Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Fennema-Notestine, Christine

    TitleAssociate Professor of Psychiatry and Radiology
    SchoolUniversity of California, San Diego
    DepartmentPsychiatry
    Address9500 Gilman Drive #0738
    CA La Jolla 92093
    Phone858-246-0605
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      Massachusetts Institute of TechnologyB.S.1990Brain and Cognitive Sciences
      University of California, San DiegoM.A.1992Psychology
      University of California, San DiegoPh.D.1995Cognitive Science and Psychology
      Collapse Awards and Honors
      1991  - 1994National Science Foundation Graduate Fellowship
      1994  - 1995McDonnell-Pew Center for Cognitive Neuroscience Graduate Fellowship
      1995  - 1996McDonnell-Pew Center for Cognitive Neuroscience Post-Doctoral Fellowship
      1996Nelson Butters Award, International Neuropsychological Society

      Collapse Overview 
      Collapse Overview

      Biography

      Dr. Fennema-Notestine is a cognitive neuroscientist with expertise in neuroimaging methods development and validation, clinical research neuroimaging, cognitive neuropsychology, and biomedical informatics. She received her B.S. in Brain and Cognitive Sciences from the Massachusetts Institute of Technology and her Ph.D. in Cognitive Science and Psychology from UCSD, supported by graduate fellowships from the National Science Foundation and McDonnell-Pew Center for Cognitive Neuroscience. Her post-doctoral work emphasized clinical applications and methods development of structural and functional neuroimaging techniques. Dr. Fennema-Notestine’s subsequent roles in national, multi-site initiatives, including the Biomedical Informatics Research Network (BIRN), led to critical methods evaluations and improved infrastructure for multi-site neuroimaging. She also served as the Director of the BIRN Data Repository and continues to play a role in national initiatives that enable data sharing and integration. Currently, Dr. Fennema-Notestine directs methods development, validation, and multi-site studies in support of the neuroimaging characterization of HIV neuropathogenesis and other disorders through NIH funded initiatives.

      Research Interests

      Dr. Fennema-Notestine’s research emphasizes development and validation of magnetic resonance imaging (MRI) methods and the clinical application of these methods to neurodegenerative and psychiatric populations, including normal aging, Alzheimer’s Disease (AD), and HIV. Currently, she is directing studies to examine statistical procedures that may improve performance of existing image analysis methods and explorations of modeling approaches to better integrate information across multiple modalities. Her work also includes enabling multi-site clinical neuroimaging initiatives to increase the power to detect subtle effects and to evaluate the potential of MRI biomarkers in monitoring disease progression and treatment efficacy. Dr. Fennema-Notestine’s work aims to provide a more sensitive characterization of underlying neuropathogenesis and to better understand the relationship between neuroimaging biomarkers and cognitive, psychiatric, and neuromedical profiles.

      Clinical Focus

      The end goal for such neuroimaging research, including support for multi-site initiatives and pooling of shared data, is to guide the development of biomarkers for establishing diagnosis and monitoring treatment efficacy, through better descriptions of disease-related brain abnormalities and their relationship to medical variables, cognition, and treatment regimens.


      Collapse Research 
      Collapse Research Activities and Funding
      Impact of Cannabinoid Use on HIV-related Brain Alterations in Young Adults
      NIH R21DA037667May 1, 2015 - Apr 30, 2017
      Role: Principal Investigator
      Multi-channel Enhancement and Validation of Subcortical Morphometry in HIV
      NIH R21NS069355Sep 25, 2009 - Aug 31, 2012
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Obermeit LC, Beltran J, Casaletto KB, Franklin DR, Letendre S, Ellis R, Fennema-Notestine C, Vaida F, Collier AC, Marra CM, Clifford D, Gelman B, Sacktor N, Morgello S, Simpson D, McCutchan JA, Grant I, Heaton RK. Evaluating the accuracy of self-report for the diagnosis of HIV-associated neurocognitive disorder (HAND): defining "symptomatic" versus "asymptomatic" HAND. J Neurovirol. 2016 Aug 24. PMID: 27557777.
        View in: PubMed
      2. Keltner JR, Connolly CG, Vaida F, Jenkinson M, Fennema-Notestine C, Archibald S, Akkari C, Schlein A, Lee J, Wang D, Kim S, Li H, Rennels A, Miller DJ, Kesidis G, Franklin DR, Sanders C, Corkran S, Grant I, Brown GG, Atkinson JH, Ellis RJ. HIV Distal Neuropathic Pain Is Associated with Smaller Ventral Posterior Cingulate Cortex. Pain Med. 2016 Aug 6. PMID: 27497320.
        View in: PubMed
      3. Spies G, Fennema-Notestine C, Cherner M, Seedat S. Changes in cognitive function in women with HIV infection and early life stress. AIDS Care. 2016 Jul 11; 1-10. PMID: 27396980.
        View in: PubMed
      4. Lansing AE, Virk A, Notestine R, Plante WY, Fennema-Notestine C. Cumulative trauma, adversity and grief symptoms associated with fronto-temporal regions in life-course persistent delinquent boys. Psychiatry Res. 2016 Jun 18; 254:92-102. PMID: 27388804.
        View in: PubMed
      5. Prom-Wormley E, Maes HH, Eric Schmitt J, Panizzon MS, Xian H, Eyler LT, Franz CE, Lyons MJ, Tsuang MT, Dale AM, Fennema-Notestine C, Kremen WS, Neale MC. Erratum to: Genetic and Environmental Contributions to the Relationships Between Brain Structure and Average Lifetime Cigarette Use. Behav Genet. 2016 May; 46(3):478-479. PMID: 27115753.
        View in: PubMed
      6. Cooley SA, Paul RH, Fennema-Notestine C, Morgan EE, Vaida F, Deng Q, Chen JA, Letendre S, Ellis R, Clifford DB, Marra CM, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Morgello S, Grant I, Ances BM. Apolipoprotein E e4 genotype status is not associated with neuroimaging outcomes in a large cohort of HIV+ individuals. J Neurovirol. 2016 Mar 28. PMID: 27021072.
        View in: PubMed
      7. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Franz CE, Jak AJ, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. Is bigger always better? The importance of cortical configuration with respect to cognitive ability. Neuroimage. 2016 Apr 1; 129:356-66. PMID: 26827810.
        View in: PubMed
      8. Fennema-Notestine C, McEvoy LK, Notestine C, Panizzon MS, Yau WY, Franz CE, Lyons MJ, Eyler LT, Neale MC, Xian H, McKenzie RE, & Kremen WS. White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure. NeuroImage: Clinical. http://dx.doi.org/10.1016/j.nicl.2016.10.001. 2016.
      9. Spies G, Ahmed-Leitao F, Fennema-Notestine C, Cherner M, Seedat S. Effects of HIV and childhood trauma on brain morphometry and neurocognitive function. J Neurovirol. 2016 Apr; 22(2):149-58. PMID: 26424107.
        View in: PubMed
      10. Docherty AR, Sawyers CK, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Chen CH, McEvoy LK, Verhulst B, Tsuang MT, Kremen WS. Genetic network properties of the human cortex based on regional thickness and surface area measures. Front Hum Neurosci. 2015; 9:440. PMID: 26347632.
        View in: PubMed
      11. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310.
        View in: PubMed
      12. Anderson AM, Fennema-Notestine C, Umlauf A, Taylor MJ, Clifford DB, Marra CM, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Morgello S, Grant I, Letendre SL. CSF biomarkers of monocyte activation and chemotaxis correlate with magnetic resonance spectroscopy metabolites during chronic HIV disease. J Neurovirol. 2015 Oct; 21(5):559-67. PMID: 26069183.
        View in: PubMed
      13. McEvoy LK, Fennema-Notestine C, Eyler LT, Franz CE, Hagler DJ, Lyons MJ, Panizzon MS, Rinker DA, Dale AM, Kremen WS. Hypertension-Related Alterations in White Matter Microstructure Detectable in Middle Age. Hypertension. 2015 Aug; 66(2):317-23. PMID: 26056337.
        View in: PubMed
      14. Shin DD, Ozyurt IB, Brown GG, Fennema-Notestine C, Liu TT. The Cerebral Blood Flow Biomedical Informatics Research Network (CBFBIRN) data repository. Neuroimage. 2016 Jan 1; 124(Pt B):1202-7. PMID: 26032887.
        View in: PubMed
      15. Prom-Wormley E, Maes HH, Schmitt JE, Panizzon MS, Xian H, Eyler LT, Franz CE, Lyons MJ, Tsuang MT, Dale AM, Fennema-Notestine C, Kremen WS, Neale MC. Genetic and environmental contributions to the relationships between brain structure and average lifetime cigarette use. Behav Genet. 2015 Mar; 45(2):157-70. PMID: 25690561.
        View in: PubMed
      16. Heaton RK, Franklin DR, Deutsch R, Letendre SL, Ellis RJ, Casaletto K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Grant I. Reply to haddow et Al. Clin Infect Dis. 2015 May 1; 60(9):1442-3. PMID: 25645217.
        View in: PubMed
      17. Docherty AR, Hagler DJ, Panizzon MS, Neale MC, Eyler LT, Fennema-Notestine C, Franz CE, Jak A, Lyons MJ, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability? Neuroimage. 2015 Feb 1; 106:154-60. PMID: 25433211.
        View in: PubMed
      18. Heaton RK, Franklin DR, Deutsch R, Letendre S, Ellis RJ, Casaletto K, Marquine MJ, Woods SP, Vaida F, Atkinson JH, Marcotte TD, McCutchan JA, Collier AC, Marra CM, Clifford DB, Gelman BB, Sacktor N, Morgello S, Simpson DM, Abramson I, Gamst AC, Fennema-Notestine C, Smith DM, Grant I. Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study. Clin Infect Dis. 2015 Feb 1; 60(3):473-80. PMID: 25362201.
        View in: PubMed
      19. Lewis GJ, Panizzon MS, Eyler L, Fennema-Notestine C, Chen CH, Neale MC, Jernigan TL, Lyons MJ, Dale AM, Kremen WS, Franz CE. Heritable influences on amygdala and orbitofrontal cortex contribute to genetic variation in core dimensions of personality. Neuroimage. 2014 Dec; 103:309-15. PMID: 25263286.
        View in: PubMed
      20. Archibald SL, McCutchan JA, Sanders C, Wolfson T, Jernigan TL, Ellis RJ, Ances BM, Collier AC, McArthur JC, Morgello S, Simpson DM, Marra C, Gelman BB, Clifford DB, Grant I, Fennema-Notestine C. Brain morphometric correlates of metabolic variables in HIV: the CHARTER study. J Neurovirol. 2014 Dec; 20(6):603-11. PMID: 25227933.
        View in: PubMed
      21. Jak AJ, Panizzon MS, Spoon KM, Fennema-Notestine C, Franz CE, Thompson WK, Jacobson KC, Xian H, Eyler LT, Vuoksimaa E, Toomey R, Lyons MJ, Neale MC, Tsuang MT, Dale AM, Kremen WS. Hippocampal Atrophy Varies by Neuropsychologically Defined MCI Among Men in Their 50s. Am J Geriatr Psychiatry. 2014 Aug 29. PMID: 25306196.
        View in: PubMed
      22. Grant I, Franklin DR, Deutsch R, Woods SP, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Heaton RK. Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline. Neurology. 2014 Jun 10; 82(23):2055-62. PMID: 24814848.
        View in: PubMed
      23. Wierenga C, Bischoff-Grethe A, Melrose AJ, Grenesko-Stevens E, Irvine Z, Wagner A, Simmons A, Matthews S, Yau WY, Fennema-Notestine C, Kaye WH. Altered BOLD Response during Inhibitory and Error Processing in Adolescents with Anorexia Nervosa. PLoS One. 2014; 9(3):e92017. PMID: 24651705.
        View in: PubMed
      24. Keltner JR, Fennema-Notestine C, Vaida F, Wang D, Franklin DR, Dworkin RH, Sanders C, McCutchan JA, Archibald SL, Miller DJ, Kesidis G, Cushman C, Kim SM, Abramson I, Taylor MJ, Theilmann RJ, Julaton MD, Notestine C, Corkran S, Cherner M, Duarte NA, Alexander T, Robinson-Papp J, Gelman BB, Simpson DM, Collier AC, Marra CM, Morgello S, Brown G, Grant I, Atkinson JH, Jernigan TL, Ellis RJ. HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter. J Neurovirol. 2014 Jun; 20(3):209-18. PMID: 24549970.
        View in: PubMed
      25. Vuoksimaa E, Panizzon MS, Chen CH, Fiecas M, Eyler LT, Fennema-Notestine C, Hagler DJ, Fischl B, Franz CE, Jak A, Lyons MJ, Neale MC, Rinker DA, Thompson WK, Tsuang MT, Dale AM, Kremen WS. The Genetic Association Between Neocortical Volume and General Cognitive Ability Is Driven by Global Surface Area Rather Than Thickness. Cereb Cortex. 2014 Feb 18. PMID: 24554725.
        View in: PubMed
      26. Eyler LT, Vuoksimaa E, Panizzon MS, Fennema-Notestine C, Neale MC, Chen CH, Jak A, Franz CE, Lyons MJ, Thompson WK, Spoon KM, Fischl B, Dale AM, Kremen WS. Conceptual and Data-based Investigation of Genetic Influences and Brain Asymmetry: A Twin Study of Multiple Structural Phenotypes. J Cogn Neurosci. 2014 May; 26(5):1100-17. PMID: 24283492.
        View in: PubMed
      27. Bischoff-Grethe A, McCurdy D, Grenesko-Stevens E, Zoe Irvine LE, Wagner A, Wendy Yau WY, Fennema-Notestine C, Wierenga CE, Fudge JL, Delgado MR, Kaye WH. Altered brain response to reward and punishment in adolescents with Anorexia nervosa. Psychiatry Res. 2013 Dec 30; 214(3):331-40. PMID: 24148909.
        View in: PubMed
      28. Kremen WS, Fennema-Notestine C, Eyler LT, Panizzon MS, Chen CH, Franz CE, Lyons MJ, Thompson WK, Dale AM. Genetics of brain structure: contributions from the Vietnam Era Twin Study of Aging. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162B(7):751-61. PMID: 24132907.
        View in: PubMed
      29. Chen CH, Fiecas M, Gutiérrez ED, Panizzon MS, Eyler LT, Vuoksimaa E, Thompson WK, Fennema-Notestine C, Hagler DJ, Jernigan TL, Neale MC, Franz CE, Lyons MJ, Fischl B, Tsuang MT, Dale AM, Kremen WS. Genetic topography of brain morphology. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17089-94. PMID: 24082094.
        View in: PubMed
      30. Chang YL, Fennema-Notestine C, Holland D, McEvoy LK, Stricker NH, Salmon DP, Dale AM, Bondi MW. APOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease. Alzheimers Dement. 2014 May; 10(3):336-48. PMID: 23896613.
        View in: PubMed
      31. Fennema-Notestine C, Ellis RJ, Archibald SL, Jernigan TL, Letendre SL, Notestine C, Taylor MJ, Theilmann RJ, Julaton MD, Croteau DJ, Wolfson T, Heaton RK, Gamst AC, Franklin DR, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I. Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection. J Neurovirol. 2013 Aug; 19(4):393-401. PMID: 23838849.
        View in: PubMed
      32. Yau WY, Bischoff-Grethe A, Theilmann RJ, Torres L, Wagner A, Kaye WH, Fennema-Notestine C. Alterations in white matter microstructure in women recovered from anorexia nervosa. Int J Eat Disord. 2013 Nov; 46(7):701-8. PMID: 23818167.
        View in: PubMed
      33. Vuoksimaa E, Panizzon MS, Chen CH, Eyler LT, Fennema-Notestine C, Fiecas MJ, Fischl B, Franz CE, Grant MD, Jak AJ, Lyons MJ, Neale MC, Thompson WK, Tsuang MT, Xian H, Dale AM, Kremen WS. Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia. 2013 May; 51(6):1124-31. PMID: 23499725.
        View in: PubMed
      34. Malan-Müller S, Hemmings SM, Spies G, Kidd M, Fennema-Notestine C, Seedat S. Shorter telomere length - A potential susceptibility factor for HIV-associated neurocognitive impairments in South African women [corrected]. PLoS One. 2013; 8(3):e58351. PMID: 23472184.
        View in: PubMed
      35. Morgan EE, Woods SP, Letendre SL, Franklin DR, Bloss C, Goate A, Heaton RK, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Ellis RJ, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Grant I, Vaida F, Clifford DB. Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. J Neurovirol. 2013 Apr; 19(2):150-6. PMID: 23408335.
        View in: PubMed
      36. Pillai JA, McEvoy LK, Hagler DJ, Holland D, Dale AM, Salmon DP, Galasko D, Fennema-Notestine C. Higher education is not associated with greater cortical thickness in brain areas related to literacy or intelligence in normal aging or mild cognitive impairment. J Clin Exp Neuropsychol. 2012; 34(9):925-35. PMID: 22905705.
        View in: PubMed
      37. Spies G, Afifi TO, Archibald SL, Fennema-Notestine C, Sareen J, Seedat S. Mental health outcomes in HIV and childhood maltreatment: a systematic review. Syst Rev. 2012; 1:30. PMID: 22742536.
        View in: PubMed
      38. Spies G, Fennema-Notestine C, Archibald SL, Cherner M, Seedat S. Neurocognitive deficits in HIV-infected women and victims of childhood trauma. AIDS Care. 2012; 24(9):1126-35. PMID: 22672200.
        View in: PubMed
      39. Eyler LT, Chen CH, Panizzon MS, Fennema-Notestine C, Neale MC, Jak A, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Prom-Wormley E, Seidman LJ, Tsuang MT, Fiecas MJ, Dale AM, Kremen WS. A comparison of heritability maps of cortical surface area and thickness and the influence of adjustment for whole brain measures: a magnetic resonance imaging twin study. Twin Res Hum Genet. 2012 Jun; 15(3):304-14. PMID: 22856366.
        View in: PubMed
      40. Kubarych TS, Prom-Wormley EC, Franz CE, Panizzon MS, Dale AM, Fischl B, Eyler LT, Fennema-Notestine C, Grant MD, Hauger RL, Hellhammer DH, Jak AJ, Jernigan TL, Lupien SJ, Lyons MJ, Mendoza SP, Neale MC, Seidman LJ, Tsuang MT, Kremen WS. A multivariate twin study of hippocampal volume, self-esteem and well-being in middle-aged men. Genes Brain Behav. 2012 Jul; 11(5):539-44. PMID: 22471516.
        View in: PubMed
      41. Archibald SL, Jacobson MW, Fennema-Notestine C, Ogasawara M, Woods SP, Letendre S, Grant I, Jernigan TL. Functional interactions of HIV-infection and methamphetamine dependence during motor programming. Psychiatry Res. 2012 Apr 30; 202(1):46-52. PMID: 22608157.
        View in: PubMed
      42. Chen CH, Gutierrez ED, Thompson W, Panizzon MS, Jernigan TL, Eyler LT, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. Hierarchical genetic organization of human cortical surface area. Science. 2012 Mar 30; 335(6076):1634-6. PMID: 22461613.
        View in: PubMed
      43. Panizzon MS, Fennema-Notestine C, Kubarych TS, Chen CH, Eyler LT, Fischl B, Franz CE, Grant MD, Hamza S, Jak A, Jernigan TL, Lyons MJ, Neale MC, Prom-Wormley EC, Seidman L, Tsuang MT, Wu H, Xian H, Dale AM, Kremen WS. Genetic and environmental influences of white and gray matter signal contrast: a new phenotype for imaging genetics? Neuroimage. 2012 Apr 15; 60(3):1686-95. PMID: 22500923.
        View in: PubMed
      44. Rimol LM, Nesvåg R, Hagler DJ, Bergmann O, Fennema-Notestine C, Hartberg CB, Haukvik UK, Lange E, Pung CJ, Server A, Melle I, Andreassen OA, Agartz I, Dale AM. Cortical volume, surface area, and thickness in schizophrenia and bipolar disorder. Biol Psychiatry. 2012 Mar 15; 71(6):552-60. PMID: 22281121.
        View in: PubMed
      45. Chen CH, Panizzon MS, Eyler LT, Jernigan TL, Thompson W, Fennema-Notestine C, Jak AJ, Neale MC, Franz CE, Hamza S, Lyons MJ, Grant MD, Fischl B, Seidman LJ, Tsuang MT, Kremen WS, Dale AM. Genetic influences on cortical regionalization in the human brain. Neuron. 2011 Nov 17; 72(4):537-44. PMID: 22099457.
        View in: PubMed
      46. Panizzon MS, Hauger RL, Eaves LJ, Chen CH, Dale AM, Eyler LT, Fischl B, Fennema-Notestine C, Franz CE, Grant MD, Jacobson KC, Jak AJ, Lyons MJ, Mendoza SP, Neale MC, Prom-Wormley E, Seidman LJ, Tsuang MT, Xian H, Kremen WS. Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men. Neuroimage. 2012 Jan 16; 59(2):1123-31. PMID: 21983185.
        View in: PubMed
      47. Troeman ZC, Spies G, Cherner M, Archibald SL, Fennema-Notestine C, Theilmann RJ, Spottiswoode B, Stein DJ, Seedat S. Impact of childhood trauma on functionality and quality of life in HIV-infected women. Health Qual Life Outcomes. 2011; 9:84. PMID: 21958030.
        View in: PubMed
      48. Stricker NH, Chang YL, Fennema-Notestine C, Delano-Wood L, Salmon DP, Bondi MW, Dale AM. Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease. Neurology. 2011 Aug 23; 77(8):713-21. PMID: 21832223.
        View in: PubMed
      49. Jernigan TL, Archibald SL, Fennema-Notestine C, Taylor MJ, Theilmann RJ, Julaton MD, Notestine C, Wolfson T, Letendre SL, Ellis RJ, Heaton RK, Gamst AC, Franklin DR, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I. Clinical factors related to brain structure in HIV: the CHARTER study. J Neurovirol. 2011 Jun; 17(3):248-57. PMID: 21544705.
        View in: PubMed
      50. McEvoy LK, Holland D, Hagler DJ, Fennema-Notestine C, Brewer JB, Dale AM. Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis. Radiology. 2011 Jun; 259(3):834-43. PMID: 21471273.
        View in: PubMed
      51. Eyler LT, Prom-Wormley E, Fennema-Notestine C, Panizzon MS, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Stevens A, Pacheco J, Perry ME, Schmitt JE, Spitzer NC, Seidman LJ, Thermenos HW, Tsuang MT, Dale AM, Kremen WS. Genetic patterns of correlation among subcortical volumes in humans: results from a magnetic resonance imaging twin study. Hum Brain Mapp. 2011 Apr; 32(4):641-53. PMID: 20572207.
        View in: PubMed
      52. Eyler LT, Prom-Wormley E, Panizzon MS, Kaup AR, Fennema-Notestine C, Neale MC, Jernigan TL, Fischl B, Franz CE, Lyons MJ, Grant M, Stevens A, Pacheco J, Perry ME, Schmitt JE, Seidman LJ, Thermenos HW, Tsuang MT, Chen CH, Thompson WK, Jak A, Dale AM, Kremen WS. Genetic and environmental contributions to regional cortical surface area in humans: a magnetic resonance imaging twin study. Cereb Cortex. 2011 Oct; 21(10):2313-21. PMID: 21378112.
        View in: PubMed
      53. Chang YL, Bondi MW, McEvoy LK, Fennema-Notestine C, Salmon DP, Galasko D, Hagler DJ, Dale AM. Global clinical dementia rating of 0.5 in MCI masks variability related to level of function. Neurology. 2011 Feb 15; 76(7):652-9. PMID: 21321338.
        View in: PubMed
      54. Lin K, Taylor MJ, Heaton R, Franklin D, Jernigan T, Fennema-Notestine C, McCutchan A, Atkinson JH, Ellis RJ, McArthur J, Morgello S, Simpson D, Collier AC, Marra C, Gelman B, Clifford D, Grant I. Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals. J Clin Exp Neuropsychol. 2011 Mar; 33(3):326-34. PMID: 21229435.
        View in: PubMed
      55. Fennema-Notestine C, Panizzon MS, Thompson WR, Chen CH, Eyler LT, Fischl B, Franz CE, Grant MD, Jak AJ, Jernigan TL, Lyons MJ, Neale MC, Seidman LJ, Tsuang MT, Xian H, Dale AM, Kremen WS. Presence of ApoE e4 allele associated with thinner frontal cortex in middle age. J Alzheimers Dis. 2011; 26 Suppl 3:49-60. PMID: 21971450.
        View in: PubMed
      56. Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC, Marra CM, Morgello S, Mindt MR, Taylor MJ, Marcotte TD, Atkinson JH, Wolfson T, Gelman BB, McArthur JC, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol. 2011 Feb; 17(1):3-16. PMID: 21174240.
        View in: PubMed
      57. Moore DJ, Letendre SL, Morris S, Umlauf A, Deutsch R, Smith DM, Little S, Rooney A, Franklin DR, Gouaux B, Leblanc S, Rosario D, Fennema-Notestine C, Heaton RK, Ellis RJ, Atkinson JH, Grant I. Neurocognitive functioning in acute or early HIV infection. J Neurovirol. 2011 Feb; 17(1):50-7. PMID: 21165782.
        View in: PubMed
      58. Heaton RK, Clifford DB, Franklin DR, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology. 2010 Dec 7; 75(23):2087-96. PMID: 21135382.
        View in: PubMed
      59. Ozyurt IB, Keator DB, Wei D, Fennema-Notestine C, Pease KR, Bockholt J, Grethe JS. Federated web-accessible clinical data management within an extensible neuroimaging database. Neuroinformatics. 2010 Dec; 8(4):231-49. PMID: 20567938.
        View in: PubMed
      60. Panizzon MS, Hauger R, Dale AM, Eaves LJ, Eyler LT, Fischl B, Fennema-Notestine C, Franz CE, Grant MD, Jak AJ, Jacobson KC, Lyons MJ, Mendoza SP, Neale MC, Prom-Wormley EC, Seidman LJ, Tsuang MT, Xian H, Kremen WS. Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. Neurology. 2010 Sep 7; 75(10):874-80. PMID: 20819998.
        View in: PubMed
      61. Karow DS, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Brewer JB, Hoh CK, Dale AM. Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. Radiology. 2010 Sep; 256(3):932-42. PMID: 20720076.
        View in: PubMed
      62. McEvoy LK, Edland SD, Holland D, Hagler DJ, Roddey JC, Fennema-Notestine C, Salmon DP, Koyama AK, Aisen PS, Brewer JB, Dale AM. Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease. Alzheimer Dis Assoc Disord. 2010 Jul-Sep; 24(3):269-77. PMID: 20683184.
        View in: PubMed
      63. Rimol LM, Hartberg CB, Nesvåg R, Fennema-Notestine C, Hagler DJ, Pung CJ, Jennings RG, Haukvik UK, Lange E, Nakstad PH, Melle I, Andreassen OA, Dale AM, Agartz I. Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder. Biol Psychiatry. 2010 Jul 1; 68(1):41-50. PMID: 20609836.
        View in: PubMed
      64. McDonald CR, Gharapetian L, McEvoy LK, Fennema-Notestine C, Hagler DJ, Holland D, Dale AM. Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment. Neurobiol Aging. 2012 Feb; 33(2):242-53. PMID: 20471718.
        View in: PubMed
      65. Kremen WS, Panizzon MS, Neale MC, Fennema-Notestine C, Prom-Wormley E, Eyler LT, Stevens A, Franz CE, Lyons MJ, Grant MD, Jak AJ, Jernigan TL, Xian H, Fischl B, Thermenos HW, Seidman LJ, Tsuang MT, Dale AM. Heritability of brain ventricle volume: converging evidence from inconsistent results. Neurobiol Aging. 2012 Jan; 33(1):1-8. PMID: 20363053.
        View in: PubMed
      66. Kremen WS, O'Brien RC, Panizzon MS, Prom-Wormley E, Eaves LJ, Eisen SA, Eyler LT, Hauger RL, Fennema-Notestine C, Fischl B, Grant MD, Hellhammer DH, Jak AJ, Jacobson KC, Jernigan TL, Lupien SJ, Lyons MJ, Mendoza SP, Neale MC, Seidman LJ, Thermenos HW, Tsuang MT, Dale AM, Franz CE. Salivary cortisol and prefrontal cortical thickness in middle-aged men: A twin study. Neuroimage. 2010 Nov 15; 53(3):1093-102. PMID: 20156572.
        View in: PubMed
      67. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer JB, Dale AM. CSF biomarkers in prediction of cerebral and clinical change in mild cognitive impairment and Alzheimer's disease. J Neurosci. 2010 Feb 10; 30(6):2088-101. PMID: 20147537.
        View in: PubMed
      68. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler DJ, Jennings RG, Karow D, Dale AM. Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010 Feb; 31(2):347-54. PMID: 20075088.
        View in: PubMed
      69. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Blennow K, Brewer JB, Dale AM. Brain atrophy in healthy aging is related to CSF levels of Aß1-42. Cereb Cortex. 2010 Sep; 20(9):2069-79. PMID: 20051356.
        View in: PubMed
      70. Chang YL, Bondi MW, Fennema-Notestine C, McEvoy LK, Hagler DJ, Jacobson MW, Dale AM. Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease. Neuropsychologia. 2010 Apr; 48(5):1237-47. PMID: 20034503.
        View in: PubMed
      71. Holland D, Brewer JB, Hagler DJ, Fennema-Notestine C, Fenema-Notestine C, Dale AM. Subregional neuroanatomical change as a biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A. 2009 Dec 8; 106(49):20954-9. PMID: 19996185.
        View in: PubMed
      72. Rimol LM, Panizzon MS, Fennema-Notestine C, Eyler LT, Fischl B, Franz CE, Hagler DJ, Lyons MJ, Neale MC, Pacheco J, Perry ME, Schmitt JE, Grant MD, Seidman LJ, Thermenos HW, Tsuang MT, Eisen SA, Kremen WS, Dale AM. Cortical thickness is influenced by regionally specific genetic factors. Biol Psychiatry. 2010 Mar 1; 67(5):493-9. PMID: 19963208.
        View in: PubMed
      73. Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Brewer JB, Dale AM. One-year brain atrophy evident in healthy aging. J Neurosci. 2009 Dec 2; 29(48):15223-31. PMID: 19955375.
        View in: PubMed
      74. Fennema-Notestine C, Hagler DJ, McEvoy LK, Fleisher AS, Wu EH, Karow DS, Dale AM. Structural MRI biomarkers for preclinical and mild Alzheimer's disease. Hum Brain Mapp. 2009 Oct; 30(10):3238-53. PMID: 19277975.
        View in: PubMed
      75. Kremen WS, Prom-Wormley E, Panizzon MS, Eyler LT, Fischl B, Neale MC, Franz CE, Lyons MJ, Pacheco J, Perry ME, Stevens A, Schmitt JE, Grant MD, Seidman LJ, Thermenos HW, Tsuang MT, Eisen SA, Dale AM, Fennema-Notestine C. Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study. Neuroimage. 2010 Jan 15; 49(2):1213-23. PMID: 19786105.
        View in: PubMed
      76. Chang YL, Jacobson MW, Fennema-Notestine C, Hagler DJ, Jennings RG, Dale AM, McEvoy LK. Level of executive function influences verbal memory in amnestic mild cognitive impairment and predicts prefrontal and posterior cingulate thickness. Cereb Cortex. 2010 Jun; 20(6):1305-13. PMID: 19776343.
        View in: PubMed
      77. McDonald CR, McEvoy LK, Gharapetian L, Fennema-Notestine C, Hagler DJ, Holland D, Koyama A, Brewer JB, Dale AM. Regional rates of neocortical atrophy from normal aging to early Alzheimer disease. Neurology. 2009 Aug 11; 73(6):457-65. PMID: 19667321.
        View in: PubMed
      78. Qiu A, Fennema-Notestine C, Dale AM, Miller MI. Regional shape abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2009 Apr 15; 45(3):656-61. PMID: 19280688.
        View in: PubMed
      79. Panizzon MS, Fennema-Notestine C, Eyler LT, Jernigan TL, Prom-Wormley E, Neale M, Jacobson K, Lyons MJ, Grant MD, Franz CE, Xian H, Tsuang M, Fischl B, Seidman L, Dale A, Kremen WS. Distinct genetic influences on cortical surface area and cortical thickness. Cereb Cortex. 2009 Nov; 19(11):2728-35. PMID: 19299253.
        View in: PubMed
      80. McEvoy LK, Fennema-Notestine C, Roddey JC, Hagler DJ, Holland D, Karow DS, Pung CJ, Brewer JB, Dale AM. Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment. Radiology. 2009 Apr; 251(1):195-205. PMID: 19201945.
        View in: PubMed
      81. Fennema-Notestine C. Enabling public data sharing: encouraging scientific discovery and education. Methods Mol Biol. 2009; 569:25-32. PMID: 19623484.
        View in: PubMed
      82. Jacobson MW, McEvoy LK, Dale A, Fennema-Notestine C. Cognitive phenotypes, brain morphometry and the detection of cognitive decline in preclinical AD. Behav Neurol. 2009; 21(1):29-37. PMID: 19847043.
        View in: PubMed
      83. Fennema-Notestine C, McEvoy LK, Hagler DJ, Jacobson MW, Dale AM. Structural neuroimaging in the detection and prognosis of pre-clinical and early AD. Behav Neurol. 2009; 21(1):3-12. PMID: 19847040.
        View in: PubMed
      84. Bug W, Astahkov V, Boline J, Fennema-Notestine C, Grethe JS, Gupta A, Kennedy DN, Rubin DL, Sanders B, Turner JA, Martone ME. Data federation in the Biomedical Informatics Research Network: tools for semantic annotation and query of distributed multiscale brain data. AMIA Annu Symp Proc. 2008; 1220. PMID: 18999211.
        View in: PubMed
      85. Bug WJ, Ascoli GA, Grethe JS, Gupta A, Fennema-Notestine C, Laird AR, Larson SD, Rubin D, Shepherd GM, Turner JA, Martone ME. The NIFSTD and BIRNLex vocabularies: building comprehensive ontologies for neuroscience. Neuroinformatics. 2008 Sep; 6(3):175-94. PMID: 18975148.
        View in: PubMed
      86. Walhovd KB, Fjell AM, Dale AM, McEvoy LK, Brewer J, Karow DS, Salmon DP, Fennema-Notestine C. Multi-modal imaging predicts memory performance in normal aging and cognitive decline. Neurobiol Aging. 2010 Jul; 31(7):1107-21. PMID: 18838195.
        View in: PubMed
      87. Fennema-Notestine C, Gamst AC, Quinn BT, Pacheco J, Jernigan TL, Thal L, Buckner R, Killiany R, Blacker D, Dale AM, Fischl B, Dickerson B, Gollub RL. Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy data. Neuroinformatics. 2007; 5(4):235-45. PMID: 17999200.
        View in: PubMed
      88. Mickes L, Wixted JT, Fennema-Notestine C, Galasko D, Bondi MW, Thal LJ, Salmon DP. Progressive impairment on neuropsychological tasks in a longitudinal study of preclinical Alzheimer's disease. Neuropsychology. 2007 Nov; 21(6):696-705. PMID: 17983283.
        View in: PubMed
      89. Bischoff-Grethe A, Ozyurt IB, Busa E, Quinn BT, Fennema-Notestine C, Clark CP, Morris S, Bondi MW, Jernigan TL, Dale AM, Brown GG, Fischl B. A technique for the deidentification of structural brain MR images. Hum Brain Mapp. 2007 Sep; 28(9):892-903. PMID: 17295313.
        View in: PubMed
      90. Gollan TH, Fennema-Notestine C, Montoya RI, Jernigan TL. The bilingual effect on Boston Naming Test performance. J Int Neuropsychol Soc. 2007 Mar; 13(2):197-208. PMID: 17286875.
        View in: PubMed
      91. Fennema-Notestine C, Ozyurt IB, Clark CP, Morris S, Bischoff-Grethe A, Bondi MW, Jernigan TL, Fischl B, Segonne F, Shattuck DW, Leahy RM, Rex DE, Toga AW, Zou KH, Brown GG. Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice location. Hum Brain Mapp. 2006 Feb; 27(2):99-113. PMID: 15986433.
        View in: PubMed
      92. Clark CP, Brown GG, Archibald SL, Fennema-Notestine C, Braun DR, Thomas LS, Sutherland AN, Gillin JC. Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression? Psychiatry Res. 2006 Jan 30; 146(1):43-51. PMID: 16380239.
        View in: PubMed
      93. Gollan TH, Montoya RI, Fennema-Notestine C, Morris SK. Bilingualism affects picture naming but not picture classification. Mem Cognit. 2005 Oct; 33(7):1220-34. PMID: 16532855.
        View in: PubMed
      94. Jernigan TL, Gamst AC, Archibald SL, Fennema-Notestine C, Mindt MR, Marcotte TD, Marcotte TL, Heaton RK, Ellis RJ, Grant I. Effects of methamphetamine dependence and HIV infection on cerebral morphology. Am J Psychiatry. 2005 Aug; 162(8):1461-72. PMID: 16055767.
        View in: PubMed
      95. Fennema-Notestine C, Archibald SL, Jacobson MW, Corey-Bloom J, Paulsen JS, Peavy GM, Gamst AC, Hamilton JM, Salmon DP, Jernigan TL. In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease. Neurology. 2004 Sep 28; 63(6):989-95. PMID: 15452288.
        View in: PubMed
      96. Archibald SL, Masliah E, Fennema-Notestine C, Marcotte TD, Ellis RJ, McCutchan JA, Heaton RK, Grant I, Mallory M, Miller A, Jernigan TL. Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss. Arch Neurol. 2004 Mar; 61(3):369-76. PMID: 15023814.
        View in: PubMed
      97. Jernigan TL, Fennema-Notestine C. White matter mapping is needed. Neurobiol Aging. 2004 Jan; 25(1):37-9. PMID: 14675728.
        View in: PubMed
      98. Jernigan TL, Gamst AC, Fennema-Notestine C, Ostergaard AL. More "mapping" in brain mapping: statistical comparison of effects. Hum Brain Mapp. 2003 Jun; 19(2):90-5. PMID: 12768533.
        View in: PubMed
      99. Murphy C, Jernigan TL, Fennema-Notestine C. Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: a structural MRI study. J Int Neuropsychol Soc. 2003 Mar; 9(3):459-71. PMID: 12666770.
        View in: PubMed
      100. Fennema-Notestine C, Stein MB, Kennedy CM, Archibald SL, Jernigan TL. Brain morphometry in female victims of intimate partner violence with and without posttraumatic stress disorder. Biol Psychiatry. 2002 Dec 1; 52(11):1089-101. PMID: 12460692.
        View in: PubMed
      101. Jernigan TL, Archibald SL, Fennema-Notestine C, Gamst AC, Stout JC, Bonner J, Hesselink JR. Effects of age on tissues and regions of the cerebrum and cerebellum. Neurobiol Aging. 2001 Jul-Aug; 22(4):581-94. PMID: 11445259.
        View in: PubMed
      102. Archibald SL, Fennema-Notestine C, Gamst A, Riley EP, Mattson SN, Jernigan TL. Brain dysmorphology in individuals with severe prenatal alcohol exposure. Dev Med Child Neurol. 2001 Mar; 43(3):148-54. PMID: 11263683.
        View in: PubMed
      103. Jernigan TL, Ostergaard AL, Fennema-Notestine C. Mesial temporal, diencephalic, and striatal contributions to deficits in single word reading, word priming, and recognition memory. J Int Neuropsychol Soc. 2001 Jan; 7(1):63-78. PMID: 11253843.
        View in: PubMed
      104. Hernandez AE, Fennema-Notestine C, Udell C, & Bates E. Lexical and sentential priming in competition: Implications for two-stage theories of lexical access. Applied Psycholinguistics. 2001; 2(22):191-215.
      105. Heindel WC, Salmon DP, Fennema-Notestine C, Chan AS. Repetition priming with nonverbal stimuli in patients with dementia of the Alzheimer type. Neuropsychology. 1998 Jan; 12(1):43-51. PMID: 9460734.
        View in: PubMed
      106. Fennema-Notestine C, Butters N, Heindel WC, & Salmon DP. Semantic homophone priming in patients with dementia of the Alzheimer's type. Neuropsychology. 1994; 4(8):579-587.
      107. Keane MM, Gabrieli JD, Fennema AC, Growdon JH, & Corkin S. Evidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease. Behavioral Neuroscience. 1991; 2(105):326-342.
      Christine Fennema's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _