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    Celsa Spina

    TitleAssociate Adjunct Professor
    SchoolUniversity of California, San Diego
    DepartmentPathology
    Address9500 Gilman Drive #0679
    CA La Jolla 92093
    Phone858-552-8585
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      Collapse Research 
      Collapse Research Activities and Funding
      Use of Protein Biomarkers to Identify Latent/Persistent HIV Infected Cell Reservoirs Without Induced Reactivation
      NIH/NIAID R21AI122389Aug 15, 2016 - Jul 31, 2018
      Role: Principal Investigator
      Control of Latent/Persistent HIV Infection in Primary CD4 T Cells
      VA I01BX001160Jul 1, 2011 - Jun 30, 2015
      Role: Principal Investigator
      MoFlo XDP High Speed Cell Sorter
      NIH/NCRR S10RR027933May 20, 2010 - May 19, 2011
      Role: Principal Investigator
      Global Gene Regulation in CD4 T Cell Signaling
      NIH/NIAID R21AI055388Apr 15, 2003 - Mar 31, 2006
      Role: Principal Investigator
      LYMPHOCYTE RESPONSE AND REGULATION IN HERPES INFECTION
      NIH/NIAID R23AI019952Jun 1, 1983 - Jul 31, 1986
      Role: Principal Investigator

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Beliakova-Bethell N, Hezareh M, Wong JK, Strain MC, Lewinski MK, Richman DD, Spina C. Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART. Virology. 2017 Aug; 508:127-133. PMID: 28527342.
        View in: PubMed
      2. White CH, Moesker B, Beliakova-Bethell N, Martins LJ, Spina C, Margolis DM, Richman DD, Planelles V, Bosque A, Woelk CH. Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model. PLoS Pathog. 2016 Nov; 12(11):e1006026. PMID: 27898737.
        View in: PubMed
      3. Dan JM, Massanella M, Smith DM, Spina C, Schrier R, Daar ES, Dube MP, Morris SR, Gianella S. Brief Report: Effect of CMV and HIV Transcription on CD57 and PD-1 T-Cell Expression During Suppressive ART. J Acquir Immune Defic Syndr. 2016 Jun 1; 72(2):133-7. PMID: 26818740.
        View in: PubMed
      4. Tokarev A, Stoneham C, Lewinski MK, Mukim A, Deshmukh S, Vollbrecht T, Spina C, Guatelli J. Pharmacologic Inhibition of Nedd8 Activation Enzyme Exposes CD4-Induced Epitopes within Env on Cells Expressing HIV-1. J Virol. 2015; 90(5):2486-502. PMID: 26676780.
        View in: PubMed
      5. Reardon B, Beliakova-Bethell N, Spina C, Singhania A, Margolis DM, Richman DR, Woelk CH. Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells. AIDS. 2015 Nov; 29(17):2235-44. PMID: 26258524.
        View in: PubMed
      6. White CH, Johnston HE, Moesker B, Manousopoulou A, Margolis DM, Richman DD, Spina C, Garbis SD, Woelk CH, Beliakova-Bethell N. Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency. Antiviral Res. 2015 Nov; 123:78-85. PMID: 26343910.
        View in: PubMed
      7. Gianella S, Massanella M, Richman DD, Little SJ, Spina C, Vargas MV, Lada SM, Daar ES, Dube MP, Haubrich RH, Morris SR, Smith DM. Cytomegalovirus Replication in Semen Is Associated with Higher Levels of Proviral HIV DNA and CD4+ T Cell Activation during Antiretroviral Treatment. J Virol. 2014 Jul 15; 88(14):7818-27. PMID: 24789781.
        View in: PubMed
      8. Wei DG, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry JP, Stepan G, Stray KM, Tsai A, Yu H, Spindler J, Kearney M, Spina C, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T. Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing. PLoS Pathog. 2014 Apr; 10(4):e1004071. PMID: 24722454.
        View in: PubMed
      9. Karris MY, Kao YT, Patel D, Dawson M, Woods SP, Vaida F, Spina C, Richman D, Little S, Smith DM. Predictors of virologic response in persons who start antiretroviral therapy during recent HIV infection. AIDS. 2014 Mar 27; 28(6):841-9. PMID: 24401640.
        View in: PubMed
      10. Spina C, Anderson J, Archin NM, Bosque A, Chan J, Famiglietti M, Greene WC, Kashuba A, Lewin SR, Margolis DM, Mau M, Ruelas D, Saleh S, Shirakawa K, Siliciano RF, Singhania A, Soto PC, Terry VH, Verdin E, Woelk C, Wooden S, Xing S, Planelles V. An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients. PLoS Pathog. 2013 Dec; 9(12):e1003834. PMID: 24385908.
        View in: PubMed
      11. Pérez-Santiago J, Gianella S, Massanella M, Spina C, Karris MY, Var SR, Patel D, Jordan PS, Young JA, Little SJ, Richman DD, Smith DM. Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013 Jul 31; 27(12):1921-31. PMID: 24180001.
        View in: PubMed
      12. Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, Spina C, Woelk CH, Richman DD. Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One. 2013; 8(4):e55943. PMID: 23573183.
        View in: PubMed
      13. Gianella S, Morris SR, Anderson C, Spina C, Vargas MV, Young JA, Richman DD, Little SJ, Smith DM. Herpes viruses and HIV-1 drug resistance mutations influence the virologic and immunologic milieu of the male genital tract. AIDS. 2013 Jan 2; 27(1):39-47. PMID: 22739399.
        View in: PubMed
      14. Beliakova-Bethell N, Zhang JX, Singhania A, Lee V, Terry VH, Richman DD, Spina C, Woelk CH. Suberoylanilide hydroxamic acid induces limited changes in the transcriptome of primary CD4(+) T cells. AIDS. 2013 Jan 2; 27(1):29-37. PMID: 23221426.
        View in: PubMed
      15. Razooky BS, Gutierrez E, Terry VH, Spina C, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab Chip. 2012 Nov 7; 12(21):4305-12. PMID: 22976503.
        View in: PubMed
      16. Soto PC, Karris MY, Spina C, Richman DD, Varki A. Cell-intrinsic mechanism involving Siglec-5 associated with divergent outcomes of HIV-1 infection in human and chimpanzee CD4 T cells. J Mol Med (Berl). 2013 Feb; 91(2):261-70. PMID: 22945238.
        View in: PubMed
      17. Gianella S, Strain MC, Rought SE, Vargas MV, Little SJ, Richman DD, Spina C, Smith DM. Associations between virologic and immunologic dynamics in blood and in the male genital tract. J Virol. 2012 Feb; 86(3):1307-15. PMID: 22114342.
        View in: PubMed
      18. Terry VH, Johnston IC, Spina C. CD44 microbeads accelerate HIV-1 infection in T cells. Virology. 2009 Jun 5; 388(2):294-304. PMID: 19394995.
        View in: PubMed
      19. Koelsch KK, Liu L, Haubrich R, May S, Havlir D, Günthard HF, Ignacio CC, Campos-Soto P, Little SJ, Shafer R, Robbins GK, D'Aquila RT, Kawano Y, Young K, Dao P, Spina C, Richman DD, Wong JK. Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro. J Infect Dis. 2008 Feb 1; 197(3):411-9. PMID: 18248304.
        View in: PubMed
      20. Stone GW, Barzee S, Snarsky V, Kee K, Spina C, Yu XF, Kornbluth RS. Multimeric soluble CD40 ligand and GITR ligand as adjuvants for human immunodeficiency virus DNA vaccines. J Virol. 2006 Feb; 80(4):1762-72. PMID: 16439533.
        View in: PubMed
      21. Lehrman G, Hogue IB, Palmer S, Jennings C, Spina C, Wiegand A, Landay AL, Coombs RW, Richman DD, Mellors JW, Coffin JM, Bosch RJ, Margolis DM. Depletion of latent HIV-1 infection in vivo: a proof-of-concept study. Lancet. 2005 Aug 13-19; 366(9485):549-55. PMID: 16099290.
        View in: PubMed
      22. Strain MC, Little SJ, Daar ES, Havlir DV, Gunthard HF, Lam RY, Daly OA, Nguyen J, Ignacio CC, Spina C, Richman DD, Wong JK. Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1. J Infect Dis. 2005 May 1; 191(9):1410-8. PMID: 15809898.
        View in: PubMed
      23. Dong T, Stewart-Jones G, Chen N, Easterbrook P, Xu X, Papagno L, Appay V, Weekes M, Conlon C, Spina C, Little S, Screaton G, van der Merwe A, Richman DD, McMichael AJ, Jones EY, Rowland-Jones SL. HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor. J Exp Med. 2004 Dec 20; 200(12):1547-57. PMID: 15596521.
        View in: PubMed
      24. Papagno L, Spina C, Marchant A, Salio M, Rufer N, Little S, Dong T, Chesney G, Waters A, Easterbrook P, Dunbar PR, Shepherd D, Cerundolo V, Emery V, Griffiths P, Conlon C, McMichael AJ, Richman DD, Rowland-Jones SL, Appay V. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004 Feb; 2(2):E20. PMID: 14966528.
        View in: PubMed
      25. Appay V, Papagno L, Spina C, Hansasuta P, King A, Jones L, Ogg GS, Little S, McMichael AJ, Richman DD, Rowland-Jones SL. Dynamics of T cell responses in HIV infection. J Immunol. 2002 Apr 1; 168(7):3660-6. PMID: 11907132.
        View in: PubMed
      26. Appay V, Dunbar PR, Callan M, Klenerman P, Gillespie GM, Papagno L, Ogg GS, King A, Lechner F, Spina C, Little S, Havlir DV, Richman DD, Gruener N, Pape G, Waters A, Easterbrook P, Salio M, Cerundolo V, McMichael AJ, Rowland-Jones SL. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med. 2002 Apr; 8(4):379-85. PMID: 11927944.
        View in: PubMed
      27. Appay V, Hansasuta P, Sutton J, Schrier RD, Wong JK, Furtado M, Havlir DV, Wolinsky SM, McMichael AJ, Richman DD, Rowland-Jones SL, Spina C. Persistent HIV-1-specific cellular responses despite prolonged therapeutic viral suppression. AIDS. 2002 Jan 25; 16(2):161-70. PMID: 11807299.
        View in: PubMed
      28. Spina C, Prince HE, Richman DD. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro. J Clin Invest. 1997 Apr 1; 99(7):1774-85. PMID: 9120023.
        View in: PubMed
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