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    Darren Casteel

    SchoolUniversity of California, San Diego
    Address9500 Gilman Drive #0652
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Study of mTOR Regulation by Rheb Using Deuterium Exchange Mass Spectrometry
      NIH/NCI K22CA124517Sep 17, 2007 - Aug 31, 2011
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kalyanaraman H, Zhuang S, Pilz RB, Casteel D. The activity of cGMP-dependent protein kinase Ia is not directly regulated by oxidation-induced disulfide formation at cysteine 43. J Biol Chem. 2017 May 19; 292(20):8262-8268. PMID: 28360102.
        View in: PubMed
      2. Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel D, Boss GR, Hansel DE. Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2a Activity and Is Targetable by Pegylated Arginine Deiminase. Am J Pathol. 2016 Dec 09. PMID: 27979310.
        View in: PubMed
      3. Cho KJ, Casteel D, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 Dec 15; 36(24):3086-3099. PMID: 27697864.
        View in: PubMed
      4. Cividini F, Scott BT, Dai A, Han W, Suarez J, Diaz-Juarez J, Diemer T, Casteel D, Dillmann WH. O-GlcNAcylation of 8-Oxoguanine DNA Glycosylase (Ogg1) Impairs Oxidative Mitochondrial DNA Lesion Repair in Diabetic Hearts. J Biol Chem. 2016 Dec 16; 291(51):26515-26528. PMID: 27816939.
        View in: PubMed
      5. Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel D, Pilz RB. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 Jan; 32(1):46-59. PMID: 27391172.
        View in: PubMed
      6. Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel D, Herberg FW, Kim C. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 2016 May 03; 24(5):710-720. PMID: 27066748; PMCID: PMC4856591 [Available on 05/03/17].
      7. Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel D, Kim C. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-33. PMID: 26769964; PMCID: PMC4786703 [Available on 03/11/17].
      8. Qin L, Reger AS, Guo E, Yang MP, Zwart P, Casteel D, Kim C. Structures of cGMP-Dependent Protein Kinase (PKG) Ia Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. Biochemistry. 2015 Jul 28; 54(29):4419-22. PMID: 26132214; PMCID: PMC4838416.
      9. Reger AS, Yang MP, Koide-Yoshida S, Guo E, Mehta S, Yuasa K, Liu A, Casteel D, Kim C. Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. J Biol Chem. 2014 Sep 12; 289(37):25393-403. PMID: 25070890; PMCID: PMC4162144.
      10. Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel D, Frangos JA, Dillmann W, Boss GR, Pilz RB. Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor. Sci Signal. 2014 May 20; 7(326):ra48. PMID: 24847117.
        View in: PubMed
      11. Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel D, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure. 2014 Jan 07; 22(1):116-24. PMID: 24239458; PMCID: PMC4019043.
      12. Fridman A, Saha A, Chan A, Casteel D, Pilz RB, Boss GR. Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate. Biochem J. 2013 Aug 15; 454(1):91-9. PMID: 23734909.
        View in: PubMed
      13. Guo DC, Regalado E, Casteel D, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA, Kim C, Milewicz DM. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 Aug 08; 93(2):398-404. PMID: 23910461; PMCID: PMC3738837.
      14. Schwappacher R, Rangaswami H, Su-Yuo J, Hassad A, Spitler R, Casteel D. cGMP-dependent protein kinase Iß regulates breast cancer cell migration and invasion via interaction with the actin/myosin-associated protein caldesmon. J Cell Sci. 2013 Apr 01; 126(Pt 7):1626-36. PMID: 23418348; PMCID: PMC3647439.
      15. Casteel D, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB. Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration. J Biol Chem. 2012 Nov 02; 287(45):38367-78. PMID: 22992742; PMCID: PMC3488105.
      16. Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel D, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 2011; 79 Suppl 10:6-20. PMID: 22020785; PMCID: PMC3692002.
      17. Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel D, Woods VL, Kornev AP, Taylor SS, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure. 2011 Sep 07; 19(9):1317-27. PMID: 21893290; PMCID: PMC3168983.
      18. Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel D. The amino terminus of cGMP-dependent protein kinase Iß increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52. PMID: 21643460.
        View in: PubMed
      19. Kim JJ, Casteel D, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim C. Co-crystal structures of PKG Iß (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413. PMID: 21526164; PMCID: PMC3080414.
      20. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel D, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB. Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts. Sci Signal. 2010 Dec 21; 3(153):ra91. PMID: 21177494; PMCID: PMC3093297.
      21. Casteel D, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C. A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem. 2010 Oct 22; 285(43):32684-8. PMID: 20826808; PMCID: PMC2963381.
      22. Casteel D, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. A DNA polymerase-{alpha}{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem. 2009 Feb 27; 284(9):5807-18. PMID: 19119139; PMCID: PMC2645831.
      23. Casteel D, Zhang T, Zhuang S, Pilz RB. cGMP-dependent protein kinase anchoring by IRAG regulates its nuclear translocation and transcriptional activity. Cell Signal. 2008 Jul; 20(7):1392-9. PMID: 18450420; PMCID: PMC2477739.
      24. Zhang T, Zhuang S, Casteel D, Looney DJ, Boss GR, Pilz RB. A cysteine-rich LIM-only protein mediates regulation of smooth muscle-specific gene expression by cGMP-dependent protein kinase. J Biol Chem. 2007 Nov 16; 282(46):33367-80. PMID: 17878170.
        View in: PubMed
      25. Casteel D, Boss GR, Pilz RB. Identification of the interface between cGMP-dependent protein kinase Ibeta and its interaction partners TFII-I and IRAG reveals a common interaction motif. J Biol Chem. 2005 Nov 18; 280(46):38211-8. PMID: 16166082.
        View in: PubMed
      26. Kambo A, Sharma VS, Casteel D, Woods VL, Pilz RB, Boss GR. Nitric oxide inhibits mammalian methylmalonyl-CoA mutase. J Biol Chem. 2005 Mar 18; 280(11):10073-82. PMID: 15647267.
        View in: PubMed
      27. Pilz RB, Casteel D. Regulation of gene expression by cyclic GMP. Circ Res. 2003 Nov 28; 93(11):1034-46. PMID: 14645134.
        View in: PubMed
      28. Chen Y, Zhuang S, Cassenaer S, Casteel D, Gudi T, Boss GR, Pilz RB. Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta. Mol Cell Biol. 2003 Jun; 23(12):4066-82. PMID: 12773552; PMCID: PMC156132.
      29. Gudi T, Chen JC, Casteel D, Seasholtz TM, Boss GR, Pilz RB. cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions. J Biol Chem. 2002 Oct 04; 277(40):37382-93. PMID: 12119292.
        View in: PubMed
      30. Casteel D, Zhuang S, Gudi T, Tang J, Vuica M, Desiderio S, Pilz RB. cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I. J Biol Chem. 2002 Aug 30; 277(35):32003-14. PMID: 12082086.
        View in: PubMed
      31. Gudi T, Casteel D, Vinson C, Boss GR, Pilz RB. NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation. Oncogene. 2000 Dec 14; 19(54):6324-33. PMID: 11175347.
        View in: PubMed
      32. von Lintig FC, Dreilinger AD, Varki NM, Wallace AM, Casteel D, Boss GR. Ras activation in human breast cancer. Breast Cancer Res Treat. 2000 Jul; 62(1):51-62. PMID: 10989985.
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      33. Idriss SD, Gudi T, Casteel D, Kharitonov VG, Pilz RB, Boss GR. Nitric oxide regulation of gene transcription via soluble guanylate cyclase and type I cGMP-dependent protein kinase. J Biol Chem. 1999 Apr 02; 274(14):9489-93. PMID: 10092632.
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      34. Casteel D, Suhasini M, Gudi T, Naima R, Pilz RB. Regulation of the erythroid transcription factor NF-E2 by cyclic adenosine monophosphate-dependent protein kinase. Blood. 1998 May 01; 91(9):3193-201. PMID: 9558374.
        View in: PubMed