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    Cornelis Murre

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMolecular Biology
    Address9500 Gilman Drive #0377
    CA La Jolla 92093
    Phone858-534-8796
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      Collapse Research 
      Collapse Research Activities and Funding
      FASEB SRC on Molecular Mechanisms of Immune Cell Development and Function
      NIH/NIAID R13AI131593Jun 1, 2017 - May 31, 2018
      Role: Principal Investigator
      San Diego Center for 4D Nucleome Research
      NIH/NIDDK U54DK107977Sep 30, 2015 - Jul 31, 2020
      Role: Principal Investigator
      Molecular Basis for gamma/delta T Lineage Specification
      NIH P01AI102853May 15, 2014 - Apr 30, 2019
      Role: Co-Investigator
      E-proteins and EBF1 in B cell differentiation
      NIH/NIAID R01AI109599Apr 15, 2014 - Mar 31, 2018
      Role: Principal Investigator
      FASEB SRC on Molecular Mechanisms of Immune Cell Development and Function
      NIH/NIAID R13AI106088Jun 1, 2013 - May 31, 2014
      Role: Principal Investigator
      The 3D-Structures of the Pre-Pro-B and Pro-B Cell Genomes
      NIH/NIAID R01AI100880May 1, 2012 - Apr 30, 2017
      Role: Principal Investigator
      The 3D-Structure of the Immunoglobulin Heavy Chain Locus
      NIH/NIAID R01AI082850Mar 1, 2009 - Feb 28, 2019
      Role: Principal Investigator
      Molecular Pathways to T-Lineage Commitment
      NIH/NIAID R01AI062770Dec 1, 2004 - Nov 30, 2010
      Role: Principal Investigator
      E2A as a Tumor Suppressor
      NIH/NCI R01CA078384Apr 1, 1999 - Jan 31, 2014
      Role: Principal Investigator
      ROLE OF PBX AND PRE B ACUTE LYMPHOBLASTOID LEUKEMIA
      NIH/NCI R01CA065797Dec 8, 1994 - Nov 30, 2004
      Role: Principal Investigator
      The role of E-proteins in B cell development
      NIH/NCI R01CA054198Apr 1, 1991 - Feb 28, 2014
      Role: Principal Investigator
      E PROTEIN AND B CELL DIFFERENTIATION
      NIH/NCI R37CA054198Apr 1, 1991 - Jan 31, 2009
      Role: Principal Investigator
      IVEM and Image Analysis Resource
      NIH/NCRR P41RR004050Dec 12, 1988 - Mar 31, 2014
      Role: Co-Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chisolm DA, Savic D, Moore AJ, Ballesteros-Tato A, León B, Crossman DK, Murre C, Myers RM, Weinmann AS. CCCTC-Binding Factor Translates Interleukin 2- and a-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs. Immunity. 2017 Aug 15; 47(2):251-267.e7. PMID: 28813658.
        View in: PubMed
      2. Miyazaki M, Miyazaki K, Chen K, Jin Y, Turner J, Moore AJ, Saito R, Yoshida K, Ogawa S, Rodewald HR, Lin YC, Kawamoto H, Murre C. The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development. Immunity. 2017 May 16; 46(5):818-834.e4. PMID: 28514688.
        View in: PubMed
      3. Zhu Y, Gong K, Denholtz M, Chandra V, Kamps MP, Alber F, Murre C. Comprehensive characterization of neutrophil genome topology. Genes Dev. 2017 Feb 06. PMID: 28167501.
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      4. Chen S, Miyazaki M, Chandra V, Fisch KM, Chang AN, Murre C. Id3 Orchestrates Germinal Center B Cell Development. Mol Cell Biol. 2016 Oct 15; 36(20):2543-52. PMID: 27457619.
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      5. Murre C. A Common Mechanism that Underpins Antibody Diversification. Cell. 2015 Nov 19; 163(5):1055-6. PMID: 26590414.
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      6. Bortnick A, Murre C. Cellular and chromatin dynamics of antibody-secreting plasma cells. Wiley Interdiscip Rev Dev Biol. 2016 Mar; 5(2):136-49. PMID: 26488117.
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      7. Benner C, Isoda T, Murre C. New roles for DNA cytosine modification, eRNA, anchors, and superanchors in developing B cell progenitors. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12776-81. PMID: 26417104.
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      8. Rother MB, Palstra RJ, Jhunjhunwala S, van Kester KA, van IJcken WF, Hendriks RW, van Dongen JJ, Murre C, van Zelm MC. Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci. Nucleic Acids Res. 2016 Jan 8; 44(1):175-86. PMID: 26384565.
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      9. Chandra V, Bortnick A, Murre C. AID targeting: old mysteries and new challenges. Trends Immunol. 2015 Sep; 36(9):527-35. PMID: 26254147.
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      10. Bossen C, Murre CS, Chang AN, Mansson R, Rodewald HR, Murre C. The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth. Nat Immunol. 2015 Jul; 16(7):775-84. PMID: 25985234.
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      11. Miyazaki M, Miyazaki K, Chen S, Chandra V, Wagatsuma K, Agata Y, Rodewald HR, Saito R, Chang AN, Varki N, Kawamoto H, Murre C. The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. Genes Dev. 2015 Feb 15; 29(4):409-25. PMID: 25691468.
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      12. Murre C. Ensuring an equal playing field for antigen receptor loci variable regions. J Exp Med. 2015 Jan 12; 212(1):2. PMID: 25582312.
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      13. Murre C. Preface. Adv Immunol. 2015; 128:xi-xii. PMID: 26477372.
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      14. Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, Liang G, Tang Z, Mathé E, Benner C, Dubois W, Nelson S, Vian L, Oliveira TY, Jankovic M, Hakim O, Gazumyan A, Pavri R, Awasthi P, Song B, Liu G, Chen L, Zhu S, Feigenbaum L, Staudt L, Murre C, Ruan Y, Robbiani DF, Pan-Hammarström Q, Nussenzweig MC, Casellas R. B Cell Super-Enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity. Cell. 2014 Dec 18; 159(7):1524-37. PMID: 25483777.
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      15. Lucas JS, Zhang Y, Dudko OK, Murre C. 3D Trajectories Adopted by Coding and Regulatory DNA Elements: First-Passage Times for Genomic Interactions. Cell. 2014 Jul 17; 158(2):339-52. PMID: 24998931.
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      16. Miyazaki M, Miyazaki K, Chen S, Itoi M, Miller M, Lu LF, Varki N, Chang AN, Broide DH, Murre C. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 2014 Aug; 15(8):767-76. PMID: 24973820.
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      17. Miyazaki K, Miyazaki M, Murre C. The establishment of B versus T cell identity. Trends Immunol. 2014 May; 35(5):205-10. PMID: 24679436.
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      18. Bortnick A, Murre C. A HESitant decision for T cells. Nat Immunol. 2013 Dec; 14(12):1209-10. PMID: 24240153.
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      19. Murre C. The epigenetics of early lymphocyte development. Cold Spring Harb Symp Quant Biol. 2013; 78:43-9. PMID: 24092471.
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      20. Murre C. Boosting lymphocyte production. Immunity. 2013 Jun 27; 38(6):1081-3. PMID: 23809155.
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      21. Lin YC, Murre C. Nuclear location and the control of developmental progression. Curr Opin Genet Dev. 2013 Apr; 23(2):104-8. PMID: 23266214.
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      22. Mansson R, Welinder E, Åhsberg J, Lin YC, Benner C, Glass CK, Lucas JS, Sigvardsson M, Murre C. Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):21028-33. PMID: 23213261.
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      23. Kreslavsky T, Gleimer M, Miyazaki M, Choi Y, Gagnon E, Murre C, Sicinski P, von Boehmer H. ß-Selection-induced proliferation is required for aß T cell differentiation. Immunity. 2012 Nov 16; 37(5):840-53. PMID: 23159226.
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      24. Lin YC, Benner C, Mansson R, Heinz S, Miyazaki K, Miyazaki M, Chandra V, Bossen C, Glass CK, Murre C. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol. 2012 Dec; 13(12):1196-204. PMID: 23064439.
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      25. Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ, Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, Agata Y. E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin ? locus. J Immunol. 2012 Jun 1; 188(11):5547-60. PMID: 22544934.
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      26. Teachenor R, Beck K, Wright LY, Shen Z, Briggs SP, Murre C. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. Mol Cell Biol. 2012 May; 32(9):1671-82. PMID: 22354994.
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      27. Bossen C, Mansson R, Murre C. Chromatin topology and the regulation of antigen receptor assembly. Annu Rev Immunol. 2012; 30:337-56. PMID: 22224771.
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      28. Yang CY, Best JA, Knell J, Yang E, Sheridan AD, Jesionek AK, Li HS, Rivera RR, Lind KC, D'Cruz LM, Watowich SS, Murre C, Goldrath AW. The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets. Nat Immunol. 2011 Dec; 12(12):1221-9. PMID: 22057289.
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      29. Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C. The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17402-7. PMID: 21972416.
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      30. Mercer EM, Lin YC, Murre C. Factors and networks that underpin early hematopoiesis. Semin Immunol. 2011 Oct; 23(5):317-25. PMID: 21930392.
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      31. Guo C, Yoon HS, Franklin A, Jain S, Ebert A, Cheng HL, Hansen E, Despo O, Bossen C, Vettermann C, Bates JG, Richards N, Myers D, Patel H, Gallagher M, Schlissel MS, Murre C, Busslinger M, Giallourakis CC, Alt FW. CTCF-binding elements mediate control of V(D)J recombination. Nature. 2011 Sep 22; 477(7365):424-30. PMID: 21909113.
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      32. Mercer EM, Lin YC, Benner C, Jhunjhunwala S, Dutkowski J, Flores M, Sigvardsson M, Ideker T, Glass CK, Murre C. Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. Immunity. 2011 Sep 23; 35(3):413-25. PMID: 21903424.
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      33. Miyazaki M, Rivera RR, Miyazaki K, Lin YC, Agata Y, Murre C. The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nat Immunol. 2011 Oct; 12(10):992-1001. PMID: 21857655.
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      34. Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, Murre CS, Birshtein BK, Schork NJ, Schlissel MS, Riblet R, Murre C, Feeney AJ. CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells. Proc Natl Acad Sci U S A. 2011 Jun 7; 108(23):9566-71. PMID: 21606361.
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      35. Welinder E, Murre C. Ldb1, a new guardian of hematopoietic stem cell maintenance. Nat Immunol. 2011 Feb; 12(2):113-4. PMID: 21245899.
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      36. Lucas JS, Bossen C, Murre C. Transcription and recombination factories: common features? Curr Opin Cell Biol. 2011 Jun; 23(3):318-24. PMID: 21169003.
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      37. Murre C. Global approaches to identify novel participants that modulate intestinal epithelial cell development. Dev Cell. 2010 Nov 16; 19(5):647-8. PMID: 21074714.
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      38. Lin YC, Jhunjhunwala S, Benner C, Heinz S, Welinder E, Mansson R, Sigvardsson M, Hagman J, Espinoza CA, Dutkowski J, Ideker T, Glass CK, Murre C. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010 Jul; 11(7):635-43. PMID: 20543837.
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      39. Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28; 38(4):576-89. PMID: 20513432.
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      40. Rothenberg EV, Murre C. Current Opinion in Immunology. Editorial overview. Curr Opin Immunol. 2010 Apr; 22(2):145-7. PMID: 20303722.
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      41. Murre C. Developmental trajectories in early hematopoiesis. Genes Dev. 2009 Oct 15; 23(20):2366-70. PMID: 19833763.
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      42. Beck K, Peak MM, Ota T, Nemazee D, Murre C. Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J Exp Med. 2009 Sep 28; 206(10):2271-84. PMID: 19752184.
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      43. Jhunjhunwala S, van Zelm MC, Peak MM, Murre C. Chromatin architecture and the generation of antigen receptor diversity. Cell. 2009 Aug 7; 138(3):435-48. PMID: 19665968.
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      44. Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C. E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors. Proc Natl Acad Sci U S A. 2009 Feb 10; 106(6):1930-5. PMID: 19181846.
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      45. Minami Y, Stuart SA, Ikawa T, Jiang Y, Banno A, Hunton IC, Young DJ, Naoe T, Murre C, Jamieson CH, Wang JY. BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17967-72. PMID: 19004799.
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      46. Ko J, Patel N, Ikawa T, Kawamoto H, Frank O, Rivera RR, Van Etten RA, Murre C. Suppression of E-protein activity interferes with the development of BCR-ABL-mediated myeloproliferative disease. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):12967-72. PMID: 18725623.
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      47. Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein JL. FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev. 2008; 3:17. PMID: 18625063.
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      48. Murre C. Nuclear geography and allelic exclusion. Nat Immunol. 2008 Jul; 9(7):718-20. PMID: 18563080.
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      49. Jhunjhunwala S, van Zelm MC, Peak MM, Cutchin S, Riblet R, van Dongen JJ, Grosveld FG, Knoch TA, Murre C. The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions. Cell. 2008 Apr 18; 133(2):265-79. PMID: 18423198.
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      50. Bhalla S, Spaulding C, Brumbaugh RL, Zagort DE, Massari ME, Murre C, Kee BL. differential roles for the E2A activation domains in B lymphocytes and macrophages. J Immunol. 2008 Feb 1; 180(3):1694-703. PMID: 18209066.
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      51. Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C. Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47. Immunity. 2007 Dec; 27(6):871-84. PMID: 18093539.
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      52. Murre C. Epigenetics of antigen-receptor gene assembly. Curr Opin Genet Dev. 2007 Oct; 17(5):415-21. PMID: 17920858.
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      53. Murre C. Defining the pathways of early adult hematopoiesis. Cell Stem Cell. 2007 Oct 11; 1(4):357-8. PMID: 18371371.
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      54. Murre C. Ribosomal proteins and the control of alphabeta T lineage development. Immunity. 2007 Jun; 26(6):751-2. PMID: 17582347.
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      55. Murre C. Regulation and function of the E2A proteins in B cell development. Adv Exp Med Biol. 2007; 596:1-7. PMID: 17338171.
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      56. Schwartz R, Engel I, Fallahi-Sichani M, Petrie HT, Murre C. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9976-81. PMID: 16782810.
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      57. Xi H, Schwartz R, Engel I, Murre C, Kersh GJ. Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Immunity. 2006 Jun; 24(6):813-26. PMID: 16782036.
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      58. Ikawa T, Kawamoto H, Goldrath AW, Murre C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J Exp Med. 2006 May 15; 203(5):1329-42. PMID: 16682500.
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      59. Murre C. Marking emerging beta- and gammadelta-selected T cells. Immunity. 2006 Jan; 24(1):11-3. PMID: 16413917.
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      60. Joosten PH, van Zoelen EJ, Murre C. Pax1/E2a double-mutant mice develop non-lethal neural tube defects that resemble human malformations. Transgenic Res. 2005 Dec; 14(6):983-7. PMID: 16315099.
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      61. Murre C. Helix-loop-helix proteins and lymphocyte development. Nat Immunol. 2005 Nov; 6(11):1079-86. PMID: 16239924.
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      62. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. PMID: 16172133.
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      63. Vincentz JW, McWhirter JR, Murre C, Baldini A, Furuta Y. Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis. 2005 Apr; 41(4):192-201. PMID: 15789410.
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      64. Sayegh CE, Sayegh C, Jhunjhunwala S, Riblet R, Murre C. Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells. Genes Dev. 2005 Feb 1; 19(3):322-7. PMID: 15687256.
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      65. Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004 Oct; 5(10):1069-77. PMID: 15361869.
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      66. O'Neil J, Shank J, Cusson N, Murre C, Kelliher M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell. 2004 Jun; 5(6):587-96. PMID: 15193261.
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      67. Murre C. Reprogramming committed B lineage cells. Cell. 2004 May 28; 117(5):556-8. PMID: 15163403.
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      68. Wright TJ, Ladher R, McWhirter J, Murre C, Schoenwolf GC, Mansour SL. Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev Biol. 2004 May 1; 269(1):264-75. PMID: 15081372.
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      69. Quong MW, Martensson A, Langerak AW, Rivera RR, Nemazee D, Murre C. Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A. J Exp Med. 2004 Apr 19; 199(8):1101-12. PMID: 15078898.
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      70. Ikawa T, Kawamoto H, Wright LY, Murre C. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity. 2004 Mar; 20(3):349-60. PMID: 15030778.
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      71. Engel I, Murre C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 2004 Jan 14; 23(1):202-11. PMID: 14685278.
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      72. Murre C. Regulating intertwining proteins. Mol Cell. 2003 Nov; 12(5):1061-2. PMID: 14636564.
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      73. Westerman BA, Murre C, Oudejans CB. The cellular Pax-Hox-helix connection. Biochim Biophys Acta. 2003 Oct 1; 1629(1-3):1-7. PMID: 14522074.
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      74. Sayegh CE, Quong MW, Agata Y, Murre C. E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat Immunol. 2003 Jun; 4(6):586-93. PMID: 12717431.
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      75. Engel I, Murre C. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11322-7. PMID: 12172006.
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      76. Kee BL, Bain G, Murre C. IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors. EMBO J. 2002 Jan 15; 21(1-2):103-13. PMID: 11782430.
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      77. Rivera R, Murre C. The regulation and function of the Id proteins in lymphocyte development. Oncogene. 2001 Dec 20; 20(58):8308-16. PMID: 11840323.
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      78. Engel I, Murre C. The function of E- and Id proteins in lymphocyte development. Nat Rev Immunol. 2001 Dec; 1(3):193-9. PMID: 11905828.
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      79. Quong MW, Romanow WJ, Murre C. E protein function in lymphocyte development. Annu Rev Immunol. 2002; 20:301-22. PMID: 11861605.
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      80. Engel I, Johns C, Bain G, Rivera RR, Murre C. Early thymocyte development is regulated by modulation of E2A protein activity. J Exp Med. 2001 Sep 17; 194(6):733-45. PMID: 11560990.
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      81. Aspland SE, Bendall HH, Murre C. The role of E2A-PBX1 in leukemogenesis. Oncogene. 2001 Sep 10; 20(40):5708-17. PMID: 11607820.
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      82. Goebel P, Janney N, Valenzuela JR, Romanow WJ, Murre C, Feeney AJ. Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells. J Exp Med. 2001 Sep 3; 194(5):645-56. PMID: 11535632.
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      83. Kee BL, Murre C. Transcription factor regulation of B lineage commitment. Curr Opin Immunol. 2001 Apr; 13(2):180-5. PMID: 11228411.
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      84. Ghosh JK, Romanow WJ, Murre C. Induction of a diverse T cell receptor gamma/delta repertoire by the helix-loop-helix proteins E2A and HEB in nonlymphoid cells. J Exp Med. 2001 Mar 19; 193(6):769-76. PMID: 11257142.
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      85. Kee BL, Rivera RR, Murre C. Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta. Nat Immunol. 2001 Mar; 2(3):242-7. PMID: 11224524.
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      86. Bain G, Cravatt CB, Loomans C, Alberola-Ila J, Hedrick SM, Murre C. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nat Immunol. 2001 Feb; 2(2):165-71. PMID: 11175815.
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      87. Murre C. Intertwining proteins in thymocyte development and cancer. Nat Immunol. 2000 Aug; 1(2):97-8. PMID: 11248796.
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      88. Kee BL, Quong MW, Murre C. E2A proteins: essential regulators at multiple stages of B-cell development. Immunol Rev. 2000 Jun; 175:138-49. PMID: 10933599.
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      89. Planells-Cases R, Caprini M, Zhang J, Rockenstein EM, Rivera RR, Murre C, Masliah E, Montal M. Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys J. 2000 Jun; 78(6):2878-91. PMID: 10827969.
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      90. Romanow WJ, Langerak AW, Goebel P, Wolvers-Tettero IL, van Dongen JJ, Feeney AJ, Murre C. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol Cell. 2000 Feb; 5(2):343-53. PMID: 10882075.
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      91. Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol. 2000 Jan; 20(2):429-40. PMID: 10611221.
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      92. Rivera RR, Johns CP, Quan J, Johnson RS, Murre C. Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3. Immunity. 2000 Jan; 12(1):17-26. PMID: 10661402.
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      93. Bain G, Quong MW, Soloff RS, Hedrick SM, Murre C. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. J Exp Med. 1999 Dec 6; 190(11):1605-16. PMID: 10587351.
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      94. Quong MW, Harris DP, Swain SL, Murre C. E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination. EMBO J. 1999 Nov 15; 18(22):6307-18. PMID: 10562543.
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      95. Engel I, Murre C. Transcription factors in hematopoiesis. Curr Opin Genet Dev. 1999 Oct; 9(5):575-9. PMID: 10508690.
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      96. McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C. Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11464-9. PMID: 10500199.
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      97. Massari ME, Grant PA, Pray-Grant MG, Berger SL, Workman JL, Murre C. A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell. 1999 Jul; 4(1):63-73. PMID: 10445028.
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      98. Engel I, Murre C. Ectopic expression of E47 or E12 promotes the death of E2A-deficient lymphomas. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):996-1001. PMID: 9927682.
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      99. Bain G, Romanow WJ, Albers K, Havran WL, Murre C. Positive and negative regulation of V(D)J recombination by the E2A proteins. J Exp Med. 1999 Jan 18; 189(2):289-300. PMID: 9892611.
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      100. Li X, Murre C, McGinnis W. Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation. EMBO J. 1999 Jan 4; 18(1):198-211. PMID: 9878063.
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      101. Murre C. Role of helix-loop-helix proteins in lymphocyte development. Cold Spring Harb Symp Quant Biol. 1999; 64:39-44. PMID: 11232313.
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      102. Kee BL, Murre C. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med. 1998 Aug 17; 188(4):699-713. PMID: 9705952.
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      103. Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C. Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. Mol Cell Biol. 1998 Jun; 18(6):3130-9. PMID: 9584154.
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      104. Bain G, Murre C. The role of E-proteins in B- and T-lymphocyte development. Semin Immunol. 1998 Apr; 10(2):143-53. PMID: 9618760.
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      105. McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C. A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 1997 Sep; 124(17):3221-32. PMID: 9310317.
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      106. Sánchez M, Jennings PA, Murre C. Conformational changes induced in Hoxb-8/Pbx-1 heterodimers in solution and upon interaction with specific DNA. Mol Cell Biol. 1997 Sep; 17(9):5369-76. PMID: 9271414.
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      107. Neuteboom ST, Murre C. Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins. Mol Cell Biol. 1997 Aug; 17(8):4696-706. PMID: 9234726.
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      108. Bain G, Engel I, Robanus Maandag EC, te Riele HP, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol. 1997 Aug; 17(8):4782-91. PMID: 9234734.
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      109. Peltenburg LT, Murre C. Specific residues in the Pbx homeodomain differentially modulate the DNA-binding activity of Hox and Engrailed proteins. Development. 1997 Mar; 124(5):1089-98. PMID: 9056783.
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      110. Bain G, Robanus Maandag EC, te Riele HP, Feeney AJ, Sheehy A, Schlissel M, Shinton SA, Hardy RR, Murre C. Both E12 and E47 allow commitment to the B cell lineage. Immunity. 1997 Feb; 6(2):145-54. PMID: 9047236.
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      111. Itkin-Ansari P, Bain G, Beattie GM, Murre C, Hayek A, Levine F. E2A gene products are not required for insulin gene expression. Endocrinology. 1996 Aug; 137(8):3540-3. PMID: 8754784.
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      112. Peltenburg LT, Murre C. Engrailed and Hox homeodomain proteins contain a related Pbx interaction motif that recognizes a common structure present in Pbx. EMBO J. 1996 Jul 1; 15(13):3385-93. PMID: 8698039.
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      113. Massari ME, Jennings PA, Murre C. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol Cell Biol. 1996 Jan; 16(1):121-9. PMID: 8524288.
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      114. Neuteboom ST, Peltenburg LT, van Dijk MA, Murre C. The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9166-70. PMID: 7568094.
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      115. van Dijk MA, Peltenburg LT, Murre C. Hox gene products modulate the DNA binding activity of Pbx1 and Pbx2. Mech Dev. 1995 Jul; 52(1):99-108. PMID: 7577680.
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      116. Roberts VJ, van Dijk MA, Murre C. Localization of Pbx1 transcripts in developing rat embryos. Mech Dev. 1995 Jun; 51(2-3):193-8. PMID: 7547467.
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      117. Robinson GL, Henderson E, Massari ME, Murre C, Stein R. c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products. Mol Cell Biol. 1995 Mar; 15(3):1398-404. PMID: 7862133.
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      118. van Dijk MA, Murre C. extradenticle raises the DNA binding specificity of homeotic selector gene products. Cell. 1994 Aug 26; 78(4):617-24. PMID: 7915200.
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      119. Murre C, Bain G, van Dijk MA, Engel I, Furnari BA, Massari ME, Matthews JR, Quong MW, Rivera RR, Stuiver MH. Structure and function of helix-loop-helix proteins. Biochim Biophys Acta. 1994 Jun 21; 1218(2):129-35. PMID: 8018712.
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      120. Rivera RR, Stuiver MH, Steenbergen R, Murre C. Ets proteins: new factors that regulate immunoglobulin heavy-chain gene expression. Mol Cell Biol. 1993 Nov; 13(11):7163-9. PMID: 8413305.
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      121. Roberts VJ, Steenbergen R, Murre C. Localization of E2A mRNA expression in developing and adult rat tissues. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7583-7. PMID: 8356060.
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      122. Van Dijk MA, Voorhoeve PM, Murre C. Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. Proc Natl Acad Sci U S A. 1993 Jul 1; 90(13):6061-5. PMID: 8327485.
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      123. Bain G, Gruenwald S, Murre C. E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins. Mol Cell Biol. 1993 Jun; 13(6):3522-9. PMID: 8497267.
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      124. Flegel WA, Singson AW, Margolis JS, Bang AG, Posakony JW, Murre C. Dpbx, a new homeobox gene closely related to the human proto-oncogene pbx1 molecular structure and developmental expression. Mech Dev. 1993 May; 41(2-3):155-61. PMID: 8100142.
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      125. Quong MW, Massari ME, Zwart R, Murre C. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol Cell Biol. 1993 Feb; 13(2):792-800. PMID: 8423802.
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      126. Lassar AB, Davis RL, Wright WE, Kadesch T, Murre C, Voronova A, Baltimore D, Weintraub H. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell. 1991 Jul 26; 66(2):305-15. PMID: 1649701.
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      127. Murre C, Voronova A, Baltimore D. B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol Cell Biol. 1991 Feb; 11(2):1156-60. PMID: 1990271.
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      128. Kamps MP, Murre C, Sun XH, Baltimore D. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell. 1990 Feb 23; 60(4):547-55. PMID: 1967983.
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      129. Mellentin JD, Murre C, Donlon TA, McCaw PS, Smith SD, Carroll AJ, McDonald ME, Baltimore D, Cleary ML. The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias. Science. 1989 Oct 20; 246(4928):379-82. PMID: 2799390.
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      130. Murre C, McCaw PS, Vaessin H, Caudy M, Jan LY, Jan YN, Cabrera CV, Buskin JN, Hauschka SD, Lassar AB. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11; 58(3):537-44. PMID: 2503252.
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      131. Murre C, McCaw PS, Baltimore D. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell. 1989 Mar 10; 56(5):777-83. PMID: 2493990.
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      132. Owen FL, Strauss WM, Murre C, Duby AD, Hiai H, Seidman JG. AKR murine thymic leukemias are from a distinct thymic cell lineage and do not express the beta chain of the T-cell antigen receptor. Proc Natl Acad Sci U S A. 1986 Oct; 83(19):7434-7. PMID: 3094008.
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      133. Leiden JM, Dialynas DP, Duby AD, Murre C, Seidman J, Strominger JL. Rearrangement and expression of T-cell antigen receptor genes in human T-lymphocyte tumor lines and normal human T-cell clones: evidence for allelic exclusion of Ti beta gene expression and preferential use of a J beta 2 gene segment. Mol Cell Biol. 1986 Sep; 6(9):3207-14. PMID: 3491297.
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      134. Quertermous T, Strauss W, Murre C, Dialynas DP, Strominger JL, Seidman JG. Human T-cell gamma genes contain N segments and have marked junctional variability. Nature. 1986 Jul 10-16; 322(6075):184-7. PMID: 3453106.
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      135. Dialynas DP, Murre C, Quertermous T, Boss JM, Leiden JM, Seidman JG, Strominger JL. Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2619-23. PMID: 3458221.
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      136. Berliner N, Duby AD, Linch DC, Murre C, Quertermous T, Knott LJ, Azin T, Newland AC, Lewis DL, Galvin MC. T cell receptor gene rearrangements define a monoclonal T cell proliferation in patients with T cell lymphocytosis and cytopenia. Blood. 1986 Apr; 67(4):914-8. PMID: 3485459.
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      137. Murre C, Parker KC, Reiss CS, Driller JP, Wiley DC, Burakoff SJ, Seidman JG. Biochemical and functional analyses of a secreted H-2Ld molecule. Mol Cell Biol. 1986 Apr; 6(4):1315-9. PMID: 3491290.
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      138. Reiss CS, Greenstein JL, Crimmins MA, Liu LL, Rao A, Maziaraz RT, Murre C, Burakoff SJ. Recognition of the alpha-1 and alpha-2 domains of H-2 molecules by allospecific cloned T cells. J Immunol. 1986 Mar 15; 136(6):2191-4. PMID: 2419424.
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      139. Quertermous T, Murre C, Dialynas D, Duby AD, Strominger JL, Waldman TA, Seidman JG. Human T-cell gamma chain genes: organization, diversity, and rearrangement. Science. 1986 Jan 17; 231(4735):252-5. PMID: 3079918.
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      140. Murre C, Waldmann RA, Morton CC, Bongiovanni KF, Waldmann TA, Shows TB, Seidman JG. Human gamma-chain genes are rearranged in leukaemic T cells and map to the short arm of chromosome 7. Nature. 1985 Aug 8-14; 316(6028):549-52. PMID: 3875797.
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      141. Bernabeu C, Maziarz R, Murre C, Terhorst C. beta 2-Microglobulin from serum associates with several class I antigens expressed on the surface of mouse L-cells. Mol Immunol. 1985 Aug; 22(8):955-60. PMID: 3900696.
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      142. Duby AD, Klein KA, Murre C, Seidman JG. A novel mechanism of somatic rearrangement predicted by a human T-cell antigen receptor beta-chain complementary DNA. Science. 1985 Jun 7; 228(4704):1204-6. PMID: 3839095.
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      143. Ozato K, Takahashi H, Appella E, Sears DW, Murre C, Seidman JG, Kimura S, Tada N. Polymorphism of murine major histocompatibility Class I antigen: assignment of putative allodeterminants to distinct positions of the amino acid sequence within the first external domain of the antigen. J Immunol. 1985 Mar; 134(3):1749-58. PMID: 2578519.
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      144. Weis JH, Murre C. Differential expression of H-2Dd and H-2Ld histocompatibility antigens. J Exp Med. 1985 Feb 1; 161(2):356-65. PMID: 3919140.
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      145. Ben-Nun A, Strauss W, Leeman SA, Cohn LE, Murre C, Duby A, Seidman JG, Glimcher LH. An Ia-positive mouse T-cell clone is functional in presenting antigen to other T cells. Immunogenetics. 1985; 22(2):123-30. PMID: 3875550.
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      146. Murre C, Choi E, Weis J, Seidman JG, Ozato K, Liu L, Burakoff SJ, Reiss CS. Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocompatibility antigens by a recombinant H-2 gene separating the first two external domains. J Exp Med. 1984 Jul 1; 160(1):167-78. PMID: 6203998.
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      147. Murre C, Reiss CS, Bernabeu C, Chen LB, Burakoff SJ, Seidman JG. Construction, expression and recognition of an H-2 molecule lacking its carboxyl terminus. Nature. 1984 Feb 2-8; 307(5950):432-6. PMID: 6363940.
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      148. Waxdal MJ, Kieda C, Murre C. Correlation between two new methods for the isolation of human monocytes: specific reversible agglutination with a carbohydrate from pokeweed and by use of the lectin PA-4. Adv Exp Med Biol. 1982; 155:233-9. PMID: 7158482.
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