Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Elizabeth Winzeler

    TitleProfessor In Residence
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0760
    CA La Jolla 92093
    Phone858-822-3339
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Lewis and Clark CollegeBA1984Art/Natural Sciences
      Oregon State UniversityMS1990Biochemistry
      Stanford University School of MedicinePh.D.1996Developmental Biology
      Staford University School of MedicinePostdoctoral1999Biochemistry
      Collapse Awards and Honors
      ASBMB2018CC Wang Award
      Medicines for Malaria Venture2017Project of the year
      Ellison Medical Research Foundation2001New Scholar Award
      WM Keck Foundation2004Distinguished Young Scholar
      American Society of Tropical Medicine and Hygiene2015Bailey Ashford Medal
      American Society for Microbiology2016Fellow

      Collapse Overview 

      Collapse Research 
      Collapse Research Activities and Funding
      Defining the targets of broad intervention antimalarial agents
      NIH/NIAID R01AI103058Aug 14, 2013 - Jul 31, 2017
      Role: Principal Investigator
      Investigating the molecular basis of primaquine resistance
      NIH R56AI091832Jul 20, 2011 - Dec 30, 2012
      Role: Principal Investigator
      Discovery of chemically validated malaria liver stage targets
      NIH/NIAID R01AI090141May 6, 2011 - Jul 31, 2020
      Role: Principal Investigator
      Functional genomic tools for in vivo study of P. vivax
      NIH/NIAID R21AI085374Jun 15, 2010 - Nov 30, 2012
      Role: Principal Investigator
      San Diego Center for Systems Biology: From Maps to Models
      NIH/NIGMS P50GM085764Jul 1, 2008 - May 31, 2019
      Role: Co-Investigator
      Experimental Annotation of the P. Falciparum Genome
      NIH/NIAID R01AI059472Jul 1, 2005 - Mar 31, 2011
      Role: Principal Investigator
      Discovery of Allelic Variation in Plasmodium falciparum
      NIH/NIAID R03AI054687Apr 1, 2003 - Mar 31, 2005
      Role: Principal Investigator
      MESSENGER RNA STABILITY IN SACCHAROMYCES CEREVISIAE
      NIH/NHGRI F32HG000185Oct 1, 1997
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Stenzel K, Chua MJ, Duffy S, Antonova-Koch Y, Meister S, Hamacher A, Kassack MU, Winzeler E, Avery VM, Kurz T, Andrews KT, Hansen FK. Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity. ChemMedChem. 2017 Aug 15. PMID: 28812327.
        View in: PubMed
      2. Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE, Alano P, Delves MJ, Lee Sim K, Winzeler E, Egan TJ, Hoffman SL, Avery VM, Fidock DA. Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nat Microbiol. 2017 Aug 14. PMID: 28808258.
        View in: PubMed
      3. LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler E, Gerwick WH, Ottilie S. Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. J Med Chem. 2017 Aug 10; 60(15):6721-6732. PMID: 28696697.
        View in: PubMed
      4. Flannery EL, Chatterjee AK, Winzeler E. Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol. 2017 Sep; 15(9):572. PMID: 28736448.
        View in: PubMed
      5. Leven M, Knaab TC, Held J, Duffy S, Meister S, Fischli C, Meitzner D, Lehmann U, Lungerich B, Kuna K, Stahlke P, Delves MJ, Buchholz M, Winzeler E, Avery VM, Mordmüller B, Wittlin S, Kurz T. 3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally. J Med Chem. 2017 Jul 27; 60(14):6036-6044. PMID: 28653845.
        View in: PubMed
      6. Winzeler E. Glycophorin alleles link to malaria protection. Science. 2017 Jun 16; 356(6343):1122-1123. PMID: 28619899.
        View in: PubMed
      7. Dhingra SK, Redhi D, Combrinck JM, Yeo T, Okombo J, Henrich PP, Cowell AN, Gupta P, Stegman ML, Hoke JM, Cooper RA, Winzeler E, Mok S, Egan TJ, Fidock DA. A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine. MBio. 2017 May 09; 8(3). PMID: 28487425.
        View in: PubMed
      8. Cowell AN, Loy DE, Sundararaman SA, Valdivia H, Fisch K, Lescano AG, Baldeviano GC, Durand S, Gerbasi V, Sutherland CJ, Nolder D, Vinetz JM, Hahn BH, Winzeler E. Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples. MBio. 2017 Feb 07; 8(1). PMID: 28174312.
        View in: PubMed
      9. Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler E, Goldberg DE. Esterase mutation is a mechanism of resistance to antimalarial compounds. Nat Commun. 2017 Jan 20; 8:14240. PMID: 28106035.
        View in: PubMed
      10. Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, Amaro RE, Podust LM, Durrant JD, Winzeler E. Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast. ACS Chem Biol. 2017 Feb 17; 12(2):422-434. PMID: 27977118.
        View in: PubMed
      11. Le Manach C, Nchinda AT, Paquet T, Gonzàlez Cabrera D, Younis Y, Han Z, Bashyam S, Zabiulla M, Taylor D, Lawrence N, White KL, Charman SA, Waterson D, Witty MJ, Wittlin S, Botha ME, Nondaba SH, Reader J, Birkholtz LM, Jiménez-Díaz MB, Martínez MS, Ferrer S, Angulo-Barturen I, Meister S, Antonova-Koch Y, Winzeler E, Street LJ, Chibale K. Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle. J Med Chem. 2016 Nov 10; 59(21):9890-9905. PMID: 27748596.
        View in: PubMed
      12. Lim MY, LaMonte G, Lee MC, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GM, Ho PC, Yeung BK, Chow ED, Lim L, Fidock DA, Diagana TT, Winzeler E, Bifani P. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat Microbiol. 2016 Sep 19; 16166. PMID: 27642791.
        View in: PubMed
      13. Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, Debbert SL, Delves M, Dennis AS, Deroose F, Duffy S, Fletcher S, Giaever G, Hallyburton I, Gamo FJ, Gebbia M, Guy RK, Hungerford Z, Kirk K, Lafuente-Monasterio MJ, Lee A, Meister S, Nislow C, Overington JP, Papadatos G, Patiny L, Pham J, Ralph SA, Ruecker A, Ryan E, Southan C, Srivastava K, Swain C, Tarnowski MJ, Thomson P, Turner P, Wallace IM, Wells TN, White K, White L, Willis P, Winzeler E, Wittlin S, Todd MH. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. ACS Cent Sci. 2016 Oct 26; 2(10):687-701. PMID: 27800551.
        View in: PubMed
      14. Baragaña B, Norcross NR, Wilson C, Porzelle A, Hallyburton I, Grimaldi R, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Wyatt PG, Delves MJ, Meister S, Duffy S, Avery VM, Winzeler E, Sinden RE, Wittlin S, Frearson JA, Gray DW, Fairlamb AH, Waterson D, Campbell SF, Willis P, Read KD, Gilbert IH. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. J Med Chem. 2016 Nov 10; 59(21):9672-9685. PMID: 27631715.
        View in: PubMed
      15. Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan GL, Duffy S, Eckley S, Itoe MA, Koolen KM, Lewis TA, Lui PS, Lukens AK, Lund E, March S, Meibalan E, Meier BC, McPhail JA, Mitasev B, Moss EL, Sayes M, Van Gessel Y, Wawer MJ, Yoshinaga T, Zeeman AM, Avery VM, Bhatia SN, Burke JE, Catteruccia F, Clardy JC, Clemons PA, Dechering KJ, Duvall JR, Foley MA, Gusovsky F, Kocken CH, Marti M, Morningstar ML, Munoz B, Neafsey DE, Sharma A, Winzeler E, Wirth DF, Scherer CA, Schreiber SL. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20; 538(7625):344-349. PMID: 27602946.
        View in: PubMed
      16. Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler E, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 Jul; 12(7):e1005763. PMID: 27467575; PMCID: PMC4965013.
      17. LaMonte G, Lim MY, Wree M, Reimer C, Nachon M, Corey V, Gedeck P, Plouffe D, Du A, Figueroa N, Yeung B, Bifani P, Winzeler E. Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance. MBio. 2016 Jul 05; 7(4). PMID: 27381290; PMCID: PMC4958248.
      18. Norcross NR, Baragaña B, Wilson C, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Porzelle A, Grimaldi R, Wittlin S, Duffy S, Avery VM, Meister S, Sanz L, Jiménez-Díaz B, Angulo-Barturen I, Ferrer S, Martínez MS, Gamo FJ, Frearson JA, Gray DW, Fairlamb AH, Winzeler E, Waterson D, Campbell SF, Willis P, Read KD, Gilbert IH. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. J Med Chem. 2016 Jul 14; 59(13):6101-20. PMID: 27314305; PMCID: PMC4947981.
      19. Corey VC, Lukens AK, Istvan ES, Lee MC, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, Prats S, Meister S, Tanaseichuk O, Wree M, Zhou Y, Willis PA, Gamo FJ, Goldberg DE, Fidock DA, Wirth DF, Winzeler E. A broad analysis of resistance development in the malaria parasite. Nat Commun. 2016 Jun 15; 7:11901. PMID: 27301419; PMCID: PMC4912613.
      20. Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Stanhope R, Prescott M, McNamara CW, Slayman CW, Amaro RE, Suzuki Y, Winzeler E. Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Sci Rep. 2016 Jun 13; 6:27806. PMID: 27291296; PMCID: PMC4904242.
      21. Lu HH, Pronin SV, Antonova-Koch Y, Meister S, Winzeler E, Shenvi RA. Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class. J Am Chem Soc. 2016 Jun 15; 138(23):7268-71. PMID: 27244042.
        View in: PubMed
      22. Hovlid ML, Winzeler E. Phenotypic Screens in Antimalarial Drug Discovery. Trends Parasitol. 2016 Sep; 32(9):697-707. PMID: 27247245; PMCID: PMC5007148 [Available on 09/01/17].
      23. Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Martínez MS, Bolscher JM, Woodland A, Luksch T, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler E, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH. Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2016 09 01; 537(7618):122. PMID: 27281209.
        View in: PubMed
      24. Ng CL, Siciliano G, Lee MC, de Almeida MJ, Corey VC, Bopp SE, Bertuccini L, Wittlin S, Kasdin RG, Le Bihan A, Clozel M, Winzeler E, Alano P, Fidock DA. CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs. Mol Microbiol. 2016 Aug; 101(3):381-93. PMID: 27073104; PMCID: PMC4958522 [Available on 08/01/17].
      25. Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. ACS Infect Dis. 2016 Nov 11; 2(11):816-826. PMID: 27933786.
        View in: PubMed
      26. Swann J, Corey V, Scherer CA, Kato N, Comer E, Maetani M, Antonova-Koch Y, Reimer C, Gagaring K, Ibanez M, Plouffe D, Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, Campo B, Winzeler E, Meister S. High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria. ACS Infect Dis. 2016 Apr 08; 2(4):281-293. PMID: 27275010.
        View in: PubMed
      27. Plouffe DM, Wree M, Du AY, Meister S, Li F, Patra K, Lubar A, Okitsu SL, Flannery EL, Kato N, Tanaseichuk O, Comer E, Zhou B, Kuhen K, Zhou Y, Leroy D, Schreiber SL, Scherer CA, Vinetz J, Winzeler E. High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission. Cell Host Microbe. 2016 Jan 13; 19(1):114-26. PMID: 26749441; PMCID: PMC4723716.
      28. Lehmann JS, Corey VC, Ricaldi JN, Vinetz JM, Winzeler E, Matthias MA. Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. Am J Trop Med Hyg. 2016 Feb; 94(2):302-13. PMID: 26711524; PMCID: PMC4751964.
      29. Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler E, Valeriote FA, Gerwick WH. Kalkipyrone B, a marine cyanobacterial ?-pyrone possessing cytotoxic and anti-fungal activities. Phytochemistry. 2016 Feb; 122:113-118. PMID: 26632528; PMCID: PMC4724546 [Available on 02/01/17].
      30. Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, Meister S, Winzeler E, Waterson D, Witty MJ, Wittlin S, Jiménez-Díaz MB, Santos Martínez M, Ferrer S, Angulo-Barturen I, Street LJ, Chibale K. A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines. J Med Chem. 2015 Nov 12; 58(21):8713-22. PMID: 26502160.
        View in: PubMed
      31. Swann J, Jamshidi N, Lewis NE, Winzeler E. Systems analysis of host-parasite interactions. Wiley Interdiscip Rev Syst Biol Med. 2015 Nov-Dec; 7(6):381-400. PMID: 26306749.
        View in: PubMed
      32. Flannery EL, Wang T, Akbari A, Corey VC, Gunawan F, Bright AT, Abraham M, Sanchez JF, Santolalla ML, Baldeviano GC, Edgel KA, Rosales LA, Lescano AG, Bafna V, Vinetz JM, Winzeler E. Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes. ACS Infect Dis. 2015 Aug 14; 1(8):367-79. PMID: 26719854; PMCID: PMC4692371.
      33. Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Martínez MS, Luksch T, Bolscher JM, Woodland A, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler E, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 06 18; 522(7556):315-20. PMID: 26085270; PMCID: PMC4700930.
      34. Suzuki Y, Assad-Garcia N, Kostylev M, Noskov VN, Wise KS, Karas BJ, Stam J, Montague MG, Hanly TJ, Enriquez NJ, Ramon A, Goldgof GM, Richter RA, Vashee S, Chuang RY, Winzeler E, Hutchison CA, Gibson DG, Smith HO, Glass JI, Venter JC. Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling. Genome Res. 2015 Mar; 25(3):435-44. PMID: 25654978; PMCID: PMC4352883.
      35. Winzeler E, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol. 2014 Nov 25; 15(11):544. PMID: 25470531; PMCID: PMC4283579.
      36. Flannery EL, McNamara CW, Kim SW, Kato TS, Li F, Teng CH, Gagaring K, Manary MJ, Barboa R, Meister S, Kuhen K, Vinetz JM, Chatterjee AK, Winzeler E. Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. ACS Chem Biol. 2015 Feb 20; 10(2):413-20. PMID: 25322084; PMCID: PMC4340351.
      37. Goel S, Muthusamy A, Miao J, Cui L, Salanti A, Winzeler E, Gowda DC. Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity. J Biol Chem. 2014 Dec 05; 289(49):34408-21. PMID: 25342752; PMCID: PMC4256368.
      38. Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen KL, Gagaring K, Borboa R, Chang J, Li C, Hollenbeck T, Tuntland T, Zeeman AM, Kocken CH, McNamara C, Kato N, Winzeler E, Yeung BK, Diagana TT, Smith PW, Roland J. Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages. ACS Med Chem Lett. 2014 Aug 14; 5(8):947-50. PMID: 25147620; PMCID: PMC4137381.
      39. Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, van de Vegte-Bolmer M, van Gemert GJ, Wirjanata G, Sebayang B, Marfurt J, Russell B, Suwanarusk R, Price RN, Nosten F, Tungtaeng A, Gettayacamin M, Sattabongkot J, Taylor J, Walker JR, Tully D, Patra KP, Flannery EL, Vinetz JM, Renia L, Sauerwein RW, Winzeler E, Glynne RJ, Diagana TT. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob Agents Chemother. 2014 Sep; 58(9):5060-7. PMID: 24913172; PMCID: PMC4135840.
      40. Bright AT, Manary MJ, Tewhey R, Arango EM, Wang T, Schork NJ, Yanow SK, Winzeler E. A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings. PLoS Negl Trop Dis. 2014 Jun; 8(6):e2882. PMID: 24901334; PMCID: PMC4046966.
      41. Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler E, Avery VM, Andrews KT, Kurz T. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. Eur J Med Chem. 2014 Jul 23; 82:204-13. PMID: 24904967.
        View in: PubMed
      42. Manary MJ, Singhakul SS, Flannery EL, Bopp SE, Corey VC, Bright AT, McNamara CW, Walker JR, Winzeler E. Identification of pathogen genomic variants through an integrated pipeline. BMC Bioinformatics. 2014 Mar 03; 15:63. PMID: 24589256; PMCID: PMC3945619.
      43. Moreno M, Tong C, Guzmán M, Chuquiyauri R, Llanos-Cuentas A, Rodriguez H, Gamboa D, Meister S, Winzeler E, Maguina P, Conn JE, Vinetz JM. Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax. Am J Trop Med Hyg. 2014 Apr; 90(4):612-6. PMID: 24534811; PMCID: PMC3973502.
      44. Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R, Gagaring K, Borboa R, Chen Z, Kuhen K, Glynne RJ, Chatterjee AK, Nagle A, Roland J, Winzeler E, Leroy D, Campo B, Diagana TT, Yeung BK, Thomas AW, Kocken CH. KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrob Agents Chemother. 2014; 58(3):1586-95. PMID: 24366744; PMCID: PMC3957848.
      45. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Nagle A, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler E. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12; 504(7479):248-253. PMID: 24284631; PMCID: PMC3940870.
      46. Flannery EL, Chatterjee AK, Winzeler E. Antimalarial drug discovery - approaches and progress towards new medicines. Nat Rev Microbiol. 2013 Dec; 11(12):849-62. PMID: 24217412; PMCID: PMC3941073.
      47. Bopp SE, Rodrigo E, González-Páez GE, Frazer M, Barnes SW, Valim C, Watson J, Walker JR, Schmedt C, Winzeler E. Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malar J. 2013 Sep 11; 12:316. PMID: 24025732; PMCID: PMC3848760.
      48. Flannery EL, Fidock DA, Winzeler E. Using genetic methods to define the targets of compounds with antimalarial activity. J Med Chem. 2013 Oct 24; 56(20):7761-71. PMID: 23927658; PMCID: PMC3880619.
      49. McCarthy JS, Griffin PM, Sekuloski S, Bright AT, Rockett R, Looke D, Elliott S, Whiley D, Sloots T, Winzeler E, Trenholme KR. Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. J Infect Dis. 2013 Nov 15; 208(10):1688-94. PMID: 23908484; PMCID: PMC3888148.
      50. Bright AT, Winzeler E. Epidemiology: resistance mapping in malaria. Nature. 2013 Jun 27; 498(7455):446-7. PMID: 23803843.
        View in: PubMed
      51. Bright AT, Alenazi T, Shokoples S, Tarning J, Paganotti GM, White NJ, Houston S, Winzeler E, Yanow SK. Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria. Emerg Infect Dis. 2013 May; 19(5):802-5. PMID: 23648098; PMCID: PMC3647516.
      52. Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler E, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. A key role for lipoic acid synthesis during Plasmodium liver stage development. Cell Microbiol. 2013 Sep; 15(9):1585-604. PMID: 23490300; PMCID: PMC3740003.
      53. Karas BJ, Jablanovic J, Sun L, Ma L, Goldgof GM, Stam J, Ramon A, Manary MJ, Winzeler E, Venter JC, Weyman PD, Gibson DG, Glass JI, Hutchison CA, Smith HO, Suzuki Y. Direct transfer of whole genomes from bacteria to yeast. Nat Methods. 2013 May; 10(5):410-2. PMID: 23542886; PMCID: PMC4034675.
      54. Spillman NJ, Allen RJ, McNamara CW, Yeung BK, Winzeler E, Diagana TT, Kirk K. Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe. 2013 Feb 13; 13(2):227-37. PMID: 23414762; PMCID: PMC3574224.
      55. Bopp SE, Manary MJ, Bright AT, Johnston GL, Dharia NV, Luna FL, McCormack S, Plouffe D, McNamara CW, Walker JR, Fidock DA, Denchi EL, Winzeler E. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. PLoS Genet. 2013; 9(2):e1003293. PMID: 23408914; PMCID: PMC3567157.
      56. Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler E, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe. 2012 Dec 13; 12(6):739-50. PMID: 23245319; PMCID: PMC4066821.
      57. Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler E, Diagana TT, Greenbaum DC. Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21486-91. PMID: 23236186; PMCID: PMC3535666.
      58. Nicolaou KC, Lu M, Totokotsopoulos S, Heretsch P, Giguère D, Sun YP, Sarlah D, Nguyen TH, Wolf IC, Smee DF, Day CW, Bopp S, Winzeler E. Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. J Am Chem Soc. 2012 Oct 17; 134(41):17320-32. PMID: 22978674; PMCID: PMC3490634.
      59. Bright AT, Tewhey R, Abeles S, Chuquiyauri R, Llanos-Cuentas A, Ferreira MU, Schork NJ, Vinetz JM, Winzeler E. Whole genome sequencing analysis of Plasmodium vivax using whole genome capture. BMC Genomics. 2012 Jun 21; 13:262. PMID: 22721170; PMCID: PMC3410760.
      60. Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S, Plikat U, Hartmann N, Staedtler F, Cotesta S, Schmitt EK, Petersen F, Supek F, Glynne RJ, Tallarico JA, Porter JA, Fishman MC, Bodenreider C, Diagana TT, Movva NR, Winzeler E. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe. 2012 Jun 14; 11(6):654-63. PMID: 22704625; PMCID: PMC3391680.
      61. Crabb BS, Beeson JG, Amino R, Ménard R, Waters A, Winzeler E, Wahlgren M, Fidock DA, Nwaka S. Perspectives: The missing pieces. Nature. 2012 Apr 25; 484(7395):S22-3. PMID: 22534528.
        View in: PubMed
      62. Nagle A, Wu T, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Lin X, Caldwell C, Ek J, Skolnik S, Liu F, Wang J, Chang J, Li C, Liu B, Hollenbeck T, Tuntland T, Isbell J, Chuan T, Alper PB, Fischli C, Brun R, Lakshminarayana SB, Rottmann M, Diagana TT, Winzeler E, Glynne R, Tully DC, Chatterjee AK. Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. J Med Chem. 2012 May 10; 55(9):4244-73. PMID: 22524250; PMCID: PMC3350218.
      63. Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler E, Sinden RE, Leroy D. The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. PLoS Med. 2012 Feb; 9(2):e1001169. PMID: 22363211; PMCID: PMC3283556.
      64. Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler E. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 09; 334(6061):1372-7. PMID: 22096101; PMCID: PMC3473092.
      65. Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler E. A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. ACS Chem Biol. 2011 Nov 18; 6(11):1214-22. PMID: 21866942; PMCID: PMC3220786.
      66. Mishra S, Rai U, Shiratsuchi T, Li X, Vanloubbeeck Y, Cohen J, Nussenzweig RS, Winzeler E, Tsuji M, Nussenzweig V. Identification of non-CSP antigens bearing CD8 epitopes in mice immunized with irradiated sporozoites. Vaccine. 2011 Oct 06; 29(43):7335-42. PMID: 21807053; PMCID: PMC3603353.
      67. Bright AT, Winzeler E. Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum. BMC Biol. 2011 Jul 19; 9:50. PMID: 21771351; PMCID: PMC3141604.
      68. Wu T, Nagle A, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Goh A, Lakshminarayana SB, Wu J, Ang HQ, Zeng P, Kang ML, Tan W, Tan M, Ye N, Lin X, Caldwell C, Ek J, Skolnik S, Liu F, Wang J, Chang J, Li C, Hollenbeck T, Tuntland T, Isbell J, Fischli C, Brun R, Rottmann M, Dartois V, Keller T, Diagana T, Winzeler E, Glynne R, Tully DC, Chatterjee AK. Imidazolopiperazines: hit to lead optimization of new antimalarial agents. J Med Chem. 2011 Jul 28; 54(14):5116-30. PMID: 21644570.
        View in: PubMed
      69. McNamara C, Winzeler E. Target identification and validation of novel antimalarials. Future Microbiol. 2011 Jun; 6(6):693-704. PMID: 21707315.
        View in: PubMed
      70. Eastman RT, Dharia NV, Winzeler E, Fidock DA. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob Agents Chemother. 2011 Aug; 55(8):3908-16. PMID: 21576453; PMCID: PMC3147642.
      71. Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler E, Goldberg DE. Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1627-32. PMID: 21205898; PMCID: PMC3029723.
      72. Dharia NV, Bright AT, Westenberger SJ, Barnes SW, Batalov S, Kuhen K, Borboa R, Federe GC, McClean CM, Vinetz JM, Neyra V, Llanos-Cuentas A, Barnwell JW, Walker JR, Winzeler E. Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20045-50. PMID: 21037109; PMCID: PMC2993397.
      73. Dharia NV, Plouffe D, Bopp SE, González-Páez GE, Lucas C, Salas C, Soberon V, Bursulaya B, Kochel TJ, Bacon DJ, Winzeler E. Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Res. 2010 Nov; 20(11):1534-44. PMID: 20829224; PMCID: PMC2963817.
      74. Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler E, Diagana TT. Spiroindolones, a potent compound class for the treatment of malaria. Science. 2010 Sep 03; 329(5996):1175-80. PMID: 20813948; PMCID: PMC3050001.
      75. Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, Plouffe D, Henson K, Wagner T, Winzeler E, Petersen F, Brun R, Dartois V, Diagana TT, Keller TH. Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. J Med Chem. 2010 Jul 22; 53(14):5155-64. PMID: 20568778.
        View in: PubMed
      76. Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ, Roos DS, Fontoura BM, Ménard R, Winzeler E, Nussenzweig V. The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med. 2010 Jul 05; 207(7):1465-74. PMID: 20584882; PMCID: PMC2901070.
      77. Deng X, Nagle A, Wu T, Sakata T, Henson K, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, Isbell J, Tully DC, Chatterjee AK, Gray NS. Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials. Bioorg Med Chem Lett. 2010 Jul 15; 20(14):4027-31. PMID: 20610151.
        View in: PubMed
      78. Bopp SE, Ramachandran V, Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C, Waters AP, Zhou Y, Wiltshire T, Winzeler E. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. PLoS One. 2010 May 28; 5(5):e10903. PMID: 20531941; PMCID: PMC2878346.
      79. Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science. 2010 May 14; 328(5980):910-2. PMID: 20466936; PMCID: PMC3109083.
      80. Westenberger SJ, McClean CM, Chattopadhyay R, Dharia NV, Carlton JM, Barnwell JW, Collins WE, Hoffman SL, Zhou Y, Vinetz JM, Winzeler E. A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. PLoS Negl Trop Dis. 2010 Apr 06; 4(4):e653. PMID: 20386602; PMCID: PMC2850316.
      81. Dharia NV, Chatterjee A, Winzeler E. Genomics and systems biology in malaria drug discovery. Curr Opin Investig Drugs. 2010 Feb; 11(2):131-8. PMID: 20112162.
        View in: PubMed
      82. Westenberger SJ, Cui L, Dharia N, Winzeler E, Cui L. Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes. BMC Genomics. 2009 Dec 16; 10:610. PMID: 20015349; PMCID: PMC2801526.
      83. Winzeler E. Advances in parasite genomics: from sequences to regulatory networks. PLoS Pathog. 2009 Oct; 5(10):e1000649. PMID: 19876395; PMCID: PMC2764844.
      84. Wu T, Nagle A, Sakata T, Henson K, Borboa R, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, Isbell J, Deng X, Gray NS, Tully DC, Chatterjee AK. Cell-based optimization of novel benzamides as potential antimalarial leads. Bioorg Med Chem Lett. 2009 Dec 15; 19(24):6970-4. PMID: 19879133; PMCID: PMC3532596.
      85. Wirth D, Daily J, Winzeler E, Mesirov JP, Regev A. In vivo profiles in malaria are consistent with a novel physiological state. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):E70; author reply E71-2. PMID: 19570993; PMCID: PMC2708753.
      86. Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler E. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol. 2009 Feb 13; 10(2):R21. PMID: 19216790.
        View in: PubMed
      87. Le Roch KG, Johnson JR, Ahiboh H, Chung DW, Prudhomme J, Plouffe D, Henson K, Zhou Y, Witola W, Yates JR, Mamoun CB, Winzeler E, Vial H. A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. BMC Genomics. 2008 Oct 30; 9:513. PMID: 18973684; PMCID: PMC2596145.
      88. Winzeler E. Malaria research in the post-genomic era. Nature. 2008 Oct 09; 455(7214):751-6. PMID: 18843360; PMCID: PMC2705782.
      89. Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, Trager R, Caldwell JS, Schultz PG, Zhou Y, Winzeler E. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):9059-64. PMID: 18579783; PMCID: PMC2440361.
      90. Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler E. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol. 2008 Jun; 4(6):347-56. PMID: 18454143.
        View in: PubMed
      91. Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, Winzeler E. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One. 2008 Feb 13; 3(2):e1570. PMID: 18270564; PMCID: PMC2215772.
      92. Young JA, Johnson JR, Benner C, Yan SF, Chen K, Le Roch KG, Zhou Y, Winzeler E. In silico discovery of transcription regulatory elements in Plasmodium falciparum. BMC Genomics. 2008 Feb 07; 9:70. PMID: 18257930; PMCID: PMC2268928.
      93. Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D, Winzeler E, Mesirov JP, Regev A. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007 Dec 13; 450(7172):1091-5. PMID: 18046333.
        View in: PubMed
      94. Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler E, Fujii H, Fontoura BM, Nussenzweig V. Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell. 2007 Nov 02; 131(3):492-504. PMID: 17981117.
        View in: PubMed
      95. Sakata T, Winzeler E. Genomics, systems biology and drug development for infectious diseases. Mol Biosyst. 2007 Dec; 3(12):841-8. PMID: 18000561.
        View in: PubMed
      96. Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. Am J Trop Med Hyg. 2007 Aug; 77(2):201-8. PMID: 17690387.
        View in: PubMed
      97. Kumar KA, Garcia CR, Chandran VR, Van Rooijen N, Zhou Y, Winzeler E, Nussenzweig V. Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity. Mol Biochem Parasitol. 2007 Nov; 156(1):32-40. PMID: 17714805.
        View in: PubMed
      98. Zhou Y, Zhou B, Chen K, Yan SF, King FJ, Jiang S, Winzeler E. Large-scale annotation of small-molecule libraries using public databases. J Chem Inf Model. 2007 Jul-Aug; 47(4):1386-94. PMID: 17608408.
        View in: PubMed
      99. Gunasekera AM, Myrick A, Le Roch K, Winzeler E, Wirth DF. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol. 2007 Sep; 117(1):87-92. PMID: 17475254.
        View in: PubMed
      100. Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol Biochem Parasitol. 2007 May; 153(1):19-30. PMID: 17307259.
        View in: PubMed
      101. Kidgell C, Winzeler E. Using the genome to dissect the molecular basis of drug resistance. Future Microbiol. 2006 Aug; 1(2):185-99. PMID: 17661664.
        View in: PubMed
      102. Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler E. A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog. 2006 Jun; 2(6):e57. PMID: 16789840; PMCID: PMC1480597.
      103. Winzeler E. Applied systems biology and malaria. Nat Rev Microbiol. 2006 Feb; 4(2):145-51. PMID: 16362033.
        View in: PubMed
      104. Carret CK, Horrocks P, Konfortov B, Winzeler E, Qureshi M, Newbold C, Ivens A. Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays. Mol Biochem Parasitol. 2005 Dec; 144(2):177-86. PMID: 16174539.
        View in: PubMed
      105. Young JA, Fivelman QL, Blair PL, de la Vega P, Le Roch KG, Zhou Y, Carucci DJ, Baker DA, Winzeler E. The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Mol Biochem Parasitol. 2005 Sep; 143(1):67-79. PMID: 16005087.
        View in: PubMed
      106. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler E, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7. PMID: 16123303.
        View in: PubMed
      107. Simpson KM, Baum J, Good RT, Winzeler E, Cowman AF, Speed TP. A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays. Int J Parasitol. 2005 Apr 30; 35(5):523-31. PMID: 15826644.
        View in: PubMed
      108. Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler E, Wirth DF. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis. 2005 Apr 01; 191(7):1196-203. PMID: 15747257; PMCID: PMC2582152.
      109. Kidgell C, Winzeler E. Elucidating genetic diversity with oligonucleotide arrays. Chromosome Res. 2005; 13(3):225-35. PMID: 15868417.
        View in: PubMed
      110. Young JA, Winzeler E. Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum. Pharmacogenomics. 2005 Jan; 6(1):17-26. PMID: 15723602.
        View in: PubMed
      111. O'Neill BM, Hanway D, Winzeler E, Romesberg FE. Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Res. 2004; 32(22):6519-30. PMID: 15598824; PMCID: PMC545462.
      112. Zhou Y, Young JA, Santrosyan A, Chen K, Yan SF, Winzeler E. In silico gene function prediction using ontology-based pattern identification. Bioinformatics. 2005 Apr 01; 21(7):1237-45. PMID: 15531612.
        View in: PubMed
      113. Le Roch KG, Johnson JR, Florens L, Zhou Y, Santrosyan A, Grainger M, Yan SF, Williamson KC, Holder AA, Carucci DJ, Yates JR, Winzeler E. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res. 2004 Nov; 14(11):2308-18. PMID: 15520293; PMCID: PMC525690.
      114. Daily JP, Le Roch KG, Sarr O, Fang X, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler E, Wirth DF. In vivo transcriptional profiling of Plasmodium falciparum. Malar J. 2004 Aug 05; 3:30. PMID: 15296511; PMCID: PMC514566.
      115. Sam-Yellowe TY, Florens L, Johnson JR, Wang T, Drazba JA, Le Roch KG, Zhou Y, Batalov S, Carucci DJ, Winzeler E, Yates JR. A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Res. 2004 Jun; 14(6):1052-9. PMID: 15140830; PMCID: PMC419783.
      116. Barrera L, Benner C, Tao YC, Winzeler E, Zhou Y. Leveraging two-way probe-level block design for identifying differential gene expression with high-density oligonucleotide arrays. BMC Bioinformatics. 2004 Apr 20; 5:42. PMID: 15099405; PMCID: PMC411067.
      117. Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, Haynes JD, De La Vega P, Holder AA, Batalov S, Carucci DJ, Winzeler E. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science. 2003 Sep 12; 301(5639):1503-8. PMID: 12893887.
        View in: PubMed
      118. Washburn MP, Koller A, Oshiro G, Ulaszek RR, Plouffe D, Deciu C, Winzeler E, Yates JR. Protein pathway and complex clustering of correlated mRNA and protein expression analyses in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3107-12. PMID: 12626741; PMCID: PMC152254.
      119. Borevitz JO, Liang D, Plouffe D, Chang HS, Zhu T, Weigel D, Berry CC, Winzeler E, Chory J. Large-scale identification of single-feature polymorphisms in complex genomes. Genome Res. 2003 Mar; 13(3):513-23. PMID: 12618383; PMCID: PMC430246.
      120. Winzeler E, Castillo-Davis CI, Oshiro G, Liang D, Richards DR, Zhou Y, Hartl DL. Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics. 2003 Jan; 163(1):79-89. PMID: 12586698; PMCID: PMC1462430.
      121. Williams RM, Primig M, Washburn BK, Winzeler E, Bellis M, Sarrauste de Menthiere C, Davis RW, Esposito RE. The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13431-6. PMID: 12370439; PMCID: PMC129690.
      122. Volkman SK, Hartl DL, Wirth DF, Nielsen KM, Choi M, Batalov S, Zhou Y, Plouffe D, Le Roch KG, Abagyan R, Winzeler E. Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science. 2002 Oct 04; 298(5591):216-8. PMID: 12364807.
        View in: PubMed
      123. Grünenfelder B, Winzeler E. Treasures and traps in genome-wide data sets: case examples from yeast. Nat Rev Genet. 2002 Sep; 3(9):653-61. PMID: 12209140.
        View in: PubMed
      124. Le Roch KG, Zhou Y, Batalov S, Winzeler E. Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. Am J Trop Med Hyg. 2002 Sep; 67(3):233-43. PMID: 12408661.
        View in: PubMed
      125. Oshiro G, Wodicka LM, Washburn MP, Yates JR, Lockhart DJ, Winzeler E. Parallel identification of new genes in Saccharomyces cerevisiae. Genome Res. 2002 Aug; 12(8):1210-20. PMID: 12176929; PMCID: PMC186640.
      126. Hanway D, Chin JK, Xia G, Oshiro G, Winzeler E, Romesberg FE. Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10605-10. PMID: 12149442; PMCID: PMC124988.
      127. Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Güldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kötter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler E, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 2002 Jul 25; 418(6896):387-91. PMID: 12140549.
        View in: PubMed
      128. Hartl DL, Volkman SK, Nielsen KM, Barry AE, Day KP, Wirth DF, Winzeler E. The paradoxical population genetics of Plasmodium falciparum. Trends Parasitol. 2002 Jun; 18(6):266-72. PMID: 12036741.
        View in: PubMed
      129. Que QQ, Winzeler E. Large-scale mutagenesis and functional genomics in yeast. Funct Integr Genomics. 2002 Sep; 2(4-5):193-8. PMID: 12192592.
        View in: PubMed
      130. Karlyshev AV, Oyston PC, Williams K, Clark GC, Titball RW, Winzeler E, Wren BW. Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. Infect Immun. 2001 Dec; 69(12):7810-9. PMID: 11705963; PMCID: PMC98877.
      131. Raghuraman MK, Winzeler E, Collingwood D, Hunt S, Wodicka L, Conway A, Lockhart DJ, Davis RW, Brewer BJ, Fangman WL. Replication dynamics of the yeast genome. Science. 2001 Oct 05; 294(5540):115-21. PMID: 11588253.
        View in: PubMed
      132. Primig M, Williams RM, Winzeler E, Tevzadze GG, Conway AR, Hwang SY, Davis RW, Esposito RE. The core meiotic transcriptome in budding yeasts. Nat Genet. 2000 Dec; 26(4):415-23. PMID: 11101837.
        View in: PubMed
      133. Oshiro G, Winzeler E. Aneuploidy--it's more common than you think. Nat Biotechnol. 2000 Jul; 18(7):715-6. PMID: 10888835.
        View in: PubMed
      134. Lockhart DJ, Winzeler E. Genomics, gene expression and DNA arrays. Nature. 2000 Jun 15; 405(6788):827-36. PMID: 10866209.
        View in: PubMed
      135. Winzeler E, Liang H, Shoemaker DD, Davis RW. Functional analysis of the yeast genome by precise deletion and parallel phenotypic characterization. Novartis Found Symp. 2000; 229:105-9; discussion 109-11. PMID: 11084935.
        View in: PubMed
      136. Winzeler E, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Liebundguth N, Lockhart DJ, Lucau-Danila A, Lussier M, M'Rabet N, Menard P, Mittmann M, Pai C, Rebischung C, Revuelta JL, Riles L, Roberts CJ, Ross-MacDonald P, Scherens B, Snyder M, Sookhai-Mahadeo S, Storms RK, Véronneau S, Voet M, Volckaert G, Ward TR, Wysocki R, Yen GS, Yu K, Zimmermann K, Philippsen P, Johnston M, Davis RW. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science. 1999 Aug 06; 285(5429):901-6. PMID: 10436161.
        View in: PubMed
      137. Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler E, Astromoff A, Davis RW. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat Genet. 1999 Mar; 21(3):278-83. PMID: 10080179.
        View in: PubMed
      138. Winzeler E, Schena M, Davis RW. Fluorescence-based expression monitoring using microarrays. Methods Enzymol. 1999; 306:3-18. PMID: 10432445.
        View in: PubMed
      139. Winzeler E, Lee B, McCusker JH, Davis RW. Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology. 1999; 118 Suppl:S73-80. PMID: 10466139.
        View in: PubMed
      140. Winzeler E, Richards DR, Conway AR, Goldstein AL, Kalman S, McCullough MJ, McCusker JH, Stevens DA, Wodicka L, Lockhart DJ, Davis RW. Direct allelic variation scanning of the yeast genome. Science. 1998 Aug 21; 281(5380):1194-7. PMID: 9712584.
        View in: PubMed
      141. Cho RJ, Campbell MJ, Winzeler E, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 1998 Jul; 2(1):65-73. PMID: 9702192.
        View in: PubMed
      142. Winzeler E, Davis RW. Functional analysis of the yeast genome. Curr Opin Genet Dev. 1997 Dec; 7(6):771-6. PMID: 9468786.
        View in: PubMed
      143. Winzeler E, Wheeler R, Shapiro L. Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype. J Mol Biol. 1997 Oct 10; 272(5):665-76. PMID: 9368649.
        View in: PubMed
      144. Winzeler E, Shapiro L. Translation of the leaderless Caulobacter dnaX mRNA. J Bacteriol. 1997 Jun; 179(12):3981-8. PMID: 9190815; PMCID: PMC179208.
      145. Winzeler E, Shapiro L. A novel promoter motif for Caulobacter cell cycle-controlled DNA replication genes. J Mol Biol. 1996 Dec 06; 264(3):412-25. PMID: 8969294.
        View in: PubMed
      146. Winzeler E, Shapiro L. Use of flow cytometry to identify a Caulobacter 4.5 S RNA temperature-sensitive mutant defective in the cell cycle. J Mol Biol. 1995 Aug 18; 251(3):346-65. PMID: 7544413.
        View in: PubMed
      147. Winzeler E, Small EW. Fluorescence anisotropy decay of ethidium bound to nucleosome core particles. 2. The torsional motion of the DNA is highly constrained and sensitive to pH. Biochemistry. 1991 May 28; 30(21):5304-13. PMID: 2036397.
        View in: PubMed
      Elizabeth's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _