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    Chambers Hughes

    TitleAssistant Professor
    SchoolUniversity of California, San Diego
    DepartmentCenter for Marine Biotechnology and Biomedecine
    Address9500 Gilman Drive #0227
    CA La Jolla 92093
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Gallagher KA, Wanger G, Henderson J, Llorente M, Hughes C, Jensen PR. Ecological implications of hypoxia-triggered shifts in secondary metabolism. Environ Microbiol. 2017 Jun; 19(6):2182-2191. PMID: 28205416.
        View in: PubMed
      2. Reimer D, Hughes C. Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts. J Nat Prod. 2017 Jan 27; 80(1):126-133. PMID: 28055208.
        View in: PubMed
      3. Castro-Falcón G, Hahn D, Reimer D, Hughes C. Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action. ACS Chem Biol. 2016 Aug 19; 11(8):2328-36. PMID: 27294329.
        View in: PubMed
      4. Richter TK, Hughes C, Moore BS. Sioxanthin, a novel glycosylated carotenoid, reveals an unusual subclustered biosynthetic pathway. Environ Microbiol. 2015 Jun; 17(6):2158-71. PMID: 25329237; PMCID: PMC4755588.
      5. Alvarez-Mico X, Jensen PR, Fenical W, Hughes C. Chlorizidine, a cytotoxic 5H-pyrrolo[2,1-a]isoindol-5-one-containing alkaloid from a marine Streptomyces sp. Org Lett. 2013 Mar 01; 15(5):988-91. PMID: 23405849; PMCID: PMC3702164.
      6. Yamanaka K, Ryan KS, Gulder TA, Hughes C, Moore BS. Flavoenzyme-catalyzed atropo-selective N,C-bipyrrole homocoupling in marinopyrrole biosynthesis. J Am Chem Soc. 2012 Aug 01; 134(30):12434-7. PMID: 22800473; PMCID: PMC3415713.
      7. Haste NM, Hughes C, Tran DN, Fenical W, Jensen PR, Nizet V, Hensler ME. Pharmacological properties of the marine natural product marinopyrrole A against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2011 Jul; 55(7):3305-12. PMID: 21502631; PMCID: PMC3122406.
      8. Hughes C, Fenical W. Antibacterials from the sea. Chemistry. 2010 Nov 08; 16(42):12512-25. PMID: 20845412; PMCID: PMC3071975.
      9. Hughes C, Kauffman CA, Jensen PR, Fenical W. Structures, reactivities, and antibiotic properties of the marinopyrroles A-F. J Org Chem. 2010 May 21; 75(10):3240-50. PMID: 20405892; PMCID: PMC2884375.
      10. Hughes C, Fenical W. Total synthesis of the ammosamides. J Am Chem Soc. 2010 Mar 03; 132(8):2528-9. PMID: 20131899; PMCID: PMC2828514.
      11. Nett M, Gulder TA, Kale AJ, Hughes C, Moore BS. Function-oriented biosynthesis of beta-lactone proteasome inhibitors in Salinispora tropica. J Med Chem. 2009 Oct 08; 52(19):6163-7. PMID: 19746976; PMCID: PMC2771571.
      12. Hughes C, Yang YL, Liu WT, Dorrestein PC, La Clair JJ, Fenical W. Marinopyrrole A target elucidation by acyl dye transfer. J Am Chem Soc. 2009 Sep 02; 131(34):12094-6. PMID: 19673475; PMCID: PMC2769490.
      13. Hughes C, MacMillan JB, Gaudêncio SP, Jensen PR, Fenical W. The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species. Angew Chem Int Ed Engl. 2009; 48(4):725-7. PMID: 19090514; PMCID: PMC2819817.
      14. Hughes C, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ. Ammosamides A and B target myosin. Angew Chem Int Ed Engl. 2009; 48(4):728-32. PMID: 19097126; PMCID: PMC2820877.
      15. Hughes C, Prieto-Davo A, Jensen PR, Fenical W. The marinopyrroles, antibiotics of an unprecedented structure class from a marine Streptomyces sp. Org Lett. 2008 Feb 21; 10(4):629-31. PMID: 18205372; PMCID: PMC2820876.
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