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    David Cauvi

    TitleAssociate Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentSurgery
    Address9500 Gilman Drive #0739
    CA La Jolla 92093
    Phone858-822-6504
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Aix-Marseille II UniversityB. Sc. Immunology1994
      Aix-Marseille II UniversityM. Sc. Immunology1996
      Aix-Marseille II UniversityPh. D. Molecular and Cellular Endocrinology2001
      The Scripps Research InstitutePost-doctoral Fellow2001Allergic response
      The Scripps Research InstituteSenior Post-doctoral Fellow2004Autoimmunity

      Collapse Overview 
      Collapse Overview
      B. Sc. Immunology, 1994, Aix-Marseille II University, Marseille, France
      M. Sc. Immunology, 1996, Aix-Marseille II University, Marseille, France
      Ph. D. Molecular and Cellular Endocrinology, 2001, Aix-Marseille II University, Marseille, France
      Post-doctoral Fellow, 2001, Allergic response, The Scripps Research Institute, La Jolla
      Senior Post-doctoral Fellow, 2004, Autoimmunity, The Scripps Research Institute, La Jolla

      Research Interests:
      1. The inflammatory response in sepsis.
      2. Xenobiotic-induced autoimmunity (Systemic Lupus Erythematosus, in collaboration with investigators at The Scripps Research Institute)


      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rivera I, Capone R, Cauvi D, Arispe N, De Maio A. Modulation of Alzheimer's amyloid ß peptide oligomerization and toxicity by extracellular Hsp70. Cell Stress Chaperones. 2017 Sep 27. PMID: 28956268.
        View in: PubMed
      2. Halbach JL, Wang AW, Hawisher D, Cauvi D, Lizardo RE, Rosas J, Reyes T, Escobedo O, Bickler SW, Coimbra R, De Maio A. Why Is Antibiotic Treatment Not Enough for Sepsis Resolution? An Evaluation in an Experimental Animal Model. Infect Immun. 2017 Sep 25. PMID: 28947644.
        View in: PubMed
      3. Cauvi D, Cauvi G, Toomey CB, Jacquinet E, Pollard KM. Interplay between IFN-? and IL-6 impacts the inflammatory response and expression of interferon-regulated genes in environmental-induced autoimmunity. Toxicol Sci. 2017 04 26. PMID: 28453771.
        View in: PubMed
      4. Chang P, Mo B, Cauvi D, Yu Y, Guo Z, Zhou J, Huang Q, Yan Q, Chen G, Liu Z. Grape seed proanthocyanidin extract protects lymphocytes against histone-induced apoptosis. PeerJ. 2017; 5:e3108. PMID: 28344907.
        View in: PubMed
      5. Bickler SW, Lizardo E, Cauvi D, De Maio A. The transition from a rural to an urban environment in Africa alters G protein-coupled receptor signaling. Med Hypotheses. 2016 Oct; 95:49-53. PMID: 27692166.
        View in: PubMed
      6. Lopez V, Cauvi D, Arispe N, De Maio A. Bacterial Hsp70 (DnaK) and mammalian Hsp70 interact differently with lipid membranes. Cell Stress Chaperones. 2016 07; 21(4):609-16. PMID: 27075190; PMCID: PMC4907991 [Available on 01/01/17].
      7. Williams MR, Cauvi D, Rivera I, Hawisher D, De Maio A. Changes in macrophage function modulated by the lipid environment. Innate Immun. 2016 Apr; 22(3):141-51. PMID: 26951856.
        View in: PubMed
      8. Kao S, Shaterian A, Cauvi D, Dang X, Chun HB, De Maio A, Costantini TW, Coimbra R, Eliceiri BP, Baird A. Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung. Exp Lung Res. 2015 Apr; 41(3):162-72. PMID: 25513848; PMCID: PMC4524537.
      9. Toomey CB, Cauvi D, Hamel JC, Ramirez AE, Pollard KM. Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity. Toxicol Sci. 2014 Dec; 142(2):339-49. PMID: 25237059; PMCID: PMC4250846.
      10. Vazquez DE, Niño DF, De Maio A, Cauvi D. Sustained expression of lipocalin-2 during polymicrobial sepsis. Innate Immun. 2015 Jul; 21(5):477-89. PMID: 25227123.
        View in: PubMed
      11. Cauvi D, Williams MR, Bermudez JA, Armijo G, De Maio A. Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis. Shock. 2014 Sep; 42(3):246-55. PMID: 24978886; PMCID: PMC4134380.
      12. Niño DF, Cauvi D, De Maio A. Itraconazole, a commonly used antifungal, inhibits Fc? receptor-mediated phagocytosis: alteration of Fc? receptor glycosylation and gene expression. Shock. 2014 Jul; 42(1):52-9. PMID: 24667630; PMCID: PMC4071940.
      13. Armijo G, Okerblom J, Cauvi D, Lopez V, Schlamadinger DE, Kim J, Arispe N, De Maio A. Interaction of heat shock protein 70 with membranes depends on the lipid environment. Cell Stress Chaperones. 2014 Nov; 19(6):877-86. PMID: 24789271; PMCID: PMC4389847.
      14. Cauvi D, Gabriel R, Kono DH, Hultman P, Pollard KM. A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity. Autoimmune Dis. 2014; 2014:260613. PMID: 24818014; PMCID: PMC4003777.
      15. Toomey CB, Cauvi D, Pollard KM. The role of decay accelerating factor in environmentally induced and idiopathic systemic autoimmune disease. Autoimmune Dis. 2014; 2014:452853. PMID: 24592327; PMCID: PMC3921935.
      16. Pollard KM, Cauvi D, Toomey CB, Morris KV, Kono DH. Interferon-? and systemic autoimmunity. Discov Med. 2013 Sep; 16(87):123-31. PMID: 23998448; PMCID: PMC3934799.
      17. Drummond R, Cauvi D, Hawisher D, Song D, Niño DF, Coimbra R, Bickler S, De Maio A. Deletion of scavenger receptor A gene in mice resulted in protection from septic shock and modulation of TLR4 signaling in isolated peritoneal macrophages. Innate Immun. 2013 Feb; 19(1):30-41. PMID: 22751446; PMCID: PMC4349423.
      18. Pollard KM, Hultman P, Toomey CB, Cauvi D, Hoffman HM, Hamel JC, Kono DH. Definition of IFN-?-related pathways critical for chemically-induced systemic autoimmunity. J Autoimmun. 2012 Dec; 39(4):323-31. PMID: 22578563; PMCID: PMC3570757.
      19. Cauvi D, Song D, Vazquez DE, Hawisher D, Bermudez JA, Williams MR, Bickler S, Coimbra R, De Maio A. Period of irreversible therapeutic intervention during sepsis correlates with phase of innate immune dysfunction. J Biol Chem. 2012 Jun 08; 287(24):19804-15. PMID: 22518839; PMCID: PMC3370166.
      20. Cauvi D, Toomey CB, Pollard KM. Depletion of complement does not impact initiation of xenobiotic-induced autoimmune disease. Immunology. 2012 Apr; 135(4):333-43. PMID: 22136142; PMCID: PMC3372748.
      21. Pollard KM, Hultman P, Toomey CB, Cauvi D, Kono DH, Konoc DH. ß2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity. J Immunotoxicol. 2011 Jul-Sep; 8(3):228-37. PMID: 21793797; PMCID: PMC3257888.
      22. Drummond R, Song D, Hawisher D, Wolf PL, Vazquez DE, Nino DF, Coimbra R, Cauvi D, De Maio A. Acute acalculous cholecystitis-like phenotype in scavenger receptor A knock-out mice. J Surg Res. 2012 May 15; 174(2):344-51. PMID: 21474146; PMCID: PMC3173564.
      23. Grabowski J, Vazquez DE, Costantini T, Cauvi D, Charles W, Bickler S, Talamini MA, Vega VL, Coimbra R, De Maio A. Tumor necrosis factor expression is ameliorated after exposure to an acidic environment. J Surg Res. 2012 Mar; 173(1):127-34. PMID: 20888586; PMCID: PMC3017641.
      24. Toomey CB, Cauvi D, Song WC, Pollard KM. Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity. Immunology. 2010 Sep; 131(1):99-106. PMID: 20408894; PMCID: PMC2966762.
      25. Cauvi D, Cauvi G, Pollard KM. Reduced expression of decay-accelerating factor 1 on CD4+ T cells in murine systemic autoimmune disease. Arthritis Rheum. 2007 Jun; 56(6):1934-44. PMID: 17530719.
        View in: PubMed
      26. Cauvi D, Cauvi G, Pollard KM. Constitutive expression of murine decay-accelerating factor 1 is controlled by the transcription factor Sp1. J Immunol. 2006 Sep 15; 177(6):3837-47. PMID: 16951346; PMCID: PMC1766464.
      27. Cauvi D, Tian X, von Loehneysen K, Robertson MW. Transport of the IgE receptor alpha-chain is controlled by a multicomponent intracellular retention signal. J Biol Chem. 2006 Apr 14; 281(15):10448-60. PMID: 16459334.
        View in: PubMed
      28. Nlend MC, Cauvi D, Venot N, Chabaud O. Role of sulfated tyrosines of thyroglobulin in thyroid hormonosynthesis. Endocrinology. 2005 Nov; 146(11):4834-43. PMID: 16037381.
        View in: PubMed
      29. Cauvi D, Venot N, Nlend MC, Chabaud OM. Thyrotropin and iodide regulate sulfate concentration in thyroid cells. Relationship to thyroglobulin sulfation. Can J Physiol Pharmacol. 2003 Dec; 81(12):1131-8. PMID: 14719032.
        View in: PubMed
      30. Venot N, Nlend MC, Cauvi D, Chabaud O. The hormonogenic tyrosine 5 of porcine thyroglobulin is sulfated. Biochem Biophys Res Commun. 2002 Oct 25; 298(2):193-7. PMID: 12387814.
        View in: PubMed
      31. Cauvi D, Nlend MC, Venot N, Chabaud O. Sulfate transport in porcine thyroid cells. Effects of thyrotropin and iodide. Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E440-8. PMID: 11500298.
        View in: PubMed
      32. Cauvi D, Penel C, Nlend MC, Venot N, Allasia C, Chabaud O. Regulation of thyroid cell volumes and fluid transport: opposite effects of TSH and iodide on cultured cells. Am J Physiol Endocrinol Metab. 2000 Sep; 279(3):E546-53. PMID: 10950821.
        View in: PubMed
      33. Nlend MC, Cauvi D, Venot N, Chabaud O. Sulfated tyrosines of thyroglobulin are involved in thyroid hormone synthesis. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):193-7. PMID: 10448091.
        View in: PubMed
      34. Nlend MC, Cauvi D, Venot N, Desruisseau S, Chabaud O. Thyrotropin regulates tyrosine sulfation of thyroglobulin. Eur J Endocrinol. 1999 Jul; 141(1):61-9. PMID: 10407225.
        View in: PubMed
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