Christopher Glass

Title(s)	Professor, Cellular and Molecular Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Overview

Dr. Glass’ primary interests are to understand the mechanisms by which sequence-specific transcription factors, co-activators and co-repressors regulate the development and function of macrophages. A major direction of his laboratory has been to define the genome-wide locations and functions of these proteins through the use of assays that are based on massively parallel DNA sequencing. The combination of these technologies with molecular, genetic, lipidomic and cell-based approaches is providing new insights into mechanisms that regulate macrophage gene expression and function that are relevant to inflammatory diseases that include diabetes, atherosclerosis and neurodegenerative diseases.

Research Focus Areas:

Gene Expression and Regulation

Genetics and Genomics

Signal Transduction

Systems Biology

Websites

	Department of Cellular and Molecular Medicine
	Glass Laboratory Website

Research

Research Activities and Funding

Defining the cell-specific epigenetic landscape leading to altered gene expression signatures in HIV-Associated Neurocognitive Disorder
NIH/NIA RF1AG061060Sep 30, 2018 - Jun 30, 2023
Role: Principal Investigator

The Enhancer Code of AD-A Genetic Approach
NIH R01AG056511Aug 1, 2018 - Mar 31, 2023
Role: Principal Investigator

Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease
NIH R01AG057706Sep 30, 2017 - May 31, 2022
Role: Co-Principal Investigator

Mechanisms controlling human microglia gene expression
NIH/NINDS R01NS096170May 15, 2016 - Apr 30, 2021
Role: Principal Investigator

Enhancer Therapy
NIH/NCI R01CA173903Sep 12, 2012 - Jul 31, 2017
Role: Principal Investigator

San Diego Center for Systems Biology: From Maps to Models
NIH P50GM085764Sep 18, 2010 - May 31, 2019
Role: Co-Investigator

PPARgamma, Toll-like receptors, and atherosclerosis
NIH/NHLBI R01HL088129May 1, 2007 - Apr 30, 2008
Role: Principal Investigator

Role of Immune Mechanisms in Athersclerosis and Inflammation
NIH P01HL088093Apr 1, 2007 - Apr 30, 2020
Role: Co-Investigator

Gene Networks controlling macrophage-adipocyte interactions in insulin
NIH/NIDDK P01DK074868Apr 1, 2006 - Apr 30, 2017
Role: Principal Investigator

Conference on PPAR/LXR
NIH/NIDDK R13DK070428Sep 20, 2004 - Aug 31, 2005
Role: Principal Investigator

LIPID MAPS
NIH U54GM069338Aug 12, 2003 - Jul 31, 2014
Role: Co-Investigator

Diabetes Research Center (DRC)
NIH P30DK063491Dec 1, 2002 - Jun 30, 2025
Role: Co-Investigator

Nuclear Receptors and Coregulators in Health and Disease
NIH U19DK062434Aug 15, 2002 - Jul 31, 2012
Role: Co-Investigator

Gordon Research Conference: Mechanisms of Hormone Action
NIH/NIDDK R13DK061960Jun 15, 2002 - May 31, 2005
Role: Principal Investigator

Summer Undergraduate Research Fellowship (SURF)
NIH/NHLBI T35HL067694May 21, 2001 - Apr 30, 2006
Role: Principal Investigator

DETECTION AND MODELS OF TOXICANT EXPOSURE
NIH P42ES010337Jul 1, 2000 - Mar 31, 2022
Role: Co-Investigator

CDNA MICROARRAYER AND SCANNING CONFOCAL LASER READER
NIH/NCRR S10RR014881Apr 1, 2000 - Mar 31, 2001
Role: Principal Investigator

Integration of transcriptional responses in macrophages
NIH/NHLBI R01HL059694Jan 1, 1998 - Dec 31, 2008
Role: Principal Investigator

SCOR in Molecular Medicine and Atherosclerosis
NIH P50HL056989Apr 23, 1997 - Mar 31, 2008
Role: Co-Investigator

Transcriptional co-regulators and macrophage gene expression
NIH/NIDDK R01DK091183Apr 1, 1991 - Jan 31, 2025
Role: Principal Investigator

Transcriptional Co-Regulators and Macrophage Gene Expression
NIH/NCI R01CA052599Apr 1, 1991 - Mar 31, 2011
Role: Principal Investigator

CELL-SPECIFIC EXPRESSION OF GROWTH HORMONE AND PROLACTIN
NIH/NIDDK F32DK007959Mar 1, 1987
Role: Principal Investigator

TRAINING GRANT IN MOLECULAR MEDICINE AND ATHEROSCLEROSIS
NIH/NHLBI T32HL007276Jul 1, 1977 - Nov 12, 2005
Role: Principal Investigator

SCOR IN ARTERIOSCLEROSIS
NIH P50HL014197Dec 1, 1976 - Apr 30, 1997
Role: Co-Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Going nuclear in metabolic and cardiovascular disease. J Clin Invest. 2006 Mar; 116(3):556-60. Glass CK. PMID: 16511587; PMCID: PMC1386116.

View in: PubMed Mentions: 38 Fields:
Med Medicine (General)
Translation:Humans Animals
The jensen symposium; a tribute to a pioneer in the field of nuclear receptor biology. Mol Cell. 2004 Feb 27; 13(4):459-67. Glass CK, McDonnell DP. PMID: 14992717.

View in: PubMed Mentions: Fields:
Cel Cell Biology Mol Molecular Biology
Potential roles of the peroxisome proliferator-activated receptor-gamma in macrophage biology and atherosclerosis. J Endocrinol. 2001 Jun; 169(3):461-4. Glass CK. PMID: 11375116.

View in: PubMed Mentions: 12 Fields:
End Endocrinology
Translation:Humans Cells
Atherosclerosis. the road ahead. Cell. 2001 Feb 23; 104(4):503-16. Glass CK, Witztum JL. PMID: 11239408.

View in: PubMed Mentions: 918 Fields:
Cel Cell Biology
Translation:Humans Animals Cells