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    Constanza Cortes

    TitleAssistant Project Scientist
    SchoolUniversity of California, San Diego
    DepartmentPediatrics
    Address9500 Gilman Drive #0642
    CA La Jolla 92093
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      Collapse Research 
      Collapse Research Activities and Funding
      Enhanced skeletal muscle proteostasis as a determinant of CNS protein quality control and neural function in the aging brain
      NIH/NIA RF1AG057264Sep 15, 2017 - Jun 30, 2022
      Role: Co-Principal Investigator

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Blessing AM, Rajapakshe K, Reddy Bollu L, Shi Y, White MA, Pham AH, Lin C, Jonsson P, Cortes C, Cheung E, La Spada AR, Bast RC, Merchant FA, Coarfa C, Frigo DE. Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression. Autophagy. 2017 Mar 04; 13(3):506-521. PMID: 27977328.
        View in: PubMed
      2. Todd TW, Kokubu H, Miranda HC, Cortes C, La Spada AR, Lim J. Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy. Elife. 2015 Aug 26; 4:e08493. PMID: 26308581; PMCID: PMC4577982.
      3. Cortes C, La Spada AR. Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? Mol Cell Neurosci. 2015 May; 66(Pt A):53-61. PMID: 25771431; PMCID: PMC4449833.
      4. Cortes C, La Spada AR. Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases. Rare Dis. 2014; 2(1):e962402. PMID: 26942099; PMCID: PMC4755247.
      5. Cortes C, Miranda HC, Frankowski H, Batlevi Y, Young JE, Le A, Ivanov N, Sopher BL, Carromeu C, Muotri AR, Garden GA, La Spada AR. Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA. Nat Neurosci. 2014 Sep; 17(9):1180-9. PMID: 25108912; PMCID: PMC4180729.
      6. Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes C, Bennett CF, Monia BP, La Spada AR, Hung G. Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy. Cell Rep. 2014 May 08; 7(3):774-84. PMID: 24746732; PMCID: PMC4356525.
      7. Cortes C, Ling SC, Guo LT, Hung G, Tsunemi T, Ly L, Tokunaga S, Lopez E, Sopher BL, Bennett CF, Shelton GD, Cleveland DW, La Spada AR. Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy. Neuron. 2014 Apr 16; 82(2):295-307. PMID: 24742458; PMCID: PMC4096235.
      8. Cortes C, La Spada AR. The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy. Drug Discov Today. 2014 Jul; 19(7):963-71. PMID: 24632005; PMCID: PMC4096219.
      9. Cortes C, Qin K, Norstrom EM, Green WN, Bindokas VP, Mastrianni JA. Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy. Int J Cell Biol. 2013; 2013:560421. PMID: 24454378; PMCID: PMC3877647.
      10. Cortes C, Qin K, Cook J, Solanki A, Mastrianni JA. Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Sträussler-Scheinker disease. J Neurosci. 2012 Sep 05; 32(36):12396-405. PMID: 22956830; PMCID: PMC3752082.
      11. Tunnell E, Wollman R, Mallik S, Cortes C, Dearmond SJ, Mastrianni JA. A novel PRNP-P105S mutation associated with atypical prion disease and a rare PrPSc conformation. Neurology. 2008 Oct 28; 71(18):1431-8. PMID: 18955686; PMCID: PMC2676963.
      12. Codelia VA, Cortes C, Moreno RD. Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa. Biochem Biophys Res Commun. 2005 Dec 02; 337(4):1337-44. PMID: 16236270.
        View in: PubMed
      13. Cortes C, Codelia VA, Manosalva I, de Lange J, De Los Reyes M, Moreno RD. Proacrosin/acrosin quantification as an indicator of acrosomal integrity in fresh and frozen dog spermatozoa. Anim Reprod Sci. 2006 Jun; 93(1-2):165-75. PMID: 16169165.
        View in: PubMed
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