Edward Koo

Title(s)Recall Faculty, Neurosciences
SchoolVc-health Sciences-schools
Address9500 Gilman Drive #
La Jolla CA 92093
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    Multidisciplinary training in basic and translational Alzheimer's disease research
    NIH T32AG066596May 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Mechanisms of abeta induced dysfunction in hippocampal neuronal circuitry
    NIH R01NS084324Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator
    Abeta42 Altering Compounds: Mechanisms of Action
    NIH R01AG029886Aug 1, 2008 - May 31, 2009
    Role: Principal Investigator
    Synaptic damage in models of beta-amyloid associated pathology
    NIH R01AG032179Sep 15, 2007 - Aug 31, 2013
    Role: Principal Investigator
    Novel Mechanisms of NSAID Action in Alzheimer's Disease
    NIH P01AG020206Apr 1, 2002 - Jun 30, 2015
    Role: Principal Investigator
    APP INTERNALIZATION--PREREQUISITE FOR ABETA FORMATION?
    NIH K04NS001812May 1, 1996 - Apr 30, 2001
    Role: Principal Investigator
    APP Trafficking and the Pathways of A Beta Formation
    NIH R01AG012376Sep 1, 1994 - Dec 31, 2008
    Role: Principal Investigator
    Training in the Neuroplasticity of Aging
    NIH T32AG000216Sep 30, 1992 - Apr 30, 2018
    Role: Principal Investigator
    UCSD Alzheimer's Disease Research Center P50
    NIH P50AG005131Sep 28, 1984 - Mar 31, 2020
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Localized APP expression results in progressive network dysfunction by disorganizing spike timing. Neuron. 2024 Jan 03; 112(1):124-140.e6. Viana da Silva S, Haberl MG, Gaur K, Patel R, Narayan G, Ledakis M, Fu ML, de Castro Vieira M, Koo EH, Leutgeb JK, Leutgeb S. PMID: 37909036; PMCID: PMC10877582.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons. iScience. 2023 Nov 17; 26(11):108152. Ho WY, Chak LL, Hor JH, Liu F, Diaz-Garcia S, Chang JC, Sanford E, Rodriguez MJ, Alagappan D, Lim SM, Cho YL, Shimizu Y, Sun AX, Tyan SH, Koo E, Kim SH, Ravits J, Ng SY, Okamura K, Ling SC. PMID: 37920668; PMCID: PMC10618709.
      View in: PubMed   Mentions:
    3. APP family member dimeric complexes are formed predominantly in synaptic compartments. Cell Biosci. 2023 Aug 02; 13(1):141. Schilling S, August A, Meleux M, Conradt C, Tremmel LM, Teigler S, Adam V, Müller UC, Koo EH, Kins S, Eggert S. PMID: 37533067; PMCID: PMC10398996.
      View in: PubMed   Mentions:
    4. Evidence for a clathrin-independent endocytic pathway for APP internalization in the neuronal somatodendritic compartment. Cell Rep. 2023 07 25; 42(7):112774. Aow J, Huang TR, Goh YT, Sun AX, Thinakaran G, Koo EH. PMID: 37450368; PMCID: PMC10449584.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity. Acta Neuropathol Commun. 2023 06 01; 11(1):87. Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S, Eggert S. PMID: 37259128; PMCID: PMC10234039.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Chronic cerebral hypoperfusion alters the CypA-EMMPRIN-gelatinase pathway: Implications for vascular dementia. J Cereb Blood Flow Metab. 2023 05; 43(5):722-735. Chai YL, Rajeev V, Poh L, Selvaraji S, Hilal S, Chen CP, Jo DG, Koo EH, Arumugam TV, Lai MK. PMID: 36537035; PMCID: PMC10108186.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    7. Enhanced cleavage of APP by co-expressed Bace1 alters the distribution of APP and its fragments in neuronal and non-neuronal cells. Mol Neurobiol. 2022 May; 59(5):3073-3090. Aow J, Huang TR, Thinakaran G, Koo EH. PMID: 35266114.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)-pilot: A feasibility study. Alzheimers Dement (N Y). 2021; 7(1):e12141. Chew KA, Xu X, Siongco P, Villaraza S, Phua AKS, Wong ZX, Chung CY, Tang N, Chew E, Henry CJ, Koo E, Chen C. PMID: 33748399; PMCID: PMC7958306.
      View in: PubMed   Mentions: 5  
    9. Machine learning classifies predictive kinematic features in a mouse model of neurodegeneration. Sci Rep. 2021 02 17; 11(1):3950. Huang R, Nikooyan AA, Xu B, Joseph MS, Damavandi HG, von Trotha N, Li L, Bhattarai A, Zadeh D, Seo Y, Liu X, Truong PA, Koo EH, Leiter JC, Lu DC. PMID: 33597593; PMCID: PMC7889656.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    10. Dysfunction in nonsense-mediated decay, protein homeostasis, mitochondrial function, and brain connectivity in ALS-FUS mice with cognitive deficits. Acta Neuropathol Commun. 2021 01 06; 9(1):9. Ho WY, Agrawal I, Tyan SH, Sanford E, Chang WT, Lim K, Ong J, Tan BSY, Moe AAK, Yu R, Wong P, Tucker-Kellogg G, Koo E, Chuang KH, Ling SC. PMID: 33407930; PMCID: PMC7789430.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    11. World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia. Alzheimers Dement. 2020 07; 16(7):1078-1094. Kivipelto M, Mangialasche F, Snyder HM, Allegri R, Andrieu S, Arai H, Baker L, Belleville S, Brodaty H, Brucki SM, Calandri I, Caramelli P, Chen C, Chertkow H, Chew E, Choi SH, Chowdhary N, Crivelli L, Torre R, Du Y, Dua T, Espeland M, Feldman HH, Hartmanis M, Hartmann T, Heffernan M, Henry CJ, Hong CH, Håkansson K, Iwatsubo T, Jeong JH, Jimenez-Maggiora G, Koo EH, Launer LJ, Lehtisalo J, Lopera F, Martínez-Lage P, Martins R, Middleton L, Molinuevo JL, Montero-Odasso M, Moon SY, Morales-Pérez K, Nitrini R, Nygaard HB, Park YK, Peltonen M, Qiu C, Quiroz YT, Raman R, Rao N, Ravindranath V, Rosenberg A, Sakurai T, Salinas RM, Scheltens P, Sevlever G, Soininen H, Sosa AL, Suemoto CK, Tainta-Cuezva M, Velilla L, Wang Y, Whitmer R, Whitmer R, Xu X, Bain LJ, Solomon A, Ngandu T, Carrillo MC. PMID: 32627328; PMCID: PMC9527644.
      View in: PubMed   Mentions: 142     Fields:    Translation:Humans
    12. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Rep. 2020 06 30; 31(13):107839. Park G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH. PMID: 32610140; PMCID: PMC7375398.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    13. Presymptomatic Increase of an Extracellular RNA in Blood Plasma Associates with the Development of Alzheimer's Disease. Curr Biol. 2020 05 18; 30(10):1771-1782.e3. Yan Z, Zhou Z, Wu Q, Chen ZB, Koo EH, Zhong S. PMID: 32220323.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    14. PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response. J Biol Chem. 2020 01 03; 295(1):237-249. Hiramatsu N, Chiang K, Aivati C, Rodvold JJ, Lee JM, Han J, Chea L, Zanetti M, Koo EH, Lin JH. PMID: 31792031; PMCID: PMC6952592.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    15. FUS-mediated dysregulation of Sema5a, an autism-related gene, in FUS mice with hippocampus-dependent cognitive deficits. Hum Mol Genet. 2019 11 15; 28(22):3777-3791. Ho WY, Chang JC, Tyan SH, Yen YC, Lim K, Tan BSY, Ong J, Tucker-Kellogg G, Wong P, Koo E, Ling SC. PMID: 31509188.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    16. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain Behav Immun. 2019 08; 80:344-357. Kim J, Selvaraji S, Kang SW, Lee WT, Chen CL, Choi H, Koo EH, Jo DG, Leong Lim K, Lim YA, Arumugam TV. PMID: 30980950.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. 2019 05; 15(5):827-842. Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC. PMID: 30669939; PMCID: PMC6526867.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    18. Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Hum Mol Genet. 2018 11 15; 27(22):3951-3963. Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH. PMID: 30137327; PMCID: PMC6216228.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    19. Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke. Brain Behav Immun. 2019 01; 75:34-47. Poh L, Kang SW, Baik SH, Ng GYQ, She DT, Balaganapathy P, Dheen ST, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV. PMID: 30195027.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    20. Microinterventional endocapsular nucleus disassembly for phacoemulsification-free full-thickness fragmentation. J Cataract Refract Surg. 2018 Aug; 44(8):932-934. Ianchulev T, Chang DF, Koo E, MacDonald S. PMID: 30115295.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    21. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death Differ. 2018 03; 25(4):663-678. Liu C, Zhang CW, Zhou Y, Wong WQ, Lee LC, Ong WY, Yoon SO, Hong W, Fu XY, Soong TW, Koo EH, Stanton LW, Lim KL, Xiao ZC, Dawe GS. PMID: 29238071; PMCID: PMC5864187.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    22. Short Aβ peptides attenuate Aβ42 toxicity in vivo. J Exp Med. 2018 01 02; 215(1):283-301. Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, Rincon-Limas D, Fernandez-Funez P, Golde TE. PMID: 29208777; PMCID: PMC5748850.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    23. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Rep. 2017 Nov 28; 21(9):2614-2627. Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, Ghosh A, Yates JR. PMID: 29186695; PMCID: PMC5726791.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    24. Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps. Bioessays. 2017 09; 39(9). Lee LC, Goh MQL, Koo EH. PMID: 28731260; PMCID: PMC5647194.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    25. APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017 05 24; 37(21):5345-5365. Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC, Kins S, Eggert S. PMID: 28450540; PMCID: PMC6596463.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    26. The Utility of Brief Cognitive Tests for Patients With Type 2 Diabetes Mellitus: A Systematic Review. J Am Med Dir Assoc. 2016 10 01; 17(10):889-95. Dong Y, Kua ZJ, Khoo EY, Koo EH, Merchant RA. PMID: 27461866.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    27. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochem Biophys Res Commun. 2016 09 09; 478(1):286-292. Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo EH. PMID: 27425247.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    28. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS One. 2015; 10(12):e0144758. Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. PMID: 26678856; PMCID: PMC4683055.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    29. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089; PMCID: PMC4782935.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    30. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Front Behav Neurosci. 2015; 9:299. Nizetic D, Chen CL, Hong W, Koo EH. PMID: 26648852; PMCID: PMC4664698.
      View in: PubMed   Mentions: 4  
    31. New tricks from an old dog: Another synaptotoxic fragment from APP. Cell Res. 2015 Nov; 25(11):1185-6. Tyan SH, Koo EH. PMID: 26503171; PMCID: PMC4650427.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimers Res Ther. 2015; 7(1):55. Ling IF, Golde TE, Galasko DR, Koo EH. PMID: 26244059; PMCID: PMC4523931.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    33. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Mol Neurodegener. 2015 Jul 14; 10:29. Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. PMID: 26169917; PMCID: PMC4501119.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E, Alzheimer's Disease Genetics Consortium, Lin CF, Dombroski BA, Cantwell LB, Partch A, Valladares O, Hakonarson H, St George-Hyslop P, Green RC, Goate AM, Foroud TM, Carney RM, Larson EB, Behrens TW, Kauwe JS, Haines JL, Farrer LA, Pericak-Vance MA, Mayeux R, Schellenberg GD, National Institute on Aging-Late-Onset Alzheimer’s Disease (NIA-LOAD) Family Study, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barmada M, Barnes LL, Beach TG, Becker JT, Beecham GW, Beekly D, Bennett DA, Bigio EH, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Burke JR, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carroll SL, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Demirci FY, Dick M, Dickson DW, Duara R, Ertekin-Taner N, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Graff-Radford NR, Growdon JH, Hamilton RL, Hamilton-Nelson KL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jarvik GP, Jicha GA, Jin LW, Jun G, Jun G, Kamboh MI, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lopez OL, Lunetta KL, Lyketsos CG, Mack WJ, Marson DC, Martin ER, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam WM, Miller BL, Miller CA, Miller JW, Montine TJ, Morris JC, Murrell JR, Olichney JM, Parisi JE, Perry W, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25531812; PMCID: PMC4324097.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    35. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. PMID: 25285942; PMCID: PMC4374637.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    36. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA, Alzheimer Disease Genetics Consortium, Albert MS, Albin RL, Apostolova LG, Arnold SE, Barber R, Barnes LL, Beach TG, Becker JT, Beekly D, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carney RM, Carrasquillo MM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cribbs DH, Crocco EA, DeCarli C, DeKosky ST, Dick M, Dickson DW, Duara R, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lin CF, Lopez OL, Lyketsos CG, Mack WJ, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Murrell JR, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Peskind E, Petersen RC, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosen HJ, Rosenberg RN, Sano M, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Valladares O, Van Deerlin VM, Van Eldik LJ, Vardarajan BN, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Wishnek S, Woltjer RL, Wright CB, Younkin SG, Yu CE, Yu L. PMID: 25199842; PMCID: PMC4314944.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    37. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. PLoS One. 2014; 9(10):e111553. Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y. PMID: 25350374; PMCID: PMC4211736.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    38. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol. 2015 Jan; 129(1):1-19. Nhan HS, Chiang K, Koo EH. PMID: 25287911; PMCID: PMC4282969.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimals
    39. Neurotoxic effects of dexmedetomidine in fetal cynomolgus monkey brains. J Toxicol Sci. 2014 Apr; 39(2):251-62. Koo E, Oshodi T, Meschter C, Ebrahimnejad A, Dong G. PMID: 24646706.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    40. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 2014 Apr 01; 53(12):1947-57. Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE. PMID: 24620716; PMCID: PMC3985764.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    41. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. PLoS One. 2014; 9(1):e84349. Wilke SA, Raam T, Antonios JK, Bushong EA, Koo EH, Ellisman MH, Ghosh A. PMID: 24454724; PMCID: PMC3890281.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    42. Emerging therapeutics for Alzheimer's disease. Annu Rev Pharmacol Toxicol. 2014; 54:381-405. Chiang K, Koo EH. PMID: 24392696.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    43. The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis? Bioessays. 2013 Oct; 35(10):844. Nhan HS, Koo EH. PMID: 24078548.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    44. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013 Sep 25; 33(39):15596-602. Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. PMID: 24068826; PMCID: PMC3782628.
      View in: PubMed   Mentions: 78     Fields:    Translation:Animals
    45. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 2013 Aug 07; 79(3):447-60. Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. PMID: 23931995; PMCID: PMC3741682.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    46. γ-Secretase inhibitors and modulators. Biochim Biophys Acta. 2013 Dec; 1828(12):2898-907. Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. PMID: 23791707; PMCID: PMC3857966.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    47. Steroids as γ-secretase modulators. FASEB J. 2013 Sep; 27(9):3775-85. Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. PMID: 23716494; PMCID: PMC3752532.
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