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    Charlie Chen

    TitleResident Physician
    SchoolUniversity of California, San Diego
    Address200 W. Arbor Drive #8890
    CA San Diego 92103
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yao G, Hu S, Yu L, Ru Y, Chen C, Liu Q, Zhang Y. Genome-wide mapping of in vivo ERa binding sites in male mouse efferent ductules. Endocrinology. 2017 Jun 22. PMID: 28645209.
        View in: PubMed
      2. Chu C, Yu L, Wu B, Ma L, Gou LT, He M, Guo Y, Li ZT, Gao W, Shi H, Liu MF, Wang H, Chen C, Drevet JR, Zhou Y, Zhang Y. A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation. J Mol Cell Biol. 2017 Jun 01; 9(3):256-259. PMID: 28486659.
        View in: PubMed
      3. Tang Y, Hong YZ, Bai HJ, Wu Q, Chen C, Lang JY, Boheler KR, Yang HT. Plant Homeo Domain Finger Protein 8 Regulates Mesodermal and Cardiac Differentiation of Embryonic Stem Cells Through Mediating the Histone Demethylation of pmaip1. Stem Cells. 2016 Jun; 34(6):1527-40. PMID: 26866517.
        View in: PubMed
      4. Zhang F, Liu Y, Zhang Z, Li J, Wan Y, Zhang L, Wang Y, Li X, Xu Y, Fu X, Zhang X, Zhang M, Zhang Z, Zhang J, Yan Q, Ye J, Wang Z, Chen C, Lin W, Li Q. 5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas. Sci Rep. 2016; 6:20882. PMID: 26864347.
        View in: PubMed
      5. Zhang F, Xu L, Xu L, Xu Q, Karsenty G, Chen C. Histone demethylase JMJD3 is required for osteoblast differentiation in mice. Sci Rep. 2015; 5:13418. PMID: 26302868; PMCID: PMC4548232.
      6. Mao H, Han G, Xu L, Zhu D, Lin H, Cao X, Yu Y, Chen C. Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram. Stem Cell Res Ther. 2015; 6:132. PMID: 26194893; PMCID: PMC4533945.
      7. Li HT, Gong T, Zhou Z, Liu YT, Cao X, He Y, Chen C, Zhou JQ. Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro. Biochem J. 2015 May 1; 467(3):507-15. PMID: 25715670.
        View in: PubMed
      8. Liu Z, Cao W, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen C, Shi Y, Zhang X. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. J Mol Cell Biol. 2015 Dec; 7(6):505-16. PMID: 25840993.
        View in: PubMed
      9. Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen C. JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol. 2015 Feb; 7(1):23-34. PMID: 25587042; PMCID: PMC4342687.
      10. Tang Y, Chen ZY, Hong YZ, Wu Q, Lin HQ, Chen C, Yang HT. Expression profiles of histone lysine demethylases during cardiomyocyte differentiation of mouse embryonic stem cells. Acta Pharmacol Sin. 2014 Jul; 35(7):899-906. PMID: 24989252; PMCID: PMC4088288.
      11. Han G, Li J, Wang Y, Li X, Mao H, Liu Y, Chen C. The hydroxylation activity of Jmjd6 is required for its homo-oligomerization. J Cell Biochem. 2012 May; 113(5):1663-70. PMID: 22189873.
        View in: PubMed
      12. Jin C, Li J, Green CD, Yu X, Tang X, Han D, Xian B, Wang D, Huang X, Cao X, Yan Z, Hou L, Liu J, Shukeir N, Khaitovich P, Chen C, Zhang H, Jenuwein T, Han JD. Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab. 2011 Aug 3; 14(2):161-72. PMID: 21803287.
        View in: PubMed
      13. Yang H, Shi L, Chen C, Li J. Mice generated after round spermatid injection into haploid two-cell blastomeres. Cell Res. 2011 May; 21(5):854-8. PMID: 21423273; PMCID: PMC3203671.
      14. Huang C, Chen J, Zhang T, Zhu Q, Xiang Y, Chen C, Jing N. The dual histone demethylase KDM7A promotes neural induction in early chick embryos. Dev Dyn. 2010 Dec; 239(12):3350-7. PMID: 20981832.
        View in: PubMed
      15. Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen C, Xu Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug; 20(8):886-98. PMID: 20567261.
        View in: PubMed
      16. Lin H, Wang Y, Wang Y, Tian F, Pu P, Yu Y, Mao H, Yang Y, Wang P, Hu L, Lin Y, Liu Y, Xu Y, Chen C. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res. 2010 Aug; 20(8):899-907. PMID: 20567262.
        View in: PubMed
      17. Zhu Z, Wang Y, Li X, Wang Y, Xu L, Wang X, Sun T, Dong X, Chen L, Mao H, Yu Y, Li J, Li J, Chen PA, Chen C. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res. 2010 Jul; 20(7):794-801. PMID: 20531378.
        View in: PubMed
      18. Huang C, Xiang Y, Wang Y, Li X, Xu L, Zhu Z, Zhang T, Zhu Q, Zhang K, Jing N, Chen C. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res. 2010 Feb; 20(2):154-65. PMID: 20084082.
        View in: PubMed
      19. Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, Arora V, Wongvipat J, Smith-Jones PM, Yoo D, Kwon A, Wasielewska T, Welsbie D, Chen C, Higano CS, Beer TM, Hung DT, Scher HI, Jung ME, Sawyers CL. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science. 2009 May 8; 324(5928):787-90. PMID: 19359544; NIHMSID: NIHMS237593.
        View in: PubMed
      20. Mao HL, Zhu ZQ, Chen C. The androgen receptor in hormone-refractory prostate cancer. Asian J Androl. 2009 Jan; 11(1):69-73. PMID: 19050686; PMCID: PMC3735219.
      21. Xiang Y, Zhu Z, Han G, Ye X, Xu B, Peng Z, Ma Y, Yu Y, Lin H, Chen AP, Chen C. JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A. 2007 Dec 4; 104(49):19226-31. PMID: 18048344; PMCID: PMC2148272.
      22. Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen C. JMJD3 is a histone H3K27 demethylase. Cell Res. 2007 Oct; 17(10):850-7. PMID: 17923864.
        View in: PubMed
      23. Chen C, Welsbie DS, Tran C, Baek SH, Chen R, Vessella R, Rosenfeld MG, Sawyers CL. Molecular determinants of resistance to antiandrogen therapy. Nat Med. 2004 Jan; 10(1):33-9. PMID: 14702632.
        View in: PubMed
      24. Chen C, Sawyers CL. NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer. Mol Cell Biol. 2002 Apr; 22(8):2862-70. PMID: 11909978; PMCID: PMC133743.
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