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    Clark Chen

    TitleAssociate Professor
    SchoolUniversity of California, San Diego
    DepartmentSurgery
    Address9500 Gilman Drive #0987
    CA La Jolla 92093
    vCardDownload vCard

      Collapse Research 
      Collapse Research Activities and Funding
      Targeting Mechanisms of Acquired Temozolomide Resistance in Glioblastoma
      NIH R01NS097649Aug 1, 2016 - May 31, 2021
      Role: Principal Investigator

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lau SK, Patel K, Kim T, Knipprath E, Kim GY, Cerviño LI, Lawson JD, Murphy KT, Sanghvi P, Carter BS, Chen C. Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors. J Neurooncol. 2017 Jan 24. PMID: 28120301.
        View in: PubMed
      2. Tringale KR, Wilson BR, Hirshman B, Zhou T, Folsom D, Norman MA, Grant I, Chen C, Carter BS. Psychiatric Disease Preceding Intracranial Tumor Diagnosis: Investigating the Association. Prim Care Companion CNS Disord. 2016 Dec 15; 18(6). PMID: 28002663.
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      3. Shaefi S, Mittel AM, Hyam JA, Boone MD, Chen C, Kasper EM. Hypothermia for severe traumatic brain injury in adults: Recent lessons from randomized controlled trials. Surg Neurol Int. 2016; 7:103. PMID: 28168089.
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      4. Brandel MG, Hirshman BR, McCutcheon BA, Tringale K, Carroll K, Richtand NM, Perry W, Chen C, Carter BS. The Association between Psychiatric Comorbidities and Outcomes for Inpatients with Traumatic Brain Injury. J Neurotrauma. 2017 Mar 01; 34(5):1005-1016. PMID: 27573722.
        View in: PubMed
      5. Wilson R, Espinosa-Diez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, Advani SJ, Li J, Khan OF, Franovic A, Weis SM, Kumar S, Coussens LM, Anderson DG, Chen C, Cheresh DA, Anand S. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016 Nov 25; 7:13597. PMID: 27886180.
        View in: PubMed
      6. Wilson BR, Tringale KR, Hirshman BR, Zhou T, Umlauf A, Taylor WR, Ciacci JD, Carter BS, Chen C. Depression After Spinal Surgery: A Comparative Analysis of the California Outcomes Database. Mayo Clin Proc. 2016 Nov 8. PMID: 27836112.
        View in: PubMed
      7. Chen C, Carter BS, Wang R, Patel KS, Hess C, Bodach ME, Tumialan LM, Oyesiku NM, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Preoperative Imaging Assessment of Patients With Suspected Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E524-6. PMID: 27635958.
        View in: PubMed
      8. Aghi MK, Chen C, Fleseriu M, Newman SA, Lucas JW, Kuo JS, Barkhoudarian G, Farrell CJ, Sheehan J, Ziu M, Dunn IF. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Management of Patients With Nonfunctioning Pituitary Adenomas: Executive Summary. Neurosurgery. 2016 Oct; 79(4):521-3. PMID: 27635956.
        View in: PubMed
      9. Rennert RC, Carroll KT, Ali MA, Hamelin T, Chang L, Lemkuil BP, Chen C. Safety of stereotactic laser ablations performed as treatment for glioblastomas in a conventional magnetic resonance imaging suite. Neurosurg Focus. 2016 Oct; 41(4):E7. PMID: 27690648.
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      10. Ali MA, Carroll KT, Rennert RC, Hamelin T, Chang L, Lemkuil BP, Sharma M, Barnholtz-Sloan JS, Myers C, Barnett GH, Smith K, Mohammadi AM, Sloan AE, Chen C. Stereotactic laser ablation as treatment for brain metastases that recur after stereotactic radiosurgery: a multiinstitutional experience. Neurosurg Focus. 2016 Oct; 41(4):E11. PMID: 27690654.
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      11. Ziu M, Dunn IF, Hess C, Fleseriu M, Bodach ME, Tumialan LM, Oyesiku NM, Patel KS, Wang R, Carter BS, Chen JY, Chen C, Patil CG, Litvack Z, Zada G, Aghi MK. Congress of Neurological Surgeons Systematic Review and Evidence-Based Guideline on Posttreatment Follow-up Evaluation of Patients With Nonfunctioning Pituitary Adenomas. Neurosurgery. 2016 Oct; 79(4):E541-3. PMID: 27635964.
        View in: PubMed
      12. Hoshide R, Cheung V, Marshall L, Kasper E, Chen C. Do corticosteroids play a role in the management of traumatic brain injury? Surg Neurol Int. 2016; 7:84. PMID: 27656315; PMCID: PMC5025911.
      13. Chen C, Depp C, Wilson B, Bartek J, Carter B. A pilot study of physician personal preferences for treatment of glioblastoma. Acta Neurochir (Wien). 2016 Oct; 158(10):1933. PMID: 27541491.
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      14. Hirshman BR, Jones LA, Carroll KT, Tang JA, Proudfoot JA, Carley KM, Carter BS, Chen C. Coevolution of Peer-Reviewed Literature and Clinical Practice in High-Grade Glioma Resection. World Neurosurg. 2016 Dec; 96:237-241. PMID: 27523637.
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      15. Chen C, Moskwa P, Zinn PO, Hirshman BR, Choi YE, Shukla SA, Fendler W, Lu J, Golub TR, Hjelmeland A, Chowdhury D. 334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas. Neurosurgery. 2016 Aug; 63 Suppl 1:197-8. PMID: 27399532.
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      16. Hirshman BR, Wilson B, James PA, Koiso T, Nagano O, Carter BS, Serizawa T, Yamamoto M, Chen C. 339 Comparative Prognostic Value of the Cumulative Intracranial Tumor Volume and Score Index for Radiosurgery in Brain Metastasis. Neurosurgery. 2016 Aug; 63 Suppl 1:199. PMID: 27399537.
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      17. Marcus LP, Marshall D, Hirshman BR, McCutcheon BA, Gonda DD, Koiso T, Hattangadi-Gluth JA, Carter BS, Yamamoto M, Chen C. Cumulative Intracranial Tumor Volume (CITV) Enhances the Prognostic Value of the Lung-Specific Graded Prognostic Assessment (GPA) Model. Neurosurgery. 2016 Aug; 79(2):246-52. PMID: 26579964.
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      18. Rennert RC, Hoshide RR, Signorelli JW, Amaro D, Sack JA, Brennan CW, Chen C. Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis. J Neurosurg. 2016 Jul 22; 1-7. PMID: 27447440.
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      19. Kalinina J, Ahn J, Devi NS, Wang L, Li Y, Olson JJ, Glantz M, Smith T, Kim EL, Giese A, Jensen RL, Chen C, Carter BS, Mao H, He M, Van Meir EG. Selective Detection of the D-enantiomer of 2-Hydroxyglutarate in the CSF of Glioma Patients with Mutated Isocitrate Dehydrogenase. Clin Cancer Res. 2016 Jun 23. PMID: 27340277.
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      20. Cloughesy TF, Landolfi J, Hogan DJ, Bloomfield S, Carter B, Chen C, Elder JB, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu PL, Piccioni D, Walbert T, Chu A, Das A, Diago OR, Gammon D, Gruber HE, Hanna M, Jolly DJ, Kasahara N, McCarthy D, Mitchell L, Ostertag D, Robbins JM, Rodriguez-Aguirre M, Vogelbaum MA. Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma. Sci Transl Med. 2016 Jun 1; 8(341):341ra75. PMID: 27252174.
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      21. Steed TC, Treiber JM, Patel K, Ramakrishnan V, Merk A, Smith AR, Carter BS, Dale AM, Chow LM, Chen C. Differential localization of glioblastoma subtype: implications on glioblastoma pathogenesis. Oncotarget. 2016 May 3; 7(18):24899-907. PMID: 27056901.
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      22. Hirshman BR, Jones LA, Tang JA, Proudfoot JA, Carley KM, Carter BS, Chen C. 'Journal Bias' in peer-reviewed literature: an analysis of the surgical high-grade glioma literature. J Neurol Neurosurg Psychiatry. 2016 Nov; 87(11):1248-1250. PMID: 27118036.
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      23. Abraham P, Rennert RC, Martin JR, Ciacci J, Taylor W, Resnick D, Kasper E, Chen C. The role of surgery for treatment of low back pain: insights from the randomized controlled Spine Patient Outcomes Research Trials. Surg Neurol Int. 2016; 7:38. PMID: 27127703.
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      24. Patel KS, Yao Y, Wang R, Carter BS, Chen C. Intraoperative magnetic resonance imaging assessment of non-functioning pituitary adenomas during transsphenoidal surgery. Pituitary. 2016 Apr; 19(2):222-31. PMID: 26323592.
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      25. Treiber JM, White NS, Steed TC, Bartsch H, Holland D, Farid N, McDonald CR, Carter BS, Dale AM, Chen C. Characterization and Correction of Geometric Distortions in 814 Diffusion Weighted Images. PLoS One. 2016; 11(3):e0152472. PMID: 27027775.
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      26. Akers JC, Ramakrishnan V, Yang I, Hua W, Mao Y, Carter BS, Chen C. Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid. Cancer Biomark. 2016 Mar 25; 17(2):125-32. PMID: 27062568.
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      27. Yao Y, Ye H, Qi Z, Mo L, Yue Q, Baral A, Hoon DS, Vera JC, Heiss JD, Chen C, Hua W, Zhang J, Jin K, Wang Y, Zang X, Mao Y, Zhou L. B7-H4(B7x)-Mediated Cross-talk between Glioma-Initiating Cells and Macrophages via the IL6/JAK/STAT3 Pathway Lead to Poor Prognosis in Glioma Patients. Clin Cancer Res. 2016 Jun 1; 22(11):2778-90. PMID: 27001312.
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      28. Marshall DC, Marcus LP, Kim TE, McCutcheon BA, Goetsch SJ, Koiso T, Alksne JF, Ott K, Carter BS, Hattangadi-Gluth JA, Yamamoto M, Chen C. Management patterns of patients with cerebral metastases who underwent multiple stereotactic radiosurgeries. J Neurooncol. 2016 May; 128(1):119-28. PMID: 26948673.
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      29. Padwal JA, Dong X, Hirshman BR, Hoi-Sang U, Carter BS, Chen C. Superior Efficacy of Gross Total Resection in Anaplastic Astrocytoma Patients Relative to Glioblastoma Patients. World Neurosurg. 2016 Jun; 90:186-93. PMID: 26924115.
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      30. Taich ZJ, Goetsch SJ, Monaco E, Carter BS, Ott K, Alksne JF, Chen C. Stereotactic Radiosurgery Treatment of Trigeminal Neuralgia: Clinical Outcomes and Prognostic Factors. World Neurosurg. 2016 Jun; 90:604-612.e11. PMID: 26915701.
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      31. Akers JC, Ramakrishnan V, Nolan JP, Duggan E, Fu CC, Hochberg FH, Chen C, Carter BS. Comparative Analysis of Technologies for Quantifying Extracellular Vesicles (EVs) in Clinical Cerebrospinal Fluids (CSF). PLoS One. 2016; 11(2):e0149866. PMID: 26901428.
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      32. Bao X, Deng K, Liu X, Feng M, Chen C, Lian W, Xing B, Yao Y, Wang R. Extended transsphenoidal approach for pituitary adenomas invading the cavernous sinus using multiple complementary techniques. Pituitary. 2016 Feb; 19(1):1-10. PMID: 26267303.
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      33. Hirshman BR, Tang JA, Jones LA, Proudfoot JA, Carley KM, Marshall L, Carter BS, Chen C. Impact of medical academic genealogy on publication patterns: An analysis of the literature for surgical resection in brain tumor patients. Ann Neurol. 2016 Feb; 79(2):169-77. PMID: 26727354.
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      34. Yang P, Zhang W, Wang Y, Peng X, Chen B, Qiu X, Li G, Li S, Wu C, Yao K, Li W, Yan W, Li J, You Y, Chen C, Jiang T. IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry. Oncotarget. 2015 Dec 1; 6(38):40896-906. PMID: 26503470.
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      35. Boone MD, Oren-Grinberg A, Robinson TM, Chen C, Kasper EM. Mannitol or hypertonic saline in the setting of traumatic brain injury: What have we learned? Surg Neurol Int. 2015; 6:177. PMID: 26673517.
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      36. Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Cavaller BM, Chen C, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:26533. PMID: 26320937.
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      37. Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, Danielson K, Subramanya V, Ghiran I, Das S, Chen C, Pusic KM, Pusic AD, Chatterjee D, Kraig RP, Balaj L, Dooner M. Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:27575. PMID: 26320942.
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      38. Cheung V, Hoshide R, Bansal V, Kasper E, Chen C. Methylprednisolone in the management of spinal cord injuries: Lessons from randomized, controlled trials. Surg Neurol Int. 2015; 6:142. PMID: 26392918.
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      39. Christ SM, Mahadevan A, Floyd SR, Lam FC, Chen C, Wong ET, Kasper EM. Stereotactic radiosurgery for brain metastases from malignant melanoma. Surg Neurol Int. 2015; 6(Suppl 12):S355-65. PMID: 26392919.
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      40. Lau SK, Zakeri K, Zhao X, Carmona R, Knipprath E, Simpson DR, Nath SK, Kim GY, Sanghvi P, Hattangadi-Gluth JA, Chen C, Murphy KT. Single-Isocenter Frameless Volumetric Modulated Arc Radiosurgery for Multiple Intracranial Metastases. Neurosurgery. 2015 Aug; 77(2):233-40. PMID: 25856109.
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      41. Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR, Chen C. Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4055-64. PMID: 26159421.
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      42. Lai G, Muller KA, Carter BS, Chen C. Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma. Surg Neurol Int. 2015; 6(Suppl 9):S295-9. PMID: 26167373.
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      43. Shen Y, Li J, Nitta M, Futalan D, Steed T, Treiber JM, Taich Z, Stevens D, Wykosky J, Chen HZ, Carter BS, Becher OJ, Kennedy R, Esashi F, Sarkaria JN, Furnari FB, Cavenee WK, Desai A, Chen C. Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition. Oncotarget. 2015 May 20; 6(14):11751-67. PMID: 26059434.
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      44. McCutcheon BA, Chang DC, Marcus L, Gonda DD, Noorbakhsh A, Chen C, Talamini MA, Carter BS. Treatment biases in traumatic neurosurgical care: a retrospective study of the Nationwide Inpatient Sample from 1998 to 2009. J Neurosurg. 2015 Aug; 123(2):406-14. PMID: 25955874.
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      45. Akers JC, Ramakrishnan V, Kim R, Phillips S, Kaimal V, Mao Y, Hua W, Yang I, Fu CC, Nolan J, Nakano I, Yang Y, Beaulieu M, Carter BS, Chen C. miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients. J Neurooncol. 2015 Jun; 123(2):205-16. PMID: 25903655.
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      46. Gilder AS, Jones KA, Hu J, Wang L, Chen C, Carter BS, Gonias SL. Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion. J Biol Chem. 2015 Jun 12; 290(24):14798-809. PMID: 25837250.
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      47. Chang DC, Marcus LP, Chen C, Carter BS. Response. J Neurosurg. 2015 Mar; 122(3):723-4. PMID: 25879089.
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      48. Wykosky J, Hu J, Gomez GG, Taylor T, Villa GR, Pizzo D, VandenBerg SR, Thorne AH, Chen C, Mischel PS, Gonias SL, Cavenee WK, Furnari FB. A Urokinase Receptor-Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma. Cancer Res. 2015 Jan 15; 75(2):394-404. PMID: 25432173.
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      49. Chen C, White NS, Farid N, Kobalka P, Hansen L, Pearn M, Dale AM. Pre-operative cellularity mapping and intra-MRI surgery: potential for improving neurosurgical biopsies. Expert Rev Med Devices. 2015 Jan; 12(1):1-5. PMID: 25373612.
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      50. Moskwa P, Zinn PO, Choi YE, Shukla SA, Fendler W, Chen C, Lu J, Golub TR, Hjelmeland A, Chowdhury D. A Functional Screen Identifies miRs That Induce Radioresistance in Glioblastomas. Mol Cancer Res. 2014 Dec; 12(12):1767-78. PMID: 25256711.
        View in: PubMed
      51. Li J, Taich ZJ, Goyal A, Gonda D, Akers J, Adhikari B, Patel K, Vandenberg S, Yan W, Bao Z, Carter BS, Wang R, Mao Y, Jiang T, Chen C. Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas. Oncotarget. 2014 Sep 15; 5(17):7342-56. PMID: 25277177.
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      52. McCutcheon BA, Ciacci JD, Marcus LP, Noorbakhsh A, Gonda DD, McCafferty R, Taylor W, Chen C, Carter BS, Chang DC. 30-Day Perioperative Outcomes in Spinal Fusion by Specialty within the NSQIP Database. Spine (Phila Pa 1976). 2014 Sep 8. PMID: 25202939.
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      53. White NS, McDonald CR, Farid N, Kuperman J, Karow D, Schenker-Ahmed NM, Bartsch H, Rakow-Penner R, Holland D, Shabaik A, Bjørnerud A, Hope T, Hattangadi-Gluth J, Liss M, Parsons JK, Chen C, Raman S, Margolis D, Reiter RE, Marks L, Kesari S, Mundt AJ, Kaine CJ, Carter BS, Bradley WG, Dale AM. Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications of Restriction Spectrum Imaging. Cancer Res. 2014 Sep 1; 74(17):4638-4652. PMID: 25183788.
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      54. Santiago-Dieppa DR, Steinberg J, Gonda D, Cheung VJ, Carter BS, Chen C. Extracellular vesicles as a platform for 'liquid biopsy' in glioblastoma patients. Expert Rev Mol Diagn. 2014 Sep; 14(7):819-25. PMID: 25136839.
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      55. Bao ZS, Chen HM, Yang MY, Zhang CB, Yu K, Ye WL, Hu BQ, Yan W, Zhang W, Akers J, Ramakrishnan V, Li J, Carter B, Liu YW, Hu HM, Wang Z, Li MY, Yao K, Qiu XG, Kang CS, You YP, Fan XL, Song WS, Li RQ, Su XD, Chen C, Jiang T. RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas. Genome Res. 2014 Nov; 24(11):1765-73. PMID: 25135958.
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      56. Lau SK, Zhao X, Carmona R, Knipprath E, Simpson DR, Nath SK, Kim GY, Hattangadi JA, Chen C, Murphy KT. Frameless single-isocenter intensity modulated stereotactic radiosurgery for simultaneous treatment of multiple intracranial metastases. Transl Cancer Res. 2014 Aug 01; 3(4):383-390. PMID: 25821723.
        View in: PubMed
      57. Kushwaha D, Ramakrishnan V, Ng K, Steed T, Nguyen T, Futalan D, Akers JC, Sarkaria J, Jiang T, Chowdhury D, Carter BS, Chen C. A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas. Oncotarget. 2014 Jun 30; 5(12):4026-39. PMID: 24994119.
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      58. Scott BJ, van Vugt VA, Rush T, Brown T, Chen C, Carter BS, Schwab R, Fanta P, Helsten T, Bazhenova L, Parker B, Pingle S, Saria MG, Brown BD, Piccioni DE, Kesari S. Concurrent intrathecal methotrexate and liposomal cytarabine for leptomeningeal metastasis from solid tumors: a retrospective cohort study. J Neurooncol. 2014 Sep; 119(2):361-8. PMID: 24942463.
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      59. Hatefi D, Hirshman B, Leys D, Lejeune JP, Marshall L, Carter BS, Kasper E, Chen C. Hemicraniectomy in the management of malignant middle cerebral artery infarction: Lessons from randomized, controlled trials. Surg Neurol Int. 2014; 5:72. PMID: 24991475.
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      60. Gonda DD, Khalessi AA, McCutcheon BA, Marcus LP, Noorbakhsh A, Chen C, Chang DC, Carter BS. Long-term follow-up of unruptured intracranial aneurysms repaired in California. J Neurosurg. 2014 Jun; 120(6):1349-57. PMID: 24724850.
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      61. Gonda DD, Cheung VJ, Muller KA, Goyal A, Carter BS, Chen C. The Cancer Genome Atlas expression profiles of low-grade gliomas. Neurosurg Focus. 2014 Apr; 36(4):E23. PMID: 24812719.
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      62. Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen C. Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 2014 Apr; 5(4):882-93. PMID: 24658464.
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      63. Nigim F, Thomas AJ, Papavassiliou E, Schneider BE, Critchlow JF, Chen C, Siracuse JJ, Zinn PO, Kasper EM. Ventriculoperitoneal shunting: Laparoscopically assisted versus conventional open surgical approaches. Asian J Neurosurg. 2014 Apr; 9(2):72-81. PMID: 25126122.
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      64. Gonda DD, Kim TE, Goetsch SJ, Kawabe T, Watanabe S, Alksne JF, Hattangadi JA, Nitta M, Ott K, Hodgens DW, Carter BS, Yamamoto M, Chen C. Prognostic Factors for stereotactic radiosurgery-treated patients with cerebral metastasis: Implications on randomised control trial design and inter-institutional collaboration. Eur J Cancer. 2014 Apr; 50(6):1148-58. PMID: 24529832.
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      65. Almanza G, Anufreichik V, Rodvold JJ, Chiu KT, Delaney A, Akers JC, Chen C, Zanetti M. Synthesis and delivery of short, noncoding RNA by B lymphocytes. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20182-7. PMID: 24277816.
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      66. Noorbakhsh A, Tang JA, Marcus LP, McCutcheon B, Gonda DD, Schallhorn CS, Talamini MA, Chang DC, Carter BS, Chen C. Gross-total resection outcomes in an elderly population with glioblastoma: a SEER-based analysis. J Neurosurg. 2014 Jan; 120(1):31-9. PMID: 24205904.
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      67. Akers JC, Ramakrishnan V, Kim R, Skog J, Nakano I, Pingle S, Kalinina J, Hua W, Kesari S, Mao Y, Breakefield XO, Hochberg FH, Van Meir EG, Carter BS, Chen C. miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development. PLoS One. 2013; 8(10):e78115. PMID: 24205116.
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      68. Cron KR, Zhu K, Kushwaha DS, Hsieh G, Merzon D, Rameseder J, Chen C, D'Andrea AD, Kozono D. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One. 2013; 8(9):e73710. PMID: 24040035.
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      69. Gonda DD, Warnke P, Sanai N, Taich Z, Kasper EM, Chen C. The value of extended glioblastoma resection: Insights from randomized controlled trials. Surg Neurol Int. 2013; 4:110. PMID: 24032085.
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      70. Chen C, Kasper E. Resolving controversies in neurosurgery through randomized controlled trials. Surg Neurol Int. 2013; 4:109. PMID: 24032084.
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      71. McDuff SG, Taich ZJ, Lawson JD, Sanghvi P, Wong ET, Barker FG, Hochberg FH, Loeffler JS, Warnke PC, Murphy KT, Mundt AJ, Carter BS, McDonald CR, Chen C. Neurocognitive assessment following whole brain radiation therapy and radiosurgery for patients with cerebral metastases. J Neurol Neurosurg Psychiatry. 2013 Dec; 84(12):1384-91. PMID: 23715918.
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      72. Waters JD, Rose B, Gonda DD, Scanderbeg DJ, Russell M, Alksne JF, Murphy K, Carter BS, Lawson J, Chen C. Immediate post-operative brachytherapy prior to irradiation and temozolomide for newly diagnosed glioblastoma. J Neurooncol. 2013 Jul; 113(3):467-77. PMID: 23673513.
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      73. Jamshidi P, Chen JY, Wang HY, Chen C. Anaplastic lymphoma kinase-positive large cell lymphoma of the anterior skull base: Report of an unusual case and review of the literature. Surg Neurol Int. 2013; 4:57. PMID: 23646267.
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      74. Waters JD, Gonda DD, Reddy H, Kasper EM, Warnke PC, Chen C. Diagnostic yield of stereotactic needle-biopsies of sub-cubic centimeter intracranial lesions. Surg Neurol Int. 2013; 4(Suppl 3):S176-81. PMID: 23682345.
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      75. Gonda DD, Akers JC, Kim R, Kalkanis SN, Hochberg FH, Chen C, Carter BS. Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles. Neurosurgery. 2013 Apr; 72(4):501-10. PMID: 23277376.
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      76. Akers JC, Gonda D, Kim R, Carter BS, Chen C. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol. 2013 May; 113(1):1-11. PMID: 23456661.
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      77. Saria MG, Corle C, Hu J, Rudnick JD, Phuphanich S, Mrugala MM, Crew LK, Bota DA, Dan Fu B, Kim RY, Brown T, Feely H, Brechlin J, Brown BD, Drappatz J, Wen PY, Chen C, Carter B, Lee JW, Kesari S. Retrospective analysis of the tolerability and activity of lacosamide in patients with brain tumors: clinical article. J Neurosurg. 2013 Jun; 118(6):1183-7. PMID: 23451905.
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      78. Lam FC, Penumaka A, Chen C, Fischer EG, Kasper EM. Fibrin sealant augmentation with autologous pericranium for duraplasty after suboccipital decompression in Chiari 1 patients: A case series. Surg Neurol Int. 2013; 4:6. PMID: 23493237.
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      79. Zhang W, Zhang J, Yan W, You G, Bao Z, Li S, Kang C, Jiang C, You Y, Zhang Y, Chen C, Song SW, Jiang T. Whole-genome microRNA expression profiling identifies a 5-microRNA signature as a prognostic biomarker in Chinese patients with primary glioblastoma multiforme. Cancer. 2013 Feb 15; 119(4):814-24. PMID: 22990979.
        View in: PubMed
      80. Salehi A, Chen C, Carter BS. Viral vectors: promising new therapeutics in the battle against glioblastoma. Expert Rev Clin Pharmacol. 2012 Sep; 5(5):489-91. PMID: 23121267.
        View in: PubMed
      81. Gonda DD, Kim TE, Warnke PC, Kasper EM, Carter BS, Chen C. Ventriculoperitoneal shunting versus endoscopic third ventriculostomy in the treatment of patients with hydrocephalus related to metastasis. Surg Neurol Int. 2012; 3:97. PMID: 23061013.
        View in: PubMed
      82. Waters JD, Sanchez C, Sahin A, Futalan D, Gonda DD, Scheer JK, Akers J, Palanichamy K, Waterman P, Chakravarti A, Weissleder R, Morse B, Marsh N, Furfine E, Chen C, Carvajal I, Carter BS. CT322, a VEGFR-2 antagonist, demonstrates anti-glioma efficacy in orthotopic brain tumor model as a single agent or in combination with temozolomide and radiation therapy. J Neurooncol. 2012 Oct; 110(1):37-48. PMID: 22875706.
        View in: PubMed
      83. Zhang W, Zhang J, Hoadley K, Kushwaha D, Ramakrishnan V, Li S, Kang C, You Y, Jiang C, Song SW, Jiang T, Chen C. miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression. Neuro Oncol. 2012 Jun; 14(6):712-9. PMID: 22570426.
        View in: PubMed
      84. Bartek J, Ng K, Bartek J, Fischer W, Carter B, Chen C. Key concepts in glioblastoma therapy. J Neurol Neurosurg Psychiatry. 2012 Jul; 83(7):753-60. PMID: 22396442.
        View in: PubMed
      85. Berry-Candelario J, Kasper E, Eskandar E, Chen C. Neurosurgical management of leukoencephalopathy, cerebral calcifications, and cysts: A case report and review of literature. Surg Neurol Int. 2011; 2:160. PMID: 22140645.
        View in: PubMed
      86. Chen C, Kasper EM, Zinn PO, Warnke PC. Management of entrapped temporal horn by temporal horn to prepontine cistern shunting. World Neurosurg. 2013 Feb; 79(2):404.e7-10. PMID: 22120406.
        View in: PubMed
      87. Kesari S, Advani SJ, Lawson JD, Kahle KT, Ng K, Carter B, Chen C. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncol. 2011 Nov; 7(11):1335-46. PMID: 22044206.
        View in: PubMed
      88. Ng K, Kim R, Kesari S, Carter B, Chen C. Genomic profiling of glioblastoma: convergence of fundamental biologic tenets and novel insights. J Neurooncol. 2012 Mar; 107(1):1-12. PMID: 22002595.
        View in: PubMed
      89. Huang M, Kennedy R, Ali AM, Moreau LA, Meetei AR, D'Andrea AD, Chen C. Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway. DNA Repair (Amst). 2011 Dec 10; 10(12):1203-12. PMID: 21975120.
        View in: PubMed
      90. Ng K, Chen C. Oncogene addiction and non-oncogene addiction in glioblastoma therapy. Chin Med J (Engl). 2011 Sep; 124(17):2565-8. PMID: 22040404.
        View in: PubMed
      91. Wang CC, Floyd SR, Chang CH, Warnke PC, Chio CC, Kasper EM, Mahadevan A, Wong ET, Chen C. Cyberknife hypofractionated stereotactic radiosurgery (HSRS) of resection cavity after excision of large cerebral metastasis: efficacy and safety of an 800 cGy × 3 daily fractions regimen. J Neurooncol. 2012 Feb; 106(3):601-10. PMID: 21879395.
        View in: PubMed
      92. Kao WH, Riker AI, Kushwaha DS, Ng K, Enkemann SA, Jove R, Buettner R, Zinn PO, Sánchez NP, Villa JL, D'Andrea AD, Sánchez JL, Kennedy RD, Chen C, Matta JL. Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol. 2011 Oct; 131(10):2139-42. PMID: 21697891.
        View in: PubMed
      93. Chen C, Kasper E, Warnke P. Palliative stereotactic-endoscopic third ventriculostomy for the treatment of obstructive hydrocephalus from cerebral metastasis. Surg Neurol Int. 2011; 2:76. PMID: 21748029.
        View in: PubMed
      94. Babu MA, Coumans JV, Carter BS, Taylor WR, Kasper EM, Roitberg BZ, Krauss WE, Chen C. A review of lumbar spinal instrumentation: evidence and controversy. J Neurol Neurosurg Psychiatry. 2011 Sep; 82(9):948-51. PMID: 21602520.
        View in: PubMed
      95. Milbury CA, Chen C, Mamon H, Liu P, Santagata S, Makrigiorgos GM. Multiplex amplification coupled with COLD-PCR and high resolution melting enables identification of low-abundance mutations in cancer samples with low DNA content. J Mol Diagn. 2011 Mar; 13(2):220-32. PMID: 21354058; PMCID: PMC3128575.
      96. Zinn PO, Colen RR, Kasper EM, Chen C. Posterior leukoencephalopathy following repair of an ileocecal anastomosis breakdown: a case report and review of the literature. J Med Case Rep. 2011; 5:20. PMID: 21247426.
        View in: PubMed
      97. Ramakrishnan V, Kushwaha D, Koay DC, Reddy H, Mao Y, Zhou L, Ng K, Zinn P, Carter B, Chen C. Post-transcriptional regulation of O(6)-methylguanine-DNA methyltransferase MGMT in glioblastomas. Cancer Biomark. 2011-2012; 10(3-4):185-93. PMID: 22674304.
        View in: PubMed
      98. Chen C, Zinn PO, Kasper EM, Ogilvy CS. Cranio-spinal migration of a metallic clip placed during arteriovenous malformation resection - A case report, review of the literature, and management strategies. BMC Neurol. 2010; 10:109. PMID: 21047415.
        View in: PubMed
      99. Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MD, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen C. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One. 2010; 5(5):e10767. PMID: 20532243.
        View in: PubMed
      100. Kahle KT, Kozono D, Ng K, Hsieh G, Zinn PO, Nitta M, Chen C. Functional genomics to explore cancer cell vulnerabilities. Neurosurg Focus. 2010 Jan; 28(1):E5. PMID: 20043720.
        View in: PubMed
      101. Chen C, Kennedy RD, Sidi S, Look AT, D'Andrea A. CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer. 2009; 8:24. PMID: 19371427.
        View in: PubMed
      102. Ng K, Nitta M, Hu L, Kesari S, Kung A, D'Andrea A, Chen C. A small interference RNA screen revealed proteasome inhibition as strategy for glioblastoma therapy. Clin Neurosurg. 2009; 56:107-18. PMID: 20214041.
        View in: PubMed
      103. Kennedy RD, Chen C, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. 2007 May; 117(5):1440-9. PMID: 17431503.
        View in: PubMed
      104. Chen C, Taniguchi T, D'Andrea A. The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. J Mol Med (Berl). 2007 May; 85(5):497-509. PMID: 17221219.
        View in: PubMed
      105. Chen C, Kennedy R, D'Andrea A. A Small Interfering Ribonucleic Acid-based Approach to Characterize Brain Tumor Resistance to Radiation Therapy 893. Neurosurgery. 2006 Aug 01; 59(2):485. PMID: 28180723.
        View in: PubMed
      106. Verhey LJ, Chen C, Chapman P, Loeffler J, Curry WT. Single-fraction stereotactic radiosurgery for intracranial targets. Neurosurg Clin N Am. 2006 Apr; 17(2):79-97, v. PMID: 16793501.
        View in: PubMed
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