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    Claude Sirlin

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentRadiology
    Address9500 Gilman Drive #0888
    CA La Jolla 92093
    Phone858-246-2203
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Havard UniversityB.A.Biology
      University of California, San FranciscoM.D.Medicine
      Collapse Awards and Honors
      Radiological Society of North America1996Research Resident Award
      Radiological Society of North America Research Roentgen 1998 - 1999Research Awards
      Elliot C. Lasser2000Award for Excellence in Research
      Stanford University2001 Radiology Teaching Award
      Society of Gastrointestinal Radiologists 2006Phillip H. Meyers Research Award
      Association of University Radiologists2007Radiology Research Alliance New Investigator Award
      ISMRM2008Outstanding Teacher Award: Case-Based Teaching Series
      UCSF2009Earl Miller Memorial Lecturer
      ESGAR2011SGR Honorary Lecturer

      Collapse Research 
      Collapse Research Activities and Funding
      QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLD
      NIH R01DK106419Jul 1, 2015 - May 31, 2020
      Role: Principal Investigator
      Development of MR-based biomarker panels for NAFLD - A NASH CRN Ancillary Study
      NIH R56DK090350Sep 30, 2010 - Aug 31, 2013
      Role: Principal Investigator
      Technical Validation of MRI Biomarkers of Liver Fat
      NIH R01DK088925Sep 15, 2010 - Jun 30, 2015
      Role: Principal Investigator
      MR Imaging of Non-Alcoholic Fatty Liver Disease
      NIH R01DK075128Sep 1, 2006 - Mar 31, 2012
      Role: Principal Investigator
      Training Clinical Scientists in Radiological Imaging
      NIH T32EB005970Apr 1, 2006 - Jun 30, 2018
      Role: Principal Investigator
      Transducible Molecular Probes for Imaging Tumors
      NIH K08CA102158Jul 18, 2003 - Jun 30, 2008
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Alquiraish MH, Valasek MA, Rizo E, Richards L, Brenner D, Sirlin C, Loomba R. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease. Gastroenterology. 2016 Oct 27. PMID: 27911262.
        View in: PubMed
      2. Patel NS, Hooker J, Gonzalez M, Bhatt A, Nguyen P, Ramirez K, Richards L, Rizo E, Hernandez C, Kisseleva T, Schnabl B, Brenner D, Sirlin C, Loomba R. Weight loss decreases magnetic resonance elastography estimated liver stiffness in nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2016 Oct 3. PMID: 27712981.
        View in: PubMed
      3. Hamilton G, Schlein AN, Middleton MS, Hooker CA, Wolfson T, Gamst AC, Loomba R, Sirlin C. In vivo triglyceride composition of abdominal adipose tissue measured by 1 H MRS at 3T. J Magn Reson Imaging. 2016 Aug 29. PMID: 27571403.
        View in: PubMed
      4. Mariappan YK, Dzyubak B, Glaser KJ, Venkatesh SK, Sirlin C, Hooker J, McGee KP, Ehman RL. Application of Modified Spin-Echo-based Sequences for Hepatic MR Elastography: Evaluation, Comparison with the Conventional Gradient-Echo Sequence, and Preliminary Clinical Experience. Radiology. 2017 Feb; 282(2):390-398. PMID: 27509543.
        View in: PubMed
      5. McClellan TR, Motosugi U, Middleton MS, Allen BC, Jaffe TA, Miller CM, Reeder SB, Sirlin C, Bashir MR. Intravenous Gadoxetate Disodium Administration Reduces Breath-holding Capacity in the Hepatic Arterial Phase: A Multi-Center Randomized Placebo-controlled Trial. Radiology. 2017 Feb; 282(2):361-368. PMID: 27509544.
        View in: PubMed
      6. Patel J, Bettencourt R, Cui J, Salotti J, Hooker J, Bhatt A, Hernandez C, Nguyen P, Aryafar H, Valasek M, Haufe W, Hooker C, Richards L, Sirlin C, Loomba R. Association of noninvasive quantitative decline in liver fat content on MRI with histologic response in nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2016 Sep; 9(5):692-701. PMID: 27582882.
        View in: PubMed
      7. Cui J, Chen CH, Lo MT, Schork N, Bettencourt R, Gonzalez MP, Bhatt A, Hooker J, Shaffer K, Nelson KE, Long MT, Brenner DA, Sirlin C, Loomba R. Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study. Hepatology. 2016 Jun 17. PMID: 27315352.
        View in: PubMed
      8. Dulai PS, Sirlin C, Loomba R. MRI and MRE for non-invasive quantitative assessment of hepatic steatosis and fibrosis in NAFLD and NASH: Clinical trials to clinical practice. J Hepatol. 2016 Nov; 65(5):1006-1016. PMID: 27312947.
        View in: PubMed
      9. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R, Richards L, Salotti J, Bhatt A, Hooker J, Haufe W, Hooker C, Brenner DA, Sirlin C, Loomba R. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. J Hepatol. 2016 Aug; 65(2):369-76. PMID: 27151177.
        View in: PubMed
      10. Tanabe M, Kanki A, Wolfson T, Costa EA, Mamidipalli A, Ferreira MP, Santillan C, Middleton MS, Gamst AC, Kono Y, Kuo A, Sirlin C. Imaging Outcomes of Liver Imaging Reporting and Data System Version 2014 Category 2, 3, and 4 Observations Detected at CT and MR Imaging. Radiology. 2016 Oct; 281(1):129-39. PMID: 27115054.
        View in: PubMed
      11. Hernando D, Sharma SD, Aliyari Ghasabeh M, Alvis BD, Arora SS, Hamilton G, Pan L, Shaffer JM, Sofue K, Szeverenyi NM, Welch EB, Yuan Q, Bashir MR, Kamel IR, Rice MJ, Sirlin C, Yokoo T, Reeder SB. Multisite, multivendor validation of the accuracy and reproducibility of proton-density fat-fraction quantification at 1.5T and 3T using a fat-water phantom. Magn Reson Med. 2016 Apr 15. PMID: 27080068.
        View in: PubMed
      12. Loomba R, Cui J, Wolfson T, Haufe W, Hooker J, Szeverenyi N, Ang B, Bhatt A, Wang K, Aryafar H, Behling C, Valasek MA, Lin GY, Gamst A, Brenner DA, Yin M, Glaser KJ, Ehman RL, Sirlin C. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. Am J Gastroenterol. 2016 Jul; 111(7):986-94. PMID: 27002798.
        View in: PubMed
      13. Lin SC, Ang B, Hernandez C, Bettencourt R, Jain R, Salotti J, Richards L, Kono Y, Bhatt A, Aryafar H, Lin GY, Valasek MA, Sirlin C, Brouha S, Loomba R. Cardiovascular risk assessment in the treatment of nonalcoholic steatohepatitis: a secondary analysis of the MOZART trial. Therap Adv Gastroenterol. 2016 Mar; 9(2):152-61. PMID: 26929777.
        View in: PubMed
      14. Jacobs K, Brouha S, Bettencourt R, Barrett-Connor E, Sirlin C, Loomba R. Association of Nonalcoholic Fatty Liver Disease With Visceral Adiposity but Not Coronary Artery Calcification in the Elderly. Clin Gastroenterol Hepatol. 2016 Sep; 14(9):1337-1344.e3. PMID: 26820400.
        View in: PubMed
      15. Schnabl B, Farshchi-Heydari S, Loomba R, Mattrey RF, Hoh CK, Sirlin C, Brenner DA, Behling CA, Vera DR. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Nucl Med Biol. 2016 Feb; 43(2):179-87. PMID: 26872443.
        View in: PubMed
      16. Tyagi A, Yeganeh O, Levin Y, Hooker JC, Hamilton GC, Wolfson T, Gamst A, Zand AK, Heba E, Loomba R, Schwimmer J, Middleton MS, Sirlin C. Intra- and inter-examination repeatability of magnetic resonance spectroscopy, magnitude-based MRI, and complex-based MRI for estimation of hepatic proton density fat fraction in overweight and obese children and adults. Abdom Imaging. 2015 Oct; 40(8):3070-7. PMID: 26350282.
        View in: PubMed
      17. Achmad E, Yokoo T, Hamilton G, Heba ER, Hooker JC, Changchien C, Schroeder M, Wolfson T, Gamst A, Schwimmer JB, Lavine JE, Sirlin C, Middleton MS. Feasibility of and agreement between MR imaging and spectroscopic estimation of hepatic proton density fat fraction in children with known or suspected nonalcoholic fatty liver disease. Abdom Imaging. 2015 Oct; 40(8):3084-90. PMID: 26205992.
        View in: PubMed
      18. Tang A, Valasek MA, Sirlin C. Update on the Liver Imaging Reporting and Data System: What the Pathologist Needs to Know. Adv Anat Pathol. 2015 Sep; 22(5):314-22. PMID: 26262514.
        View in: PubMed
      19. Yokoo T, Wolfson T, Iwaisako K, Peterson MR, Mani H, Goodman Z, Changchien C, Middleton MS, Gamst AC, Mazhar SM, Kono Y, Ho SB, Sirlin C. Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T. Biomed Res Int. 2015; 2015:387653. PMID: 26421287.
        View in: PubMed
      20. Loomba R, Schork N, Chen CH, Bettencourt R, Bhatt A, Ang B, Nguyen P, Hernandez C, Richards L, Salotti J, Lin S, Seki E, Nelson KE, Sirlin C, Brenner D. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Gastroenterology. 2015 Aug 20. PMID: 26299412.
        View in: PubMed
      21. Heba ER, Desai A, Zand KA, Hamilton G, Wolfson T, Schlein AN, Gamst A, Loomba R, Sirlin C, Middleton MS. Accuracy and the effect of possible subject-based confounders of magnitude-based MRI for estimating hepatic proton density fat fraction in adults, using MR spectroscopy as reference. J Magn Reson Imaging. 2016 Feb; 43(2):398-406. PMID: 26201284.
        View in: PubMed
      22. Hamilton G, Middleton MS, Hooker JC, Haufe WM, Forbang NI, Allison MA, Loomba R, Sirlin C. In vivo breath-hold (1) H MRS simultaneous estimation of liver proton density fat fraction, and T1 and T2 of water and fat, with a multi-TR, multi-TE sequence. J Magn Reson Imaging. 2015 Dec; 42(6):1538-43. PMID: 26114603.
        View in: PubMed
      23. Merkle EM, Zech CJ, Bartolozzi C, Bashir MR, Ba-Ssalamah A, Huppertz A, Lee JM, Ricke J, Sakamoto M, Sirlin C, Ye SL, Zeng M. Consensus report from the 7th International Forum for Liver Magnetic Resonance Imaging. Eur Radiol. 2016 Mar; 26(3):674-82. PMID: 26070500.
        View in: PubMed
      24. Sirlin C. Imaging Techniques for Hepatocellular Carcinoma. Gastroenterol Hepatol (N Y). 2015 Jun; 11(6):403-5. PMID: 27118935.
        View in: PubMed
      25. Shah A, Tang A, Santillan C, Sirlin C. Cirrhotic liver: What's that nodule? The LI-RADS approach. J Magn Reson Imaging. 2016 Feb; 43(2):281-94. PMID: 25996905.
        View in: PubMed
      26. Costa EA, Cunha GM, Smorodinsky E, Cruite I, Tang A, Marks RM, Clark L, Wolfson T, Gamst A, Sicklick JK, Hemming A, Peterson MR, Middleton MS, Sirlin C. Diagnostic Accuracy of Preoperative Gadoxetic Acid-enhanced 3-T MR Imaging for Malignant Liver Lesions by Using Ex Vivo MR Imaging-matched Pathologic Findings as the Reference Standard. Radiology. 2015 Sep; 276(3):775-86. PMID: 25875972.
        View in: PubMed
      27. Zand KA, Shah A, Heba E, Wolfson T, Hamilton G, Lam J, Chen J, Hooker JC, Gamst AC, Middleton MS, Schwimmer JB, Sirlin C. Accuracy of multiecho magnitude-based MRI (M-MRI) for estimation of hepatic proton density fat fraction (PDFF) in children. J Magn Reson Imaging. 2015 Nov; 42(5):1223-32. PMID: 25847512.
        View in: PubMed
      28. Hope TA, Fowler KJ, Sirlin C, Costa EA, Yee J, Yeh BM, Heiken JP. Hepatobiliary agents and their role in LI-RADS. Abdom Imaging. 2015 Mar; 40(3):613-25. PMID: 25287679.
        View in: PubMed
      29. Marks RM, Ryan A, Heba ER, Tang A, Wolfson TJ, Gamst AC, Sirlin C, Bashir MR. Diagnostic per-patient accuracy of an abbreviated hepatobiliary phase gadoxetic Acid-enhanced MRI for hepatocellular carcinoma surveillance. AJR Am J Roentgenol. 2015 Mar; 204(3):527-35. PMID: 25714281.
        View in: PubMed
      30. Loomba R, Sirlin C, Ang B, Bettencourt R, Jain R, Salotti J, Soaft L, Hooker J, Kono Y, Bhatt A, Hernandez L, Nguyen P, Noureddin M, Haufe W, Hooker C, Yin M, Ehman R, Lin GY, Valasek MA, Brenner DA, Richards L. Ezetimibe for the treatment of nonalcoholic steatohepatitis: Assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Hepatology. 2015 Apr; 61(4):1239-50. PMID: 25482832.
        View in: PubMed
      31. Schwimmer JB, Middleton MS, Behling C, Newton KP, Awai HI, Paiz MN, Lam J, Hooker JC, Hamilton G, Fontanesi J, Sirlin C. Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease. Hepatology. 2015 Jun; 61(6):1887-95. PMID: 25529941.
        View in: PubMed
      32. Arulanandan A, Ang B, Bettencourt R, Hooker J, Behling C, Lin GY, Valasek MA, Ix JH, Schnabl B, Sirlin C, Loomba R. Association Between Quantity of Liver Fat and Cardiovascular Risk in Patients With Nonalcoholic Fatty Liver Disease Independent of Nonalcoholic Steatohepatitis. Clin Gastroenterol Hepatol. 2015 Aug; 13(8):1513-1520.e1. PMID: 25661453.
        View in: PubMed
      33. Artz NS, Haufe WM, Hooker CA, Hamilton G, Wolfson T, Campos GM, Gamst AC, Schwimmer JB, Sirlin C, Reeder SB. Reproducibility of MR-based liver fat quantification across field strength: Same-day comparison between 1.5T and 3T in obese subjects. J Magn Reson Imaging. 2015 Sep; 42(3):811-7. PMID: 25620624.
        View in: PubMed
      34. Tang A, Chen J, Le TA, Changchien C, Hamilton G, Middleton MS, Loomba R, Sirlin C. Cross-sectional and longitudinal evaluation of liver volume and total liver fat burden in adults with nonalcoholic steatohepatitis. Abdom Imaging. 2015 Jan; 40(1):26-37. PMID: 25015398.
        View in: PubMed
      35. Lin SC, Heba E, Wolfson T, Ang B, Gamst A, Han A, Erdman JW, O'Brien WD, Andre MP, Sirlin C, Loomba R. Noninvasive Diagnosis of Nonalcoholic Fatty Liver Disease and Quantification of Liver Fat Using a New Quantitative Ultrasound Technique. Clin Gastroenterol Hepatol. 2015 Jul; 13(7):1337-1345.e6. PMID: 25478922.
        View in: PubMed
      36. Loomba R, Wolfson T, Ang B, Hooker J, Behling C, Peterson M, Valasek M, Lin G, Brenner D, Gamst A, Ehman R, Sirlin C. Magnetic resonance elastography predicts advanced fibrosis in patients with nonalcoholic fatty liver disease: A prospective study. Hepatology. 2014 Dec; 60(6):1920-8. PMID: 25103310.
        View in: PubMed
      37. Choi JY, Lee JM, Sirlin C. CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features. Radiology. 2014 Oct; 273(1):30-50. PMID: 25247563.
        View in: PubMed
      38. Murphy P, Hooker J, Ang B, Wolfson T, Gamst A, Bydder M, Middleton M, Peterson M, Behling C, Loomba R, Sirlin C. Associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative diffusion-weighted MRI measurements in adults. J Magn Reson Imaging. 2015 Jun; 41(6):1629-38. PMID: 25256692.
        View in: PubMed
      39. Tang A, Desai A, Hamilton G, Wolfson T, Gamst A, Lam J, Clark L, Hooker J, Chavez T, Ang BD, Middleton MS, Peterson M, Loomba R, Sirlin C. Accuracy of MR Imaging-estimated Proton Density Fat Fraction for Classification of Dichotomized Histologic Steatosis Grades in Nonalcoholic Fatty Liver Disease. Radiology. 2015 Feb; 274(2):416-25. PMID: 25247408.
        View in: PubMed
      40. Patel NS, Doycheva I, Peterson MR, Hooker J, Kisselva T, Schnabl B, Seki E, Sirlin C, Loomba R. Effect of weight loss on magnetic resonance imaging estimation of liver fat and volume in patients with nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2015 Mar; 13(3):561-568.e1. PMID: 25218667.
        View in: PubMed
      41. Choi JY, Lee JM, Sirlin C. CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part I. Development, Growth, and Spread: Key Pathologic and Imaging Aspects. Radiology. 2014 Sep; 272(3):635-54. PMID: 25153274.
        View in: PubMed
      42. Bashir MR, Sirlin C, Reeder SB. On confirmation bias in imaging research. J Magn Reson Imaging. 2015 May; 41(5):1163-4. PMID: 25124454.
        View in: PubMed
      43. Santillan CS, Tang A, Cruite I, Shah A, Sirlin C. Understanding LI-RADS: A Primer for Practical Use. Magn Reson Imaging Clin N Am. 2014 Aug; 22(3):337-352. PMID: 25086933.
        View in: PubMed
      44. Jha RC, Mitchell DG, Weinreb JC, Santillan CS, Yeh BM, Francois R, Sirlin C. LI-RADS categorization of benign and likely benign findings in patients at risk of hepatocellular carcinoma: a pictorial atlas. AJR Am J Roentgenol. 2014 Jul; 203(1):W48-69. PMID: 24951229.
        View in: PubMed
      45. Bonekamp S, Tang A, Mashhood A, Wolfson T, Changchien C, Middleton MS, Clark L, Gamst A, Loomba R, Sirlin C. Spatial distribution of MRI-Determined hepatic proton density fat fraction in adults with nonalcoholic fatty liver disease. J Magn Reson Imaging. 2014 Jun; 39(6):1525-32. PMID: 24987758.
        View in: PubMed
      46. Smorodinsky E, Ansdell DS, Foster ZW, Mazhar SM, Cruite I, Wolfson T, Sugay SB, Iussich G, Shiehmorteza M, Kono Y, Kuo A, Sirlin C. Risk of nephrogenic systemic fibrosis is low in patients with chronic liver disease exposed to gadolinium-based contrast agents. J Magn Reson Imaging. 2015 May; 41(5):1259-67. PMID: 24811860.
        View in: PubMed
      47. Choi JY, Kim H, Sun M, Sirlin C. Histogram Analysis of Hepatobiliary Phase MR Imaging as a Quantitative Value for Liver Cirrhosis: Preliminary Observations. Yonsei Med J. 2014 May 1; 55(3):651-9. PMID: 24719131.
        View in: PubMed
      48. Hernando D, Levin YS, Sirlin C, Reeder SB. Quantification of liver iron with MRI: State of the art and remaining challenges. J Magn Reson Imaging. 2014 Nov; 40(5):1003-21. PMID: 24585403.
        View in: PubMed
      49. Patel NS, Peterson MR, Lin GY, Feldstein A, Schnabl B, Bettencourt R, Seki E, Sirlin C, Loomba R. Insulin Resistance Increases MRI-Estimated Pancreatic Fat in Nonalcoholic Fatty Liver Disease and Normal Controls. Gastroenterol Res Pract. 2013; 2013:498296. PMID: 24348536.
        View in: PubMed
      50. Sirlin C, Hussain HK, Jonas E, Kanematsu M, Min Lee J, Merkle EM, Peck-Radosavljevic M, Reeder SB, Ricke J, Sakamoto M. Consensus report from the 6th International forum for liver MRI using gadoxetic acid. J Magn Reson Imaging. 2014 Sep; 40(3):516-29. PMID: 24923695.
        View in: PubMed
      51. Negrete LM, Middleton MS, Clark L, Wolfson T, Gamst AC, Lam J, Changchien C, Deyoung-Dominguez IM, Hamilton G, Loomba R, Schwimmer J, Sirlin C. Inter-examination precision of magnitude-based MRI for estimation of segmental hepatic proton density fat fraction in obese subjects. J Magn Reson Imaging. 2014 May; 39(5):1265-71. PMID: 24136736.
        View in: PubMed
      52. Noureddin M, Lam J, Peterson MR, Middleton M, Hamilton G, Le TA, Bettencourt R, Changchien C, Brenner DA, Sirlin C, Loomba R. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013 Dec; 58(6):1930-40. PMID: 23696515.
        View in: PubMed
      53. Awai HI, Newton KP, Sirlin C, Behling C, Schwimmer JB. Evidence and recommendations for imaging liver fat in children, based on systematic review. Clin Gastroenterol Hepatol. 2014 May; 12(5):765-73. PMID: 24090729.
        View in: PubMed
      54. Levin YS, Yokoo T, Wolfson T, Gamst AC, Collins J, Achmad EA, Hamilton G, Middleton MS, Loomba R, Sirlin C. Effect of echo-sampling strategy on the accuracy of out-of-phase and in-phase multiecho gradient-Echo MRI hepatic fat fraction estimation. J Magn Reson Imaging. 2014 Mar; 39(3):567-75. PMID: 23720420.
        View in: PubMed
      55. Liau J, Shiehmorteza M, Girard OM, Sirlin C, Bydder M. Evaluation of MRI fat fraction in the liver and spine pre and post SPIO infusion. Magn Reson Imaging. 2013 Jul; 31(6):1012-6. PMID: 23602721.
        View in: PubMed
      56. Johnson BL, Schroeder ME, Wolfson T, Gamst AC, Hamilton G, Shiehmorteza M, Loomba R, Schwimmer JB, Reeder S, Middleton MS, Sirlin C. Effect of flip angle on the accuracy and repeatability of hepatic proton density fat fraction estimation by complex data-based, T1-independent, T2*-corrected, spectrum-modeled MRI. J Magn Reson Imaging. 2014 Feb; 39(2):440-7. PMID: 23596052.
        View in: PubMed
      57. Tang A, Tan J, Sun M, Hamilton G, Bydder M, Wolfson T, Gamst AC, Middleton M, Brunt EM, Loomba R, Lavine JE, Schwimmer JB, Sirlin C. Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology. 2013 May; 267(2):422-31. PMID: 23382291.
        View in: PubMed
      58. Murphy P, Wolfson T, Gamst A, Sirlin C, Bydder M. Error model for reduction of cardiac and respiratory motion effects in quantitative liver DW-MRI. Magn Reson Med. 2013 Nov; 70(5):1460-9. PMID: 23280855.
        View in: PubMed
      59. Mashhood A, Railkar R, Yokoo T, Levin Y, Clark L, Fox-Bosetti S, Middleton MS, Riek J, Kauh E, Dardzinski BJ, Williams D, Sirlin C, Shire NJ. Reproducibility of hepatic fat fraction measurement by magnetic resonance imaging. J Magn Reson Imaging. 2013 Jun; 37(6):1359-70. PMID: 23172799.
        View in: PubMed
      60. Sirlin C. Invited commentary. Radiographics. 2012 Nov-Dec; 32(7):1995-8; discussion 1998. PMID: 23304704.
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      61. Bahl G, Cruite I, Wolfson T, Gamst AC, Collins JM, Chavez AD, Barakat F, Hassanein T, Sirlin C. Noninvasive classification of hepatic fibrosis based on texture parameters from double contrast-enhanced magnetic resonance images. J Magn Reson Imaging. 2012 Nov; 36(5):1154-61. PMID: 22851409.
        View in: PubMed
      62. Reeder SB, Hu HH, Sirlin C. Proton density fat-fraction: a standardized MR-based biomarker of tissue fat concentration. J Magn Reson Imaging. 2012 Nov; 36(5):1011-4. PMID: 22777847.
        View in: PubMed
      63. Le TA, Chen J, Changchien C, Peterson MR, Kono Y, Patton H, Cohen BL, Brenner D, Sirlin C, Loomba R. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatology. 2012 Sep; 56(3):922-32. PMID: 22431131.
        View in: PubMed
      64. Hu HH, Börnert P, Hernando D, Kellman P, Ma J, Reeder S, Sirlin C. ISMRM workshop on fat-water separation: insights, applications and progress in MRI. Magn Reson Med. 2012 Aug; 68(2):378-88. PMID: 22693111.
        View in: PubMed
      65. Kang BK, Yu ES, Lee SS, Lee Y, Kim N, Sirlin C, Cho EY, Yeom SK, Byun JH, Park SH, Lee MG. Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard. Invest Radiol. 2012 Jun; 47(6):368-75. PMID: 22543969.
        View in: PubMed
      66. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):E1369-76. PMID: 22538808.
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      67. Lee JT, Liau J, Murphy P, Schroeder ME, Sirlin C, Bydder M. Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging. Magn Reson Imaging. 2012 May; 30(4):572-8. PMID: 22285877.
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      68. Hansen KH, Schroeder ME, Hamilton G, Sirlin C, Bydder M. Robustness of fat quantification using chemical shift imaging. Magn Reson Imaging. 2012 Feb; 30(2):151-7. PMID: 22055856.
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      69. Reeder SB, Cruite I, Hamilton G, Sirlin C. Quantitative Assessment of Liver Fat with Magnetic Resonance Imaging and Spectroscopy. J Magn Reson Imaging. 2011 Oct; 34(4):spcone. PMID: 22025886.
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      70. Reeder SB, Cruite I, Hamilton G, Sirlin C. Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. 2011 Oct; 34(4):729-49. PMID: 21928307.
        View in: PubMed
      71. Liau J, Lee J, Schroeder ME, Sirlin C, Bydder M. Cardiac motion in diffusion-weighted MRI of the liver: artifact and a method of correction. J Magn Reson Imaging. 2012 Feb; 35(2):318-27. PMID: 21959926.
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      72. Kang GH, Cruite I, Shiehmorteza M, Wolfson T, Gamst AC, Hamilton G, Bydder M, Middleton MS, Sirlin C. Reproducibility of MRI-determined proton density fat fraction across two different MR scanner platforms. J Magn Reson Imaging. 2011 Oct; 34(4):928-34. PMID: 21769986.
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      73. Sirlin C. Science to practice: Can T1rho imaging be used to diagnose and assess the severity of hepatic fibrosis? Radiology. 2011 Jun; 259(3):619-20. PMID: 21602499.
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      74. Hines CD, Frydrychowicz A, Hamilton G, Tudorascu DL, Vigen KK, Yu H, McKenzie CA, Sirlin C, Brittain JH, Reeder SB. T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. J Magn Reson Imaging. 2011 Apr; 33(4):873-81. PMID: 21448952.
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      75. Yu H, Shimakawa A, Hines CD, McKenzie CA, Hamilton G, Sirlin C, Brittain JH, Reeder SB. Combination of complex-based and magnitude-based multiecho water-fat separation for accurate quantification of fat-fraction. Magn Reson Med. 2011 Jul; 66(1):199-206. PMID: 21695724.
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      82. Sirlin C, Reeder SB. Magnetic resonance imaging quantification of liver iron. Magn Reson Imaging Clin N Am. 2010 Aug; 18(3):359-81, ix. PMID: 21094445.
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      83. Ganesan K, Achmad E, Sirlin C, Bouvet M, Datnow B, Weidner N, Peterson MR. Amphicrine carcinoma of the liver. Ann Diagn Pathol. 2011 Oct; 15(5):355-7. PMID: 20952282.
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      84. Cruite I, Schroeder M, Merkle EM, Sirlin C. Gadoxetate disodium-enhanced MRI of the liver: part 2, protocol optimization and lesion appearance in the cirrhotic liver. AJR Am J Roentgenol. 2010 Jul; 195(1):29-41. PMID: 20566795.
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      85. Mwangi I, Hanna RF, Kased N, Malek P, Shiehmorteza M, Wolfson T, Gamst A, Sirlin C. Apparent diffusion coefficient of fibrosis and regenerative nodules in the cirrhotic liver at MRI. AJR Am J Roentgenol. 2010 Jun; 194(6):1515-22. PMID: 20489091.
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      86. Yokoo T, Bae WC, Hamilton G, Karimi A, Borgstede JP, Bowen BC, Sirlin C, Chung CB, Crues JV, Bradley WG, Bydder GM. A quantitative approach to sequence and image weighting. J Comput Assist Tomogr. 2010 May-Jun; 34(3):317-31. PMID: 20498530.
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      88. Schwimmer JB, Dunn W, Norman GJ, Pardee PE, Middleton MS, Kerkar N, Sirlin C. SAFETY study: alanine aminotransferase cutoff values are set too high for reliable detection of pediatric chronic liver disease. Gastroenterology. 2010 Apr; 138(4):1357-64, 1364.e1-2. PMID: 20064512.
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      89. Lindbäck SM, Gabbert C, Johnson BL, Smorodinsky E, Sirlin C, Garcia N, Pardee PE, Kistler KD, Schwimmer JB. Pediatric nonalcoholic fatty liver disease: a comprehensive review. Adv Pediatr. 2010; 57(1):85-140. PMID: 21056736.
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      90. Mazhar SM, Shiehmorteza M, Kohl CA, Middleton MS, Sirlin C. Nephrogenic systemic fibrosis in liver disease: a systematic review. J Magn Reson Imaging. 2009 Dec; 30(6):1313-22. PMID: 19937937.
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      91. Faria SC, Ganesan K, Mwangi I, Shiehmorteza M, Viamonte B, Mazhar S, Peterson M, Kono Y, Santillan C, Casola G, Sirlin C. MR imaging of liver fibrosis: current state of the art. Radiographics. 2009 Oct; 29(6):1615-35. PMID: 19959511.
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      92. Loomba R, Sirlin C, Schwimmer JB, Lavine JE. Advances in pediatric nonalcoholic fatty liver disease. Hepatology. 2009 Oct; 50(4):1282-93. PMID: 19637286.
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      93. Shiehmorteza M, Sirlin C, Wolfson T, Gamst A, Soumekh AE, Heaton SP, Kohl CA, Pinto N, Bydder M. Effect of shot number on the calculated apparent diffusion coefficient in phantoms and in human liver in diffusion-weighted echo-planar imaging. J Magn Reson Imaging. 2009 Sep; 30(3):547-53. PMID: 19711409.
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      94. Sirlin C. Invited commentary. Radiographics. 2009 Sep-Oct; 29(5):1277-80. PMID: 19764109.
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      95. Hamilton G, Middleton MS, Bydder M, Yokoo T, Schwimmer JB, Kono Y, Patton HM, Lavine JE, Sirlin C. Effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging. 2009 Jul; 30(1):145-52. PMID: 19557733.
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      96. Yokoo T, Bydder M, Hamilton G, Middleton MS, Gamst AC, Wolfson T, Hassanein T, Patton HM, Lavine JE, Schwimmer JB, Sirlin C. Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology. 2009 Apr; 251(1):67-76. PMID: 19221054.
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      97. Schwimmer JB, Celedon MA, Lavine JE, Salem R, Campbell N, Schork NJ, Shiehmorteza M, Yokoo T, Chavez A, Middleton MS, Sirlin C. Heritability of nonalcoholic fatty liver disease. Gastroenterology. 2009 May; 136(5):1585-92. PMID: 19208353.
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      98. Cassidy FH, Yokoo T, Aganovic L, Hanna RF, Bydder M, Middleton MS, Hamilton G, Chavez AD, Schwimmer JB, Sirlin C. Fatty liver disease: MR imaging techniques for the detection and quantification of liver steatosis. Radiographics. 2009 Jan-Feb; 29(1):231-60. PMID: 19168847.
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      99. Mazhar SM, Shiehmorteza M, Sirlin C. Noninvasive assessment of hepatic steatosis. Clin Gastroenterol Hepatol. 2009 Feb; 7(2):135-40. PMID: 19118644.
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      100. Yokoo T, Collins JM, Hanna RF, Bydder M, Middleton MS, Sirlin C. Effects of intravenous gadolinium administration and flip angle on the assessment of liver fat signal fraction with opposed-phase and in-phase imaging. J Magn Reson Imaging. 2008 Jul; 28(1):246-51. PMID: 18581393.
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      101. Bydder M, Hamilton G, Yokoo T, Sirlin C. Optimal phased-array combination for spectroscopy. Magn Reson Imaging. 2008 Jul; 26(6):847-50. PMID: 18486392.
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      102. Hanna RF, Aguirre DA, Kased N, Emery SC, Peterson MR, Sirlin C. Cirrhosis-associated hepatocellular nodules: correlation of histopathologic and MR imaging features. Radiographics. 2008 May-Jun; 28(3):747-69. PMID: 18480482.
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      103. Yeh BM, Joe BN, Sirlin C, Webb EM, Westphalen AC, Qayyum A, Coakley FV. Vascular contact with soft tissue: a sign of mesenteric masses at computed tomography. J Comput Assist Tomogr. 2008 Mar-Apr; 32(2):185-90. PMID: 18379299.
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      104. Bydder M, Yokoo T, Hamilton G, Middleton MS, Chavez AD, Schwimmer JB, Lavine JE, Sirlin C. Relaxation effects in the quantification of fat using gradient echo imaging. Magn Reson Imaging. 2008 Apr; 26(3):347-59. PMID: 18093781.
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      105. Hanna RF, Kased N, Kwan SW, Gamst AC, Santosa AC, Hassanein T, Sirlin C. Double-contrast MRI for accurate staging of hepatocellular carcinoma in patients with cirrhosis. AJR Am J Roentgenol. 2008 Jan; 190(1):47-57. PMID: 18094293.
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      106. Leite NP, Kased N, Hanna RF, Brown MA, Pereira JM, Cunha R, Sirlin C. Cross-sectional imaging of extranodal involvement in abdominopelvic lymphoproliferative malignancies. Radiographics. 2007 Nov-Dec; 27(6):1613-34. PMID: 18025507.
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      107. Hughes-Cassidy F, Chavez AD, Schlang A, Hassanein T, Gamst A, Wolfson T, Sirlin C. Superparamagnetic iron oxides and low molecular weight gadolinium chelates are synergistic for direct visualization of advanced liver fibrosis. J Magn Reson Imaging. 2007 Sep; 26(3):728-37. PMID: 17685418.
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      108. Kuo MD, Gollub J, Sirlin C, Ooi C, Chen X. Radiogenomic analysis to identify imaging phenotypes associated with drug response gene expression programs in hepatocellular carcinoma. J Vasc Interv Radiol. 2007 Jul; 18(7):821-31. PMID: 17609439.
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      109. Hamer OW, Schlottmann K, Sirlin C, Feuerbach S. Technology insight: advances in liver imaging. Nat Clin Pract Gastroenterol Hepatol. 2007 Apr; 4(4):215-28. PMID: 17404589.
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      110. Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G. Acute appendicitis: diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings. Eur Radiol. 2007 Aug; 17(8):2055-61. PMID: 17180324.
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      111. Hall FM, Casola G, Sirlin C, Furtado CD, Aguirre DA, Brown MA. Callback and follow-up guidelines for whole-body CT screening. Radiology. 2006 Nov; 241(2):627-8; author reply 628-9. PMID: 17057082.
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      112. Gandhi SN, Brown MA, Wong JG, Aguirre DA, Sirlin C. MR contrast agents for liver imaging: what, when, how. Radiographics. 2006 Nov-Dec; 26(6):1621-36. PMID: 17102040.
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      113. Hamer OW, Aguirre DA, Casola G, Lavine JE, Woenckhaus M, Sirlin C. Fatty liver: imaging patterns and pitfalls. Radiographics. 2006 Nov-Dec; 26(6):1637-53. PMID: 17102041.
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      114. Patton HM, Sirlin C, Behling C, Middleton M, Schwimmer JB, Lavine JE. Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr. 2006 Oct; 43(4):413-27. PMID: 17033514.
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      115. Aguirre DA, Behling CA, Alpert E, Hassanein TI, Sirlin C. Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging. Radiology. 2006 May; 239(2):425-37. PMID: 16641352.
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      116. Brown MA, Mattrey RF, Stamato S, Sirlin C. MRI of the female pelvis using vaginal gel. AJR Am J Roentgenol. 2005 Nov; 185(5):1221-7. PMID: 16247138.
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      117. Aguirre DA, Santosa AC, Casola G, Sirlin C. Abdominal wall hernias: imaging features, complications, and diagnostic pitfalls at multi-detector row CT. Radiographics. 2005 Nov-Dec; 25(6):1501-20. PMID: 16284131.
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      118. Yoo RY, Sirlin C, Gottschalk M, Chang RJ. Ovarian imaging by magnetic resonance in obese adolescent girls with polycystic ovary syndrome: a pilot study. Fertil Steril. 2005 Oct; 84(4):985-95. PMID: 16213854.
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      119. Hamer OW, Sirlin C, Strotzer M, Borisch I, Zorger N, Feuerbach S, Völk M. Chest radiography with a flat-panel detector: image quality with dose reduction after copper filtration. Radiology. 2005 Nov; 237(2):691-700. PMID: 16192324.
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      120. Furtado CD, Aguirre DA, Sirlin C, Dang D, Stamato SK, Lee P, Sani F, Brown MA, Levin DL, Casola G. Whole-body CT screening: spectrum of findings and recommendations in 1192 patients. Radiology. 2005 Nov; 237(2):385-94. PMID: 16170016.
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      121. Hamer OW, Aguirre DA, Casola G, Sirlin C. Imaging features of perivascular fatty infiltration of the liver: initial observations. Radiology. 2005 Oct; 237(1):159-69. PMID: 16100085.
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      122. Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G. CT appearance of the normal appendix in adults. Eur Radiol. 2005 Oct; 15(10):2096-103. PMID: 15912331.
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      123. Brown MA, Sirlin C. Female pelvis. Magn Reson Imaging Clin N Am. 2005 May; 13(2):381-95. PMID: 15935318.
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      124. Farahmand N, Sirlin C, Brown MA, Shragg GP, Fortlage D, Hoyt DB, Casola G. Hypotensive patients with blunt abdominal trauma: performance of screening US. Radiology. 2005 May; 235(2):436-43. PMID: 15798158.
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      125. Laufik M, Buono D, Casola G, Sirlin C. Delayed traumatic bladder rupture. AJR Am J Roentgenol. 2005 Mar; 184(3 Suppl):S99-S101. PMID: 15728038.
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      126. Brown MA, Sirlin C, Farahmand N, Hoyt DB, Casola G. Screening sonography in pregnant patients with blunt abdominal trauma. J Ultrasound Med. 2005 Feb; 24(2):175-81; quiz 183-184. PMID: 15661948.
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      127. Pereira JM, Sirlin C, Pinto PS, Casola G. CT and MR imaging of extrahepatic fatty masses of the abdomen and pelvis: techniques, diagnosis, differential diagnosis, and pitfalls. Radiographics. 2005 Jan-Feb; 25(1):69-85. PMID: 15653588.
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      128. Sirlin C, Vera DR, Corbeil JA, Caballero MB, Buxton RB, Mattrey RF. Gadolinium-DTPA-dextran: a macromolecular MR blood pool contrast agent. Acad Radiol. 2004 Dec; 11(12):1361-9. PMID: 15596374.
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      129. Aguirre DA, Casola G, Sirlin C. Abdominal wall hernias: MDCT findings. AJR Am J Roentgenol. 2004 Sep; 183(3):681-90. PMID: 15333356.
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      130. Pereira JM, Sirlin C, Pinto PS, Jeffrey RB, Stella DL, Casola G. Disproportionate fat stranding: a helpful CT sign in patients with acute abdominal pain. Radiographics. 2004 May-Jun; 24(3):703-15. PMID: 15143223.
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      131. Pinto PS, Sirlin C, Andrade-Barreto OA, Brown MA, Mindelzun RE, Mattrey RF. Cisterna chyli at routine abdominal MR imaging: a normal anatomic structure in the retrocrural space. Radiographics. 2004 May-Jun; 24(3):809-17. PMID: 15143230.
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      132. Sirlin C, Brown MA, Andrade-Barreto OA, Deutsch R, Fortlage DA, Hoyt DB, Casola G. Blunt abdominal trauma: clinical value of negative screening US scans. Radiology. 2004 Mar; 230(3):661-8. PMID: 14990832.
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      133. Kono Y, Pinnell SP, Sirlin C, Sparks SR, Georgy B, Wong W, Mattrey RF. Carotid arteries: contrast-enhanced US angiography--preliminary clinical experience. Radiology. 2004 Feb; 230(2):561-8. PMID: 14699188.
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      134. Sirlin C, Brown MA, Deutsch R, Andrade-Barreto OA, Fortlage DA, Hoyt DB, Casola G. Screening US for blunt abdominal trauma: objective predictors of false-negative findings and missed injuries. Radiology. 2003 Dec; 229(3):766-74. PMID: 14657314.
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      135. Brown MA, Sirlin C, Hoyt DB, Casola G. Screening ultrasound in blunt abdominal trauma. J Intensive Care Med. 2003 Sep-Oct; 18(5):253-60. PMID: 15035759.
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