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Christina Sigurdson
Title
Adjunct Professor
School
University of California, San Diego
Department
Medicine
Address
9500 Gilman Drive #0612
CA La Jolla 92093
Phone
858-534-0978
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Research
Research Activities and Funding
UCSD Research Training Program for Veterinarians
NIH
T32OD017863
May 2, 2014 - Apr 30, 2019
Role: Principal Investigator
Mechanisms of Prion Spread
NIH/NINDS
R01NS076896
Sep 15, 2012 - Apr 30, 2022
Role: Principal Investigator
Mechanisms of Prion Aggregation and Species Barriers
NIH/NINDS
R01NS069566
Mar 15, 2011 - Jun 30, 2021
Role: Principal Investigator
Infectious prion generation by mouse transgenesis
NIH/NINDS
R21NS055116
Aug 15, 2007 - Jul 31, 2010
Role: Principal Investigator
BRIDGES TO THE BACCALAUREATE PROGRAM AT SAN DIEGO MESA COLLEGE
NIH/NIGMS
R25GM073590
Jul 1, 2005 - May 31, 2019
Role: Co-Principal Investigator
CWD: ROLE OF THE LYMPHOID TISSUE PHASE IN PRION DISEASE
NIH/NIAID
K08AI001802
Aug 1, 2000 - Jul 31, 2005
Role: Principal Investigator
Bibliographic
Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can
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Timeline
Publications by year:
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Aguilar-Calvo P, Bett C, Sevillano AM, Kurt TD, Lawrence J, Soldau K, Hammarström P, Nilsson KPR,
Sigurdson C
. Generation of novel neuroinvasive prions following intravenous challenge. Brain Pathol. 2018 Mar 05. PMID: 29505163.
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PubMed
Bett C, Lawrence J, Kurt TD, Orru C, Aguilar-Calvo P, Kincaid AE, Surewicz WK, Caughey B, Wu C,
Sigurdson C
. Enhanced neuroinvasion by smaller, soluble prions. Acta Neuropathol Commun. 2017 Apr 21; 5(1):32. PMID: 28431576.
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PubMed
Aguilar-Calvo P, Xiao X, Bett C, Eraña H, Soldau K, Castilla J, Nilsson KP, Surewicz WK,
Sigurdson C
. Post-translational modifications in PrP expand the conformational diversity of prions in vivo. Sci Rep. 2017 Mar 08; 7:43295. PMID: 28272426.
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PubMed
Kurt TD,
Sigurdson C
. Cross-species transmission of CWD prions. Prion. 2016; 10(1):83-91. PMID: 26809254; PMCID: PMC4981193 [Available on 01/25/17].
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PubMed
,
PubMed Central
Shirani H, Linares M,
Sigurdson C
, Lindgren M, Norman P, Nilsson KP. A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry. 2015 Oct 19; 21(43):15133-7. PMID: 26388448; PMCID: PMC4641461.
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PubMed
,
PubMed Central
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q,
Sigurdson C
. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. PMID: 25961458; PMCID: PMC4497774.
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PubMed
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PubMed Central
Hiramatsu N, Chiang WC, Kurt TD,
Sigurdson C
, Lin JH. Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol. 2015 Jul; 185(7):1800-8. PMID: 25956028; PMCID: PMC4484218.
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PubMed
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PubMed Central
Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q,
Sigurdson C
. Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. PMID: 25705888; PMCID: PMC4396485.
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PubMed
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PubMed Central
Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L,
Sigurdson C
. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. PLoS One. 2014; 9(11):e113765. PMID: 25429466; PMCID: PMC4245998.
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PubMed
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PubMed Central
Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E,
Sigurdson C
. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. FASEB J. 2015 Mar; 29(3):911-9. PMID: 25422367.
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PubMed
Magnusson K, Simon R, Sjölander D,
Sigurdson C
, Hammarström P, Nilsson KP. Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands. Prion. 2014; 8(4):319-29. PMID: 25495506; PMCID: PMC4601348.
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PubMed
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PubMed Central
Kurt TD, Jiang L, Bett C, Eisenberg D,
Sigurdson C
. A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the ß2-a2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-7. PMID: 24596090; PMCID: PMC4036184.
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PubMed
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PubMed Central
Kurt TD, Bett C, Fernández-Borges N, Joshi-Barr S, Hornemann S, Rülicke T, Castilla J, Wüthrich K, Aguzzi A,
Sigurdson C
. Prion transmission prevented by modifying the ß2-a2 loop structure of host PrPC. J Neurosci. 2014 Jan 15; 34(3):1022-7. PMID: 24431459; PMCID: PMC3891945.
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PubMed
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PubMed Central
Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E,
Sigurdson C
. De novo prion aggregates trigger autophagy in skeletal muscle. J Virol. 2014 Feb; 88(4):2071-82. PMID: 24307586; PMCID: PMC3911572.
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PubMed
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PubMed Central
Klingstedt T, Shirani H, Åslund KO, Cairns NJ,
Sigurdson C
, Goedert M, Nilsson KP. The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry. 2013 Jul 29; 19(31):10179-92. PMID: 23780508; PMCID: PMC3884759.
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PubMed
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PubMed Central
Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB,
Sigurdson C
. Defining the conformational features of anchorless, poorly neuroinvasive prions. PLoS Pathog. 2013; 9(4):e1003280. PMID: 23637596; PMCID: PMC3630170.
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PubMed
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PubMed Central
Perrott MR,
Sigurdson C
, Mason GL, Hoover EA. Mucosal transmission and pathogenesis of chronic wasting disease in ferrets. J Gen Virol. 2013 Feb; 94(Pt 2):432-42. PMID: 23100363; PMCID: PMC3709615.
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PubMed
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PubMed Central
Cao K, Farahi M, Dakanali M, Chang WM,
Sigurdson C
, Theodorakis EA, Yang J. Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-ß and prion plaques in brain. J Am Chem Soc. 2012 Oct 24; 134(42):17338-41. PMID: 22866977; PMCID: PMC3480552.
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PubMed
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PubMed Central
Mitchell GB,
Sigurdson C
, O'Rourke KI, Algire J, Harrington NP, Walther I, Spraker TR, Balachandran A. Experimental oral transmission of chronic wasting disease to reindeer (Rangifer tarandus tarandus). PLoS One. 2012; 7(6):e39055. PMID: 22723928; PMCID: PMC3377593.
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PubMed
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PubMed Central
Bett C, Fernández-Borges N, Kurt TD, Lucero M, Nilsson KP, Castilla J,
Sigurdson C
. Structure of the ß2-a2 loop and interspecies prion transmission. FASEB J. 2012 Jul; 26(7):2868-76. PMID: 22490928; PMCID: PMC3382101.
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PubMed
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PubMed Central
Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M,
Sigurdson C
. Prion infection promotes extensive accumulation of a-synuclein in aged human a-synuclein transgenic mice. Prion. 2012 Apr-Jun; 6(2):184-90. PMID: 22460692; PMCID: PMC3366356.
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PubMed
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PubMed Central
Bett C, Joshi-Barr S, Lucero M, Trejo M, Liberski P, Kelly JW, Masliah E,
Sigurdson C
. Biochemical properties of highly neuroinvasive prion strains. PLoS Pathog. 2012 Feb; 8(2):e1002522. PMID: 22319450; PMCID: PMC3271082.
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PubMed
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PubMed Central
Sigurdson C
, Joshi-Barr S, Bett C, Winson O, Manco G, Schwarz P, Rülicke T, Nilsson KP, Margalith I, Raeber A, Peretz D, Hornemann S, Wüthrich K, Aguzzi A. Spongiform encephalopathy in transgenic mice expressing a point mutation in the ß2-a2 loop of the prion protein. J Neurosci. 2011 Sep 28; 31(39):13840-7. PMID: 21957246; PMCID: PMC3205959.
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PubMed
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PubMed Central
Chang WM, Dakanali M, Capule CC,
Sigurdson C
, Yang J, Theodorakis EA. ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue. ACS Chem Neurosci. 2011 May 18; 2(5):249-255. PMID: 21743829.
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PubMed
Sigurdson C
, Bartz JC, Nilsson KP. Tracking protein aggregate interactions. Prion. 2011 Apr-Jun; 5(2):52-5. PMID: 21597336; PMCID: PMC3166500.
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PubMed
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PubMed Central
Ligios C, Cancedda MG, Carta A, Santucciu C, Maestrale C, Demontis F, Saba M, Patta C, DeMartini JC, Aguzzi A,
Sigurdson C
. Sheep with scrapie and mastitis transmit infectious prions through the milk. J Virol. 2011 Jan; 85(2):1136-9. PMID: 21084475; PMCID: PMC3020009.
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PubMed
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PubMed Central
Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR,
Sigurdson C
, O'Connor DT, Hook V. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. J Proteome Res. 2010 Oct 01; 9(10):5002-24. PMID: 20695487; PMCID: PMC2996463.
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PubMed
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PubMed Central
Nilsson KP, Joshi-Barr S, Winson O,
Sigurdson C
. Prion strain interactions are highly selective. J Neurosci. 2010 Sep 08; 30(36):12094-102. PMID: 20826672; PMCID: PMC2951977.
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PubMed
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PubMed Central
Sandberg MK, Al-Doujaily H,
Sigurdson C
, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7. PMID: 20610667; PMCID: PMC3052602.
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PubMed
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PubMed Central
Sigurdson C
, Nilsson KP, Hornemann S, Manco G, Fernández-Borges N, Schwarz P, Castilla J, Wüthrich K, Aguzzi A. A molecular switch controls interspecies prion disease transmission in mice. J Clin Invest. 2010 Jul; 120(7):2590-9. PMID: 20551516; PMCID: PMC2898603.
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PubMed
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PubMed Central
Aslund A,
Sigurdson C
, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, Aguzzi A, Hammarström P, Nilsson KP. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem Biol. 2009 Aug 21; 4(8):673-84. PMID: 19624097; PMCID: PMC2886514.
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PubMed
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PubMed Central
Sigurdson C
, Heikenwalder M, Manco G, Barthel M, Schwarz P, Stecher B, Krautler NJ, Hardt WD, Seifert B, MacPherson AJ, Corthesy I, Aguzzi A. Bacterial colitis increases susceptibility to oral prion disease. J Infect Dis. 2009 Jan 15; 199(2):243-52. PMID: 19072552; PMCID: PMC2822447.
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PubMed
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PubMed Central
Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S,
Sigurdson C
, Aguzzi A. Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity. 2008 Dec 19; 29(6):998-1008. PMID: 19100703.
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PubMed
Sigurdson C
, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rülicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wüthrich K, Aguzzi A. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):304-9. PMID: 19073920; PMCID: PMC2629180.
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PubMed
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PubMed Central
Polymenidou M, Moos R, Scott M,
Sigurdson C
, Shi YZ, Yajima B, Hafner-Bratkovic I, Jerala R, Hornemann S, Wuthrich K, Bellon A, Vey M, Garen G, James MN, Kav N, Aguzzi A. The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes. PLoS One. 2008; 3(12):e3872. PMID: 19060956; PMCID: PMC2592702.
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PubMed
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PubMed Central
Sigurdson C
. A prion disease of cervids: chronic wasting disease. Vet Res. 2008 Jul-Aug; 39(4):41. PMID: 18381058.
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PubMed
Aguzzi A,
Sigurdson C
, Heikenwaelder M. Molecular mechanisms of prion pathogenesis. Annu Rev Pathol. 2008; 3:11-40. PMID: 18233951.
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PubMed
Sigurdson C
, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wüthrich K, Aguzzi A. Prion strain discrimination using luminescent conjugated polymers. Nat Methods. 2007 Dec; 4(12):1023-30. PMID: 18026110.
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PubMed
Sigurdson C
, Aguzzi A. Chronic wasting disease. Biochim Biophys Acta. 2007 Jun; 1772(6):610-8. PMID: 17223321; PMCID: PMC2680674.
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PubMed
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PubMed Central
Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hays SA, Hayes-Klug J, Seelig DM, Wild MA, Wolfe LL, Spraker TR, Miller MW,
Sigurdson C
, Telling GC, Hoover EA. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006 Oct 06; 314(5796):133-6. PMID: 17023660.
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PubMed
Sigurdson C
, Manco G, Schwarz P, Liberski P, Hoover EA, Hornemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A. Strain fidelity of chronic wasting disease upon murine adaptation. J Virol. 2006 Dec; 80(24):12303-11. PMID: 17020952; PMCID: PMC1676299.
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PubMed
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PubMed Central
Angers RC, Browning SR, Seward TS,
Sigurdson C
, Miller MW, Hoover EA, Telling GC. Prions in skeletal muscles of deer with chronic wasting disease. Science. 2006 Feb 24; 311(5764):1117. PMID: 16439622.
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PubMed
Ligios C,
Sigurdson C
, Santucciu C, Carcassola G, Manco G, Basagni M, Maestrale C, Cancedda MG, Madau L, Aguzzi A. PrPSc in mammary glands of sheep affected by scrapie and mastitis. Nat Med. 2005 Nov; 11(11):1137-8. PMID: 16270061.
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PubMed
Sigurdson C
, Polymenidou M, Aguzzi A. Reconstructing prions: fibril assembly from simple yeast to complex mammals. Neurodegener Dis. 2005; 2(1):1-5. PMID: 16908997.
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PubMed
Sigurdson C
, Glatzel M, Aguzzi A. Comment on "Failure to detect prion protein (PrPres) by immunohistochemistry in striated muscle tissues of animals experimentally inoculated with agents of transmissible spongiform encephalopathy". Vet Pathol. 2005 Jan; 42(1):107. PMID: 15657284.
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PubMed
Aguzzi A,
Sigurdson C
. Antiprion immunotherapy: to suppress or to stimulate? Nat Rev Immunol. 2004 Sep; 4(9):725-36. PMID: 15343371.
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PubMed
Heikenwalder M, Polymenidou M, Junt T,
Sigurdson C
, Wagner H, Akira S, Zinkernagel R, Aguzzi A. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat Med. 2004 Feb; 10(2):187-92. PMID: 14745443.
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PubMed
Sigurdson C
, Miller MW. Other animal prion diseases. Br Med Bull. 2003; 66:199-212. PMID: 14522860.
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PubMed
Sigurdson C
, Barillas-Mury C, Miller MW, Oesch B, van Keulen LJ, Langeveld JP, Hoover EA. PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer. J Gen Virol. 2002 Oct; 83(Pt 10):2617-28. PMID: 12237446.
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PubMed
Wild MA, Spraker TR,
Sigurdson C
, O'Rourke KI, Miller MW. Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy. J Gen Virol. 2002 Oct; 83(Pt 10):2629-34. PMID: 12237447.
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PubMed
View timeline visualization
Year
Publications
2002
2
2003
1
2004
2
2005
3
2006
4
2007
1
2008
5
2009
2
2010
5
2011
3
2012
6
2013
3
2014
5
2015
4
2016
1
2017
2
2018
1
Christina's Networks
Concepts
Derived automatically from this person's publications.
PrPC Proteins
Prions
Prion Diseases
Wasting Disease, Chronic
PrPSc Proteins
See all (239) concept(s)
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People in Profiles who have published with this person.
Masliah, Eliezer
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Sevillano Mantas, Alejandro
Ghassemian, Majid
Theodorakis, Emmanuel
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