Calvin Yeang

Title(s)	Assistant Professor Of Clinical, Medicine
School	Vc-health Sciences-schools
Address	9500 Gilman Drive # La Jolla CA 92093
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Research

Research Activities and Funding

Defining the Role of Lipoprotein(a) and its Oxidized Phospholipids in the Development and Progression of Calcific Aortic Valve Disease Using Unique Transgenic Mouse Models
NIH K08HL150271Feb 17, 2020 - Jan 31, 2025
Role: Principal Investigator

The Role of Lipoprotein(a) and Oxidized Phospholipids in the Development and Treatment of Aortic Valve Stenosis
American Heart Association 17POST33660462Jul 1, 2017 - Jun 30, 2019

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Lipoprotein(a) Testing Trends in a Large Academic Health System in the United States. J Am Heart Assoc. 2023 09 19; 12(18):e031255. Bhatia HS, Hurst S, Desai P, Zhu W, Yeang C. PMID: 37702041; PMCID: PMC10547299.

View in: PubMed Mentions: 3 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans
Lipoprotein(a) and the pooled cohort equations for ASCVD risk prediction: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2023 09; 381:117217. Bhatia HS, Rikhi R, Allen TS, Yeang C, Guan W, Garg PK, Tsai MY, Criqui MH, Shapiro MD, Tsimikas S. PMID: 37607461; PMCID: PMC10659123.

View in: PubMed Mentions: Fields:
Vas Vascular Diseases
Translation:Humans
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. 2022 08 09; 55(8):1386-1401.e10. Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, Schlachetzki J, Challcombe J, Fixsen BR, Sakai M, Li RZ, Fields H, Mokry M, Tsai RG, Bejar R, Prange K, de Winther M, Shadel GS, Glass CK. PMID: 35931086; PMCID: PMC9718507.

View in: PubMed Mentions: 13 Fields:
All Allergy and Immunology
Translation:Humans Cells
Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol. J Am Coll Cardiol. 2022 03 22; 79(11):1035-1046. Yeang C, Karwatowska-Prokopczuk E, Su F, Dinh B, Xia S, Witztum JL, Tsimikas S. PMID: 35300814; PMCID: PMC8972555.

View in: PubMed Mentions: 23 Fields:
Car Cardiology
Translation:Humans
Trends in testing and prevalence of elevated Lp(a) among patients with aortic valve stenosis. Atherosclerosis. 2022 05; 349:144-150. Bhatia HS, Ma GS, Taleb A, Wilkinson M, Kahn AM, Cotter B, Yeang C, DeMaria AN, Patel MP, Mahmud E, Reeves RR, Tsimikas S. PMID: 35144769; PMCID: PMC9674369.

View in: PubMed Mentions: 2 Fields:
Vas Vascular Diseases
Translation:Humans
Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease. Curr Opin Hematol. 2022 01 01; 29(1):1-7. Cobo I, Tanaka T, Glass CK, Yeang C. PMID: 34654019; PMCID: PMC8639635.

View in: PubMed Mentions: 17 Fields:
Hem Hematology
Translation:Humans Cells
Novel method for quantification of lipoprotein(a)-cholesterol: implications for improving accuracy of LDL-C measurements. J Lipid Res. 2021; 62:100053. Yeang C, Witztum JL, Tsimikas S. PMID: 33636163; PMCID: PMC8042377.

View in: PubMed Mentions: 22 Fields:
Bio Biochemistry
The interconnection between lipoprotein(a), lipoprotein(a) cholesterol and true LDL-cholesterol in the diagnosis of familial hypercholesterolemia. Curr Opin Lipidol. 2020 12; 31(6):305-312. Yeang C, Willeit P, Tsimikas S. PMID: 33027223.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Humans
Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a). J Lipid Res. 2020 09; 61(9):1263-1270. Gonen A, Yang X, Yeang C, Alekseeva E, Koschinsky M, Witztum JL, Boffa M, Tsimikas S. PMID: 32641432; PMCID: PMC7469883.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Animals Cells PHPublic Health
Statin therapy increases lipoprotein(a) levels. Eur Heart J. 2020 06 21; 41(24):2275-2284. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31111151.

View in: PubMed Mentions: 122 Fields:
Car Cardiology
Translation:Humans
Short-term regulation of hematopoiesis by lipoprotein(a) results in the production of pro-inflammatory monocytes. Int J Cardiol. 2020 09 15; 315:81-85. Schnitzler JG, Poels K, Stiekema LCA, Yeang C, Tsimikas S, Kroon J, Stroes ESG, Lutgens E, Seijkens TTP. PMID: 32387421.

View in: PubMed Mentions: 6 Fields:
Car Cardiology
Translation:Animals Cells
Atherogenic Lipoprotein(a) Increases Vascular Glycolysis, Thereby Facilitating Inflammation and Leukocyte Extravasation. Circ Res. 2020 05 08; 126(10):1346-1359. Schnitzler JG, Hoogeveen RM, Ali L, Prange KHM, Waissi F, van Weeghel M, Bachmann JC, Versloot M, Borrelli MJ, Yeang C, De Kleijn DPV, Houtkooper RH, Koschinsky ML, de Winther MPJ, Groen AK, Witztum JL, Tsimikas S, Stroes ESG, Kroon J. PMID: 32160811; PMCID: PMC7208285.

View in: PubMed Mentions: 50 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals Cells
ApoCIII-Lp(a) complexes in conjunction with Lp(a)-OxPL predict rapid progression of aortic stenosis. Heart. 2020 05; 106(10):738-745. Capoulade R, Torzewski M, Mayr M, Chan KL, Mathieu P, Bossé Y, Dumesnil JG, Tam J, Teo KK, Burnap SA, Schmid J, Gobel N, Franke UFW, Sanchez A, Witztum JL, Yang X, Yeang C, Arsenault B, Després JP, Pibarot P, Tsimikas S. PMID: 32054669.

View in: PubMed Mentions: 16 Fields:
Car Cardiology
Translation:Humans
Ancient Remedy for a Modern Disease: Will Celastrol Become a Treatment for Aortic Valve Stenosis? JACC Basic Transl Sci. 2020 Jan; 5(1):50-52. Yeang C, Tsimikas S. PMID: 32043488; PMCID: PMC7000881.

View in: PubMed Mentions: 2
Statins and increases in Lp(a): an inconvenient truth that needs attention. Eur Heart J. 2020 01 01; 41(1):192-193. Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. PMID: 31893480.

View in: PubMed Mentions: 11 Fields:
Car Cardiology
Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis. J Lipid Res. 2019 12; 60(12):2082-2089. Boffa MB, Marar TT, Yeang C, Viney NJ, Xia S, Witztum JL, Koschinsky ML, Tsimikas S. PMID: 31551368; PMCID: PMC6889713.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry
Translation:Humans CTClinical Trials
Lipoprotein(a) in Patients Undergoing Transcatheter Aortic Valve Replacement. Angiology. 2019 Apr; 70(4):332-336. Ma GS, Wilkinson MJ, Reeves RR, Yeang C, DeMaria AN, Cotter B, Patel M, Mahmud E, Tsimikas S. PMID: 30700108.

View in: PubMed Mentions: 4 Fields:
Vas Vascular Diseases
Translation:Humans Cells
Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids. Cardiovasc Res. 2019 01 01; 115(1):179-189. Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DY, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A. PMID: 29850765; PMCID: PMC6302283.

View in: PubMed Mentions: 30 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Animals Cells
Association of Mild to Moderate Aortic Valve Stenosis Progression With Higher Lipoprotein(a) and Oxidized Phospholipid Levels: Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. 2018 12 01; 3(12):1212-1217. Capoulade R, Yeang C, Chan KL, Pibarot P, Tsimikas S. PMID: 30476957; PMCID: PMC6583098.

View in: PubMed Mentions: 33 Fields:
Car Cardiology
Translation:Humans Cells
Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 09; 561(7724):E43. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 30013121.

View in: PubMed Mentions: 4 Fields:
Sci Science
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature. 2018 06; 558(7709):301-306. Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL. PMID: 29875409; PMCID: PMC6033669.

View in: PubMed Mentions: 183 Fields:
Sci Science
Translation:Animals Cells
Relationship between "LDL-C", estimated true LDL-C, apolipoprotein B-100, and PCSK9 levels following lipoprotein(a) lowering with an antisense oligonucleotide. J Clin Lipidol. 2018 May - Jun; 12(3):702-710. Viney NJ, Yeang C, Yang X, Xia S, Witztum JL, Tsimikas S. PMID: 29574075.

View in: PubMed Mentions: 15 Fields:
Bio Biochemistry Met Metabolism
Translation:Humans CTClinical Trials
PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol. 2018 01 23; 71(3):321-335. Senders ML, Que X, Cho YS, Yeang C, Groenen H, Fay F, Calcagno C, Meerwaldt AE, Green S, Miu P, Lobatto ME, Reiner T, Fayad ZA, Witztum JL, Mulder WJM, Pérez-Medina C, Tsimikas S. PMID: 29348025; PMCID: PMC5995462.

View in: PubMed Mentions: 21 Fields:
Car Cardiology
Translation:Humans Animals
Lipoprotein(a) Associated Molecules are Prominent Components in Plasma and Valve Leaflets in Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2017 Jun; 2(3):229-240. Torzewski M, Ravandi A, Yeang C, Edel A, Bhindi R, Kath S, Twardowski L, Schmid J, Yang X, Franke UFW, Witztum JL, Tsimikas S. PMID: 29147686; PMCID: PMC5685511.

View in: PubMed Mentions: 38
Novel Lipoprotein(a) Catabolism Pathway via Apolipoprotein(a) Recycling: Adding the Plasminogen Receptor PlgRKT to the List. Circ Res. 2017 03 31; 120(7):1050-1052. Yeang C, Gordts PL, Tsimikas S. PMID: 28360338; PMCID: PMC5470738.

View in: PubMed Mentions: 7 Fields:
Car Cardiology Vas Vascular Diseases
The Prevalence of Lipoprotein(a) Measurement and Degree of Elevation Among 2710 Patients With Calcific Aortic Valve Stenosis in an Academic Echocardiography Laboratory Setting. Angiology. 2017 Oct; 68(9):795-798. Wilkinson MJ, Ma GS, Yeang C, Ang L, Strachan M, DeMaria AN, Tsimikas S, Cotter B. PMID: 28068801.

View in: PubMed Mentions: 4 Fields:
Vas Vascular Diseases
Translation:Humans
Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: Implications for clinical practice interpretation of Lp(a)-mediated risk. J Clin Lipidol. 2016 Nov - Dec; 10(6):1389-1396. Yeang C, Clopton PC, Tsimikas S. PMID: 27919356; PMCID: PMC8545497.

View in: PubMed Mentions: 11 Fields:
Bio Biochemistry Met Metabolism
Translation:Humans
Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans. Circulation. 2016 Aug 23; 134(8):611-24. van der Valk FM, Bekkering S, Kroon J, Yeang C, Van den Bossche J, van Buul JD, Ravandi A, Nederveen AJ, Verberne HJ, Scipione C, Nieuwdorp M, Joosten LA, Netea MG, Koschinsky ML, Witztum JL, Tsimikas S, Riksen NP, Stroes ES. PMID: 27496857; PMCID: PMC4995139.

View in: PubMed Mentions: 183 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Cells CTClinical Trials
Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis. Curr Opin Cardiol. 2016 07; 31(4):440-50. Yeang C, Wilkinson MJ, Tsimikas S. PMID: 27205885; PMCID: PMC4956483.

View in: PubMed Mentions: 24 Fields:
Car Cardiology
Translation:Humans
PCSK9 Association With Lipoprotein(a). Circ Res. 2016 06 24; 119(1):29-35. Tavori H, Christian D, Minnier J, Plubell D, Shapiro MD, Yeang C, Giunzioni I, Croyal M, Duell PB, Lambert G, Tsimikas S, Fazio S. PMID: 27121620; PMCID: PMC4920709.

View in: PubMed Mentions: 40 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals Cells
The role of lipoprotein(a) in progression of renal disease: Causality or reverse causality? J Diabetes Complications. 2016 07; 30(5):755-7. Yeang C, Tsimikas S. PMID: 27118508.

View in: PubMed Mentions: Fields:
End Endocrinology
Translation:Humans
Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a). J Clin Lipidol. 2016 May-Jun; 10(3):594-603. Yeang C, Hung MY, Byun YS, Clopton P, Yang X, Witztum JL, Tsimikas S. PMID: 27206947.

View in: PubMed Mentions: 33 Fields:
Bio Biochemistry Met Metabolism
Translation:Humans Cells
Experimental Animal Models Evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and Aortic Stenosis. Cardiovasc Drugs Ther. 2016 Feb; 30(1):75-85. Yeang C, Cotter B, Tsimikas S. PMID: 26780907.

View in: PubMed Mentions: 12 Fields:
Car Cardiology Dru Drug Therapy Vas Vascular Diseases
Translation:Humans Animals
Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis. J Am Coll Cardiol. 2015 Sep 15; 66(11):1236-1246. Capoulade R, Chan KL, Yeang C, Mathieu P, Bossé Y, Dumesnil JG, Tam JW, Teo KK, Mahmut A, Yang X, Witztum JL, Arsenault BJ, Després JP, Pibarot P, Tsimikas S. PMID: 26361154.

View in: PubMed Mentions: 130 Fields:
Car Cardiology
Translation:Humans Cells
'LDL-C' = LDL-C + Lp(a)-C: implications of achieved ultra-low LDL-C levels in the proprotein convertase subtilisin/kexin type 9 era of potent LDL-C lowering. Curr Opin Lipidol. 2015 Jun; 26(3):169-78. Yeang C, Witztum JL, Tsimikas S. PMID: 25943842.

View in: PubMed Mentions: 42 Fields:
Bio Biochemistry
Translation:Humans Animals
HDL-C, ABCA1-mediated cholesterol efflux, and lipoprotein(a): insights into a potential novel physiologic role of lipoprotein(a). J Lipid Res. 2015 Jul; 56(7):1241-4. Yeang C, Tsimikas S. PMID: 26014961; PMCID: PMC4479328.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Humans Cells
Imaging of oxidation-specific epitopes with targeted nanoparticles to detect high-risk atherosclerotic lesions: progress and future directions. J Cardiovasc Transl Res. 2014 Nov; 7(8):719-36. Briley-Saebo K, Yeang C, Witztum JL, Tsimikas S. PMID: 25297940; PMCID: PMC4233166.

View in: PubMed Mentions: 9 Fields:
Car Cardiology Vas Vascular Diseases
Translation:Humans Animals
Subcellular targeting domains of sphingomyelin synthase 1 and 2. Nutr Metab (Lond). 2011 Dec 14; 8:89. Yeang C, Ding T, Chirico WJ, Jiang XC. PMID: 22168400; PMCID: PMC3264500.

View in: PubMed Mentions: 12
Role of phospholipid transfer protein in high-density lipoprotein- mediated reverse cholesterol transport. Curr Atheroscler Rep. 2011 Jun; 13(3):242-8. Yazdanyar A, Yeang C, Jiang XC. PMID: 21365262; PMCID: PMC3085729.

View in: PubMed Mentions: 21 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3):L430-40. Gowda S, Yeang C, Wadgaonkar S, Anjum F, Grinkina N, Cutaia M, Jiang XC, Wadgaonkar R. PMID: 21191108; PMCID: PMC3284317.

View in: PubMed Mentions: 23 Fields:
Cel Cell Biology Mol Molecular Biology Phy Physiology Pul Pulmonary Medicine
Translation:Animals Cells
Diet-induced lipid accumulation in phospholipid transfer protein-deficient mice: its atherogenicity and potential mechanism. J Lipid Res. 2010 Oct; 51(10):2993-3002. Yeang C, Qin S, Chen K, Wang DQ, Jiang XC. PMID: 20543142; PMCID: PMC2936749.

View in: PubMed Mentions: 3 Fields:
Bio Biochemistry
Translation:Animals
The domain responsible for sphingomyelin synthase (SMS) activity. Biochim Biophys Acta. 2008 Oct; 1781(10):610-7. Yeang C, Varshney S, Wang R, Zhang Y, Ye D, Jiang XC. PMID: 18694848; PMCID: PMC3426831.

View in: PubMed Mentions: 28 Fields:
Bio Biochemistry Bio Biophysics
Translation:Humans Cells
Phospholipid transfer protein-deficient mice absorb less cholesterol. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):2014-21. Liu R, Iqbal J, Yeang C, Wang DQ, Hussain MM, Jiang XC. PMID: 17641249.

View in: PubMed Mentions: 17 Fields:
Vas Vascular Diseases
Translation:Animals Cells