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    Emmanuel Theodorakis

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentChemistry and Biochemistry
    Address9500 Gilman Drive #0358
    CA La Jolla 92093
    Phone858-822-0456
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Chemical Biology of Caged Garcinia Xanthones
      NIH/NCI R01CA133002Sep 11, 2008 - Aug 31, 2013
      Role: Principal Investigator
      Synthesis of Bioactive Marine Natural Products
      NIH/NIGMS R01GM081484Jul 1, 2008 - Apr 30, 2012
      Role: Principal Investigator
      Total Synthesis of Bioactive Natural Products
      NIH/NCI R01CA086079Mar 1, 2001 - Feb 28, 2006
      Role: Principal Investigator
      TOPOISOMERASE II POISONING AND ANTICANCER DRUG DESIGN
      NIH/NCI R01CA085600Feb 2, 2001 - Jan 31, 2005
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Ke H, Morrisey JM, Qu S, Chantarasriwong O, Mather MW, Theodorakis E, Vaidya AB. Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity. Antimicrob Agents Chemother. 2017 Jan; 61(1). PMID: 27799215.
        View in: PubMed
      2. Haidekker MA, Theodorakis E. Ratiometric mechanosensitive fluorescent dyes: Design and applications. J Mater Chem C Mater Opt Electron Devices. 2016 Apr 14; 4(14):2707-2718. PMID: 27127631.
        View in: PubMed
      3. Theodoraki MA, Rezende CO, Chantarasriwong O, Corben AD, Theodorakis E, Alpaugh ML. Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening. Oncotarget. 2015 Aug 28; 6(25):21255-67. PMID: 26101913; PMCID: PMC4673263.
      4. Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis E, Walsh DM, Yang J, Shah JV. Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. ACS Chem Neurosci. 2015 Sep 16; 6(9):1503-8. PMID: 26212450; PMCID: PMC4814290.
      5. Nicolaou KC, Shah AA, Korman H, Khan T, Shi L, Worawalai W, Theodorakis E. Total Synthesis and Structural Revision of Antibiotic CJ-16,264. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9203-8. PMID: 26096055; PMCID: PMC4530996.
      6. Lacoske MH, Xu J, Mansour N, Gao C, Theodorakis E. Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates. Org Chem Front. 2015 Apr 01; 2(4):388-393. PMID: 26257916.
        View in: PubMed
      7. Kocsis LS, Elbel KM, Hardigree BA, Brummond KM, Haidekker MA, Theodorakis E. Cyclopenta[b]naphthalene cyanoacrylate dyes: synthesis and evaluation as fluorescent molecular rotors. Org Biomol Chem. 2015 Mar 14; 13(10):2965-73. PMID: 25614187; PMCID: PMC4339457.
      8. Bai F, Morcos F, Sohn YS, Darash-Yahana M, Rezende CO, Lipper CH, Paddock ML, Song L, Luo Y, Holt SH, Tamir S, Theodorakis E, Jennings PA, Onuchic JN, Mittler R, Nechushtai R. The Fe-S cluster-containing NEET proteins mitoNEET and NAF-1 as chemotherapeutic targets in breast cancer. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3698-703. PMID: 25762074; PMCID: PMC4378444.
      9. Papakyriakou A, Zervoudi E, Tsoukalidou S, Mauvais FX, Sfyroera G, Mastellos DC, van Endert P, Theodorakis E, Vourloumis D, Stratikos E. 3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. J Med Chem. 2015 Feb 12; 58(3):1524-43. PMID: 25635706.
        View in: PubMed
      10. Williams RT, Yu AL, Diccianni MB, Theodorakis E, Batova A. Erratum: renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res. 2014 Dec 05; 33:95. PMID: 25480670; PMCID: PMC4272799.
      11. Lacoske MH, Theodorakis E. Spirotetronate polyketides as leads in drug discovery. J Nat Prod. 2015 Mar 27; 78(3):562-75. PMID: 25434976; PMCID: PMC4380204.
      12. Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis E, Martín-Sanz P, Palladino MA, Boscá L. Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110?/d subunits and inhibition of NF-?B. Chem Biol. 2014 Aug 14; 21(8):955-66. PMID: 25065531.
        View in: PubMed
      13. Caro-Diaz EJ, Aung A, Xu J, Varghese S, Theodorakis E. Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors. Org Chem Front. 2014 Apr 01; 1(2):135-139. PMID: 24910777.
        View in: PubMed
      14. Shih YR, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, Nguyen S, Siu M, Theodorakis E, Gianneschi NC, Vecchio KS, Chien S, Lee OK, Varghese S. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):990-5. PMID: 24395775; PMCID: PMC3903237.
      15. Xu J, Lacoske MH, Theodorakis E. Neurotrophic natural products: chemistry and biology. Angew Chem Int Ed Engl. 2014 Jan 20; 53(4):956-87. PMID: 24353244; PMCID: PMC3945720.
      16. Williams RT, Yu AL, Diccianni MB, Theodorakis E, Batova A. Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy. J Exp Clin Cancer Res. 2013 Aug 20; 32:57. PMID: 23958461; PMCID: PMC3765946.
      17. Papakyriakou A, Zervoudi E, Theodorakis E, Saveanu L, Stratikos E, Vourloumis D. Novel selective inhibitors of aminopeptidases that generate antigenic peptides. Bioorg Med Chem Lett. 2013 Sep 01; 23(17):4832-6. PMID: 23916253.
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      18. Trzoss L, Xu J, Lacoske MH, Theodorakis E. Synthesis of the tetracyclic core of Illicium sesquiterpenes using an organocatalyzed asymmetric Robinson annulation. Beilstein J Org Chem. 2013; 9:1135-40. PMID: 23843905; PMCID: PMC3701413.
      19. Elbel KM, Guizzunti G, Theodoraki MA, Xu J, Batova A, Dakanali M, Theodorakis E. A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones. Org Biomol Chem. 2013 May 28; 11(20):3341-8. PMID: 23563530; PMCID: PMC3654788.
      20. Saitman A, Theodorakis E. Synthesis of a highly functionalized core of verrillin. Org Lett. 2013 May 17; 15(10):2410-3. PMID: 23627293; PMCID: PMC3766406.
      21. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis E. Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry. 2013 May 10; 19(20):6398-408. PMID: 23526661; PMCID: PMC3875175.
      22. Saitman A, Sullivan SD, Theodorakis E. A strategy toward the synthesis of C13-oxidized cembrenolides. Tetrahedron Lett. 2013 Mar 20; 54(12):1612-1615. PMID: 23626379.
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      23. Martínez-Montero S, Fernández S, Sanghvi YS, Theodorakis E, Detorio MA, McBrayer TR, Whitaker T, Schinazi RF, Gotor V, Ferrero M. Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides. Bioorg Med Chem. 2012 Dec 01; 20(23):6885-93. PMID: 23085031; PMCID: PMC3489957.
      24. Cao K, Farahi M, Dakanali M, Chang WM, Sigurdson CJ, Theodorakis E, Yang J. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-ß and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. PMID: 22866977; PMCID: PMC3480552.
      25. Dakanali M, Do TH, Horn A, Chongchivivat A, Jarusreni T, Lichlyter D, Guizzunti G, Haidekker MA, Theodorakis E. Self-calibrating viscosity probes: design and subcellular localization. Bioorg Med Chem. 2012 Jul 15; 20(14):4443-50. PMID: 22698784; PMCID: PMC3390230.
      26. Guizzunti G, Batova A, Chantarasriwong O, Dakanali M, Theodorakis E. Subcellular localization and activity of gambogic acid. Chembiochem. 2012 May 29; 13(8):1191-8. PMID: 22532297; PMCID: PMC3359389.
      27. Xu J, Caro-Diaz EJ, Batova A, Sullivan SD, Theodorakis E. Formal synthesis of (-)-englerin A and cytotoxicity studies of truncated englerins. Chem Asian J. 2012 May; 7(5):1052-60. PMID: 22415793; PMCID: PMC3338859.
      28. Xu J, Caro-Diaz EJ, Trzoss L, Theodorakis E. Nature-inspired total synthesis of (-)-fusarisetin A. J Am Chem Soc. 2012 Mar 21; 134(11):5072-5. PMID: 22390338; PMCID: PMC3310296.
      29. Xu J, Caro-Diaz EJ, Lacoske MH, Hung CI, Jamora C, Theodorakis E. Fusarisetin A: Scalable Total Synthesis and Related Studies. Chem Sci. 2012 Jan 01; 3(12):3378-3386. PMID: 23227303.
        View in: PubMed
      30. Saitman A, Rulliere P, Sullivan SD, Theodorakis E. Total synthesis of norcembrenolide B and scabrolide D. Org Lett. 2011 Nov 04; 13(21):5854-7. PMID: 21973225; PMCID: PMC3204162.
      31. Howell S, Dakanali M, Theodorakis E, Haidekker MA. Intrinsic and extrinsic temperature-dependency of viscosity-sensitive fluorescent molecular rotors. J Fluoresc. 2012 Jan; 22(1):457-65. PMID: 21947609; PMCID: PMC3272777.
      32. Fischer D, Nguyen TX, Trzoss L, Dakanali M, Theodorakis E. Intramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids. Tetrahedron Lett. 2011 Sep 21; 52(38):4920-4923. PMID: 21857757.
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      33. Guizzunti G, Theodorakis E, Yu AL, Zurzolo C, Batova A. Cluvenone induces apoptosis via a direct target in mitochondria: a possible mechanism to circumvent chemo-resistance? Invest New Drugs. 2012 Oct; 30(5):1841-8. PMID: 21898184; PMCID: PMC3405192.
      34. Trzoss L, Xu J, Lacoske MH, Mobley WC, Theodorakis E. Enantioselective synthesis of (-)-jiadifenin, a potent neurotrophic modulator. Org Lett. 2011 Sep 02; 13(17):4554-7. PMID: 21812392; PMCID: PMC3163030.
      35. Nguyen TX, Dakanali M, Trzoss L, Theodorakis E. Enantioselective synthesis of the ABC ring motif of norzoanthamine based on asymmetric Robinson annulation reactions. Org Lett. 2011 Jul 01; 13(13):3308-11. PMID: 21615125; PMCID: PMC3153989.
      36. Chang WM, Dakanali M, Capule CC, Sigurdson CJ, Yang J, Theodorakis E. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. PMID: 21743829.
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      37. Ling T, Xu J, Smith R, Ali A, Cantrell CL, Theodorakis E. Synthesis of (-)-callicarpenal, a potent arthropod-repellent. Tetrahedron. 2011 Apr 29; 67(17):3023-3029. PMID: 21643472.
        View in: PubMed
      38. Yoon HJ, Dakanali M, Lichlyter D, Chang WM, Nguyen KA, Nipper ME, Haidekker MA, Theodorakis E. Synthesis and evaluation of self-calibrating ratiometric viscosity sensors. Org Biomol Chem. 2011 May 07; 9(9):3530-40. PMID: 21437318; PMCID: PMC3157677.
      39. Xu J, Trzoss L, Chang WK, Theodorakis E. Enantioselective total synthesis of (-)-jiadifenolide. Angew Chem Int Ed Engl. 2011 Apr 11; 50(16):3672-6. PMID: 21400650; PMCID: PMC3159889.
      40. Nipper ME, Dakanali M, Theodorakis E, Haidekker MA. Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors. Biochimie. 2011 Jun; 93(6):988-94. PMID: 21354253; PMCID: PMC3095221.
      41. Batova A, Altomare D, Chantarasriwong O, Ohlsen KL, Creek KE, Lin YC, Messersmith A, Yu AL, Yu J, Theodorakis E. The synthetic caged garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity. Mol Cancer Ther. 2010 Nov; 9(11):2869-78. PMID: 20881270; PMCID: PMC2978789.
      42. Haidekker MA, Theodorakis E. Environment-sensitive behavior of fluorescent molecular rotors. J Biol Eng. 2010 Sep 15; 4:11. PMID: 20843326; PMCID: PMC2949793.
      43. Chantarasriwong O, Batova A, Chavasiri W, Theodorakis E. Chemistry and biology of the caged Garcinia xanthones. Chemistry. 2010 Sep 03; 16(33):9944-62. PMID: 20648491; PMCID: PMC3144150.
      44. Xu J, Caro-Diaz EJ, Theodorakis E. Enantioselective formal synthesis of (-)-englerin A via a Rh-catalyzed [4 + 3] cycloaddition reaction. Org Lett. 2010 Aug 20; 12(16):3708-11. PMID: 20669919; PMCID: PMC2927118.
      45. Mustafic A, Huang HM, Theodorakis E, Haidekker MA. Imaging of flow patterns with fluorescent molecular rotors. J Fluoresc. 2010 Sep; 20(5):1087-98. PMID: 20405175; PMCID: PMC2937142.
      46. Sutharsan J, Lichlyter D, Wright NE, Dakanali M, Haidekker MA, Theodorakis E. Molecular rotors: Synthesis and evaluation as viscosity sensors. Tetrahedron. 2010 Apr 03; 66(14):2582-2588. PMID: 20694175.
        View in: PubMed
      47. Guizzunti G, Brady TP, Fischer D, Malhotra V, Theodorakis E. Chemical biology studies on norrisolide. Bioorg Med Chem. 2010 Mar 15; 18(6):2115-22. PMID: 20189813; PMCID: PMC2838712.
      48. Sutharsan J, Dakanali M, Capule CC, Haidekker MA, Yang J, Theodorakis E. Rational design of amyloid binding agents based on the molecular rotor motif. ChemMedChem. 2010 Jan; 5(1):56-60. PMID: 20024978; PMCID: PMC2837554.
      49. Chantarasriwong O, Cho WC, Batova A, Chavasiri W, Moore C, Rheingold AL, Theodorakis E. Evaluation of the pharmacophoric motif of the caged Garcinia xanthones. Org Biomol Chem. 2009 Dec 07; 7(23):4886-94. PMID: 19907779; PMCID: PMC2927871.
      50. Pongkittiphan V, Theodorakis E, Chavasiri W. Hexachloroethane: a highly efficient reagent for the synthesis of chlorosilanes from hydrosilanes. Tetrahedron Lett. 2009 Sep 09; 50(36):5080-5082. PMID: 20360997.
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      51. Díaz-Rodríguez A, Sanghvi YS, Fernández S, Schinazi RF, Theodorakis E, Ferrero M, Gotor V. Synthesis and anti-HIV activity of conformationally restricted bicyclic hexahydroisobenzofuran nucleoside analogs. Org Biomol Chem. 2009 Apr 07; 7(7):1415-23. PMID: 19300828.
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      52. Nipper ME, Majd S, Mayer M, Lee JC, Theodorakis E, Haidekker MA. Characterization of changes in the viscosity of lipid membranes with the molecular rotor FCVJ. Biochim Biophys Acta. 2008 Apr; 1778(4):1148-53. PMID: 18258179.
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      53. Díaz-Rodríguez A, Fernández S, Sanghvi YS, Theodorakis E, Gotor V, Ferrero M. Synthesis of 2',3'-cyclohexene bicyclic nucleoside analogues as antiviral compounds. Nucleic Acids Symp Ser (Oxf). 2008; (52):99-100. PMID: 18776272.
        View in: PubMed
      54. Haidekker MA, Theodorakis E. Molecular rotors--fluorescent biosensors for viscosity and flow. Org Biomol Chem. 2007 Jun 07; 5(11):1669-78. PMID: 17520133.
        View in: PubMed
      55. Traves PG, Hortelano S, Zeini M, Chao TH, Lam T, Neuteboom ST, Theodorakis E, Palladino MA, Castrillo A, Bosca L. Selective activation of liver X receptors by acanthoic acid-related diterpenes. Mol Pharmacol. 2007 Jun; 71(6):1545-53. PMID: 17329499.
        View in: PubMed
      56. Fischer D, Theodorakis E, Haidekker MA. Synthesis and use of an in-solution ratiometric fluorescent viscosity sensor. Nat Protoc. 2007; 2(1):227-36. PMID: 17401358.
        View in: PubMed
      57. Batova A, Lam T, Wascholowski V, Yu AL, Giannis A, Theodorakis E. Synthesis and evaluation of caged Garcinia xanthones. Org Biomol Chem. 2007 Feb 07; 5(3):494-500. PMID: 17252132.
        View in: PubMed
      58. Guizzunti G, Brady TP, Malhotra V, Theodorakis E. Trifunctional norrisolide probes for the study of Golgi vesiculation. Bioorg Med Chem Lett. 2007 Jan 15; 17(2):320-5. PMID: 17110104; PMCID: PMC1853282.
      59. Haidekker MA, Akers WJ, Fischer D, Theodorakis E. Optical fiber-based fluorescent viscosity sensor. Opt Lett. 2006 Sep 01; 31(17):2529-31. PMID: 16902608.
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      60. Guizzunti G, Brady TP, Malhotra V, Theodorakis E. Chemical analysis of norrisolide-induced Golgi vesiculation. J Am Chem Soc. 2006 Apr 05; 128(13):4190-1. PMID: 16568969.
        View in: PubMed
      61. Alexander MD, Burkart MD, Leonard MS, Portonovo P, Liang B, Ding X, Joullié MM, Gulledge BM, Aggen JB, Chamberlin AR, Sandler J, Fenical W, Cui J, Gharpure SJ, Polosukhin A, Zhang HR, Evans PA, Richardson AD, Harper MK, Ireland CM, Vong BG, Brady TP, Theodorakis E, La Clair JJ. A central strategy for converting natural products into fluorescent probes. Chembiochem. 2006 Mar; 7(3):409-16. PMID: 16432909.
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      62. Haidekker MA, Brady TP, Lichlyter D, Theodorakis E. A ratiometric fluorescent viscosity sensor. J Am Chem Soc. 2006 Jan 18; 128(2):398-9. PMID: 16402812.
        View in: PubMed
      63. Brady TP, Kim SH, Wen K, Kim C, Theodorakis E. Norrisolide: total synthesis and related studies. Chemistry. 2005 Dec 09; 11(24):7175-90. PMID: 16163770.
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      64. Haidekker MA, Brady TP, Lichlyter D, Theodorakis E. Effects of solvent polarity and solvent viscosity on the fluorescent properties of molecular rotors and related probes. Bioorg Chem. 2005 Dec; 33(6):415-25. PMID: 16182338.
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      65. Peyssonnaux C, Datta V, Cramer T, Doedens A, Theodorakis E, Gallo RL, Hurtado-Ziola N, Nizet V, Johnson RS. HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest. 2005 Jul; 115(7):1806-15. PMID: 16007254; PMCID: PMC1159132.
      66. Lee H, Lee K, Jung JK, Cho J, Theodorakis E. Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants. Bioorg Med Chem Lett. 2005 Jun 02; 15(11):2745-8. PMID: 15911250.
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      67. Chao TH, Lam T, Vong BG, Través PG, Hortelano S, Chowdhury C, Bahjat FR, Lloyd GK, Moldawer LL, Boscá L, Palladino MA, Theodorakis E. A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation. Chembiochem. 2005 Jan; 6(1):133-44. PMID: 15540220.
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      68. Brady TP, Wallace EK, Kim SH, Guizzunti G, Malhotra V, Theodorakis E. Fragmentation of Golgi membranes by norrisolide and designed analogues. Bioorg Med Chem Lett. 2004 Oct 18; 14(20):5035-9. PMID: 15380194.
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      69. Haidekker MA, Brady TP, Chalian SH, Akers W, Lichlyter D, Theodorakis E. Hydrophilic molecular rotor derivatives-synthesis and characterization. Bioorg Chem. 2004 Aug; 32(4):274-89. PMID: 15210341.
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      70. Vong BG, Kim SH, Abraham S, Theodorakis E. Stereoselective total synthesis of (-)-borrelidin. Angew Chem Int Ed Engl. 2004 Jul 26; 43(30):3947-51. PMID: 15274222.
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      71. Oka N, Sanghvi YS, Theodorakis E. 3,3(')-Oxybis(dimethoxytrityl chloride) (O-DMTCl): synthesis and applications of a novel bifunctional protecting group. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3241-4. PMID: 15149683.
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      72. Tisdale EJ, Slobodov I, Theodorakis E. Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels-Alder/Claisen rearrangement. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12030-5. PMID: 15210986; PMCID: PMC514429.
      73. Ghosh S, Rivas F, Fischer D, González MA, Theodorakis E. Stereoselective synthesis of the ABC ring system of norzoanthamine. Org Lett. 2004 Mar 18; 6(6):941-4. PMID: 15012070.
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      74. Brady TP, Kim SH, Wen K, Theodorakis E. Stereoselective total synthesis of (+)-norrisolide. Angew Chem Int Ed Engl. 2004 Jan 30; 43(6):739-42. PMID: 14755708.
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      75. Tisdale EJ, Slobodov I, Theodorakis E. Biomimetic total synthesis of forbesione and desoxymorellin utilizing a tandem Claisen/Diels--Alder/Claisen rearrangement. Org Biomol Chem. 2003 Dec 21; 1(24):4418-22. PMID: 14727628.
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      76. Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis E. Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorg Med Chem Lett. 2003 Oct 06; 13(19):3217-21. PMID: 12951096.
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      77. Palladino MA, Bahjat FR, Theodorakis E, Moldawer LL. Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov. 2003 Sep; 2(9):736-46. PMID: 12951580.
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      78. Chow S, Wen K, Sanghvi YS, Theodorakis E. Novel synthesis of 2'-O-methylguanosine. Bioorg Med Chem Lett. 2003 May 19; 13(10):1631-4. PMID: 12729629.
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      79. Vong BG, Abraham S, Xiang AX, Theodorakis E. Synthetic studies on borrelidin: enantioselective synthesis of the C1-C12 fragment. Org Lett. 2003 May 15; 5(10):1617-20. PMID: 12735735.
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      80. Tisdale EJ, Li H, Vong BG, Kim SH, Theodorakis E. Regioselective synthesis of the tricyclic core of lateriflorone. Org Lett. 2003 May 01; 5(9):1491-4. PMID: 12713306.
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      81. Chow S, Wen K, Sanghvi YS, Theodorakis E. MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):583-7. PMID: 14565233.
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      82. Haidekker MA, Brady T, Wen K, Okada C, Stevens HY, Snell JM, Frangos JA, Theodorakis E. Phospholipid-bound molecular rotors: synthesis and characterization. Bioorg Med Chem. 2002 Nov; 10(11):3627-36. PMID: 12213479.
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      83. Wen K, Chow S, Sanghvi YS, Theodorakis E. Synthesis of 2'-O-methoxyethylguanosine using a novel silicon-based protecting group. J Org Chem. 2002 Nov 01; 67(22):7887-9. PMID: 12398522.
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      84. Ling T, Poupon E, Rueden EJ, Kim SH, Theodorakis E. Unified synthesis of quinone sesquiterpenes based on a radical decarboxylation and quinone addition reaction. J Am Chem Soc. 2002 Oct 16; 124(41):12261-7. PMID: 12371868.
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      85. Haidekker MA, Tsai AG, Brady T, Stevens HY, Frangos JA, Theodorakis E, Intaglietta M. A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1609-14. PMID: 11959622.
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      86. Tisdale EJ, Chowdhury C, Vong BG, Li H, Theodorakis E. Regioselective synthesis of the bridged tricyclic core of Garcinia natural products via intramolecular aryl acrylate cycloadditions. Org Lett. 2002 Mar 21; 4(6):909-12. PMID: 11893183.
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      87. Ling T, Poupon E, Rueden EJ, Theodorakis E. Synthesis of (-)-ilimaquinone via a radical decarboxylation and quinone addition reaction. Org Lett. 2002 Mar 07; 4(5):819-22. PMID: 11869136.
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      88. Ling T, Chowdhury C, Kramer BA, Vong BG, Palladino MA, Theodorakis E. Enantioselective synthesis of the antiinflammatory agent (-)-acanthoic acid. J Org Chem. 2001 Dec 28; 66(26):8843-53. PMID: 11749614.
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      89. Jamora C, Theodoraki MA, Malhotra V, Theodorakis E. Investigation of the biological mode of action of clerocidin using whole cell assays. Bioorg Med Chem. 2001 Jun; 9(6):1365-70. PMID: 11408157.
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      90. Haidekker MA, Ling T, Anglo M, Stevens HY, Frangos JA, Theodorakis E. New fluorescent probes for the measurement of cell membrane viscosity. Chem Biol. 2001 Feb; 8(2):123-31. PMID: 11251287.
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      91. Ling T, Kramer BA, Palladino MA, Theodorakis E. Stereoselective synthesis of (-)-acanthoic acid. Org Lett. 2000 Jul 13; 2(14):2073-6. PMID: 10891233.
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      92. Drouet KE, Theodorakis E. Stereoselective total synthesis of reveromycin B and C19-epi-reveromycin B. Chemistry. 2000 Jun 02; 6(11):1987-2001. PMID: 10894398.
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      93. Drouet KE, Ling T, Tran HV, Theodorakis E. Enantioselective synthesis of the [6,6] spiroketal core of reveromycin A. Org Lett. 2000 Jan 27; 2(2):207-10. PMID: 10814283.
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