Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Bruce Hamilton

    TitleProfessor
    SchoolUniversity of California, San Diego
    DepartmentMedicine
    Address9500 Gilman Drive #0644
    CA La Jolla 92093
    Phone858-822-1055
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      1999 - 2003Pew Scholar in the Biomedical Sciences
      Office of National Drug Control Policy2001Certificate of Appreciation
      March of Dimes1999 - 2001Basil O’Connor Starter Scholars Award
      1993 - 1996Helen Hay Whitney Foundation Fellowship

      Collapse Research 
      Collapse Research Activities and Funding
      Zfp423 Mechanisms in Joubert Syndrome and Related Disorders
      NIH R01NS097534Feb 1, 2017 - Jan 31, 2022
      Role: Principal Investigator
      Mouse models of ZNF804A
      NIH R21MH109960Apr 15, 2016 - Mar 31, 2018
      Role: Principal Investigator
      Synthetic Lethal Modifier of a New Ciliopathy Gene
      NIH R01GM102958Jul 27, 2012 - Apr 30, 2016
      Role: Principal Investigator
      Genetic Analysis of Neural Stem Cells
      NIH R01NS060109Dec 15, 2007 - Nov 30, 2013
      Role: Principal Investigator
      Genetic Mechanisms in Cerebellum Malformations
      NIH R01NS054871May 7, 2007 - Mar 31, 2013
      Role: Principal Investigator
      Sympathetic Neuroeffector Junctions &Blood Pressure
      NIH P01HL058120Jun 1, 1999 - May 31, 2012
      Role: Co-Investigator
      Genetic Modifier Activity and Network Properties of Nxf1
      NIH R01GM086912Dec 1, 1998 - Dec 31, 2020
      Role: Principal Investigator
      GENETIC DISSECTION OF A NEURODEGENERATION PATHWAY
      NIH R01MH059207Dec 1, 1998 - Nov 30, 2009
      Role: Principal Investigator
      Training Program in Basic and Clinical Genetics
      NIH T32GM008666Jul 1, 1998 - Jun 30, 2017
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Benyamin B, Maihofer AX, Schork AJ, Hamilton B, Rao F, Schmid-SchÖnbein GW, Zhang K, Mahata M, Stridsberg M, Schork NJ, Biswas N, Hook VY, Wei Z, Montgomery GW, Martin NG, Nievergelt CM, Whitfield JB, O'Connor DT. Identification of Novel Loci Affecting Circulating Chromogranins and Related Peptides. Hum Mol Genet. 2016 Dec 22. PMID: 28011710.
        View in: PubMed
      2. Hamilton B. Deep Reads: Favorites from a Few Different Shelves. PLoS Genet. 2016 Dec; 12(12):e1006476. PMID: 27977693.
        View in: PubMed
      3. Thomas GD, Hanna RN, Vasudevan NT, Hamers AA, Romanoski CE, McArdle S, Ross KD, Blatchley A, Yoakum D, Hamilton B, Mikulski Z, Jain MK, Glass CK, Hedrick CC. Deleting an Nr4a1 Super-Enhancer Subdomain Ablates Ly6C(low) Monocytes while Preserving Macrophage Gene Function. Immunity. 2016 Oct 31. PMID: 27814941.
        View in: PubMed
      4. Hong CJ, Hamilton B. Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. PLoS Genet. 2016 Oct; 12(10):e1006357. PMID: 27727273.
        View in: PubMed
      5. Zhang S, Ross KD, Seidner GA, Gorman MR, Poon TH, Wang X, Keithley EM, Lee PN, Martindale MQ, Joiner WJ, Hamilton B. Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies. PLoS Genet. 2015 Jul; 11(7):e1005344. PMID: 26131556.
        View in: PubMed
      6. Concepcion D, Ross KD, Hutt KR, Yeo GW, Hamilton B. Nxf1 natural variant E610G is a semi-dominant suppressor of IAP-induced RNA processing defects. PLoS Genet. 2015 Apr; 11(4):e1005123. PMID: 25835743.
        View in: PubMed
      7. Martindale VE, Hamilton B. Bringing evidence to the practice of human performance. Aerosp Med Hum Perform. 2015 Jan; 86(1):64-6. PMID: 25565539.
        View in: PubMed
      8. Hilliard N, Fassett WE, Hamilton B. Report of the Academy Presidents: Leading key initiatives as part of APhA's strategic plan. J Am Pharm Assoc (2003). 2014 Mar-Apr; 54(2):102-20. PMID: 24632926.
        View in: PubMed
      9. Radley JJ, Anderson RM, Hamilton B, Alcock JA, Romig-Martin SA. Chronic stress-induced alterations of dendritic spine subtypes predict functional decrements in an hypothalamo-pituitary-adrenal-inhibitory prefrontal circuit. J Neurosci. 2013 Sep 4; 33(36):14379-91. PMID: 24005291.
        View in: PubMed
      10. Cho YW, Hong CJ, Hou A, Gent PM, Zhang K, Won KJ, Hamilton B. Zfp423 binds autoregulatory sites in p19 cell culture model. PLoS One. 2013; 8(6):e66514. PMID: 23762491.
        View in: PubMed
      11. Hamilton B. Retrotransposon activates ectopic Ptf1 expression: a short tail. PLoS Genet. 2013; 9(2):e1003331. PMID: 23468657.
        View in: PubMed
      12. Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, Wang H, Hurd TW, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CJ, Hamilton B, Cervenka I, Ganji RS, Bryja V, Arts HH, van Reeuwijk J, Oud MM, Letteboer SJ, Roepman R, Husson H, Ibraghimov-Beskrovnaya O, Yasunaga T, Walz G, Eley L, Sayer JA, Schermer B, Liebau MC, Benzing T, Le Corre S, Drummond I, Janssen S, Allen SJ, Natarajan S, O'Toole JF, Attanasio M, Saunier S, Antignac C, Koenekoop RK, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson JG, Andreoli SP, Doherty DG, Lindstrad A, Golzio C, Katsanis N, Pape L, Abboud EB, Al-Rajhi AA, Lewis RA, Omran H, Lee EY, Wang S, Sekiguchi JM, Saunders R, Johnson CA, Garner E, Vanselow K, Andersen JS, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto EA, Hildebrandt F. Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell. 2012 Aug 3; 150(3):533-48. PMID: 22863007.
        View in: PubMed
      13. Hamilton B, Yu BD. Modifier genes and the plasticity of genetic networks in mice. PLoS Genet. 2012; 8(4):e1002644. PMID: 22511884.
        View in: PubMed
      14. Hamilton B, Fu XD. Tracking intron removal in real time. Dev Cell. 2011 Dec 13; 21(6):979-80. PMID: 22172665.
        View in: PubMed
      15. Rao F, Chiron S, Wei Z, Fung MM, Chen Y, Wen G, Khandrika S, Ziegler MG, Benyamin B, Montgomery G, Whitfield JB, Martin NG, Waalen J, Hamilton B, Mahata SK, O'Connor DT. Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins. Am J Hypertens. 2012 Jan; 25(1):29-40. PMID: 21918574.
        View in: PubMed
      16. Alcaraz WA, Chen E, Valdes P, Kim E, Lo YH, Vo J, Hamilton B. Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice. Hum Mol Genet. 2011 Oct 1; 20(19):3822-30. PMID: 21729880.
        View in: PubMed
      17. Concepcion D, Johannes F, Lo YH, Yao J, Fong J, Hamilton B. Modifier genes for mouse phosphatidylinositol transfer protein a (vibrator) that bypass juvenile lethality. Genetics. 2011 Apr; 187(4):1185-91. PMID: 21321132.
        View in: PubMed
      18. Zhang K, Chen Y, Wen G, Mahata M, Rao F, Fung MM, Vaingankar S, Biswas N, Gayen JR, Friese RS, Mahata SK, Hamilton B, O'Connor DT. Catecholamine storage vesicles: role of core protein genetic polymorphisms in hypertension. Curr Hypertens Rep. 2011 Feb; 13(1):36-45. PMID: 21104344.
        View in: PubMed
      19. Hamilton B, Naismith SL, Scott EM, Purcell S, Hickie IB. Disability is already pronounced in young people with early stages of affective disorders: data from an early intervention service. J Affect Disord. 2011 Jun; 131(1-3):84-91. PMID: 21112640.
        View in: PubMed
      20. Chen Y, Rao F, Wen G, Gayen JR, Zhang K, Vaingankar SM, Biswas N, Mahata M, Friese RS, Fung MM, Salem RM, Nievergelt C, Bhatnagar V, Hook VY, Ziegler MG, Mahata SK, Hamilton B, O'Connor DT. Naturally occurring genetic variants in human chromogranin A (CHGA) associated with hypertension as well as hypertensive renal disease. Cell Mol Neurobiol. 2010 Nov; 30(8):1395-400. PMID: 21061160.
        View in: PubMed
      21. Chen Y, Salem RM, Rao F, Fung MM, Bhatnagar V, Pandey B, Mahata M, Waalen J, Nievergelt CM, Lipkowitz MS, Hamilton B, Mahata SK, O'Connor DT. Common charge-shift mutation Glu65Lys in K+ channel ß1-Subunit KCNMB1: pleiotropic consequences for glomerular filtration rate and progressive renal disease. Am J Nephrol. 2010; 32(5):414-24. PMID: 20861615.
        View in: PubMed
      22. Chen Y, Zhang K, Wen G, Rao F, Sanchez AP, Wang L, Rodriguez-Flores JL, Mahata M, Mahata SK, Waalen J, Ziegler MG, Hamilton B, O'Connor DT. Human dopamine ß-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure. Am J Hypertens. 2011 Jan; 24(1):24-32. PMID: 20814407.
        View in: PubMed
      23. McCance DR, Holmes VA, Maresh MJ, Patterson CC, Walker JD, Pearson DW, Young IS. Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet. 2010 Jul 24; 376(9737):259-66. PMID: 20580423.
        View in: PubMed
      24. Rodríguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, Mahata SK, Subramaniam S, Hamilton B, O'Connor DT. Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach. Mamm Genome. 2010 Apr; 21(3-4):195-204. PMID: 20204374.
        View in: PubMed
      25. Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, Sanchez AP, Mahata M, Taupenot L, Sun P, Mahata SK, Tayo B, Schork NJ, Ziegler MG, Hamilton B, O'Connor DT. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. J Hypertens. 2010 Jan; 28(1):76-86. PMID: 20009769.
        View in: PubMed
      26. Hamilton B. Letter to the editor on "Threonine 53 in alpha-synuclein is conserved in long-living non-primate animals". Biochem Biophys Res Commun. 2010 Jan 1; 391(1):1154. PMID: 19903454.
        View in: PubMed
      27. Shih PA, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton B, O'Connor DT. Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab. 2009 Nov; 94(11):4557-66. PMID: 19820027.
        View in: PubMed
      28. Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, Waalen J, Cockburn MG, Hamilton B, Mahata SK, O'Connor DT. Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. J Am Coll Cardiol. 2009 Sep 1; 54(10):944-54. PMID: 19712806.
        View in: PubMed
      29. Chen Y, Mahata M, Rao F, Khandrika S, Courel M, Fung MM, Zhang K, Stridsberg M, Ziegler MG, Hamilton B, Lipkowitz MS, Taupenot L, Nievergelt C, Mahata SK, O'Connor DT. Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis. J Am Soc Nephrol. 2009 Jul; 20(7):1623-32. PMID: 19520754.
        View in: PubMed
      30. Concepcion D, Flores-García L, Hamilton B. Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet. 2009 May; 5(5):e1000484. PMID: 19436707.
        View in: PubMed
      31. Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, Vaingankar SM, Wen G, Salem RM, Das M, Cockburn MG, Schork NJ, Ziegler MG, Hamilton B, Mahata SK, Taupenot L, O'Connor DT. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81. PMID: 19017515.
        View in: PubMed
      32. Chen Y, Rao F, Rodriguez-Flores JL, Mahapatra NR, Mahata M, Wen G, Salem RM, Shih PA, Das M, Schork NJ, Ziegler MG, Hamilton B, Mahata SK, O'Connor DT. Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure. Kidney Int. 2008 Jul; 74(1):115-25. PMID: 18432188.
        View in: PubMed
      33. Salem RM, Cadman PE, Chen Y, Rao F, Wen G, Hamilton B, Rana BK, Smith DW, Stridsberg M, Ward HJ, Mahata M, Mahata SK, Bowden DW, Hicks PJ, Freedman BI, Schork NJ, O'Connor DT. Chromogranin A polymorphisms are associated with hypertensive renal disease. J Am Soc Nephrol. 2008 Mar; 19(3):600-14. PMID: 18235090.
        View in: PubMed
      34. Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, Mahata SK, Gent PM, Das M, Cooper RS, Chakravarti A, Zhou H, Schork NJ, O'connor DT, Hamilton B. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet. 2007 Jul 15; 16(14):1752-64. PMID: 17584765.
        View in: PubMed
      35. Harold D, Jehu L, Turic D, Hollingworth P, Moore P, Summerhayes P, Moskvina V, Foy C, Archer N, Hamilton B, Lovestone S, Powell J, Brayne C, Rubinsztein DC, Jones L, O'Donovan MC, Owen MJ, Williams J. Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5; 144B(4):448-52. PMID: 17440933.
        View in: PubMed
      36. Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, Mahata M, Kennedy BP, Salem RM, Stridsberg M, Abel K, Smith DW, Eskin E, Schork NJ, Hamilton B, Ziegler MG, Mahata SK, O'Connor DT. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation. 2007 May 1; 115(17):2271-81. PMID: 17438154.
        View in: PubMed
      37. Rao F, Wessel J, Wen G, Zhang L, Rana BK, Kennedy BP, Greenwood TA, Salem RM, Chen Y, Khandrika S, Hamilton B, Smith DW, Holstein-Rathlou NH, Ziegler MG, Schork NJ, O'Connor DT. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism. Hypertension. 2007 May; 49(5):1015-31. PMID: 17353515.
        View in: PubMed
      38. Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, Rana BK, Kennedy BP, Khandrika S, Huang P, Lillie EO, Shih PA, Smith DW, Wen G, Hamilton B, Ziegler MG, Witztum JL, Schork NJ, Schmid-Schönbein GW, O'Connor DT. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci. J Hypertens. 2007 Feb; 25(2):329-43. PMID: 17211240.
        View in: PubMed
      39. Comer DM, Sharpe PC, Hull D, Hamilton B. A myeloproliferative disease and pseudohyperkalaemia. Br J Hosp Med (Lond). 2007 Jan; 68(1):47. PMID: 17260719.
        View in: PubMed
      40. Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton B. Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19424-9. PMID: 17151198.
        View in: PubMed
      41. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, Mahapatra NR, Lillie EO, Cadman PE, Friese RS, Hamilton B, Hook VY, Mahata SK, Taupenot L, O'Connor DT. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006 Nov; 8(6):621-33. PMID: 17026486.
        View in: PubMed
      42. Bhatnagar V, Xu G, Hamilton B, Truong DM, Eraly SA, Wu W, Nigam SK. Analyses of 5' regulatory region polymorphisms in human SLC22A6 (OAT1) and SLC22A8 (OAT3). J Hum Genet. 2006; 51(6):575-80. PMID: 16648942.
        View in: PubMed
      43. Gold DA, Gent PM, Hamilton B. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res. 2007 Apr 6; 1140:19-25. PMID: 16427031.
        View in: PubMed
      44. Xu G, Bhatnagar V, Wen G, Hamilton B, Eraly SA, Nigam SK. Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)]. Kidney Int. 2005 Oct; 68(4):1491-9. PMID: 16164626.
        View in: PubMed
      45. Concepcion D, Seburn KL, Wen G, Frankel WN, Hamilton B. Mutation rate and predicted phenotypic target sizes in ethylnitrosourea-treated mice. Genetics. 2004 Oct; 168(2):953-9. PMID: 15514066.
        View in: PubMed
      46. Mahata SK, Mahata M, Wen G, Wong WB, Mahapatra NR, Hamilton B, O'Connor DT. The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. Mol Pharmacol. 2004 Nov; 66(5):1180-91. PMID: 15326220.
        View in: PubMed
      47. Hamilton B. alpha-Synuclein A53T substitution associated with Parkinson disease also marks the divergence of Old World and New World primates. Genomics. 2004 Apr; 83(4):739-42. PMID: 15028296.
        View in: PubMed
      48. Wen G, Mahata SK, Cadman P, Mahata M, Ghosh S, Mahapatra NR, Rao F, Stridsberg M, Smith DW, Mahboubi P, Schork NJ, O'Connor DT, Hamilton B. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. Am J Hum Genet. 2004 Feb; 74(2):197-207. PMID: 14740315.
        View in: PubMed
      49. Gold DA, Baek SH, Schork NJ, Rose DW, Larsen DD, Sachs BD, Rosenfeld MG, Hamilton B. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003 Dec 18; 40(6):1119-31. PMID: 14687547.
        View in: PubMed
      50. Floyd JA, Gold DA, Concepcion D, Poon TH, Wang X, Keithley E, Chen D, Ward EJ, Chinn SB, Friedman RA, Yu HT, Moriwaki K, Shiroishi T, Hamilton B. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Nat Genet. 2003 Nov; 35(3):221-8. PMID: 14517553.
        View in: PubMed
      51. Alb JG, Cortese JD, Phillips SE, Albin RL, Nagy TR, Hamilton B, Bankaitis VA. Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J Biol Chem. 2003 Aug 29; 278(35):33501-18. PMID: 12788952.
        View in: PubMed
      52. Eraly SA, Hamilton B, Nigam SK. Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. Biochem Biophys Res Commun. 2003 Jan 10; 300(2):333-42. PMID: 12504088.
        View in: PubMed
      Bruce's Networks
      Concepts
      Derived automatically from this person's publications.
      _
      Co-Authors
      People in Profiles who have published with this person.
      _
      Similar People
      People who share similar concepts with this person.
      _
      Same Department
      Physical Neighbors
      People whose addresses are nearby this person.
      _