92093
    Phone858-534-6914
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      Collapse Research 
      Collapse Research Activities and Funding
      Discovering Neural Biomarkers of Language and Social Development in ASD Toddlers
      NIH/NIDCD R01DC016385Sep 1, 2017 - Aug 31, 2022
      Role: Principal Investigator
      Developmental Functional Genomics in ASD Toddlers
      NIH/NIMH R01MH110558Sep 1, 2016 - Jun 30, 2021
      Role: Principal Investigator
      Biomarkers of Autism at 12 months: From Brain Overgrowth to Genes
      NIH/NIMH P50MH081755Aug 6, 2007 - Jun 30, 2014
      Role: Principal Investigator
      SMALL INSTRUMENTATION GRANT
      NIH/NINDS S15NS033747Sep 1, 1994 - Aug 31, 1996
      Role: Principal Investigator
      MRL Neuroanatomy in Autism: From Infancy to Childhoood
      NIH/NINDS R01NS019855Sep 10, 1983 - Jul 31, 2007
      Role: Principal Investigator
      fMRI Studies of Neural Dysfunction in Autistic Toddlers
      NIH/NIMH R01MH036840Jul 1, 1982 - Jul 31, 2013
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bacon EC, Courchesne E, Barnes CC, Cha D, Pence S, Schreibman L, Stahmer AC, Pierce K. Rethinking the idea of late autism spectrum disorder onset. Dev Psychopathol. 2017 Aug 14; 1-17. PMID: 28803559.
        View in: PubMed
      2. Geisheker MR, Heymann G, Wang T, Coe BP, Turner TN, Stessman HAF, Hoekzema K, Kvarnung M, Shaw M, Friend K, Liebelt J, Barnett C, Thompson EM, Haan E, Guo H, Anderlid BM, Nordgren A, Lindstrand A, Vandeweyer G, Alberti A, Avola E, Vinci M, Giusto S, Pramparo T, Pierce K, Nalabolu S, Michaelson JJ, Sedlacek Z, Santen GWE, Peeters H, Hakonarson H, Courchesne E, Romano C, Kooy RF, Bernier RA, Nordenskjöld M, Gecz J, Xia K, Zweifel LS, Eichler EE. Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci. 2017 Aug; 20(8):1043-1051. PMID: 28628100.
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      3. Stessman HA, Xiong B, Coe BP, Wang T, Hoekzema K, Fenckova M, Kvarnung M, Gerdts J, Trinh S, Cosemans N, Vives L, Lin J, Turner TN, Santen G, Ruivenkamp C, Kriek M, van Haeringen A, Aten E, Friend K, Liebelt J, Barnett C, Haan E, Shaw M, Gecz J, Anderlid BM, Nordgren A, Lindstrand A, Schwartz C, Kooy RF, Vandeweyer G, Helsmoortel C, Romano C, Alberti A, Vinci M, Avola E, Giusto S, Courchesne E, Pramparo T, Pierce K, Nalabolu S, Amaral DG, Scheffer IE, Delatycki MB, Lockhart PJ, Hormozdiari F, Harich B, Castells-Nobau A, Xia K, Peeters H, Nordenskjöld M, Schenck A, Bernier RA, Eichler EE. Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nat Genet. 2017 Feb 13. PMID: 28191889.
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      4. Pierce K, Courchesne E, Bacon E. To Screen or Not to Screen Universally for Autism is not the Question: Why the Task Force Got It Wrong. J Pediatr. 2016 Sep; 176:182-94. PMID: 27421956.
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      5. Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J. Frequency and Complexity of De Novo Structural Mutation in Autism. Am J Hum Genet. 2016 Apr 7; 98(4):667-79. PMID: 27018473.
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      6. Pramparo T, Lombardo MV, Campbell K, Barnes CC, Marinero S, Solso S, Young J, Mayo M, Dale A, Ahrens-Barbeau C, Murray SS, Lopez L, Lewis N, Pierce K, Courchesne E. Cell cycle networks link gene expression dysregulation, mutation, and brain maldevelopment in autistic toddlers. Mol Syst Biol. 2015; 11(12):841. PMID: 26668231.
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      7. Solso S, Xu R, Proudfoot J, Hagler DJ, Campbell K, Venkatraman V, Carter Barnes C, Ahrens-Barbeau C, Pierce K, Dale A, Eyler L, Courchesne E. Diffusion Tensor Imaging Provides Evidence of Possible Axonal Overconnectivity in Frontal Lobes in Autism Spectrum Disorder Toddlers. Biol Psychiatry. 2016 Apr 15; 79(8):676-84. PMID: 26300272.
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      8. Lombardo MV, Pierce K, Eyler LT, Carter Barnes C, Ahrens-Barbeau C, Solso S, Campbell K, Courchesne E. Different functional neural substrates for good and poor language outcome in autism. Neuron. 2015 Apr 22; 86(2):567-77. PMID: 25864635.
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      9. Pramparo T, Pierce K, Lombardo MV, Carter Barnes C, Marinero S, Ahrens-Barbeau C, Murray SS, Lopez L, Xu R, Courchesne E. Prediction of autism by translation and immune/inflammation coexpressed genes in toddlers from pediatric community practices. JAMA Psychiatry. 2015 Apr 1; 72(4):386-94. PMID: 25739104.
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      10. Bacon EC, Dufek S, Schreibman L, Stahmer AC, Pierce K, Courchesne E. Measuring outcome in an early intervention program for toddlers with autism spectrum disorder: use of a curriculum-based assessment. Autism Res Treat. 2014; 2014:964704. PMID: 24711926.
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      11. Manning JH, Courchesne E, Fox PT. Intrinsic connectivity network mapping in young children during natural sleep. Neuroimage. 2013 Dec; 83:288-93. PMID: 23727317.
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      12. Morgan JT, Chana G, Abramson I, Semendeferi K, Courchesne E, Everall IP. Abnormal microglial-neuronal spatial organization in the dorsolateral prefrontal cortex in autism. Brain Res. 2012 May 25; 1456:72-81. PMID: 22516109.
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      13. Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592. PMID: 22457638.
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      14. Chow ML, Winn ME, Li HR, April C, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples. Front Genet. 2012; 3:11. PMID: 22375143.
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      15. Eyler LT, Pierce K, Courchesne E. A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism. Brain. 2012 Mar; 135(Pt 3):949-60. PMID: 22350062.
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      16. Courchesne E, Mouton PR, Calhoun ME, Semendeferi K, Ahrens-Barbeau C, Hallet MJ, Barnes CC, Pierce K. Neuron number and size in prefrontal cortex of children with autism. JAMA. 2011 Nov 9; 306(18):2001-10. PMID: 22068992.
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      17. Chow ML, Li HR, Winn ME, April C, Barnes CC, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples. BMC Genomics. 2011; 12:449. PMID: 21906392.
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      18. Jacob S, Brune CW, Badner JA, Ernstrom K, Courchesne E, Lord C, Leventhal BL, Cook EH, Kim SJ. Family-based association testing of glutamate transporter genes in autism. Psychiatr Genet. 2011 Aug; 21(4):212-3. PMID: 21085054.
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      19. Dinstein I, Pierce K, Eyler L, Solso S, Malach R, Behrmann M, Courchesne E. Disrupted neural synchronization in toddlers with autism. Neuron. 2011 Jun 23; 70(6):1218-25. PMID: 21689606.
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      20. Courchesne E, Campbell K, Solso S. Brain growth across the life span in autism: age-specific changes in anatomical pathology. Brain Res. 2011 Mar 22; 1380:138-45. PMID: 20920490.
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      21. Morgan JT, Chana G, Pardo CA, Achim C, Semendeferi K, Buckwalter J, Courchesne E, Everall IP. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol Psychiatry. 2010 Aug 15; 68(4):368-76. PMID: 20674603.
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      22. Schumann CM, Bloss CS, Barnes CC, Wideman GM, Carper RA, Akshoomoff N, Pierce K, Hagler D, Schork N, Lord C, Courchesne E. Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism. J Neurosci. 2010 Mar 24; 30(12):4419-27. PMID: 20335478.
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      23. Schumann CM, Barnes CC, Lord C, Courchesne E. Amygdala enlargement in toddlers with autism related to severity of social and communication impairments. Biol Psychiatry. 2009 Nov 15; 66(10):942-9. PMID: 19726029.
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      24. Kim SJ, Brune CW, Kistner EO, Christian SL, Courchesne E, Cox NJ, Cook EH. Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism. Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5; 147B(7):1116-25. PMID: 18361419.
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      25. Redcay E, Courchesne E. Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder. Biol Psychiatry. 2008 Oct 1; 64(7):589-98. PMID: 18672231.
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      26. Kleinhans NM, Müller RA, Cohen DN, Courchesne E. Atypical functional lateralization of language in autism spectrum disorders. Brain Res. 2008 Jul 24; 1221:115-25. PMID: 18555209.
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      27. Kennedy DP, Courchesne E. Functional abnormalities of the default network during self- and other-reflection in autism. Soc Cogn Affect Neurosci. 2008 Jun; 3(2):177-90. PMID: 19015108.
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      28. Brune CW, Kim SJ, Hanna GL, Courchesne E, Lord C, Leventhal BL, Cook EH. Family-Based Association Testing of OCD-associated SNPs of SLC1A1 in an autism sample. Autism Res. 2008 Apr; 1(2):108-13. PMID: 19360657.
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      29. Redcay E, Haist F, Courchesne E. Functional neuroimaging of speech perception during a pivotal period in language acquisition. Dev Sci. 2008 Mar; 11(2):237-52. PMID: 18333980.
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      30. Kennedy DP, Courchesne E. The intrinsic functional organization of the brain is altered in autism. Neuroimage. 2008 Feb 15; 39(4):1877-85. PMID: 18083565.
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      31. Courchesne E, Pierce K, Schumann CM, Redcay E, Buckwalter JA, Kennedy DP, Morgan J. Mapping early brain development in autism. Neuron. 2007 Oct 25; 56(2):399-413. PMID: 17964254.
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      32. Redcay E, Kennedy DP, Courchesne E. fMRI during natural sleep as a method to study brain function during early childhood. Neuroimage. 2007 Dec; 38(4):696-707. PMID: 17904385.
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      33. Kleinhans NM, Schweinsburg BC, Cohen DN, Müller RA, Courchesne E. N-acetyl aspartate in autism spectrum disorders: regional effects and relationship to fMRI activation. Brain Res. 2007 Aug 8; 1162:85-97. PMID: 17612510.
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      34. Akshoomoff N, Farid N, Courchesne E, Haas R. Abnormalities on the neurological examination and EEG in young children with pervasive developmental disorders. J Autism Dev Disord. 2007 May; 37(5):887-93. PMID: 17048091.
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      35. Bloss CS, Courchesne E. MRI neuroanatomy in young girls with autism: a preliminary study. J Am Acad Child Adolesc Psychiatry. 2007 Apr; 46(4):515-23. PMID: 17420687.
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      36. Kennedy DP, Semendeferi K, Courchesne E. No reduction of spindle neuron number in frontoinsular cortex in autism. Brain Cogn. 2007 Jul; 64(2):124-9. PMID: 17353073.
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      37. Belmonte MK, Mazziotta JC, Minshew NJ, Evans AC, Courchesne E, Dager SR, Bookheimer SY, Aylward EH, Amaral DG, Cantor RM, Chugani DC, Dale AM, Davatzikos C, Gerig G, Herbert MR, Lainhart JE, Murphy DG, Piven J, Reiss AL, Schultz RT, Zeffiro TA, Levi-Pearl S, Lajonchere C, Colamarino SA. Offering to share: how to put heads together in autism neuroimaging. J Autism Dev Disord. 2008 Jan; 38(1):2-13. PMID: 17347882.
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      38. Gaffrey MS, Kleinhans NM, Haist F, Akshoomoff N, Campbell A, Courchesne E, Müller RA. Atypical [corrected] participation of visual cortex during word processing in autism: an fMRI study of semantic decision. Neuropsychologia. 2007 Apr 9; 45(8):1672-84. PMID: 17336346.
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      39. DiCicco-Bloom E, Lord C, Zwaigenbaum L, Courchesne E, Dager SR, Schmitz C, Schultz RT, Crawley J, Young LJ. The developmental neurobiology of autism spectrum disorder. J Neurosci. 2006 Jun 28; 26(26):6897-906. PMID: 16807320.
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      40. Kennedy DP, Redcay E, Courchesne E. Failing to deactivate: resting functional abnormalities in autism. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8275-80. PMID: 16702548.
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      41. Redcay E, Courchesne E. When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry. 2005 Jul 1; 58(1):1-9. PMID: 15935993.
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      42. Courchesne E, Pierce K. Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection. Curr Opin Neurobiol. 2005 Apr; 15(2):225-30. PMID: 15831407.
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      43. Courchesne E, Pierce K. Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity. Int J Dev Neurosci. 2005 Apr-May; 23(2-3):153-70. PMID: 15749242.
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      44. Kemmotsu N, Villalobos ME, Gaffrey MS, Courchesne E, Müller RA. Activity and functional connectivity of inferior frontal cortex associated with response conflict. Brain Res Cogn Brain Res. 2005 Jul; 24(2):335-42. PMID: 15993771.
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      45. Carper RA, Courchesne E. Localized enlargement of the frontal cortex in early autism. Biol Psychiatry. 2005 Jan 15; 57(2):126-33. PMID: 15652870.
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      46. Teder-Sälejärvi WA, Pierce KL, Courchesne E, Hillyard SA. Auditory spatial localization and attention deficits in autistic adults. Brain Res Cogn Brain Res. 2005 May; 23(2-3):221-34. PMID: 15820630.
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      47. Courchesne E, Redcay E, Morgan JT, Kennedy DP. Autism at the beginning: microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism. Dev Psychopathol. 2005; 17(3):577-97. PMID: 16262983.
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      48. Haist F, Adamo M, Westerfield M, Courchesne E, Townsend J. The functional neuroanatomy of spatial attention in autism spectrum disorder. Dev Neuropsychol. 2005; 27(3):425-58. PMID: 15843105.
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      49. Müller RA, Cauich C, Rubio MA, Mizuno A, Courchesne E. Abnormal activity patterns in premotor cortex during sequence learning in autistic patients. Biol Psychiatry. 2004 Sep 1; 56(5):323-32. PMID: 15336514.
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      50. Pierce K, Haist F, Sedaghat F, Courchesne E. The brain response to personally familiar faces in autism: findings of fusiform activity and beyond. Brain. 2004 Dec; 127(Pt 12):2703-16. PMID: 15319275.
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      51. Allen G, Müller RA, Courchesne E. Cerebellar function in autism: functional magnetic resonance image activation during a simple motor task. Biol Psychiatry. 2004 Aug 15; 56(4):269-78. PMID: 15312815.
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      52. Courchesne E, Redcay E, Kennedy DP. The autistic brain: birth through adulthood. Curr Opin Neurol. 2004 Aug; 17(4):489-96. PMID: 15247547.
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      53. Makeig S, Delorme A, Westerfield M, Jung TP, Townsend J, Courchesne E, Sejnowski TJ. Electroencephalographic brain dynamics following manually responded visual targets. PLoS Biol. 2004 Jun; 2(6):e176. PMID: 15208723.
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      54. Akshoomoff N, Lord C, Lincoln AJ, Courchesne RY, Carper RA, Townsend J, Courchesne E. Outcome classification of preschool children with autism spectrum disorders using MRI brain measures. J Am Acad Child Adolesc Psychiatry. 2004 Mar; 43(3):349-57. PMID: 15076269.
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      55. Courchesne E. Brain development in autism: early overgrowth followed by premature arrest of growth. Ment Retard Dev Disabil Res Rev. 2004; 10(2):106-11. PMID: 15362165.
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      56. Müller RA, Kleinhans N, Kemmotsu N, Pierce K, Courchesne E. Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning. Am J Psychiatry. 2003 Oct; 160(10):1847-62. PMID: 14514501.
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      57. Courchesne E, Carper R, Akshoomoff N. Evidence of brain overgrowth in the first year of life in autism. JAMA. 2003 Jul 16; 290(3):337-44. PMID: 12865374.
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      58. Allen G, Courchesne E. Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autism. Am J Psychiatry. 2003 Feb; 160(2):262-73. PMID: 12562572.
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      59. Müller RA, Kleinhans N, Courchesne E. Linguistic theory and neuroimaging evidence: an fMRI study of Broca's area in lexical semantics. Neuropsychologia. 2003; 41(9):1199-207. PMID: 12753959.
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      60. Jones W, Hesselink J, Courchesne E, Duncan T, Matsuda K, Bellugi U. Cerebellar abnormalities in infants and toddlers with Williams syndrome. Dev Med Child Neurol. 2002 Oct; 44(10):688-94. PMID: 12418794.
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      61. Carper RA, Moses P, Tigue ZD, Courchesne E. Cerebral lobes in autism: early hyperplasia and abnormal age effects. Neuroimage. 2002 Aug; 16(4):1038-51. PMID: 12202091.
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      62. Müller RA, Kleinhans N, Pierce K, Kemmotsu N, Courchesne E. Functional MRI of motor sequence acquisition: effects of learning stage and performance. Brain Res Cogn Brain Res. 2002 Aug; 14(2):277-93. PMID: 12067701.
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      63. Veenstra-VanderWeele J, Kim SJ, Lord C, Courchesne R, Akshoomoff N, Leventhal BL, Courchesne E, Cook EH. Transmission disequilibrium studies of the serotonin 5-HT2A receptor gene (HTR2A) in autism. Am J Med Genet. 2002 Apr 8; 114(3):277-83. PMID: 11920848.
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      64. Kim SJ, Herzing LB, Veenstra-VanderWeele J, Lord C, Courchesne R, Leventhal BL, Ledbetter DH, Courchesne E, Cook EH. Mutation screening and transmission disequilibrium study of ATP10C in autism. Am J Med Genet. 2002 Mar 8; 114(2):137-43. PMID: 11857573.
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      65. Courchesne E. Abnormal early brain development in autism. Mol Psychiatry. 2002; 7 Suppl 2:S21-3. PMID: 12142938.
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      66. Akshoomoff N, Pierce K, Courchesne E. The neurobiological basis of autism from a developmental perspective. Dev Psychopathol. 2002; 14(3):613-34. PMID: 12349876.
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      67. Courchesne E, Karns CM, Davis HR, Ziccardi R, Carper RA, Tigue ZD, Chisum HJ, Moses P, Pierce K, Lord C, Lincoln AJ, Pizzo S, Schreibman L, Haas RH, Akshoomoff NA, Courchesne RY. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology. 2001 Jul 24; 57(2):245-54. PMID: 11468308.
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      68. Courchesne E, Chisum HJ, Townsend J, Cowles A, Covington J, Egaas B, Harwood M, Hinds S, Press GA. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology. 2000 Sep; 216(3):672-82. PMID: 10966694.
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      69. Courchesne E, Müller RA, Saitoh O. Brain weight in autism: normal in the majority of cases, megalencephalic in rare cases. Neurology. 1999 Mar 23; 52(5):1057-9. PMID: 10102428.
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      70. Courchesne E. Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr Opin Neurobiol. 1997 Apr; 7(2):269-78. PMID: 9142760.
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